LOCUS       NM_001143685            2177 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens carboxylesterase 5A (CES5A), transcript variant 1,
            mRNA.
ACCESSION   NM_001143685
VERSION     NM_001143685.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2177)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2177)
  AUTHORS   Holmes,R.S., Wright,M.W., Laulederkind,S.J., Cox,L.A., Hosokawa,M.,
            Imai,T., Ishibashi,S., Lehner,R., Miyazaki,M., Perkins,E.J.,
            Potter,P.M., Redinbo,M.R., Robert,J., Satoh,T., Yamashita,T.,
            Yan,B., Yokoi,T., Zechner,R. and Maltais,L.J.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
REFERENCE   3  (bases 1 to 2177)
  AUTHORS   Holmes,R.S., Cox,L.A. and VandeBerg,J.L.
  TITLE     Mammalian carboxylesterase 3: comparative genomics and proteomics
  JOURNAL   Genetica 138 (7), 695-708 (2010)
   PUBMED   20422440
REFERENCE   4  (bases 1 to 2177)
  AUTHORS   Holmes,R.S., Cox,L.A. and Vandeberg,J.L.
  TITLE     A new class of mammalian carboxylesterase CES6
  JOURNAL   Comp Biochem Physiol Part D Genomics Proteomics 4 (3), 209-217
            (2009)
   PUBMED   20161041
REFERENCE   5  (bases 1 to 2177)
  AUTHORS   Holmes,R.S., Cox,L.A. and Vandeberg,J.L.
  TITLE     Mammalian carboxylesterase 5: comparative biochemistry and genomics
  JOURNAL   Comp Biochem Physiol Part D Genomics Proteomics 3 (3), 195-204
            (2008)
   PUBMED   19727319
REFERENCE   6  (bases 1 to 2177)
  AUTHORS   Miyazaki,M., Kamiie,K., Soeta,S., Taira,H. and Yamashita,T.
  TITLE     Molecular cloning and characterization of a novel
            carboxylesterase-like protein that is physiologically present at
            high concentrations in the urine of domestic cats (Felis catus)
  JOURNAL   Biochem J 370 (Pt 1), 101-110 (2003)
   PUBMED   12401131
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC147362.2, DA698987.1,
            BC117126.1, BC069548.1, AY907669.1 and BC039073.1.
            
            On May 17, 2019 this sequence version replaced NM_001143685.1.
            
            Summary: This gene encodes a member of the carboxylesterase large
            family. The family members are responsible for the hydrolysis or
            transesterification of various xenobiotics, such as cocaine and
            heroin, and endogenous substrates with ester, thioester, or amide
            bonds. They also participate in fatty acyl and cholesterol ester
            metabolism, and may play a role in the blood-brain barrier system.
            This gene, also called CES5, is predominantly expressed in
            peripheral tissues, including brain, kidney, lung and testis. It
            encodes a secreted enzyme. Because of high levels in the urine of
            male domestic cats, this enzyme is also called cauxin
            (carboxylesterase-like urinary excreted protein). The enzyme
            functions in regulating the production of a pheromone precursor and
            may contribute to lipid and cholesterol transfer processes within
            male reproductive fluids. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jun 2010].
