LOCUS       NM_001364782            3145 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens carboxylesterase 4A (CES4A), transcript variant 6,
            mRNA.
ACCESSION   NM_001364782 XM_005255896
VERSION     NM_001364782.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3145)
  AUTHORS   Holmes,R.S., Wright,M.W., Laulederkind,S.J., Cox,L.A., Hosokawa,M.,
            Imai,T., Ishibashi,S., Lehner,R., Miyazaki,M., Perkins,E.J.,
            Potter,P.M., Redinbo,M.R., Robert,J., Satoh,T., Yamashita,T.,
            Yan,B., Yokoi,T., Zechner,R. and Maltais,L.J.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
REFERENCE   2  (bases 1 to 3145)
  AUTHORS   Holmes,R.S., Cox,L.A. and VandeBerg,J.L.
  TITLE     Mammalian carboxylesterase 3: comparative genomics and proteomics
  JOURNAL   Genetica 138 (7), 695-708 (2010)
   PUBMED   20422440
REFERENCE   3  (bases 1 to 3145)
  AUTHORS   Holmes,R.S., Cox,L.A. and Vandeberg,J.L.
  TITLE     A new class of mammalian carboxylesterase CES6
  JOURNAL   Comp Biochem Physiol Part D Genomics Proteomics 4 (3), 209-217
            (2009)
   PUBMED   20161041
REFERENCE   4  (bases 1 to 3145)
  AUTHORS   Hosokawa,M., Furihata,T., Yaginuma,Y., Yamamoto,N., Koyano,N.,
            Fujii,A., Nagahara,Y., Satoh,T. and Chiba,K.
  TITLE     Genomic structure and transcriptional regulation of the rat, mouse,
            and human carboxylesterase genes
  JOURNAL   Drug Metab Rev 39 (1), 1-15 (2007)
   PUBMED   17364878
  REMARK    Review article
REFERENCE   5  (bases 1 to 3145)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009084.9.
            
            On Jul 7, 2018 this sequence version replaced XM_005255896.4.
            
            Summary: This gene encodes a member of the carboxylesterase large
            family. The family members are responsible for the hydrolysis or
            transesterification of various xenobiotics, such as cocaine and
            heroin, and endogenous substrates with ester, thioester, or amide
            bonds. They also participate in fatty acyl and cholesterol ester
            metabolism, and may play a role in the blood-brain barrier system.
            This gene, also called CES6, encodes a secreted enzyme, and may
            play a role in the detoxification of drugs and xenobiotics in
            neural and other tissues of the body and in the cerebrospinal
            fluid. Multiple transcript variants encoding different isoforms
            have been reported, but the full-length nature and/or biological
            validity of some variants have not been determined. [provided by
            RefSeq, Jun 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2144333,
                              SAMEA2145893 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            inferred exon combination        :: based on alignments, homology
            MANE Ensembl match               :: ENST00000648724.3/
                                                ENSP00000497868.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               AC009084.9         103441-103682
            243-444             AC009084.9         110480-110681
            445-586             AC009084.9         115490-115631
            587-720             AC009084.9         115709-115842
            721-874             AC009084.9         116160-116313
            875-979             AC009084.9         117922-118026
            980-1084            AC009084.9         118108-118212
            1085-1123           AC009084.9         118367-118405
