LOCUS       NM_001042475            7373 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens centrosomal protein 85 like (CEP85L), transcript
            variant 1, mRNA.
ACCESSION   NM_001042475
VERSION     NM_001042475.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7373)
  AUTHORS   Leduc-Pessah,H., White-Brown,A., Miller,E., McMillan,H.J. and
            Boycott,K.M.
  TITLE     Further characterization of CEP85L-associated lissencephaly type
            10: Report of a three-generation family and review of the
            literature
  JOURNAL   Am J Med Genet A 191 (12), 2878-2883 (2023)
   PUBMED   37621218
  REMARK    GeneRIF: Further characterization of CEP85L-associated
            lissencephaly type 10: Report of a three-generation family and
            review of the literature.
            Review article
REFERENCE   2  (bases 1 to 7373)
  AUTHORS   Poursaei,E., Daneshmandpour,Y., Aghaei Moghadam,E., Abolghasemi,M.,
            Jamshidi,J., Baradaran,B., Asadi,M., Kazeminasab,S. and
            Emamalizadeh,B.
  TITLE     LRP8 (rs5177) and CEP85L (rs11756438) are contributed to
            schizophrenia susceptibility in Iranian population
  JOURNAL   Psychiatr Genet 30 (6), 162-165 (2020)
   PUBMED   33079740
  REMARK    GeneRIF: LRP8 (rs5177) and CEP85L (rs11756438) are contributed to
            schizophrenia susceptibility in Iranian population.
REFERENCE   3  (bases 1 to 7373)
  AUTHORS   Tsai,M.H., Muir,A.M., Wang,W.J., Kang,Y.N., Yang,K.C., Chao,N.H.,
            Wu,M.F., Chang,Y.C., Porter,B.E., Jansen,L.A., Sebire,G.,
            Deconinck,N., Fan,W.L., Su,S.C., Chung,W.H., Almanza Fuerte,E.P.,
            Mehaffey,M.G., Ng,C.C., Chan,C.K., Lim,K.S., Leventer,R.J.,
            Lockhart,P.J., Riney,K., Damiano,J.A., Hildebrand,M.S.,
            Mirzaa,G.M., Dobyns,W.B., Berkovic,S.F., Scheffer,I.E., Tsai,J.W.
            and Mefford,H.C.
  CONSRTM   University of Washington Center for Mendelian Genomics
  TITLE     Pathogenic Variants in CEP85L Cause Sporadic and Familial Posterior
            Predominant Lissencephaly
  JOURNAL   Neuron 106 (2), 237-245 (2020)
   PUBMED   32097630
  REMARK    GeneRIF: Pathogenic Variants in CEP85L Cause Sporadic and Familial
            Posterior Predominant Lissencephaly.
REFERENCE   4  (bases 1 to 7373)
  AUTHORS   Kodani,A., Kenny,C., Lai,A., Gonzalez,D.M., Stronge,E.,
            Sejourne,G.M., Isacco,L., Partlow,J.N., O'Donnell,A., McWalter,K.,
            Byrne,A.B., Barkovich,A.J., Yang,E., Hill,R.S., Gawlinski,P.,
            Wiszniewski,W., Cohen,J.S., Fatemi,S.A., Baranano,K.W., Sahin,M.,
            Vossler,D.G., Yuskaitis,C.J. and Walsh,C.A.
  TITLE     Posterior Neocortex-Specific Regulation of Neuronal Migration by
            CEP85L Identifies Maternal Centriole-Dependent Activation of CDK5
  JOURNAL   Neuron 106 (2), 246-255 (2020)
   PUBMED   32097629
  REMARK    GeneRIF: Posterior Neocortex-Specific Regulation of Neuronal
            Migration by CEP85L Identifies Maternal Centriole-Dependent
            Activation of CDK5.
