LOCUS       NM_006090               2203 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens choline/ethanolamine phosphotransferase 1 (CEPT1),
            transcript variant 1, mRNA.
ACCESSION   NM_006090
VERSION     NM_006090.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2203)
  AUTHORS   Liu,X., Chen,Z., Yan,Y., Zandkarimi,F., Nie,L., Li,Q., Horbath,A.,
            Olszewski,K., Kondiparthi,L., Mao,C., Lee,H., Zhuang,L.,
            Poyurovsky,M., Stockwell,B.R., Chen,J. and Gan,B.
  TITLE     Proteomic analysis of ferroptosis pathways reveals a role of CEPT1
            in suppressing ferroptosis
  JOURNAL   Protein Cell 15 (9), 686-703 (2024)
   PUBMED   38430542
  REMARK    GeneRIF: Proteomic analysis of ferroptosis pathways reveals a role
            of CEPT1 in suppressing ferroptosis.
REFERENCE   2  (bases 1 to 2203)
  AUTHORS   Wang,Z., Yang,M., Yang,Y., He,Y. and Qian,H.
  TITLE     Structural basis for catalysis of human choline/ethanolamine
            phosphotransferase 1
  JOURNAL   Nat Commun 14 (1), 2529 (2023)
   PUBMED   37137909
  REMARK    GeneRIF: Structural basis for catalysis of human
            choline/ethanolamine phosphotransferase 1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2203)
  AUTHORS   Zayed,M.A., Jin,X., Yang,C., Belaygorod,L., Engel,C., Desai,K.,
            Harroun,N., Saffaf,O., Patterson,B.W., Hsu,F.F. and
            Semenkovich,C.F.
  TITLE     CEPT1-Mediated Phospholipogenesis Regulates Endothelial Cell
            Function and Ischemia-Induced Angiogenesis Through PPARalpha
  JOURNAL   Diabetes 70 (2), 549-561 (2021)
   PUBMED   33214136
  REMARK    GeneRIF: CEPT1-Mediated Phospholipogenesis Regulates Endothelial
            Cell Function and Ischemia-Induced Angiogenesis Through PPARalpha.
REFERENCE   4  (bases 1 to 2203)
  AUTHORS   Horibata,Y. and Sugimoto,H.
  TITLE     Differential contributions of choline phosphotransferases CPT1 and
            CEPT1 to the biosynthesis of choline phospholipids
  JOURNAL   J Lipid Res 62, 100100 (2021)
   PUBMED   34331935
  REMARK    GeneRIF: Differential contributions of choline phosphotransferases
            CPT1 and CEPT1 to the biosynthesis of choline phospholipids.
REFERENCE   5  (bases 1 to 2203)
  AUTHORS   Horibata,Y., Ando,H. and Sugimoto,H.
  TITLE     Locations and contributions of the phosphotransferases EPT1 and
            CEPT1 to the biosynthesis of ethanolamine phospholipids
  JOURNAL   J Lipid Res 61 (8), 1221-1231 (2020)
   PUBMED   32576654
  REMARK    GeneRIF: Locations and contributions of the phosphotransferases
            EPT1 and CEPT1 to the biosynthesis of ethanolamine phospholipids.
REFERENCE   6  (bases 1 to 2203)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   7  (bases 1 to 2203)
  AUTHORS   Henneberry,A.L., Wright,M.M. and McMaster,C.R.
  TITLE     The major sites of cellular phospholipid synthesis and molecular
            determinants of Fatty Acid and lipid head group specificity
  JOURNAL   Mol Biol Cell 13 (9), 3148-3161 (2002)
   PUBMED   12221122
REFERENCE   8  (bases 1 to 2203)
  AUTHORS   Wright,M.M. and McMaster,C.R.