            1124-1264           AC009084.9         118936-119076
            1265-1345           AC009084.9         119645-119725
            1346-1499           AC009084.9         120092-120245
            1500-1628           AC009084.9         121243-121371
            1629-1701           AC009084.9         121597-121669
            1702-3145           AC009084.9         123826-125269
FEATURES             Location/Qualifiers
     source          1..3145
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..3145
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /note="carboxylesterase 4A"
                     /db_xref="GeneID:283848"
                     /db_xref="HGNC:HGNC:26741"
     exon            1..242
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..1870
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /note="isoform 6 precursor is encoded by transcript
                     variant 6; carboxylesterase 8 (putative); carboxylesterase
                     6"
                     /codon_start=1
                     /product="carboxylesterase 4A isoform 6 precursor"
                     /protein_id="NP_001351711.1"
                     /db_xref="CCDS:CCDS92173.1"
                     /db_xref="GeneID:283848"
                     /db_xref="HGNC:HGNC:26741"
                     /translation="MRWILCWSLTLCLMAQTALGALHTKRPQVVTKYGTLQGKQMHVG
                     KTPIQVFLGVPFSRPPLGILRFAPPEPPEPWKGIRDATTYPPGCLQESWGQLASMYVS
                     TRERYKWLRFSEDCLYLNVYAPARAPGDPQLPVMVWFPGGAFIVGAASSYEGSDLAAR
                     EKVVLVFLQHRLGIFGFLSTDDSHARGNWGLLDQMAALRWVQENIAAFGGDPGNVTLF
                     GQSAGAMSISGLMMSPLASGLFHRAISQSGTALFRLFITSNPLKVAKKVAHLAGCNHN
                     STQILVNCLRALSGTKVMRVSNKMRFLQLNFQRDPEEIIWSMSPVVDGVVIPDDPLVL
                     LTQGKVSSVPYLLGVNNLEFNWLLPYIMKFPLNRQAMRKETITKMLWSTRTLLNITKE
                     QVPLVVEEYLDNVNEHDWKMLRNRMMDIVQDATFVYATLQTAHYHRDAGLPVYLYEFE
                     HHARGIIVKPRTDGADHGDEMYFLFGGPFATGLSMGKEKALSLQMMKYWANFARTGNP
                     NDGNLPCWPRYNKDEKYLQLDFTTRVGMKLKEKKMAFWMSLYQSQRPEKQRQF"
     exon            243..444
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     exon            445..586
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     exon            587..720
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     exon            721..874
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     exon            875..979
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1084
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1123
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1264
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1345
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1499
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1628
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1701
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..3145
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2443..2448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /note="hexamer: AATAAA"
     polyA_site      2486
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /note="major polyA site"
ORIGIN      
        1 agagacaagg ctgtgggctg gtcagaagct ggttacaatt cctcccgccc cagtacttgc
       61 tggcagggat taagagcaga taaaagtgtg ctcacacact gtagacacgg ctaccatgcc
      121 atccacagtg ttgccatcca cagtgttgcc atcactcctg cccacagcag gagctggctg
      181 gagcatgagg tggattctgt gctggagcct caccctctgc ctgatggcgc agacggcctt
      241 gggtgccttg cacaccaaga ggcctcaagt ggtcaccaaa tatggaaccc tgcaaggaaa
