LOCUS       NM_004344               1413 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens centrin 2 (CETN2), mRNA.
ACCESSION   NM_004344
VERSION     NM_004344.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1413)
  AUTHORS   Arslanhan,M.D., Cengiz-Emek,S., Odabasi,E., Steib,E., Hamel,V.,
            Guichard,P. and Firat-Karalar,E.N.
  TITLE     CCDC15 localizes to the centriole inner scaffold and controls
            centriole length and integrity
  JOURNAL   J Cell Biol 222 (12) (2023)
   PUBMED   37934472
REFERENCE   2  (bases 1 to 1413)
  AUTHORS   Qiu,P.Y., Deng,X.H. and Li,L.
  TITLE     High expression of CETN2 is associated with platinum resistance and
            poor prognosis in epithelial ovarian cancer
  JOURNAL   Clin Transl Oncol 25 (5), 1340-1352 (2023)
   PUBMED   36527574
  REMARK    GeneRIF: High expression of CETN2 is associated with platinum
            resistance and poor prognosis in epithelial ovarian cancer.
REFERENCE   3  (bases 1 to 1413)
  AUTHORS   O'Neill,A.C., Uzbas,F., Antognolli,G., Merino,F., Draganova,K.,
            Jack,A., Zhang,S., Pedini,G., Schessner,J.P., Cramer,K.,
            Schepers,A., Metzger,F., Esgleas,M., Smialowski,P., Guerrini,R.,
            Falk,S., Feederle,R., Freytag,S., Wang,Z., Bahlo,M., Jungmann,R.,
            Bagni,C., Borner,G.H.H., Robertson,S.P., Hauck,S.M. and Gotz,M.
  TITLE     Spatial centrosome proteome of human neural cells uncovers
            disease-relevant heterogeneity
  JOURNAL   Science 376 (6599), eabf9088 (2022)
   PUBMED   35709258
REFERENCE   4  (bases 1 to 1413)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 1413)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   6  (bases 1 to 1413)
  AUTHORS   Wolfrum,U. and Salisbury,J.L.
  TITLE     Expression of centrin isoforms in the mammalian retina
  JOURNAL   Exp Cell Res 242 (1), 10-17 (1998)
   PUBMED   9665797
REFERENCE   7  (bases 1 to 1413)
  AUTHORS   Chatterjee,A., Tanaka,T., Parrish,J.E. and Herman,G.E.
  TITLE     Refined mapping of caltractin in human Xq28 and in the homologous
            region of the mouse X chromosome places the gene within the bare
            patches (Bpa) and striated (Str) critical regions
  JOURNAL   Mamm Genome 6 (11), 802-804 (1995)
   PUBMED   8597638
REFERENCE   8  (bases 1 to 1413)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
REFERENCE   9  (bases 1 to 1413)
  AUTHORS   Tanaka,T., Okui,K. and Nakamura,Y.
  TITLE     Assignment of the human caltractin gene (CALT) to Xq28 by
            fluorescence in situ hybridization
  JOURNAL   Genomics 24 (3), 609-610 (1994)
   PUBMED   7713520
REFERENCE   10 (bases 1 to 1413)
  AUTHORS   Lee,V.D. and Huang,B.
  TITLE     Molecular cloning and centrosomal localization of human caltractin
  JOURNAL   Proc Natl Acad Sci U S A 90 (23), 11039-11043 (1993)
   PUBMED   8248209
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X72964.1 and U82671.5.
            
            On Aug 31, 2019 this sequence version replaced NM_004344.2.
