LOCUS       NM_138363               2754 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens centrosomal protein 95 (CEP95), transcript variant 1,
            mRNA.
ACCESSION   NM_138363
VERSION     NM_138363.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2754)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 2754)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2754)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2754)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2754)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2754)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 2754)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2754)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   9  (bases 1 to 2754)
  AUTHORS   Bandyopadhyay,S., Chiang,C.Y., Srivastava,J., Gersten,M., White,S.,
            Bell,R., Kurschner,C., Martin,C., Smoot,M., Sahasrabudhe,S.,
            Barber,D.L., Chanda,S.K. and Ideker,T.
  TITLE     A human MAP kinase interactome
  JOURNAL   Nat Methods 7 (10), 801-805 (2010)
   PUBMED   20936779
REFERENCE   10 (bases 1 to 2754)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP357015.1 and BC009518.1.
            
            On Nov 23, 2018 this sequence version replaced NM_138363.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009518.1, SRR1803612.79384.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000556440.7/ ENSP00000450461.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                BP357015.1         242-304
            64-2754             BC009518.1         1-2691
FEATURES             Location/Qualifiers
     source          1..2754
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.3"
     gene            1..2754
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /note="centrosomal protein 95"
                     /db_xref="GeneID:90799"
                     /db_xref="HGNC:HGNC:25141"
     exon            1..140
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..2587
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain containing 45; centrosomal protein of
                     95 kDa; coiled-coil domain-containing protein 45;
                     centrosomal protein 95kDa"
                     /codon_start=1
                     /product="centrosomal protein of 95 kDa isoform 1"
                     /protein_id="NP_612372.1"
                     /db_xref="CCDS:CCDS45763.1"
                     /db_xref="GeneID:90799"
                     /db_xref="HGNC:HGNC:25141"
                     /translation="MAGSDAEWVTIANNLLFKCHIHLRIHELQDCDANVFIALYQSIL
                     GEKVPDLIVIPRSQEDDAHNVQAVIDSLALDYLQVSLSHITGENIVKGDKESIKNLLE
                     IFDGLLEYLTERISETSHEKSETEQYFKESDRGERLEEPESTKESKSSWKRVSFGRCS
                     LSSEMLGPSWDGDEAESTGEIIRLGDTAHTFSLRSNGAQCPNEMLSKKALASPSSKSH
                     EDMLYPPSVLSKSRTSFVEDTETLSVSGIPNARKLGEPIRAAIPLHPPYHPSEPRAPC
                     PIGKEYLHSSHCSPAVNSTGEHTEFSGDLDDGLFLISKLPKGSKWEVYPAQVQGPRTR
                     KPPKGKRNENRATASSCNSPFPQRPRKRLTEQELHDVSEKLSQRLSELDWMLKSALGD
                     RIKEKTDHKEENTGNEEVEDGTEETLSQHSDGIVEYGPKKSRPGLSMRRKPPYRSHSL
                     SPSPVNKHKQFHLERKRQRKPRETDVRQFQAQAFTEAFERELRRHKVQENIGPLRIHE
                     KEEETEKIYRGEAVRKGTPECSQPWKIYSRKTTTQSLRGGLPKPNKAVPMKVSEHSLL
                     PLMLEQFPFLYVSGPTLSKMWKQQIAQVEQLKKEACRENRSKKKLQDEIEEALRRHDL
                     LTTLVKKEYEHNKRLQDFKDCIRRQRLTQSKIKENRQQIVRARKYYDDYRVQLCAKMM
                     RMRTREEMIFKKLFEEGLNIQKQRLRDLRNYAKEKRDEQRRRHQDELDSMENYYKDQF
                     SLLAEAISQEHQELKAREKSQAQTLHKVKRELRSKMEKEIQQLQDMITQNDDDVFFRE
                     LEAERFRSRLQLASFQYSKSPSL"
     exon            141..269
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /inference="alignment:Splign:2.1.0"
     exon            270..377
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /inference="alignment:Splign:2.1.0"
     exon            378..488
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /inference="alignment:Splign:2.1.0"
     exon            489..594
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /inference="alignment:Splign:2.1.0"
     exon            595..710
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /inference="alignment:Splign:2.1.0"
     exon            711..836
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /inference="alignment:Splign:2.1.0"
     exon            837..1030
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1143
