LOCUS       NM_005454               1231 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens cerberus 1, DAN family BMP antagonist (CER1), mRNA.
ACCESSION   NM_005454
VERSION     NM_005454.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1231)
  AUTHORS   Mydlarova Blascakova,M., Mydlar,J., Tomkova,Z., Hudakova,R.,
            Poracova,J., Hricova,K., Zigova,M., Petrejcikova,E., Omelka,R.,
            Bauerova,M., Burikova,A. and Vaskova,J.
  TITLE     CER 1 gene polymorphism in postmenopausal Roma and non-Roma Slovak
            women in connection with osteoporosis
  JOURNAL   Eur Rev Med Pharmacol Sci 25 (22), 6881-6893 (2021)
   PUBMED   34859850
  REMARK    GeneRIF: CER 1 gene polymorphism in postmenopausal Roma and
            non-Roma Slovak women in connection with osteoporosis.
REFERENCE   2  (bases 1 to 1231)
  AUTHORS   Aykul,S. and Martinez-Hackert,E.
  TITLE     New Ligand Binding Function of Human Cerberus and Role of
            Proteolytic Processing in Regulating Ligand-Receptor Interactions
            and Antagonist Activity
  JOURNAL   J Mol Biol 428 (3), 590-602 (2016)
   PUBMED   26802359
  REMARK    GeneRIF: Cerberus binds and inhibits Nodal, Activin B, BMP-6, and
            BMP-7 but not BMP-2 or Activin A.
REFERENCE   3  (bases 1 to 1231)
  AUTHORS   Koromila,T., Georgoulias,P., Dailiana,Z., Ntzani,E.E., Samara,S.,
            Chassanidis,C., Aleporou-Marinou,V. and Kollia,P.
  TITLE     CER1 gene variations associated with bone mineral density, bone
            markers, and early menopause in postmenopausal women
  JOURNAL   Hum Genomics 7 (1), 21 (2013)
   PUBMED   24138842
  REMARK    GeneRIF: No significant association between the studied DKK1
            variations and osteoporosis was found, while CER1 variations seem
            to play a significant role in the determination of osteoporosis,
            combined with bone markers, in postmenopausal osteoporotic women.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1231)
  AUTHORS   Iwashita,H., Shiraki,N., Sakano,D., Ikegami,T., Shiga,M., Kume,K.
            and Kume,S.
  TITLE     Secreted cerberus1 as a marker for quantification of definitive
            endoderm differentiation of the pluripotent stem cells
  JOURNAL   PLoS One 8 (5), e64291 (2013)
   PUBMED   23717584
  REMARK    GeneRIF: results show that Cer1 (or CER1) serves as a good marker
            for quantification of definitive endoderm differentiation of mouse
            and human ES/iPS cells
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1231)
  AUTHORS   Koromila,T., Dailiana,Z., Samara,S., Chassanidis,C., Tzavara,C.,
            Patrinos,G.P., Aleporou-Marinou,V. and Kollia,P.
  TITLE     Novel sequence variations in the CER1 gene are strongly associated
            with low bone mineral density and risk of osteoporotic fracture in
            postmenopausal women
  JOURNAL   Calcif Tissue Int 91 (1), 15-23 (2012)
   PUBMED   22543871
  REMARK    GeneRIF: CER1 gene variations play a significant role in
            determining BMD and vertebral or hip fractures, which might be
            helpful in clinical practice to identify patients with increased
            fracture risk
REFERENCE   6  (bases 1 to 1231)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   7  (bases 1 to 1231)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   8  (bases 1 to 1231)
  AUTHORS   Lah,M., Brodnicki,T., Maccarone,P., Nash,A., Stanley,E. and
            Harvey,R.P.
  TITLE     Human cerberus related gene CER1 maps to chromosome 9
  JOURNAL   Genomics 55 (3), 364-366 (1999)
   PUBMED   10049596
REFERENCE   9  (bases 1 to 1231)
  AUTHORS   Hsu,D.R., Economides,A.N., Wang,X., Eimon,P.M. and Harland,R.M.
  TITLE     The Xenopus dorsalizing factor Gremlin identifies a novel family of
            secreted proteins that antagonize BMP activities
  JOURNAL   Mol Cell 1 (5), 673-683 (1998)
   PUBMED   9660951
REFERENCE   10 (bases 1 to 1231)
  AUTHORS   Biben,C., Stanley,E., Fabri,L., Kotecha,S., Rhinn,M.,
            Drinkwater,C., Lah,M., Wang,C.C., Nash,A., Hilton,D., Ang,S.L.,
            Mohun,T. and Harvey,R.P.
  TITLE     Murine cerberus homologue mCer-1: a candidate anterior patterning
            molecule
  JOURNAL   Dev Biol 194 (2), 135-151 (1998)
   PUBMED   9501024
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390732.10, CD652441.1,
            AF400435.1 and BU071333.1.