  TITLE     PC and PE synthesis: mixed micellar analysis of the
            cholinephosphotransferase and ethanolaminephosphotransferase
            activities of human choline/ethanolamine phosphotransferase 1
            (CEPT1)
  JOURNAL   Lipids 37 (7), 663-672 (2002)
   PUBMED   12216837
  REMARK    GeneRIF: A yeast expression system devoid of endogenous
            cholinephosphotransferase and ethanolaminephosphotransferase
            activities to assess the diradylglycerol specificity of CEPT1
REFERENCE   9  (bases 1 to 2203)
  AUTHORS   Henneberry,A.L., Wistow,G. and McMaster,C.R.
  TITLE     Cloning, genomic organization, and characterization of a human
            cholinephosphotransferase
  JOURNAL   J Biol Chem 275 (38), 29808-29815 (2000)
   PUBMED   10893425
REFERENCE   10 (bases 1 to 2203)
  AUTHORS   Henneberry,A.L. and McMaster,C.R.
  TITLE     Cloning and expression of a human
            choline/ethanolaminephosphotransferase: synthesis of
            phosphatidylcholine and phosphatidylethanolamine
  JOURNAL   Biochem J 339 (Pt 2) (Pt 2), 291-298 (1999)
   PUBMED   10191259
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB992025.1, AF068302.1,
            AL355816.14 and BU618567.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006090.4.
            
            Summary: This gene codes for a
            choline/ethanolaminephosphotransferase, which functions in the
            synthesis of choline- or ethanolamine- containing phospholipids.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK023381.1, AF068302.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357172.9/ ENSP00000349696.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                CB992025.1         40-76
            38-1963             AF068302.1         8-1933
            1964-1968           AL355816.14        104902-104906
            1969-2203           BU618567.1         18-252              c
FEATURES             Location/Qualifiers
     source          1..2203
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..2203
                     /gene="CEPT1"
                     /note="choline/ethanolamine phosphotransferase 1"
                     /db_xref="GeneID:10390"
                     /db_xref="HGNC:HGNC:24289"
                     /db_xref="MIM:616751"
     exon            1..85
                     /gene="CEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            86..497
                     /gene="CEPT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1409
                     /gene="CEPT1"
                     /EC_number="2.7.8.2"
                     /EC_number="2.7.8.1"
                     /EC_number="2.7.8.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     1-alkenyl-2-acylglycerol choline phosphotransferase"
                     /codon_start=1
                     /product="choline/ethanolaminephosphotransferase 1 isoform
                     1"
                     /protein_id="NP_006081.1"
                     /db_xref="CCDS:CCDS830.1"
                     /db_xref="GeneID:10390"
                     /db_xref="HGNC:HGNC:24289"
                     /db_xref="MIM:616751"
                     /translation="MSGHRSTRKRCGDSHPESPVGFGHMSTTGCVLNKLFQLPTPPLS
                     RHQLKRLEEHRYQSAGRSLLEPLMQGYWEWLVRRVPSWIAPNLITIIGLSINICTTIL
                     LVFYCPTATEQAPLWAYIACACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSL
                     STVFVVLGTCIAVQLGTNPDWMFFCCFAGTFMFYCAHWQTYVSGTLRFGIIDVTEVQI
                     FIIIMHLLAVIGGPPFWQSMIPVLNIQMKIFPALCTVAGTIFSCTNYFRVIFTGGVGK
                     NGSTIAGTSVLSPFLHIGSVITLAAMIYKKSAVQLFEKHPCLYILTFGFVSAKITNKL
                     VVAHMTKSEMHLHDTAFIGPALLFLDQYFNSFIDEYIVLWIALVFSFFDLIRYCVSVC
                     NQIASHLHIHVFRIKVSTAHSNHH"
     exon            498..645