REFERENCE   5  (bases 1 to 7373)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 7373)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   7  (bases 1 to 7373)
  AUTHORS   Eijgelsheim,M., Newton-Cheh,C., Sotoodehnia,N., de Bakker,P.I.,
            Muller,M., Morrison,A.C., Smith,A.V., Isaacs,A., Sanna,S., Dorr,M.,
            Navarro,P., Fuchsberger,C., Nolte,I.M., de Geus,E.J., Estrada,K.,
            Hwang,S.J., Bis,J.C., Ruckert,I.M., Alonso,A., Launer,L.J.,
            Hottenga,J.J., Rivadeneira,F., Noseworthy,P.A., Rice,K.M., Perz,S.,
            Arking,D.E., Spector,T.D., Kors,J.A., Aulchenko,Y.S., Tarasov,K.V.,
            Homuth,G., Wild,S.H., Marroni,F., Gieger,C., Licht,C.M.,
            Prineas,R.J., Hofman,A., Rotter,J.I., Hicks,A.A., Ernst,F.,
            Najjar,S.S., Wright,A.F., Peters,A., Fox,E.R., Oostra,B.A.,
            Kroemer,H.K., Couper,D., Volzke,H., Campbell,H., Meitinger,T.,
            Uda,M., Witteman,J.C., Psaty,B.M., Wichmann,H.E., Harris,T.B.,
            Kaab,S., Siscovick,D.S., Jamshidi,Y., Uitterlinden,A.G.,
            Folsom,A.R., Larson,M.G., Wilson,J.F., Penninx,B.W., Snieder,H.,
            Pramstaller,P.P., van Duijn,C.M., Lakatta,E.G., Felix,S.B.,
            Gudnason,V., Pfeufer,A., Heckbert,S.R., Stricker,B.H.,
            Boerwinkle,E. and O'Donnell,C.J.
  TITLE     Genome-wide association analysis identifies multiple loci related
            to resting heart rate
  JOURNAL   Hum Mol Genet 19 (19), 3885-3894 (2010)
   PUBMED   20639392
  REMARK    GeneRIF: Observational study, meta-analysis, and genome-wide
            association study of gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 7373)
  AUTHORS   Vasan,R.S., Glazer,N.L., Felix,J.F., Lieb,W., Wild,P.S.,
            Felix,S.B., Watzinger,N., Larson,M.G., Smith,N.L., Dehghan,A.,
            Grosshennig,A., Schillert,A., Teumer,A., Schmidt,R., Kathiresan,S.,
            Lumley,T., Aulchenko,Y.S., Konig,I.R., Zeller,T., Homuth,G.,
            Struchalin,M., Aragam,J., Bis,J.C., Rivadeneira,F., Erdmann,J.,
            Schnabel,R.B., Dorr,M., Zweiker,R., Lind,L., Rodeheffer,R.J.,
            Greiser,K.H., Levy,D., Haritunians,T., Deckers,J.W., Stritzke,J.,
            Lackner,K.J., Volker,U., Ingelsson,E., Kullo,I., Haerting,J.,
            O'Donnell,C.J., Heckbert,S.R., Stricker,B.H., Ziegler,A.,
            Reffelmann,T., Redfield,M.M., Werdan,K., Mitchell,G.F., Rice,K.,
            Arnett,D.K., Hofman,A., Gottdiener,J.S., Uitterlinden,A.G.,
            Meitinger,T., Blettner,M., Friedrich,N., Wang,T.J., Psaty,B.M., van
            Duijn,C.M., Wichmann,H.E., Munzel,T.F., Kroemer,H.K.,
            Benjamin,E.J., Rotter,J.I., Witteman,J.C., Schunkert,H.,
            Schmidt,H., Volzke,H. and Blankenberg,S.
