LOCUS       NM_016174               2308 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cerebral endothelial cell adhesion molecule (CERCAM),
            transcript variant 1, mRNA.
ACCESSION   NM_016174
VERSION     NM_016174.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2308)
  AUTHORS   Zuo,Y., Xu,X., Chen,M. and Qi,L.
  TITLE     The oncogenic role of the cerebral endothelial cell adhesion
            molecule (CERCAM) in bladder cancer cells in vitro and in vivo
  JOURNAL   Cancer Med 10 (13), 4437-4450 (2021)
   PUBMED   34105305
  REMARK    GeneRIF: The oncogenic role of the cerebral endothelial cell
            adhesion molecule (CERCAM) in bladder cancer cells in vitro and in
            vivo.
REFERENCE   2  (bases 1 to 2308)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2308)
  AUTHORS   Starzyk,R.M., Rosenow,C., Frye,J., Leismann,M., Rodzinski,E.,
            Putney,S. and Tuomanen,E.I.
  TITLE     Cerebral cell adhesion molecule: a novel leukocyte adhesion
            determinant on blood-brain barrier capillary endothelium
  JOURNAL   J Infect Dis 181 (1), 181-187 (2000)
   PUBMED   10608765
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX871555.1 and BC098432.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016174.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098432.1, SRR1803612.283684.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372838.9/ ENSP00000361929.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                CX871555.1         378-402
            26-2308             BC098432.1         1-2283
FEATURES             Location/Qualifiers
     source          1..2308
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..2308
                     /gene="CERCAM"
                     /gene_synonym="CEECAM1; GLT25D3"
                     /note="cerebral endothelial cell adhesion molecule"
                     /db_xref="GeneID:51148"
                     /db_xref="HGNC:HGNC:23723"
                     /db_xref="MIM:616626"
     exon            1..218
                     /gene="CERCAM"
                     /gene_synonym="CEECAM1; GLT25D3"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1809
                     /gene="CERCAM"
                     /gene_synonym="CEECAM1; GLT25D3"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; cerebral endothelial cell adhesion molecule 1;
                     glycosyltransferase 25 domain containing 3; cerebral cell
                     adhesion molecule; glycosyltransferase 25 family member 3;
                     probable inactive glycosyltransferase 25 family member 3"
                     /codon_start=1
                     /product="inactive glycosyltransferase 25 family member 3
                     isoform a precursor"
                     /protein_id="NP_057258.3"
                     /db_xref="CCDS:CCDS6901.2"
                     /db_xref="GeneID:51148"
                     /db_xref="HGNC:HGNC:23723"
                     /db_xref="MIM:616626"
                     /translation="MRAARAAPLLQLLLLLGPWLEAAGVAESPLPAVVLAILARNAEH
                     SLPHYLGALERLDYPRARMALWCATDHNVDNTTEMLQEWLAAVGDDYAAVVWRPEGEP
                     RFYPDEEGPKHWTKERHQFLMELKQEALTFARNWGADYILFADTDNILTNNQTLRLLM
                     GQGLPVVAPMLDSQTYYSNFWCGITPQGYYRRTAEYFPTKNRQRRGCFRVPMVHSTFL
                     ASLRAEGADQLAFYPPHPNYTWPFDDIIVFAYACQAAGVSVHVCNEHRYGYMNVPVKS
                     HQGLEDERVNFIHLILEALVDGPRMQASAHVTRPSKRPSKIGFDEVFVISLARRPDRR
                     ERMLASLWEMEISGRVVDAVDGWMLNSSAIRNLGVDLLPGYQDPYSGRTLTKGEVGCF
                     LSHYSIWEEVVARGLARVLVFEDDVRFESNFRGRLERLMEDVEAEKLSWDLIYLGRKQ
                     VNPEKETAVEGLPGLVVAGYSYWTLAYALRLAGARKLLASQPLRRMLPVDEFLPIMFD
                     QHPNEQYKAHFWPRDLVAFSAQPLLAAPTHYAGDAEWLSDTETSSPWDDDSGRLISWS
                     GSQKTLRSPRLDLTGSSGHSLQPQPRDEL"
     exon            219..329
                     /gene="CERCAM"
                     /gene_synonym="CEECAM1; GLT25D3"
                     /inference="alignment:Splign:2.1.0"
     exon            330..447
                     /gene="CERCAM"
                     /gene_synonym="CEECAM1; GLT25D3"
                     /inference="alignment:Splign:2.1.0"
     exon            448..582
                     /gene="CERCAM"
                     /gene_synonym="CEECAM1; GLT25D3"
                     /inference="alignment:Splign:2.1.0"
     exon            583..787
                     /gene="CERCAM"
                     /gene_synonym="CEECAM1; GLT25D3"