            
            Summary:  Caltractin belongs to a family of calcium-binding
            proteins and is a structural component of the centrosome.  The high
            level of conservation from algae to humans and its association with
            the centrosome suggested that caltractin plays a fundamental role
            in the structure and function of the microtubule-organizing center,
            possibly required for the proper duplication and segregation of the
            centrosome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X72964.1, BC005334.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147596, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370277.5/ ENSP00000359300.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1080              X72964.1           1-1080
            1081-1413           U82671.5           115753-116085       c
FEATURES             Location/Qualifiers
     source          1..1413
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1413
                     /gene="CETN2"
                     /gene_synonym="CALT; CEN2"
                     /note="centrin 2"
                     /db_xref="GeneID:1069"
                     /db_xref="HGNC:HGNC:1867"
                     /db_xref="MIM:300006"
     exon            1..50
                     /gene="CETN2"
                     /gene_synonym="CALT; CEN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..566
                     /gene="CETN2"
                     /gene_synonym="CALT; CEN2"
                     /note="caltractin (20kD calcium-binding protein); centrin,
                     EF-hand protein, 2"
                     /codon_start=1
                     /product="centrin-2"
                     /protein_id="NP_004335.1"
                     /db_xref="CCDS:CCDS14716.1"
                     /db_xref="GeneID:1069"
                     /db_xref="HGNC:HGNC:1867"
                     /db_xref="MIM:300006"
                     /translation="MASNFKKANMASSSQRKRMSPKPELTEEQKQEIREAFDLFDADG
                     TGTIDVKELKVAMRALGFEPKKEEIKKMISEIDKEGTGKMNFGDFLTVMTQKMSEKDT
                     KEEILKAFKLFDDDETGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVSEQ
                     EFLRIMKKTSLY"
     exon            51..209
                     /gene="CETN2"
                     /gene_synonym="CALT; CEN2"
                     /inference="alignment:Splign:2.1.0"
     exon            210..338
                     /gene="CETN2"
                     /gene_synonym="CALT; CEN2"
                     /inference="alignment:Splign:2.1.0"
     exon            339..476
                     /gene="CETN2"
                     /gene_synonym="CALT; CEN2"
                     /inference="alignment:Splign:2.1.0"
     exon            477..1413
                     /gene="CETN2"
                     /gene_synonym="CALT; CEN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1058..1063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CETN2"
                     /gene_synonym="CALT; CEN2"
                     /note="hexamer: AGTAAA"
     polyA_site      1080
                     /gene="CETN2"
                     /gene_synonym="CALT; CEN2"
                     /note="major polyA site"
     regulatory      1363..1368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CETN2"
                     /gene_synonym="CALT; CEN2"
                     /note="hexamer: AATAAA"
     polyA_site      1404
                     /gene="CETN2"
                     /gene_synonym="CALT; CEN2"
     polyA_site      1413
                     /gene="CETN2"
                     /gene_synonym="CALT; CEN2"
ORIGIN      
        1 agtgtacacg tcggttgcct aacaaccggc agcggactcc tttggctatg gcctccaact
       61 ttaagaaggc aaacatggca tcaagttctc agcgaaaaag aatgagccct aagcctgagc
      121 ttactgaaga gcaaaagcag gagatccggg aagcttttga tcttttcgat gcggatggaa
      181 ctggcaccat agatgttaaa gaactgaagg tggcaatgag ggccctgggc tttgaaccca
      241 agaaagaaga aattaagaaa atgataagtg aaattgataa ggaagggaca ggaaaaatga
      301 actttggtga ctttttaact gtgatgaccc agaaaatgtc tgagaaagat actaaagaag
      361 aaatcctgaa agctttcaag ctctttgatg atgatgaaac tgggaagatt tcgttcaaaa
      421 atctgaaacg cgtggccaag gagttgggtg agaacctgac tgatgaggag ctgcaggaaa
      481 tgattgatga agctgatcga gatggagatg gagaggtcag tgagcaagag ttcctgcgca
      541 tcatgaaaaa gaccagcctc tattaagatc agtgtcttct ttttctactg caagcacatg
      601 taactagatt tagtgcctgc catggtgtga aatctggctt ttgagaacac aaacttttcc
      661 cccacggacc tccctttatc actttaatag tgaccttgag cctattttag ccgtttggaa
      721 gtgttctttg atattacagt tctttgtaaa atgacctgcg aattacccta attctcaaaa
      781 gcaaaacaag agcacacaag cgtgaagaaa aggatcttaa agctttgagc acctgccatt
      841 ttgccttgca tcgtttccct cgtcatgcat ttccacatat ccacaaacac agaacgactt
      901 tagacaagca catgttacac ctgtgttgcc acaagcagtc attcttgacg gctccagttt
      961 ttatttgaca cttgagttta gttttctctt ttataaaccc agtgaactcc tgcactggca
     1021 tttggatgtg tgttaatgct atttgttttg tcttaaaagt aaaacctttc tcagtttgaa
     1081 cttgtattct ctaaggatga gttctttagc tttgcttatg agttcctctt ctcaattatt
     1141 gtgttgaagg cagcctatta gatacaaaac tccttaccag cctatggaca gaaaatgaat
     1201 aatcctttgc tactttcctg gcatgaattg ctttttgcct tggaaggctg ctggtttgta
     1261 aaactagcag aatttttata tcacctaagc ctaaatgatg ctctaaaaat agttttggca
     1321 aagctaagac tggaaaagag tcttgttagt aatttgtgct tgaataaaat ggggagagcc
     1381 aggctaacgc aacactagga tggattcagc caa
//