  TITLE     Genetic variants associated with cardiac structure and function: a
            meta-analysis and replication of genome-wide association data
  JOURNAL   JAMA 302 (2), 168-178 (2009)
   PUBMED   19584346
  REMARK    GeneRIF: Meta-analysis and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   9  (bases 1 to 7373)
  AUTHORS   Newton-Cheh,C., Eijgelsheim,M., Rice,K.M., de Bakker,P.I., Yin,X.,
            Estrada,K., Bis,J.C., Marciante,K., Rivadeneira,F.,
            Noseworthy,P.A., Sotoodehnia,N., Smith,N.L., Rotter,J.I.,
            Kors,J.A., Witteman,J.C., Hofman,A., Heckbert,S.R., O'Donnell,C.J.,
            Uitterlinden,A.G., Psaty,B.M., Lumley,T., Larson,M.G. and
            Stricker,B.H.
  TITLE     Common variants at ten loci influence QT interval duration in the
            QTGEN Study
  JOURNAL   Nat Genet 41 (4), 399-406 (2009)
   PUBMED   19305408
REFERENCE   10 (bases 1 to 7373)
  AUTHORS   Scanlan,M.J., Gout,I., Gordon,C.M., Williamson,B., Stockert,E.,
            Gure,A.O., Jager,D., Chen,Y.T., Mackay,A., O'Hare,M.J. and Old,L.J.
  TITLE     Humoral immunity to human breast cancer: antigen definition and
            quantitative analysis of mRNA expression
  JOURNAL   Cancer Immun 1, 4 (2001)
   PUBMED   12747765
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC048977.1, BC064835.1, AF308284.1, AL589993.5 and BC045657.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001042475.2.
            
            Summary: The protein encoded by this gene was identified as a
            breast cancer antigen. Nothing more is known of its function at
            this time. Three transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.66579.1,
                                           SRR1803612.273934.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368491.8/ ENSP00000357477.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-730               BC048977.1         267-996
            731-2028            BC064835.1         489-1786
            2029-2883           AF308284.1         931-1785
            2884-6080           AL589993.5         84632-87828         c
            6081-7373           BC045657.1         2933-4225
FEATURES             Location/Qualifiers
     source          1..7373
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.31"
     gene            1..7373
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; LIS10; NY-BR-15"
                     /note="centrosomal protein 85 like"
                     /db_xref="GeneID:387119"
                     /db_xref="HGNC:HGNC:21638"
                     /db_xref="MIM:618865"
     exon            1..395
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; LIS10; NY-BR-15"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..2740
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; LIS10; NY-BR-15"
                     /note="isoform a is encoded by transcript variant 1;
                     serologically defined breast cancer antigen NY-BR-15;
                     centrosomal protein of 85 kDa-like; centrosomal protein
                     85kDa-like"
                     /codon_start=1