            
            On May 17, 2019 this sequence version replaced NM_005454.2.
            
            Summary: This gene encodes a cytokine member of the cysteine knot
            superfamily, characterized by nine conserved cysteines and a
            cysteine knot region. The cerberus-related cytokines, together with
            Dan and DRM/Gremlin, represent a group of bone morphogenetic
            protein (BMP) antagonists that can bind directly to BMPs and
            inhibit their activity. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD652441.1, SRR1803614.23361.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153733, SAMEA2162328
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380911.4/ ENSP00000370297.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AL390732.10        126060-126075       c
            17-61               CD652441.1         21-65
            62-865              AF400435.1         1-804
            866-1222            BU071333.1         13-369              c
            1223-1231           AL390732.10        123066-123074       c
FEATURES             Location/Qualifiers
     source          1..1231
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p22.3"
     gene            1..1231
                     /gene="CER1"
                     /gene_synonym="DAND4"
                     /note="cerberus 1, DAN family BMP antagonist"
                     /db_xref="GeneID:9350"
                     /db_xref="HGNC:HGNC:1862"
                     /db_xref="MIM:603777"
     exon            1..568
                     /gene="CER1"
                     /gene_synonym="DAND4"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..865
                     /gene="CER1"
                     /gene_synonym="DAND4"
                     /note="cerberus-related 1; cerberus-related protein; DAN
                     domain family member 4; cerberus 1, cysteine knot
                     superfamily, homolog"
                     /codon_start=1
                     /product="cerberus precursor"
                     /protein_id="NP_005445.1"
                     /db_xref="CCDS:CCDS6476.1"
                     /db_xref="GeneID:9350"
                     /db_xref="HGNC:HGNC:1862"
                     /db_xref="MIM:603777"
                     /translation="MHLLLFQLLVLLPLGKTTRHQDGRQNQSSLSPVLLPRNQRELPT
                     GNHEEAEEKPDLFVAVPHLVATSPAGEGQRQREKMLSRFGRFWKKPEREMHPSRDSDS
                     EPFPPGTQSLIQPIDGMKMEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHEVHWE
                     TCRTVPFSQTITHEGCEKVVVQNNLCFGKCGSVHFPGAAQHSHTSCSHCLPAKFTTMH
                     LPLNCTELSSVIKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA"
     exon            569..1231
                     /gene="CER1"
                     /gene_synonym="DAND4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagaatgag cctctccttt gggcctcatc atttacaaaa gaagcttggg cccctgacag
       61 catgcatctc ctcttatttc agctgctggt actcctgcct ctaggaaaga ccacacggca
      121 ccaggatggc cgccagaatc agagttctct ttcccccgta ctcctgccaa ggaatcaaag
      181 agagcttccc acaggcaacc atgaggaagc tgaggagaag ccagatctgt ttgtcgcagt
      241 gccacacctt gtagccacca gccctgcagg ggaaggccag aggcagagag agaagatgct
      301 gtccagattt ggcaggttct ggaagaagcc tgagagagaa atgcatccat ccagggactc
      361 agatagtgag cccttcccac ctgggaccca gtccctcatc cagccgatag atggaatgaa
      421 aatggagaaa tctcctcttc gggaagaagc caagaaattc tggcaccact tcatgttcag
      481 aaaaactccg gcttctcagg gggtcatctt gcccatcaaa agccatgaag tacattggga
      541 gacctgcagg acagtgccct tcagccagac tataacccac gaaggctgtg aaaaagtagt
      601 tgttcagaac aacctttgct ttgggaaatg cgggtctgtt cattttcctg gagccgcgca
      661 gcactcccat acctcctgct ctcactgttt gcctgccaag ttcaccacga tgcacttgcc
      721 actgaactgc actgaacttt cctccgtgat caaggtggtg atgctggtgg aggagtgcca
      781 gtgcaaggtg aagacggagc atgaagatgg acacatccta catgctggct cccaggattc
      841 ctttatccca ggagtttcag cttgaagagc tatcccacta ttacctttga aaagcaaaac
      901 cacaacagca aagatgctga ttattcagtc tgaaaatgtt aagtgggtac ataacatttt
      961 cagggaaagg tgacttgaaa cgtagtttta aattagaacg atagaggaaa tgatattagt
     1021 ctagttattg gtacacgttt gagaccttgt ctcagctctg ccactaacta gccgtagaat
     1081 gttaagttgt aaaacctttc tccatctaaa gattttcatc tataaatgac ggacccgacc
     1141 tagatgattg ctaaaatcct ttccactact aatattccgt gatgcatttt ctccaagttt
     1201 gggtaaaagc cctccatcta aagaaggaaa a
//
