LOCUS       NM_004066               1735 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens centrin 1 (CETN1), mRNA.
ACCESSION   NM_004066
VERSION     NM_004066.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1735)
  AUTHORS   Sudhakar,D.V.S., Phanindranath,R., Jaishankar,S., Ramani,A.,
            Kalamkar,K.P., Kumar,U., Pawar,A.D., Dada,R., Singh,R., Gupta,N.J.,
            Deenadayal,M., Tolani,A.D., Sharma,Y., Anand,A., Gopalakrishnan,J.
            and Thangaraj,K.
  TITLE     Exome sequencing and functional analyses revealed CETN1 variants
            leads to impaired cell division and male fertility
  JOURNAL   Hum Mol Genet 32 (4), 533-542 (2023)
   PUBMED   36048845
  REMARK    GeneRIF: Exome sequencing and functional analyses revealed CETN1
            variants leads to impaired cell division and male fertility.
REFERENCE   2  (bases 1 to 1735)
  AUTHORS   Laporte,M.H., Bouhlel,I.B., Bertiaux,E., Morrison,C.G., Giroud,A.,
            Borgers,S., Azimzadeh,J., Bornens,M., Guichard,P., Paoletti,A. and
            Hamel,V.
  TITLE     Human SFI1 and Centrin form a complex critical for centriole
            architecture and ciliogenesis
  JOURNAL   EMBO J 41 (21), e112107 (2022)
   PUBMED   36125182
  REMARK    GeneRIF: Human SFI1 and Centrin form a complex critical for
            centriole architecture and ciliogenesis.
REFERENCE   3  (bases 1 to 1735)
  AUTHORS   Phanindranath,R., Sudhakar,D.V.S., Thangaraj,K. and Sharma,Y.
  TITLE     Conformational scanning of individual EF-hand motifs of calcium
            sensor protein centrin-1
  JOURNAL   Biochem Biophys Res Commun 570, 67-73 (2021)
   PUBMED   34273620
  REMARK    GeneRIF: Conformational scanning of individual EF-hand motifs of
            calcium sensor protein centrin-1.
REFERENCE   4  (bases 1 to 1735)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1735)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1735)
  AUTHORS   Tsang,W.Y., Spektor,A., Luciano,D.J., Indjeian,V.B., Chen,Z.,
            Salisbury,J.L., Sanchez,I. and Dynlacht,B.D.
  TITLE     CP110 cooperates with two calcium-binding proteins to regulate
            cytokinesis and genome stability
  JOURNAL   Mol Biol Cell 17 (8), 3423-3434 (2006)
   PUBMED   16760425
  REMARK    GeneRIF: These data demonstrate a functional role for CaM binding
            to CP110 and suggest that CP110 cooperates with CaM and centrin to
            regulate progression through cytokinesis.
REFERENCE   7  (bases 1 to 1735)
  AUTHORS   Zhao,Z.S., Lim,J.P., Ng,Y.W., Lim,L. and Manser,E.
  TITLE     The GIT-associated kinase PAK targets to the centrosome and
            regulates Aurora-A
  JOURNAL   Mol Cell 20 (2), 237-249 (2005)
   PUBMED   16246726
REFERENCE   8  (bases 1 to 1735)
  AUTHORS   Lutz,W., Lingle,W.L., McCormick,D., Greenwood,T.M. and
            Salisbury,J.L.
  TITLE     Phosphorylation of centrin during the cell cycle and its role in
            centriole separation preceding centrosome duplication
  JOURNAL   J Biol Chem 276 (23), 20774-20780 (2001)
   PUBMED   11279195
REFERENCE   9  (bases 1 to 1735)
  AUTHORS   Laoukili,J., Perret,E., Middendorp,S., Houcine,O., Guennou,C.,
            Marano,F., Bornens,M. and Tournier,F.
  TITLE     Differential expression and cellular distribution of centrin
            isoforms during human ciliated cell differentiation in vitro
  JOURNAL   J Cell Sci 113 (Pt 8), 1355-1364 (2000)
   PUBMED   10725219
REFERENCE   10 (bases 1 to 1735)
  AUTHORS   Errabolu,R., Sanders,M.A. and Salisbury,J.L.
  TITLE     Cloning of a cDNA encoding human centrin, an EF-hand protein of
            centrosomes and mitotic spindle poles
  JOURNAL   J Cell Sci 107 (Pt 1), 9-16 (1994)
   PUBMED   8175926
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC029515.1, AP001178.4 and
            AI198628.1.
            
            On May 17, 2019 this sequence version replaced NM_004066.2.