                     /gene="CEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            646..787
                     /gene="CEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..872
                     /gene="CEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1004
                     /gene="CEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1163
                     /gene="CEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1289
                     /gene="CEPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..2203
                     /gene="CEPT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2069..2074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEPT1"
                     /note="hexamer: AATATA"
     polyA_site      2089
                     /gene="CEPT1"
                     /note="major polyA site"
     regulatory      2176..2181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEPT1"
                     /note="hexamer: AATAAA"
     polyA_site      2203
                     /gene="CEPT1"
                     /note="major polyA site"
ORIGIN      
        1 gtcgtgaacg tgctgccgcc gatcagtcac ccagtcggct ggagtcggag gcgatatttc
       61 taggggtgta cttgttgggg tcagggtaag caccagccac aaaaacctac aaaagaaggg
      121 aaattactgt ctttaaatat taaaaaaaaa caagatccat gagtgggcat cgatcaacaa
      181 ggaaaagatg tggagattct cacccggagt ccccagtggg cttcgggcat atgagtacta
      241 caggatgtgt attaaataaa ttgtttcagt taccaacacc accattgtca agacaccaac
      301 taaagcggct agaagaacac agatatcaaa gtgctggacg gtccctgctt gagcccttaa
      361 tgcaagggta ttgggaatgg ctcgttagaa gagttccctc ctggattgcc ccaaatctca
      421 tcaccatcat tggactgtca ataaacatct gtacaactat tttattagtc ttctactgcc
      481 ctacagctac agagcaggca cctctgtggg catatattgc ttgtgcctgt ggccttttca
      541 tttaccagtc tttggatgct attgatggga aacaggcaag aagaaccaat agtagttctc
      601 ctctgggaga actttttgat catggctgtg attcactatc aacagttttt gtggttcttg
      661 gaacttgtat tgcagtgcag ctggggacaa accctgattg gatgtttttt tgttgttttg
      721 cggggacatt tatgttctat tgtgcgcact ggcaaacgta tgtttctgga acattgcgat
      781 ttggaataat tgatgtgact gaagtgcaaa tcttcataat aatcatgcat ttgctggcag
      841 tgattggagg accacctttt tggcaatcta tgattccagt gctgaatatt caaatgaaaa
      901 tttttcctgc actttgtact gtagcaggga ccatattttc ctgtacaaat tacttccgtg
      961 taatcttcac aggtggtgtt ggcaaaaatg gatcaacaat agcaggaaca agtgtccttt
     1021 ctccttttct ccatattgga tcagtgatta cattagctgc aatgatctac aagaaatctg
     1081 cagttcagct ttttgaaaag catccctgtc tttatatact gacatttggt tttgtgtctg
     1141 ctaaaatcac taataagctt gtggttgcac acatgacgaa aagtgaaatg catttgcatg
     1201 acacagcatt cataggtccg gcacttttgt ttctggacca gtattttaac agctttattg
     1261 atgaatatat tgtactttgg attgccctgg ttttctcttt ctttgatttg atccgctact
     1321 gtgtcagtgt ttgcaatcag attgcgtctc acctgcacat acatgtcttc agaatcaagg
     1381 tctctacagc tcattctaat catcattaat gatgtaattg gtatatagga acatcatgtt
     1441 ttctgcagga aagaaagtaa catattaagg agaatggggg tggataagaa caaatataat
     1501 ttataataat caatgttgta taacttttat tctttattat tggtaacacg ccctaactat
     1561 cctgtgtgag aatgggaatt tcaagtccca tcttgtaaat tgtatatgtt gtcatgcagg
     1621 gtttgggcca agaaagcatg cagaaaaaaa tgccatgtga ttgtaattat cctggattca
     1681 gaataatact gtgatgggga gccagatccg cagtggtgga gagttctaat gttgactgtt
     1741 tgcaggccaa aagatgattg ctttataatt ttaacaaatc attgtctttt agtaacatcc
     1801 ttgtttagtg tcttctcaag ctttctttac tgaggaattc agcttgtgac acagatacat
     1861 cccactagct tgtgaggtgg aactagtaat aaagaccttg aatttggatt gaaaagtttc
     1921 ctatctttac attgttgagg aagtcctttt tttttttttt ttttttttaa ttgctcaaga
     1981 aatgattctc tcacaggctt gggaaatcct gttagcatgc agaataatgt ggtaactttg
     2041 tcaatttccc attttatttt tttaaataaa tatatgatct aaaagccaac tttttctcag
     2101 ttttactcag tggaaagata aactaagttt taatgttatt tttttaaatt taagcaaaat
     2161 ttatttctgt tctttaataa ataagaaaat gtggtccact gca
//
