LOCUS       NM_182628               2117 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cilia and flagella associated protein 100 (CFAP100),
            mRNA.
ACCESSION   NM_182628
VERSION     NM_182628.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2117)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2117)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2117)
  AUTHORS   Sigg,M.A., Menchen,T., Lee,C., Johnson,J., Jungnickel,M.K.,
            Choksi,S.P., Garcia,G. 3rd, Busengdal,H., Dougherty,G.W.,
            Pennekamp,P., Werner,C., Rentzsch,F., Florman,H.M., Krogan,N.,
            Wallingford,J.B., Omran,H. and Reiter,J.F.
  TITLE     Evolutionary Proteomics Uncovers Ancient Associations of Cilia with
            Signaling Pathways
  JOURNAL   Dev Cell 43 (6), 744-762 (2017)
   PUBMED   29257953
REFERENCE   4  (bases 1 to 2117)
  AUTHORS   Yamamoto,R., Song,K., Yanagisawa,H.A., Fox,L., Yagi,T.,
            Wirschell,M., Hirono,M., Kamiya,R., Nicastro,D. and Sale,W.S.
  TITLE     The MIA complex is a conserved and novel dynein regulator essential
            for normal ciliary motility
  JOURNAL   J Cell Biol 201 (2), 263-278 (2013)
   PUBMED   23569216
REFERENCE   5  (bases 1 to 2117)
  AUTHORS   Kwon,Y.J., Lee,S.J., Koh,J.S., Kim,S.H., Lee,H.W., Kang,M.C.,
            Bae,J.B., Kim,Y.J. and Park,J.H.
  TITLE     Genome-wide analysis of DNA methylation and the gene expression
            change in lung cancer
  JOURNAL   J Thorac Oncol 7 (1), 20-33 (2012)
   PUBMED   22011669
  REMARK    GeneRIF: We confirmed that the expression of CCDC37 in squamous
            cell carcinoma is regulated by DNA methylation of its specific
            promoter region.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC063919.15, AK097402.1, BC101367.2 and AC073439.26.
            
            On Nov 23, 2018 this sequence version replaced NM_182628.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK097402.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000352312.6/ ENSP00000344749.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC063919.15        35943-35972         c
            31-234              AK097402.1         1-204
            235-1362            BC101367.2         135-1262
            1363-2116           AK097402.1         1333-2086
            2117-2117           AC073439.26        7671-7671
FEATURES             Location/Qualifiers
     source          1..2117
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.3"
     gene            1..2117
                     /gene="CFAP100"
                     /gene_synonym="CCDC37; MIA1"
                     /note="cilia and flagella associated protein 100"
                     /db_xref="GeneID:348807"
                     /db_xref="HGNC:HGNC:26842"
     exon            1..70
                     /gene="CFAP100"
                     /gene_synonym="CCDC37; MIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            71..178
                     /gene="CFAP100"
                     /gene_synonym="CCDC37; MIA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1965
                     /gene="CFAP100"
                     /gene_synonym="CCDC37; MIA1"
                     /note="coiled-coil domain-containing protein 37;
                     coiled-coil domain containing 37"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 100"
                     /protein_id="NP_872434.2"
                     /db_xref="CCDS:CCDS3037.1"
                     /db_xref="GeneID:348807"
                     /db_xref="HGNC:HGNC:26842"
                     /translation="MSEIPSTIVSKNMTNDKNSLESMNISSSSSTEENPKKQARKNEE
                     HGPDPSANPFHLSGDVDFFLLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSL
                     RRQLQLEDKQEDLEARAEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFL
                     LQYALDVKRREIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAA
                     EKETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQE
                     KKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMR
                     LGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLD
                     VFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKE
                     EDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLT
                     IIEHQLDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARAR
                     AQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEEELLFFFT"
     exon            179..259
                     /gene="CFAP100"
                     /gene_synonym="CCDC37; MIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..354
                     /gene="CFAP100"
                     /gene_synonym="CCDC37; MIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            355..547
                     /gene="CFAP100"