                     /product="centrosomal protein of 85 kDa-like isoform a"
                     /protein_id="NP_001035940.1"
                     /db_xref="CCDS:CCDS43498.1"
                     /db_xref="GeneID:387119"
                     /db_xref="HGNC:HGNC:21638"
                     /db_xref="MIM:618865"
                     /translation="MWGRFLAPEASGRDSPGGARSFPAGPDYSSAWLPANESLWQATT
                     VPSNHRNNHIRRHSIASDSGDTGIGTSCSDSVEDHSTSSGTLSFKPSQSLITLPTAHV
                     MPSNSSASISKLRESLTPDGSKWSTSLMQTLGNHSRGEQDSSLDMKDFRPLRKWSSLS
                     KLTAPDNCGQGGTVCREESRNGLEKIGKAKALTSQLRTIGPSCLHDSMEMLRLEDKEI
                     NKKRSSTLDCKYKFESCSKEDFRASSSTLRRQPVDMTYSALPESKPIMTSSEAFEPPK
                     YLMLGQQAVGGVPIQPSVRTQMWLTEQLRTNPLEGRNTEDSYSLAPWQQQQIEDFRQG
                     SETPMQVLTGSSRQSYSPGYQDFSKWESMLKIKEGLLRQKEIVIDRQKQQITHLHERI
                     RDNELRAQHAMLGHYVNCEDSYVASLQPQYENTSLQTPFSEESVSHSQQGEFEQKLAS
                     TEKEVLQLNEFLKQRLSLFSEEKKKLEEKLKTRDRYISSLKKKCQKESEQNKEKQRRI
                     ETLEKYLADLPTLDDVQSQSLQLQILEEKNKNLQEALIDTEKKLEEIKKQCQDKETQL
                     ICQKKKEKELVTTVQSLQQKVERCLEDGIRLPMLDAKQLQNENDNLRQQNETASKIID
                     SQQDEIDRMILEIQSMQGKLSKEKLTTQKMMEELEKKERNVQRLTKALLENQRQTDET
                     CSLLDQGQEPDQSRQQTVLSKRPLFDLTVIDQLFKEMSCCLFDLKALCSILNQRAQGK
                     EPNLSLLLGIRSMNCSAEETENDHSTETLTKKLSDVCQLRRDIDELRTTISDRYAQDM
                     GDNCITQ"
     exon            396..554
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; LIS10; NY-BR-15"
                     /inference="alignment:Splign:2.1.0"
     exon            555..1342
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; LIS10; NY-BR-15"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1461
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; LIS10; NY-BR-15"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1579
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; LIS10; NY-BR-15"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1759
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; LIS10; NY-BR-15"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1912
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; LIS10; NY-BR-15"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2067
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; LIS10; NY-BR-15"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2185
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; LIS10; NY-BR-15"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2236
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; LIS10; NY-BR-15"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2344
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; LIS10; NY-BR-15"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2576
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; LIS10; NY-BR-15"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..7373
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; LIS10; NY-BR-15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7353..7358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; LIS10; NY-BR-15"
                     /note="hexamer: AATAAA"