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1273
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1427
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1567
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1660
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1793
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1963
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2038
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2191
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2338
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2410
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2754
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2734..2739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /note="hexamer: AATAAA"
     polyA_site      2754
                     /gene="CEP95"
                     /gene_synonym="CCDC45"
                     /note="major polyA site"
ORIGIN      
        1 cttccccgcg ctttggttcg tgcgtccgcg ccccagtgtc gggtctgcgt ggatcggtcc
       61 ttccaggaca ccgtcgcctt cccggccgcg tcggagtccg gcggcgacct gcctctgaaa
      121 catggcaggc tcggatgctg agtgggtaac cattgccaat aaccttcttt ttaagtgtca
      181 tatacatctg agaatacatg aacttcaaga ctgtgatgct aatgttttta ttgctcttta
      241 tcagtctatt ttgggagaaa aggtaccaga cctcatagtt attcctagga gtcaagaaga
      301 tgatgcacac aatgtacaag cagtaattga ttcactggcc ttggactact tgcaggtcag
      361 cttgtctcac ataacaggag aaaatatagt gaaaggagat aaagaatcta ttaagaatct
      421 cctggaaata tttgatggtt tgttggagta tcttacagaa cgcatcagtg aaacatctca
      481 tgagaaaagt gaaactgaac agtattttaa agaatctgat cgaggagaac gtttggaaga
      541 gccagaaagt actaaagaat ctaaatcatc atggaaaaga gtttcttttg ggaggtgctc
      601 cttgtcttct gagatgttgg gcccctcttg ggatggagat gaagcagaat ccactggtga
      661 aatcattaga cttggagaca cagcacacac cttttctcta agaagtaatg gtgctcaatg
      721 tcctaatgaa atgctgtcta aaaaagcctt agcctcacca agttctaaat cacatgaaga
      781 tatgttgtac cctcctagtg ttttgtccaa gagtaggaca tcctttgttg aagacacgga
      841 aaccctttct gtgagtggga ttccaaatgc taggaagcta ggggagccta tccgagcagc
      901 tattccttta catccaccct accacccttc agagcctcga gcaccctgcc ccataggaaa
      961 agaatacttg cattcaagtc actgctcccc agccgtaaat tctactggag agcatacgga
     1021 attttctggg gatctagatg atggactttt cttaatttcc aagttgccta aaggcagcaa
     1081 atgggaagta tatccagctc aggtccaagg gcctaggaca aggaagcctc ccaaaggaaa
     1141 aagaaatgaa aacagagcta cagcctcatc ctgcaattca cctttccccc agaggccaag
     1201 aaagagatta acagaacaag aattacatga tgtatcagaa aaactctctc agcggctttc
     1261 tgaactagat tggatgttaa aaagtgctct gggtgatcgg attaaagaaa agactgacca
     1321 taaagaagaa aatactggaa atgaggaggt agaggatgga actgaggaga cactgtctca
     1381 gcacagtgat ggcatcgtgg agtatgggcc aaagaagtca aggccaggac tttccatgcg
     1441 tagaaagcca ccctacagat cccattcgct ctctccatct ccagttaaca aacacaaaca
     1501 gttccacttg gagagaaaaa ggcagcgcaa gccaagagaa acagatgtcc gccaattcca
     1561 agcacaggcg tttactgaag catttgaaag ggaactaaga agacataaag ttcaagagaa
     1621 tattggacct ctaagaatac atgagaagga ggaggaaaca gaaaaaatat acagaggaga
     1681 agctgttcgt aaaggaactc cagaatgtag tcagccctgg aagatttact ctagaaaaac
     1741 cacaacgcag agtctaagag gtggcctccc aaagccaaat aaagcagttc caatgaaagt
     1801 aagtgaacac agtctcctgc cccttatgct ggagcagttt ccgtttcttt atgtttctgg
     1861 cccaacacta agcaaaatgt ggaaacagca aattgcacag gttgaacagc ttaagaaaga
     1921 agcatgtaga gaaaatcgat caaagaagaa actccaagat gaaatagaag aagccctaag
     1981 aaggcatgac ctccttacta cccttgtcaa gaaagaatat gaacataaca agagactgca
     2041 agacttcaag gactgcattc gtaggcaaag gttgacccaa tcaaagataa aagaaaatcg
     2101 acagcaaatc gttcgtgctc gaaaatatta tgatgattat agagttcagt tgtgtgcaaa
     2161 aatgatgaga atgaggaccc gggaagaaat gatatttaag aaactgtttg aagaaggttt
     2221 aaacattcaa aagcaaagat tacgagacct aagaaactat gccaaagaaa agcgagatga
     2281 acaaaggaga cgccaccagg atgaactgga ctccatggag aactactata aggaccagtt
     2341 ttcattgctg gcagaagcca tatcacagga acatcaagaa cttaaagcca gagagaaatc
     2401 tcaggcccag acattacata aggtgaagag ggagctgaga tctaagatgg agaaggaaat
     2461 tcagcagctg caggacatga taacacagaa tgatgatgat gttttcttcc gggaactgga
     2521 agctgagcgc ttcagatctc ggcttcagct ggcttccttt cagtacagta aaagtccctc
     2581 cctatgaggc cagacttgat aatagtaggt gaaggttctg gaggccttta ccaggacaga
     2641 gctagaatcg agccagtaaa cagtctaagc cagaaaaata attttcaaat gctttacctg
     2701 tattttcatt ccagtacttt ttatgatttt ttaaataaaa attgttttct aaaa
//
