LOCUS       NM_001190202            2610 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens carboxylesterase 4A (CES4A), transcript variant 4,
            mRNA.
ACCESSION   NM_001190202
VERSION     NM_001190202.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2610)
  AUTHORS   Holmes,R.S., Wright,M.W., Laulederkind,S.J., Cox,L.A., Hosokawa,M.,
            Imai,T., Ishibashi,S., Lehner,R., Miyazaki,M., Perkins,E.J.,
            Potter,P.M., Redinbo,M.R., Robert,J., Satoh,T., Yamashita,T.,
            Yan,B., Yokoi,T., Zechner,R. and Maltais,L.J.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
REFERENCE   2  (bases 1 to 2610)
  AUTHORS   Holmes,R.S., Cox,L.A. and VandeBerg,J.L.
  TITLE     Mammalian carboxylesterase 3: comparative genomics and proteomics
  JOURNAL   Genetica 138 (7), 695-708 (2010)
   PUBMED   20422440
REFERENCE   3  (bases 1 to 2610)
  AUTHORS   Holmes,R.S., Cox,L.A. and Vandeberg,J.L.
  TITLE     A new class of mammalian carboxylesterase CES6
  JOURNAL   Comp Biochem Physiol Part D Genomics Proteomics 4 (3), 209-217
            (2009)
   PUBMED   20161041
REFERENCE   4  (bases 1 to 2610)
  AUTHORS   Hosokawa,M., Furihata,T., Yaginuma,Y., Yamamoto,N., Koyano,N.,
            Fujii,A., Nagahara,Y., Satoh,T. and Chiba,K.
  TITLE     Genomic structure and transcriptional regulation of the rat, mouse,
            and human carboxylesterase genes
  JOURNAL   Drug Metab Rev 39 (1), 1-15 (2007)
   PUBMED   17364878
  REMARK    Review article
REFERENCE   5  (bases 1 to 2610)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC306014.1, AK295483.1,
            BC064573.1 and AC009084.9.
            
            On Jul 7, 2018 this sequence version replaced NM_001190202.1.
            
            Summary: This gene encodes a member of the carboxylesterase large
            family. The family members are responsible for the hydrolysis or
            transesterification of various xenobiotics, such as cocaine and
            heroin, and endogenous substrates with ester, thioester, or amide
            bonds. They also participate in fatty acyl and cholesterol ester
            metabolism, and may play a role in the blood-brain barrier system.
            This gene, also called CES6, encodes a secreted enzyme, and may
            play a role in the detoxification of drugs and xenobiotics in
            neural and other tissues of the body and in the cerebrospinal
            fluid. Multiple transcript variants encoding different isoforms
            have been reported, but the full-length nature and/or biological
            validity of some variants have not been determined. [provided by
            RefSeq, Jun 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK295483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                DC306014.1         27-61
            36-1507             AK295483.1         2-1473
            1508-1934           BC064573.1         1504-1930
            1935-2610           AC009084.9         124594-125269
FEATURES             Location/Qualifiers
     source          1..2610
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..2610
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /note="carboxylesterase 4A"
                     /db_xref="GeneID:283848"
                     /db_xref="HGNC:HGNC:26741"
     exon            1..241
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1258
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /note="isoform 4 is encoded by transcript variant 4;
                     carboxylesterase 8 (putative); carboxylesterase 6"
                     /codon_start=1
                     /product="carboxylesterase 4A isoform 4"
                     /protein_id="NP_001177131.1"
                     /db_xref="CCDS:CCDS54025.1"
                     /db_xref="GeneID:283848"
                     /db_xref="HGNC:HGNC:26741"
                     /translation="MYVSTRERYKWLRFSEDCLYLNVYAPARAPGDPQLPVMVWFPGG
                     AFIVGAASSYEGSDLAAREKVVLVFLQHRLGIFGFLRWRGRTDDSHARGNWGLLDQMA
                     ALRWVQENIAAFGGDPGNVTLFGQSAGAMSISGLMMSPLASGLFHRAISQSGTALFRL
                     FITSNPLKVAKKVAHLAGCNHNSTQILVNCLRALSGTKVMRVSNKMRFLQLNFQRDPE
                     EIIWSMSPVVDGVVIPDDPLVLLTQGKVSSVPYLLGVNNLEFNWLLPYIMKFPLNRQA
                     MRKETITKMLWSTRTLLNITKEQVPLVVEEYLDNVNEHDWKMLRNRMMDIVQDATFVY