     polyA_site      7373
                     /gene="CEP85L"
                     /gene_synonym="bA57K17.2; C6orf204; LIS10; NY-BR-15"
                     /note="major polyA site"
ORIGIN      
        1 agagaacccg cagctgcaac ttcgcctgga gcctttgagc ctgggctcag ccggggatct
       61 agcagccgtc accgccgagt cgccgcttcc ccggcgcggg cctcagccca gccggcttgg
      121 ccatggcagg cgccggcagt gcggcgaatc tggcccctgc gctccccgcc cgtagctgag
      181 cagccgttaa ccagccatcc cgcctttcct cctgcccgtg tcgccgaggc ccacgctccg
      241 cgcaagtttc cgccgccgaa gaagcaggag gacggacgtg aggagtcggg cgtccctggc
      301 ccacccggcc ctctcgcccg cgatgtgggg gcgcttcctg gctccggagg ccagcggccg
      361 ggatagcccc ggcggagccc gcagcttccc tgccggccca gattattcat cagcatggct
      421 acctgctaat gaatcattgt ggcaggccac aactgttcca tctaaccatc gaaataacca
      481 tatcaggaga cacagtatag cttctgacag tggagacact ggcattggaa cttcctgttc
      541 tgatagcgtg gaagatcatt caacttcaag tggcacatta tcttttaagc ctagtcaatc
      601 attgattact cttcctactg cccatgtgat gccgtctaat tccagcgctt caatttccaa
      661 acttagggaa tcattgacac cagatggctc aaaatggagt acaagcctca tgcaaacatt
      721 gggaaaccac agtagggggg agcaggactc ttccctagac atgaaggact tccggccact
      781 tcggaaatgg tcatctttat ccaaactcac tgccccggat aactgtggcc agggtggcac
      841 tgtatgcaga gaagagtcaa ggaatggttt ggagaagata gggaaggcta aggctttaac
      901 atcacaactg aggacaattg ggcctagctg tttacatgat agtatggaga tgcttaggtt
      961 agaggacaag gaaataaata aaaaacggtc atcaactctg gactgcaagt ataaatttga
     1021 gagctgtagc aaggaggact ttagagcctc ttcctctact cttaggagac agcctgtaga
     1081 catgacatat agtgccttac ctgaaagcaa gcccattatg acaagctcag aggcttttga
     1141 acctccaaaa tatttaatgc ttggtcaaca ggcagtaggt ggagttccca ttcagccttc
     1201 cgtaaggact cagatgtggc ttacagagca gctgcggaca aatcctttgg aaggtagaaa
     1261 tacagaggat tcttacagtt tagctccttg gcaacagcag caaattgaag actttcgaca
     1321 aggaagtgaa acaccaatgc aggttttgac tggatcatct cgtcaaagtt attcacctgg
     1381 ctatcaggat ttcagtaagt gggaatcaat gttgaaaata aaagaaggac ttctaaggca
     1441 gaaagaaatt gtaatcgatc ggcagaagca acaaattacc cacctgcatg agaggataag
     1501 ggataatgaa ttacgggctc aacatgccat gttaggacat tatgtaaatt gtgaggattc
     1561 ttatgtggct agtttgcagc cacaatatga gaacacttca ctccagacac cattttcaga
     1621 ggaatcagtt tcccattccc aacaagggga atttgagcaa aagcttgcat ctactgagaa
     1681 agaagtttta cagcttaatg agtttctcaa acaaagacta agcctattta gtgaagagaa
     1741 gaagaaacta gaggaaaaac ttaaaactag agatcgatac atcagtagtc tgaaaaagaa
     1801 atgccagaag gaatctgaac aaaacaaaga aaagcagaga agaattgaga ccttggaaaa
     1861 gtatctggct gatcttccaa ctctagatga tgtacagagt cagagtctac agctgcagat
     1921 tctggaagaa aaaaataaga atttacaaga ggctttgata gatacagaaa aaaaacttga
     1981 agagatcaaa aagcagtgtc aagataaaga gacacagtta atatgccaga aaaagaaaga
     2041 aaaggagtta gtaactaccg ttcagagttt gcaacaaaaa gtagaaagat gccttgaaga
     2101 tggaatccgc cttcccatgt tagatgcaaa acagcttcag aatgaaaatg ataatctcag
     2161 acaacaaaat gagactgcta gtaagataat agacagccaa caagatgaga ttgacagaat
     2221 gattttagaa attcagtcta tgcaaggaaa gctttctaaa gagaaactga ccactcaaaa
     2281 gatgatggaa gagctggaaa agaaagaaag aaatgtacag agattaacaa aagcattgct