                     /inference="alignment:Splign:2.1.0"
     exon            788..907
                     /gene="CERCAM"
                     /gene_synonym="CEECAM1; GLT25D3"
                     /inference="alignment:Splign:2.1.0"
     exon            908..984
                     /gene="CERCAM"
                     /gene_synonym="CEECAM1; GLT25D3"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1091
                     /gene="CERCAM"
                     /gene_synonym="CEECAM1; GLT25D3"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1224
                     /gene="CERCAM"
                     /gene_synonym="CEECAM1; GLT25D3"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1352
                     /gene="CERCAM"
                     /gene_synonym="CEECAM1; GLT25D3"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1556
                     /gene="CERCAM"
                     /gene_synonym="CEECAM1; GLT25D3"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1809
                     /gene="CERCAM"
                     /gene_synonym="CEECAM1; GLT25D3"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..2308
                     /gene="CERCAM"
                     /gene_synonym="CEECAM1; GLT25D3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2285..2290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CERCAM"
                     /gene_synonym="CEECAM1; GLT25D3"
                     /note="hexamer: AATAAA"
     polyA_site      2308
                     /gene="CERCAM"
                     /gene_synonym="CEECAM1; GLT25D3"
                     /note="major polyA site"
ORIGIN      
        1 gcagccgccc aagcgcccgc catgcgcgct gcccgcgccg cgccgctgct ccagctgctg
       61 ctcctgctgg ggccgtggct ggaggctgcg ggcgttgcgg agtcgccgct gcccgccgtg
      121 gtccttgcca tcctggcccg caatgccgaa cactcgctgc cccactacct gggcgctctg
      181 gagcggctgg actacccccg ggccaggatg gccctctggt gtgccacgga ccacaatgtg
      241 gacaacacca cagagatgct gcaggagtgg ctggcggctg tgggcgatga ctatgctgct
      301 gtggtctgga ggcctgaggg cgagcccagg ttctacccag atgaagaggg tcccaagcac
      361 tggaccaaag aaaggcacca gtttctgatg gagctgaagc aggaagccct cacctttgcc
      421 aggaactggg gggccgacta tatcctgttt gcagacacag acaacattct gaccaacaat
      481 cagactctgc ggcttctcat ggggcagggg cttccagtgg tggccccaat gctggactcc
      541 cagacctact actccaactt ctggtgtggg atcacccccc agggctacta ccgccgcaca
      601 gccgagtact tccccaccaa gaaccgccag cgccggggct gcttccgtgt ccccatggtc
      661 cactccacct tccttgcatc cctgcgggct gaaggggcag accagcttgc tttctacccg
      721 ccacatccca actacacttg gcctttcgac gacatcatcg tcttcgccta tgcctgccag
      781 gctgctgggg tctccgtcca cgtgtgcaat gagcaccgtt atgggtacat gaatgtgccg
      841 gtgaaatccc accaggggct ggaagacgag agggtcaact tcatccacct gatcttagaa
      901 gcactagtgg acggcccccg catgcaggcc tcagctcatg tgactcggcc ctctaagagg
      961 cccagcaaga tagggtttga cgaggtcttt gtcatcagcc tggctcgcag gcctgaccgt
     1021 cgggaacgca tgctcgcctc gctctgggag atggagatct ctgggagggt ggtggacgct
     1081 gtggatggct ggatgctcaa cagcagtgcc atcaggaacc tcggcgtaga cctgctcccg
     1141 ggctaccagg acccttactc gggccgcact ctgaccaagg gcgaggtggg ctgcttcctc
     1201 agccattact ccatctggga agaggtggtt gccaggggcc tggcccgggt cctggtgttt
     1261 gaggatgacg tgcgctttga gagcaacttc agggggcggc tggagcggct gatggaggat
     1321 gtggaggcag agaaactgtc ttgggacctg atctacctcg gacggaagca ggtgaaccct
     1381 gagaaggaga cggccgtgga ggggctgccg ggcctggtgg tggctgggta ctcctactgg
     1441 acgctggcct atgccctgcg tctggcgggt gcccgcaagc tgctggcctc acagcctctg
     1501 cgccgcatgc tgcccgtgga cgagttcctg cccatcatgt tcgaccagca ccccaacgag
     1561 cagtacaagg cacacttctg gccacgggac ctggtggcct tctccgccca gcccctgctc
     1621 gctgccccta cccactatgc cggggacgcc gagtggctca gtgacacgga gacatcctct
     1681 ccatgggatg atgacagcgg ccgcctcatc agctggagcg gctcccaaaa gaccctgcgc
     1741 agcccccgcc tggacctgac tggcagcagc gggcacagcc tccaacccca gccccgagat
     1801 gagctctagg tccaggtgat gactgcaaag cagtgtccag gagcaggcca ctactgccca
     1861 gagagcagag gaggaggttg ttggcaggga ctgcagatcc tgtcagacct ggccaccacc
     1921 ttgggcatgg ccactctgcc ctctggacct gtctttcatc gggagaaacc actcagagat
     1981 ggatcccatt ccctaaaggt ctcacagcaa aggagcagga ctcccaggcc cctgtaccct
     2041 gcctggcctg attcagggcc ttgtggcccc cagcttctgt ttcaagctgg gcagacccca
     2101 ggatcccttc cctccctaag gactcagctg aggggcccct ctgccccctt ctacctccac
     2161 ctcagcaccc tcccccagct tgatgtttgg gtctccccag caccctcctc cctggccggt
     2221 gcaaagtaca gggaggtaaa gcaggaccct tgcagacatg ttgcccagca cacagtaggc
     2281 cctcaataaa agccatttgc actttaaa
//