                     /gene_synonym="CCDC37; MIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            548..615
                     /gene="CFAP100"
                     /gene_synonym="CCDC37; MIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            616..779
                     /gene="CFAP100"
                     /gene_synonym="CCDC37; MIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..860
                     /gene="CFAP100"
                     /gene_synonym="CCDC37; MIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1042
                     /gene="CFAP100"
                     /gene_synonym="CCDC37; MIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1084
                     /gene="CFAP100"
                     /gene_synonym="CCDC37; MIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1211
                     /gene="CFAP100"
                     /gene_synonym="CCDC37; MIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1263
                     /gene="CFAP100"
                     /gene_synonym="CCDC37; MIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1415
                     /gene="CFAP100"
                     /gene_synonym="CCDC37; MIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1551
                     /gene="CFAP100"
                     /gene_synonym="CCDC37; MIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1757
                     /gene="CFAP100"
                     /gene_synonym="CCDC37; MIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1851
                     /gene="CFAP100"
                     /gene_synonym="CCDC37; MIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2117
                     /gene="CFAP100"
                     /gene_synonym="CCDC37; MIA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2096..2101
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP100"
                     /gene_synonym="CCDC37; MIA1"
                     /note="hexamer: AATAAA"
     polyA_site      2117
                     /gene="CFAP100"
                     /gene_synonym="CCDC37; MIA1"
                     /note="major polyA site"
ORIGIN      
        1 aagagccctg ctcctggagc tgagaactgc agcgcggagg cttcggagcg agccggggca
       61 gtcggggtcg gtgaggatct cctttagaag aggagaagcc ttgcatcaac ctcttgggcc
      121 tcagccaaga tgtctgagat accgtccact atagtctcca agaacatgac caatgacaag
      181 aacagcctgg aatccatgaa catcagctct tcttcaagca ctgaagagaa cccaaagaaa
      241 caggcaagaa aaaacgaaga acatggtcct gacccttcag cgaacccttt ccacttatct
      301 ggggatgtgg atttcttctt gctcagagat caggagcgga ataaggctct ctccgaacgg
      361 cagcagcaga agacgatgcg ggtgcaccag aagatgacct actcctcgaa agtgtcggct
      421 aagcacacca gcctgcggcg gcagctgcag ctggaggaca agcaggagga cctggaggcg
      481 cgcgccgagg ccgagcatca gcgcgccttc cgcgactaca cgacctggaa gctcaccttg
      541 accaaagaaa agaatgtgga gcctgagaac atgagtggct acattaagca gaagcggcaa
      601 atgttcctcc tccagtatgc cctggatgtc aagcggagag agatccagcg gctggagacg
      661 ctggcgacca aagaggaggc caggctggag cgggccgaga aatccctgga gaaggacgcc
      721 gccttgttcg acgagttcgt cagggagaat gactgcagct ccgtgcaggc catgagagcg
      781 gctgagaagg agaccaaagc caagatagag aagatccttg agatccggga cctcaccacc
      841 cagattgtta atatcaaaag tgagatctcc agatttgaag acactctgaa gcattacaag
      901 gtctataagg atttcctata caagctgtcg cccaaggagt ggcttgaaga acaggaaaag
      961 aaacactcgt ttctcaaaaa ggccaaggag gtctccgagg cttccaaaga gagcagtgtt
     1021 aactccacac caggggacaa aggaccaggg atcaagggca aggcgagctc catgtgggcc
     1081 aaagagggtc agggtacaaa gaagccctgg aggtttctgc agacgatgcg gctggggcgg
     1141 agcccgtctt acctgagcag cccccagcaa ggcagccagc ccagcgagtc cagcggtggc
     1201 gactccagag ggtcgaactc tcccatcccc cccacgcagg aggacaccga cagcgatggg
     1261 gaggaaccac agctgtactt cacggagccc cagcagctcc tggatgtctt ccgagagctg
     1321 gaggagcaga acctgtcgct gatccagaac agccaggaga cggagaagac cctggaggag
     1381 ctgagccaca ccctgaaaca cacccagatc cgcatggaca gggaggtcaa ccagctgaag
     1441 cagtgggtca ccacaatgat gatgtccatc accaaggagg aggacacagc agctgagctg
     1501 gagctcaaag cccgagtctt ccacttcggc gagtacaagg gcgatcagca ggataagctg
     1561 ctagagagcc tgaactgcaa ggtgctggat gtgtaccggc actgcaccgg cacccagcag
     1621 gaggccaacc tgggcaccgt gcagatgctg accatcattg agcaccagct ggatgagctg
     1681 ctagagaacc tggagcacgt gccccaggtc aagatcgagc aggccgagag ggcaaaggag
     1741 aaggagcggc gcatcagact tcgagaagag aagctccaga tgcaaaagat cctacaggag
     1801 gagcatctgc agcgggcccg ggcgcgcgcc caggctgaga tcaagaagaa gagaggcagg
     1861 acactggtat gccgctcacg acccccagcc cacaggatca aacaacagtc tgagcacaca
     1921 ctgatggaca aggaggagga ggagctgcta tttttcttta cttaatcttc gcagaccata
     1981 gctgttctgg ctgaaggctt agcaaagatg ttggcagagg aagcagagac tgggctgggt
     2041 ctcgagtggc ccaactgagt cctctctgtc tcctgtgtgc tcccttcctc acctgaataa
     2101 attcatgtct ctctgga
//