      301 acagatgcat gtggggaaga cacccatcca agtcttttta ggagtcccct tctccagacc
      361 tcctctaggt atcctcaggt ttgcacctcc agaacccccg gagccctgga aaggaatcag
      421 agatgctacc acctacccgc ctgggtgcct gcaggagtcc tggggccagc tggcctcgat
      481 gtacgtcagc acgcgggaac ggtacaagtg gctgcgcttc agcgaggact gtctgtacct
      541 gaacgtgtac gcgccggcgc gcgcgcccgg ggatccccag ctgccagtga tggtctggtt
      601 cccgggaggc gccttcatcg tgggcgctgc ttcttcgtac gagggctctg acttggccgc
      661 ccgcgagaaa gtggtgctgg tgtttctgca gcacaggctc ggcatcttcg gcttcctgag
      721 cacggacgac agccacgcgc gcgggaactg ggggctgctg gaccagatgg cggctctgcg
      781 ctgggtgcag gagaacatcg cagccttcgg gggagaccca ggaaatgtga ccctgttcgg
      841 ccagtcggcg ggggccatga gcatctcagg actgatgatg tcacccctag cctcgggtct
      901 cttccatcgg gccatttccc agagtggcac cgcgttattc agacttttca tcactagtaa
      961 cccactgaaa gtggccaaga aggttgccca cctggctgga tgcaaccaca acagcacaca
     1021 gatcctggta aactgcctga gggcactatc agggaccaag gtgatgcgtg tgtccaacaa
     1081 gatgagattc ctccaactga acttccagag agacccggaa gagattatct ggtccatgag
     1141 ccctgtggtg gatggtgtgg tgatcccaga tgaccctttg gtgctcctga cccaggggaa
     1201 ggtttcatct gtgccctacc ttctaggtgt caacaacctg gaattcaatt ggctcttgcc
     1261 ttatatcatg aagttcccgc taaaccggca ggcgatgaga aaggaaacca tcactaagat
     1321 gctctggagt acccgcaccc tgttgaatat caccaaggag caggtaccac ttgtggtgga
     1381 ggagtacctg gacaatgtca atgagcatga ctggaagatg ctacgaaacc gtatgatgga
     1441 catagttcaa gatgccactt tcgtgtatgc cacactgcag actgctcact accaccgaga
     1501 tgccggcctc cctgtctacc tgtatgaatt tgagcaccac gctcgtggaa taatcgtcaa
     1561 accccgcact gatggggcag accatgggga tgagatgtac ttcctctttg ggggcccctt
     1621 cgccacaggc ctttccatgg gtaaggagaa ggcacttagc ctccagatga tgaaatactg
     1681 ggccaacttt gcccgcacag gaaaccccaa tgatgggaat ctgccctgct ggccacgcta
     1741 caacaaggat gaaaagtacc tgcagctgga ttttaccaca agagtgggca tgaagctcaa
     1801 ggagaagaag atggcttttt ggatgagtct gtaccagtct caaagacctg agaagcagag
     1861 gcaattctaa gggtggctat gcaggaagga gccaaagagg ggtttgcccc caccatccag
     1921 gccctgggga gactagccat ggacatacct ggggacaaga gttctaccca ccccagttta
     1981 gaactgcagg agctccctgc tgcctccagg ccaaagctag agcttttgcc tgttgtgtgg
     2041 gacctgcact gccctttcca gcctgacatc ccatgatgcc cctctacttc actgttgaca
     2101 tccagttagg ccaggccctg tcaacaccac actgtgctca gctctccagc ctcaggacaa
     2161 cctctttttt tcccttcttc aaatcctccc acccttcaat gtctccttgt gactccttct
     2221 tatgggaggt cgacccagac tgccactgcc cctgtcactg cacccagctt ggcatttacc
     2281 atccatcctg ctcaaccttg tgcctgtctg ttcacattgg cctggaggcc tagggcaggt
     2341 tgtgacatgg agcaaacttt tggtagtttg ggatcttctc tcccacccac acttatctcc
     2401 cccagggcca ctccaaagtc tatacacagg ggtggtctct tcaataaaga agtgttgatt
     2461 agacctgaat ttctccacct ataaaatggg tgtgtgaagt gaatgatgtc tcaatttgag
     2521 ccctgagaga aaggaagtat tgctgcctgt tccttagtgg gctgtgcctg gatgctacac
     2581 tcagtcaaag ggtgctactg caaagttgcc tggggtacaa aacacttgcc ttttgccttc
     2641 atggtctcaa gtgcacccct caggacagcc acaccccacg ctcacttgtc catcagttta
     2701 ggtcttagtg ccacatctag attcctctgg cctctcctgc agcccgtgtg tatcccagcc
     2761 tgtcccacag ttttgtttcg ttgttttgtg gggttttttt tttttttttt gagacggagt
     2821 tttgctcttg tcacccaggc tggagtgcaa tgatgaaatc tcagctcact gcagcctcag
     2881 tctcccgagt tcaagcgatt ctcctgcctc agcctcccaa gtagctgaga ttacagatgc
     2941 ccaccaccat gcccggctta tttttgtatt tttagtagag atagggtttc atcatgtcag
     3001 ccaggctggt ctcaaactcc tgacctcagg taatccaccc gtctcagcct gctgaagtgc
     3061 tggaattaca ggcatgagcc accatgcctg gccactgtgg gctttttggt ggtaaaatac
     3121 acacgacaaa ttttaccatt ttaac
//