                     ATLQTAHYHRETPMMGICPAGHATTRMKSTCSWILPQEWA"
     exon            242..387
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     exon            388..541
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     exon            542..646
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     exon            647..751
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     exon            752..790
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     exon            791..931
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1012
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1166
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..2610
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1908..1913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /note="hexamer: AATAAA"
     polyA_site      1951
                     /gene="CES4A"
                     /gene_synonym="CES6; CES8"
                     /note="major polyA site"
ORIGIN      
        1 agacgctgcc tggattttgc tttgggttcc gtcttctcac tgcggaccct ggattgaaac
       61 gatctccccg cggccgccgc cgctacctgg tgcccgcagg tgcctgcagg agtcctgggg
      121 ccagctggcc tcgatgtacg tcagcacgcg ggaacggtac aagtggctgc gcttcagcga
      181 ggactgtctg tacctgaacg tgtacgcgcc ggcgcgcgcg cccggggatc cccagctgcc
      241 agtgatggtc tggttcccgg gaggcgcctt catcgtgggc gctgcttctt cgtacgaggg
      301 ctctgacttg gccgcccgcg agaaagtggt gctggtgttt ctgcagcaca ggctcggcat
      361 cttcggcttc ctgaggtggc ggggccgcac ggacgacagc cacgcgcgcg ggaactgggg
      421 gctgctggac cagatggcgg ctctgcgctg ggtgcaggag aacatcgcag ccttcggggg
      481 agacccagga aatgtgaccc tgttcggcca gtcggcgggg gccatgagca tctcaggact
      541 gatgatgtca cccctagcct cgggtctctt ccatcgggcc atttcccaga gtggcaccgc
      601 gttattcaga cttttcatca ctagtaaccc actgaaagtg gccaagaagg ttgcccacct
      661 ggctggatgc aaccacaaca gcacacagat cctggtaaac tgcctgaggg cactatcagg
      721 gaccaaggtg atgcgtgtgt ccaacaagat gagattcctc caactgaact tccagagaga
      781 cccggaagag attatctggt ccatgagccc tgtggtggat ggtgtggtga tcccagatga
      841 ccctttggtg ctcctgaccc aggggaaggt ttcatctgtg ccctaccttc taggtgtcaa
      901 caacctggaa ttcaattggc tcttgcctta tatcatgaag ttcccgctaa accggcaggc
      961 gatgagaaag gaaaccatca ctaagatgct ctggagtacc cgcaccctgt tgaatatcac
     1021 caaggagcag gtaccacttg tggtggagga gtacctggac aatgtcaatg agcatgactg
     1081 gaagatgcta cgaaaccgta tgatggacat agttcaagat gccactttcg tgtatgccac
     1141 actgcagact gctcactacc accgagaaac cccaatgatg ggaatctgcc ctgctggcca
     1201 cgctacaaca aggatgaaaa gtacctgcag ctggatttta ccacaagagt gggcatgaag
     1261 ctcaaggaga agaagatggc tttttggatg agtctgtacc agtctcaaag acctgagaag
     1321 cagaggcaat tctaagggtg gctatgcagg aaggagccaa agaggggttt gcccccacca
     1381 tccaggccct ggggagacta gccatggaca tacctgggga caagagttct acccacccca
     1441 gtttagaact gcaggagctc cctgctgcct ccaggccaaa gctagagctt ttgcctgttg
     1501 tgtgggacct gcactgccct ttccagcctg acatcccatg atgcccctct acttcactgt
     1561 tgacatccag ttaggccagg ccctgtcaac accacactgt gctcagctct ccagcctcag
     1621 gacaacctct ttttttccct tcttcaaatc ctcccaccct tcaatgtctc cttgtgactc
     1681 cttcttatgg gaggtcgacc cagactgcca ctgcccctgt cactgcaccc agcttggcat
     1741 ttaccatcca tcctgctcaa ccttgtgcct gtctgttcac attggcctgg aggcctaggg
     1801 caggttgtga catggagcaa acttttggta gtttgggatc ttctctccca cccacactta
     1861 tctcccccag ggccactcca aagtctatac acaggggtgg tctcttcaat aaagaagtgt
     1921 tgattagacc tgaatttctc cacctataaa atgggtgtgt gaagtgaatg atgtctcaat
     1981 ttgagccctg agagaaagga agtattgctg cctgttcctt agtgggctgt gcctggatgc
     2041 tacactcagt caaagggtgc tactgcaaag ttgcctgggg tacaaaacac ttgccttttg
     2101 ccttcatggt ctcaagtgca cccctcagga cagccacacc ccacgctcac ttgtccatca
     2161 gtttaggtct tagtgccaca tctagattcc tctggcctct cctgcagccc gtgtgtatcc
     2221 cagcctgtcc cacagttttg tttcgttgtt ttgtggggtt tttttttttt tttttgagac
     2281 ggagttttgc tcttgtcacc caggctggag tgcaatgatg aaatctcagc tcactgcagc
     2341 ctcagtctcc cgagttcaag cgattctcct gcctcagcct cccaagtagc tgagattaca
     2401 gatgcccacc accatgcccg gcttattttt gtatttttag tagagatagg gtttcatcat
     2461 gtcagccagg ctggtctcaa actcctgacc tcaggtaatc cacccgtctc agcctgctga
     2521 agtgctggaa ttacaggcat gagccaccat gcctggccac tgtgggcttt ttggtggtaa
     2581 aatacacacg acaaatttta ccattttaac
//