            
            Transcript Variant: This variant (1) has an alternate 5' sequence,
            as compared to variant 3. The resulting isoform (1) is shorter and
            has a different N-terminus, as compared to isoform 3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069501.1, AY907669.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2144335 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290567.14/ ENSP00000290567.9
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC147362.2         19852-19854
            4-30                DA698987.1         1-27
            31-122              BC117126.1         1-92
            123-469             BC069548.1         90-436
            470-470             AC147362.2         23501-23501
            471-1492            BC117126.1         441-1462
            1493-1493           AC147362.2         45519-45519
            1494-1921           BC117126.1         1464-1891
            1922-2079           AY907669.1         1846-2003
            2080-2177           BC039073.1         2090-2187
FEATURES             Location/Qualifiers
     source          1..2177
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..2177
                     /gene="CES5A"
                     /gene_synonym="CAUXIN; CES4C1; CES5; CES7; HEL126"
                     /note="carboxylesterase 5A"
                     /db_xref="GeneID:221223"
                     /db_xref="HGNC:HGNC:26459"
                     /db_xref="MIM:618678"
     exon            1..225
                     /gene="CES5A"
                     /gene_synonym="CAUXIN; CES4C1; CES5; CES7; HEL126"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1880
                     /gene="CES5A"
                     /gene_synonym="CAUXIN; CES4C1; CES5; CES7; HEL126"
                     /EC_number="3.1.1.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; carboxylesterase 7; carboxylesterase 5;
                     carboxylesterase-like urinary excreted protein homolog;
                     epididymis luminal protein 126"
                     /codon_start=1
                     /product="carboxylesterase 5A isoform 1 precursor"
                     /protein_id="NP_001137157.1"
                     /db_xref="CCDS:CCDS45490.1"
                     /db_xref="GeneID:221223"
                     /db_xref="HGNC:HGNC:26459"
                     /db_xref="MIM:618678"
                     /translation="MSGNWVHPGQILIWAIWVLAAPTKGPSAEGPQRNTRLGWIQGKQ
                     VTVLGSPVPVNVFLGVPFAAPPLGSLRFTNPQPASPWDNLREATSYPNLCLQNSEWLL
                     LDQHMLKVHYPKFGVSEDCLYLNIYAPAHADTGSKLPVLVWFPGGAFKTGSASIFDGS
                     ALAAYEDVLVVVVQYRLGIFGFFTTWDQHAPGNWAFKDQVAALSWVQKNIEFFGGDPS
                     SVTIFGESAGAISVSSLILSPMAKGLFHKAIMESGVAIIPYLEAHDYEKSEDLQVVAH
                     FCGNNASDSEALLRCLRTKPSKELLTLSQKTKSFTRVVDGAFFPNEPLDLLSQKAFKA
                     IPSIIGVNNHECGFLLPMKEAPEILSGSNKSLALHLIQNILHIPPQYLHLVANEYFHD
                     KHSLTEIRDSLLDLLGDVFFVVPALITARYHRDAGAPVYFYEFRHRPQCFEDTKPAFV
                     KADHADEVRFVFGGAFLKGDIVMFEGATEEEKLLSRKMMKYWATFARTGNPNGNDLSL
                     WPAYNLTEQYLQLDLNMSLGQRLKEPRVDFWTSTIPLILSASDMLHSPLSSLTFLSLL
                     QPFFFFCAP"
     exon            226..430
                     /gene="CES5A"
                     /gene_synonym="CAUXIN; CES4C1; CES5; CES7; HEL126"
                     /inference="alignment:Splign:2.1.0"
     exon            431..569
                     /gene="CES5A"
                     /gene_synonym="CAUXIN; CES4C1; CES5; CES7; HEL126"
                     /inference="alignment:Splign:2.1.0"
     exon            570..703
                     /gene="CES5A"
                     /gene_synonym="CAUXIN; CES4C1; CES5; CES7; HEL126"
                     /inference="alignment:Splign:2.1.0"
     exon            704..857
                     /gene="CES5A"
                     /gene_synonym="CAUXIN; CES4C1; CES5; CES7; HEL126"
                     /inference="alignment:Splign:2.1.0"
     exon            858..962
                     /gene="CES5A"
                     /gene_synonym="CAUXIN; CES4C1; CES5; CES7; HEL126"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1067
                     /gene="CES5A"
                     /gene_synonym="CAUXIN; CES4C1; CES5; CES7; HEL126"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1208
                     /gene="CES5A"