     2341 tgaaaaccaa agacaaacag atgagacatg ctctttattg gatcagggcc aggaacctga
     2401 ccaatctagg cagcagacag ttctttccaa acggccacta tttgatttga ctgtgattga
     2461 tcagctgttc aaggaaatgt cctgttgttt gtttgacttg aaagcattgt gtagtattct
     2521 taatcagcgt gctcagggca aggagcctaa tctttcatta ttactgggaa taagatcaat
     2581 gaactgttca gctgaagaga ctgagaatga ccacagcaca gaaacactca ctaaaaagct
     2641 gtcagatgtg tgccagttac gaagagacat tgatgaatta aggactacaa tatcagaccg
     2701 ctatgctcag gacatgggag acaactgcat tactcagtga tcaagtgtta gtcccacagc
     2761 aataatgacc tgttgtttaa atgctgctgt gttatggagc cataatggaa ggttgcaagt
     2821 gacatgactt gcacttaggg attttttttc tgtggatttg ttttgttgaa ggggagaagg
     2881 gaagtgaaga gattttgaag gggcttatct aatcaggcaa aaagaaaaaa aatcaaatta
     2941 cctttggaaa atatgataaa atctacaagg aaaaaaatgt ctatattctc aaactactga
     3001 ttgtaggacc aagctgtgaa gagtaccctt cacatgaagg agtaggattc cttttaatcc
     3061 tatagctttg tgtgtttgtg tgtgcatgta tgtgtgttgt tgtgtgtgtg tgcacgtgct
     3121 ttattcacaa atttataagg gtttctaggg tcagagcaga gcttctgaga aaggcacacg
     3181 ctgtttattc ttatatttct ttcatataga agcttgtgtt gtactttggg attttcagtg
     3241 gctggctgaa caagagttca aacagcaggc aagtgttgtc atggtagtac aggaggcaaa
     3301 accatttata ttttgaacac ttactgcact gataggatgt ttgtggttga gctgatttta
     3361 gtactgtaga taggtcagct gtttttccag agtgattgtg gatttcccaa gaggtgtgaa
     3421 attttgacgt gatgctcttt ttccttagca ttgtaatgta tgtgttacaa gaaaggttaa
     3481 cataacttga actaatttta acatgttcct tactatttac aattttttat ttatatgttt
     3541 tatatatata catatataaa tgtaaacaaa gccatatata attaataaag gcattggatc
     3601 attattataa aaggaagatt aacaaagtta ccctggaaca atagcttact tatccaaatc
     3661 tcaacattta cattttaaca gttttgtatg tttcaaagtt gaaactactg taagagaaag
     3721 ccaatactat ttatatctga atcaacagta gcataaacat tttttaattg agattgtatt
     3781 ttaatccctt ttgttaaagt acattaacaa cagtttttca caggatatga acttggcgaa
     3841 attagttctt aatctgaatt acagggtatt actatgaaat gcagttgatt ttgcagtaga
     3901 cgtacagtca tttaaacttc caaatgagtg ttgtccatgt ttctgttggt attttggaag
     3961 gattatacat tttattgcct tcagcattga ttatgttctt ttgaatatac ttagttttgg
     4021 cgaaagcctt gtcctttgta agttggtttg atcttgtgat gcaaccaagt ctcatttagg
     4081 tcaagactaa ataagagatg gaggggtaga gggtgtgact caagcaggat aatattgatt
     4141 tgataaagag catatcacat gcctgttttc ttgccagata aagggcatag cacatgcctg
     4201 ttttcttata tactagaata aaggctctcc taggaaagat ttttcttaaa tatttaaaag
     4261 tgaaaatgtg agacaaggcc ttcaaggaga ctacccagga agatacacag tttaaaatgt
     4321 tggctataca gctctcaata gattatttta tagttatagt tgaataatca gttataatac
     4381 actgtaaaga aatcagattt tccttctgtt tggtgtctga gtccttcctg ctcttcttac
     4441 ttctgagaat ctgggcacta agaaatcagt aagtacattg tagtgctcct gcatcccaga
     4501 gtccttaacc taaggagggt cttagtcact ggtaagaact tggctttcta attatattca
     4561 cttggttttt aacattagta gcttgacgat aatcagggta tagtaaattt ccaccaaaaa
     4621 tgtgatgcga agaattctgc cttggtcctt tatggtaaaa cagataataa cgtctaaaat
     4681 agatcagcca caagtgcagc aaatattttt acactctctt tgaatagaat cccaaccacc
     4741 ctcccccatg attttagaaa taaaggcttc ctaaaataat agaacaaatt ggcaaacaat
     4801 cactaattgg accagtaggt tcttacttaa atatctctcc tagattttta gtgtatgttt