            
            Summary: The protein encoded by this gene plays important roles in
            the determination of centrosome position and segregation, and in
            the process of microtubule severing. This protein is localized to
            the centrosome of interphase cells, and redistributes to the region
            of the spindle poles during mitosis, reflecting the dynamic
            behavior of the centrosome during the cell cycle. [provided by
            RefSeq, Jan 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR5189667.349026.1,
                                        SRR5189667.282530.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327228.5/ ENSP00000319052.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-821               BC029515.1         24-844
            822-826             AP001178.4         8887-8891
            827-1248            BC029515.1         851-1272
            1249-1574           AI198628.1         91-416              c
            1575-1575           AP001178.4         9640-9640
            1576-1641           AI198628.1         24-89               c
            1642-1735           AP001178.4         9707-9800
FEATURES             Location/Qualifiers
     source          1..1735
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.32"
     gene            1..1735
                     /gene="CETN1"
                     /gene_synonym="CEN1; CETN"
                     /note="centrin 1"
                     /db_xref="GeneID:1068"
                     /db_xref="HGNC:HGNC:1866"
                     /db_xref="MIM:603187"
     exon            1..1735
                     /gene="CETN1"
                     /gene_synonym="CEN1; CETN"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..548
                     /gene="CETN1"
                     /gene_synonym="CEN1; CETN"
                     /note="EF-hand protein; calcium binding protein;
                     caltractin; centrin, EF-hand protein, 1; testicular tissue
                     protein Li 37"
                     /codon_start=1
                     /product="centrin-1"
                     /protein_id="NP_004057.1"
                     /db_xref="CCDS:CCDS11820.1"
                     /db_xref="GeneID:1068"
                     /db_xref="HGNC:HGNC:1866"
                     /db_xref="MIM:603187"
                     /translation="MASGFKKPSAASTGQKRKVAPKPELTEDQKQEVREAFDLFDVDG
                     SGTIDAKELKVAMRALGFEPRKEEMKKMISEVDREGTGKISFNDFLAVMTQKMSEKDT
                     KEEILKAFRLFDDDETGKISFKNLKRVANELGENLTDEELQEMIDEADRDGDGEVNEE
                     EFLRIMKKTSLY"
     regulatory      687..692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CETN1"
                     /gene_synonym="CEN1; CETN"
                     /note="hexamer: AATAAT"
     regulatory      690..695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CETN1"
                     /gene_synonym="CEN1; CETN"
                     /note="hexamer: AATAGA"
     polyA_site      707
                     /gene="CETN1"
                     /gene_synonym="CEN1; CETN"
     polyA_site      714
                     /gene="CETN1"
                     /gene_synonym="CEN1; CETN"
                     /note="major polyA site"
     regulatory      1566..1571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CETN1"
                     /gene_synonym="CEN1; CETN"
                     /note="hexamer: AGTAAA"
     polyA_site      1584
                     /gene="CETN1"
                     /gene_synonym="CEN1; CETN"
     regulatory      1619..1624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CETN1"
                     /gene_synonym="CEN1; CETN"
                     /note="hexamer: TATAAA"
     polyA_site      1641
                     /gene="CETN1"
                     /gene_synonym="CEN1; CETN"
ORIGIN      
        1 gttgggacca cggcggccag agcggcagga tggcttccgg cttcaagaag cccagcgctg
       61 cctccaccgg ccaaaagaga aaggtggcac ctaagcccga gctcactgag gatcagaagc
      121 aagaagttcg ggaagcattt gacctcttcg acgtggacgg aagtgggacc atcgacgcga
      181 aggagctgaa ggtggccatg agagcgctgg gcttcgaacc caggaaggaa gagatgaaga
      241 aaatgatctc cgaggtggac agggaaggca cggggaagat cagcttcaat gacttcctgg
      301 ccgtgatgac gcagaagatg tccgagaagg acaccaaaga agaaatcctg aaggccttca
      361 ggctctttga tgacgatgag accgggaaga tctcgttcaa aaacctgaag cgtgtggcca
      421 acgagctggg ggagaacctc acggatgagg agctgcagga gatgatcgac gaagctgatc
      481 gggatgggga cggcgaagtg aacgaggagg agttccttcg gatcatgaag aagaccagcc
      541 tttactgaag tcggttcaga agctaaagtg actctctggg ttgcctgctt ccattttgtg
      601 aaaccttaga ggacagcggc tgcctgtccc ttcttcaccc cctcaccccc ataatttgtc
      661 tagatctatt tccatatctc tagttcaata atagaatttg aaagatgctt gtaatgtgag
      721 ttttgggttt taattctcaa gagtcaacct ggagcacatg aggttaaaca aagggccctg
      781 aagtttgagt gcgccctcca tttgccctgt gctgaacttg ctgttcatct gttgatctgg
      841 aggcaggaca gcttctggga cacacaaaaa tgtggttccc tttgtcactt ctttggtggt
      901 cttaaattat cttgcttcat atatcattcc ttaaattcca gtcattgttc cagcataatg
      961 agatggaatc tgccagtaga tttgcctagc ctgtccactt agctgaatac cagtttgaag
     1021 gaaaacaggg tggccactta caaacttacg gagctcagga cagataatct tataaagaat
     1081 agacttgctt gggtggtagt acgttgtgca attttgacta ttcactggct ttatacctgc
     1141 aaatgattct tcgttcatgt gtaaattgtc caccatgggt ttatctaggg ctagtatgta
     1201 tacctgggct acagaataaa aataaaatct aatactggcc caagcaaagt ataatttgct
     1261 taagaggtta cgctaacaaa cgattttgag taaatattta caaatgtagg atcttagttt
     1321 aggaaattat aacaaatacc ttaatataac attttaagct acttatagtc cttggaaata
     1381 gcaacaaata tcttagttat tggactatta taaccttagt catcttatta ctgcttgatt
     1441 atgagacact ctccctgcta atccttagaa catcttggtt cttggtactt gacttttagc
     1501 ccctctgaca tatagttgat gtcagagtgt ctggcatttc agtagtgctc tattttacaa
     1561 atcccagtaa actgctccac tgtggcttgt ttatgtgtta atactgcttg ttttctgtta
     1621 taaattattt tttgctttgg agtaagatat catcattttg catagctaca aatctgaagt
     1681 taaagaaaat tttaaaaatg taattgtggg aaaataacaa atagatctgc tgaga
//