                     /gene_synonym="CAUXIN; CES4C1; CES5; CES7; HEL126"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1277
                     /gene="CES5A"
                     /gene_synonym="CAUXIN; CES4C1; CES5; CES7; HEL126"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1425
                     /gene="CES5A"
                     /gene_synonym="CAUXIN; CES4C1; CES5; CES7; HEL126"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1575
                     /gene="CES5A"
                     /gene_synonym="CAUXIN; CES4C1; CES5; CES7; HEL126"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1648
                     /gene="CES5A"
                     /gene_synonym="CAUXIN; CES4C1; CES5; CES7; HEL126"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..2177
                     /gene="CES5A"
                     /gene_synonym="CAUXIN; CES4C1; CES5; CES7; HEL126"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2092..2097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CES5A"
                     /gene_synonym="CAUXIN; CES4C1; CES5; CES7; HEL126"
                     /note="hexamer: AATAAA"
     polyA_site      2115
                     /gene="CES5A"
                     /gene_synonym="CAUXIN; CES4C1; CES5; CES7; HEL126"
                     /note="major polyA site"
     regulatory      2154..2159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CES5A"
                     /gene_synonym="CAUXIN; CES4C1; CES5; CES7; HEL126"
                     /note="hexamer: AATAAA"
     polyA_site      2177
                     /gene="CES5A"
                     /gene_synonym="CAUXIN; CES4C1; CES5; CES7; HEL126"
                     /note="major polyA site"
ORIGIN      
        1 attgttctga tgctgatctt cagtaactct gctgcctctg cctgcctatt cagcatttgc
       61 ctgttaacag gaagctcttt ctggctccca actgaagctc tctgaggcca gcagccgccg
      121 tcaatgttca cagagtgcag gcaggcagcc aaatgagtgg gaattgggtg cacccaggcc
      181 agatcctaat ttgggctatc tgggtccttg cagcccccac caaagggcct tctgctgaag
      241 ggccacagag gaacaccagg ctgggatgga ttcagggcaa gcaagtcact gtgctgggaa
      301 gccctgtgcc tgtgaacgtg ttcctcggag tcccctttgc tgctcccccg ctgggatccc
      361 tgcgatttac gaacccgcag cctgcatcgc cctgggataa cttgcgagaa gccacctcct
      421 accctaattt gtgcctccag aactcagagt ggctgctctt agatcaacat atgctcaagg
      481 tgcattaccc gaaattcgga gtgtcagaag actgcctcta cctgaacatc tatgcgcctg
      541 cccacgccga tacaggctcc aagctccccg tcttggtgtg gttcccagga ggtgccttca
      601 agactggctc agcctccatc tttgatgggt ccgccctggc tgcctatgag gacgtgctgg
      661 ttgtggtcgt ccagtaccgg ctaggaatat ttggtttctt caccacatgg gatcagcatg
      721 ctccggggaa ctgggccttc aaggaccagg tggctgctct gtcctgggtc cagaagaaca
      781 tcgagttctt cggtggggac cccagctctg tgaccatctt tggcgagtcc gcgggagcca
      841 taagtgtttc tagtcttata ctgtctccca tggccaaagg cttattccac aaagccatca
      901 tggagagtgg ggtggccatc atcccttacc tggaggccca tgattatgag aagagtgagg
      961 acctgcaggt ggttgcacat ttctgtggta acaatgcgtc agactctgag gccctgctga
     1021 ggtgcctgag gacaaaaccc tccaaggagc tgctgaccct cagccagaaa acaaagtctt
     1081 tcactcgagt ggttgatggt gctttctttc ctaatgagcc tctagatcta ttgtctcaga
     1141 aagcatttaa agcaattcct tccatcatcg gagtcaataa ccacgagtgt ggcttcctgc
     1201 tgcctatgaa ggaggctcct gagatcctca gtggctccaa caagtccctt gccctccatc
     1261 tgatacaaaa catcctgcac atcccgcctc agtatttgca ccttgtggct aatgaatact
     1321 tccatgacaa gcactccctg actgaaatcc gagacagtct tctggacttg cttggagatg
     1381 tgttctttgt ggtccctgca ctgatcacag ctcgatatca cagagatgct ggtgcacctg
     1441 tctacttcta tgagtttcgg caccggcctc agtgctttga agacacgaag ccagcttttg
     1501 tcaaagccga ccacgctgat gaagtccgct ttgtgttcgg tggtgccttc ctgaaggggg
     1561 acattgttat gttcgaagga gccacggagg aggagaagtt actgagccgg aagatgatga
     1621 aatactgggc tacctttgct cgaaccggga atcctaatgg gaacgacctg tctctgtggc
     1681 cagcttataa tctgactgag cagtacctcc agctggactt gaacatgagc ctcggacaga
     1741 gactcaaaga accgcgggtg gatttttgga ccagcaccat ccccctgatc ctgtctgcct
     1801 ccgacatgct ccacagtcct ctttcttcct taactttcct ctctctcctc cagcctttct
     1861 ttttcttttg tgctccttga gaagttatct ttctgtgatt ttggtttccc ttctcctccc
     1921 ataatttctc ccgcaatcat tagcttcttt ctgagctcag ctgctttcta tggggatcct
     1981 tgcaaaacaa gctgctttcg ctgatatttt atggacttag gaatgatcct tacagaattc
     2041 ttttcaacat caaaaagtgc aatttgtctt ggaaggcaac aagatttctt caataaattt
     2101 ggaagagggc tggcctatta gttgtcataa taatggtttt gtaactcata tgaaataaaa
     2161 tcagaatgta aaatagg
//