     4861 tgggatttta tgggtttatt tatttttttt tttttaagca gacgttacag tttgttttaa
     4921 tctactatag atacgttttt gttttttggc ttagttgggg ataaaataat ttatttgtaa
     4981 gttagctttc taaaacttag agaaagtaat ttaattcacg tatcttaaaa ataaaattcc
     5041 aaagttaaaa aatttctgac ttagtaggaa gttaacaaaa ctactgctga tgcatttcag
     5101 tttccaaaat ctgtaccctc cccccataaa aaagggagtt aagatgtgct agtttaagta
     5161 gttagctgaa ttatagattg atcctcttaa aatctggagt ttgtaaaggg gcctacataa
     5221 acagtagata gacttggagg gattttgtgg gggaattgaa actaatagta ttctatctag
     5281 tttgtcagta tttacttttt gatttttatt tttcagaaaa ttttcctttc ccaggacacc
     5341 ctcttgtatt agaatatcct cttctgtatc acattaaaaa cagattttac tgttagacca
     5401 aataagatgg gcaaatagca acactagagc atctcaccca gtttgaacta ggatgttcgt
     5461 ggaagttatg acaccaatat attcctgaaa tgaaaattaa cctaaatttt aaagtgaatc
     5521 tatttgaaaa tttacttaga taatgaaacc tcgttttaat tgtgcttttt gtgaatccaa
     5581 cacttgtttg cttagaaagt atcttatcca gtattaatat tttgttcttt tgggttttaa
     5641 agttgagctt attcagcctc aatcacatta cagcaagcat aaagtaacag ttgactcaat
     5701 gaaagaccca aattgcctgt acagataaaa ttcactgaat caaaggcaca atagctatct
     5761 tttcacttga gctcagaaaa gtaaaatggc ttaatttgaa ctattaattt tcagtggcct
     5821 ctaattaaac aaaaacaaaa aaccacaaat actggctagg taagatattc ctgaggtcat
     5881 tttaaaagaa gtgtggcacc taggattcaa tatttaatgc taacagtatt atattttagt
     5941 gaaatttatt ttggtggtga cagtttatta aacctaatta gacttctttc aatagcttgt
     6001 tgtagagaca atctcaaggg ctggaaagtg ttgctaaaat gaatgtcata catttctgat
     6061 atactaagga gcttataaag taattctttc atagtgcaag aattattaat ttcttagagg
     6121 atgtttttaa aggagctact taattgggaa aatgttcttt aaatatcagt aatagttcat
     6181 taagtaacat agtagctaag aacatggact atattttcac agcatagttc agcttaggca
     6241 cacctttagt ttggattatt ggcattctct tacgtaggaa ttatatcatt gtagatatgt
     6301 aattatggta ataagcaatt ttcataacca tgctcactca gactatatca tttgaaactg
     6361 ccatgtttcc atttttgaca attcatgttc acaaaacaac aggaacaatt tcctatttgg
     6421 tataaagagc aaaatttcca actttgcccc aaaatgccat gggtggcata ttgccatatg
     6481 attatatcat atatttaatc atgtatggga aagattttgg attttttttc ttatttaaaa
     6541 aagtgctaaa tataagaata tagttttaaa tcagcaagtc taataacact attgcagctg
     6601 tacacagaga gaaccttttg tgcctttttg cctgcagtaa gcatttattt ctattttaca
     6661 tgagttctaa gaatgttgat gattattgca ccttgttctt ctgtatataa acttgattaa
     6721 ggaatttttt tttttaaagc aaggagccgt tttttgttac taggtggata ccttagtaaa
     6781 catgagggga attatcagat agatgtcttt ggagcccagc cttccctgtg tagtgagctg
     6841 gaaactcctt tagattgtat tcattggtgt gtatgtatat gtacatatat gtataaatag
     6901 ttaaatacat aaacataaaa cttaacatcg cattgttgtg atgacaagaa gtagtaaggt
     6961 gctaggtggt tacattaaaa agcacagcac agtgtataat cagtcactat gactggtggt
     7021 tttgtaagct gggttcagtt tttgaaccac ccagaatacc tcatgtgtaa atacagtgtt
     7081 catgacttaa ttgaaataca gttattgttt aaaaaaaaaa aaaaagaatg tgaagccact
     7141 ggttggctta tgccttctga tctatcattc ttgcctcttt ttttgtaaag gggttttctt
     7201 cttgttgttc tgttttttaa tagggtttac agctagaatt ttgaatgcca aagttctatt
     7261 tattaaatta agaaaaaagt tttcaatgtt aatggctagt atttttccac tggactattg
     7321 tttgttgatg ttggaatttg tatttacaga gaaataaatt ttttataaaa aga
//
