LOCUS       NM_001330691           11233 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens centrosomal protein 78 (CEP78), transcript variant 3,
            mRNA.
ACCESSION   NM_001330691 XM_017015193
VERSION     NM_001330691.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11233)
  AUTHORS   Zhu,T., Zhang,Y., Sheng,X., Zhang,X., Chen,Y., Zhu,H., Guo,Y.,
            Qi,Y., Zhao,Y., Zhou,Q., Chen,X., Guo,X. and Zhao,C.
  TITLE     Absence of CEP78 causes photoreceptor and sperm flagella
            impairments in mice and a human individual
  JOURNAL   Elife 12, e76157 (2023)
   PUBMED   36756949
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11233)
  AUTHORS   Zhang,X., Zheng,R., Liang,C., Liu,H., Zhang,X., Ma,Y., Liu,M.,
            Zhang,W., Yang,Y., Liu,M., Jiang,C., Ren,Q., Wang,Y., Chen,S.,
            Yang,Y. and Shen,Y.
  TITLE     Loss-of-function mutations in CEP78 cause male infertility in
            humans and mice
  JOURNAL   Sci Adv 8 (40), eabn0968 (2022)
   PUBMED   36206347
  REMARK    GeneRIF: Loss-of-function mutations in CEP78 cause male infertility
            in humans and mice.
REFERENCE   3  (bases 1 to 11233)
  AUTHORS   Lahteenoja,L., Hakli,S., Tuupanen,S., Kuismin,O., Palosaari,T.,
            Rahikkala,E. and Falck,A.
  TITLE     A novel frameshift variant in CEP78 associated with nonsyndromic
            retinitis pigmentosa, and a review of CEP78-related phenotypes
  JOURNAL   Ophthalmic Genet 43 (2), 152-158 (2022)
   PUBMED   35240912
  REMARK    GeneRIF: A novel frameshift variant in CEP78 associated with
            nonsyndromic retinitis pigmentosa, and a review of CEP78-related
            phenotypes.
            Review article
REFERENCE   4  (bases 1 to 11233)
  AUTHORS   Igelman,A.D., Ku,C., da Palma,M.M., Georgiou,M., Schiff,E.R.,
            Lam,B.L., Sankila,E.M., Ahn,J., Pyers,L., Vincent,A., Ferraz
            Sallum,J.M., Zein,W.M., Oh,J.K., Maldonado,R.S., Ryu,J.,
            Tsang,S.H., Gorin,M.B., Webster,A.R., Michaelides,M., Yang,P. and
            Pennesi,M.E.
  TITLE     Expanding the clinical phenotype in patients with disease causing
            variants associated with atypical Usher syndrome
  JOURNAL   Ophthalmic Genet 42 (6), 664-673 (2021)
   PUBMED   34223797
  REMARK    GeneRIF: Expanding the clinical phenotype in patients with disease
            causing variants associated with atypical Usher syndrome.
REFERENCE   5  (bases 1 to 11233)
  AUTHORS   Goncalves,A.B., Hasselbalch,S.K., Joensen,B.B., Patzke,S.,
            Martens,P., Ohlsen,S.K., Quinodoz,M., Nikopoulos,K., Suleiman,R.,
            Damso Jeppesen,M.P., Weiss,C., Christensen,S.T., Rivolta,C.,
            Andersen,J.S., Farinelli,P. and Pedersen,L.B.
  TITLE     CEP78 functions downstream of CEP350 to control biogenesis of
            primary cilia by negatively regulating CP110 levels
  JOURNAL   Elife 10, e63731 (2021)
   PUBMED   34259627
  REMARK    GeneRIF: CEP78 functions downstream of CEP350 to control biogenesis
            of primary cilia by negatively regulating CP110 levels.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11233)
  AUTHORS   Nikopoulos,K., Farinelli,P., Giangreco,B., Tsika,C.,
            Royer-Bertrand,B., Mbefo,M.K., Bedoni,N., Kjellstrom,U., El
            Zaoui,I., Di Gioia,S.A., Balzano,S., Cisarova,K., Messina,A.,
            Decembrini,S., Plainis,S., Blazaki,S.V., Khan,M.I., Micheal,S.,
            Boldt,K., Ueffing,M., Moulin,A.P., Cremers,F.P.M., Roepman,R.,
            Arsenijevic,Y., Tsilimbaris,M.K., Andreasson,S. and Rivolta,C.
  TITLE     Mutations in CEP78 Cause Cone-Rod Dystrophy and Hearing Loss
            Associated with Primary-Cilia Defects
  JOURNAL   Am J Hum Genet 99 (3), 770-776 (2016)
   PUBMED   27588451
  REMARK    GeneRIF: data strongly suggest that mutations in CEP78 cause a
            previously undescribed clinical entity of a ciliary nature
            characterized by blindness and deafness but clearly distinct from
            Usher syndrome, a condition for which visual impairment is due to
            retinitis pigmentosa
REFERENCE   7  (bases 1 to 11233)
  AUTHORS   Brunk,K., Zhu,M., Barenz,F., Kratz,A.S., Haselmann-Weiss,U.,
            Antony,C. and Hoffmann,I.
  TITLE     Cep78 is a new centriolar protein involved in Plk4-induced
            centriole overduplication
  JOURNAL   J Cell Sci 129 (14), 2713-2718 (2016)
   PUBMED   27246242
  REMARK    GeneRIF: the interaction between Cep78 and the N-terminal catalytic
            domain of Plk4 is a new and important element in the centrosome
            overduplication process.
REFERENCE   8  (bases 1 to 11233)
  AUTHORS   Zhang,M., Duan,T., Wang,L., Tang,J., Luo,R., Zhang,R. and Kang,T.
  TITLE     Low expression of centrosomal protein 78 (CEP78) is associated with
            poor prognosis of colorectal cancer patients
  JOURNAL   Chin J Cancer 35 (1), 62 (2016)
   PUBMED   27357513
  REMARK    GeneRIF: CEP78 functions as a tumor suppressor in colorectal cancer
            and low CEP78 expression leads to shorter survival in colorectal
            cancer patients.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 11233)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   10 (bases 1 to 11233)
  AUTHORS   Andersen,J.S., Wilkinson,C.J., Mayor,T., Mortensen,P., Nigg,E.A.
            and Mann,M.
  TITLE     Proteomic characterization of the human centrosome by protein
            correlation profiling
  JOURNAL   Nature 426 (6966), 570-574 (2003)
   PUBMED   14654843
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA970400.1, BE267999.1,
            DA935092.1, BG287960.1, BM759819.1, AL353705.23, BC091515.1 and
            CB241629.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001330691.2.
            
            Summary: This gene encodes a centrosomal protein that is both
            required for the regulation of centrosome-related events during the
            cell cycle, and required for ciliogenesis. The encoded protein has
            an N-terminal leucine-rich repeat (LRR) domain with six consecutive
            LRR repeats, and a C-terminal coiled-coil domain. It interacts with
            the N-terminal catalytic domain of polo-like kinase 4 (PLK4) and
            colocalizes with PLK4 to the distal end of the centriole. Naturally
            occurring mutations in this gene cause defects in primary cilia
            that result in retinal degeneration and sensorineural hearing loss
            which are associated with cone-rod degeneration disease as well as
            Usher syndrome. Low expression of this gene is associated with poor
            prognosis of colorectal cancer patients. [provided by RefSeq, Mar
            2017].
            
            Transcript Variant: This variant (3) uses an alternate splice site
            in the central coding region, an alternate exon structure in the 3'
            coding region, and differs in the 3' UTR, compared to variant 1.
            Variants 3 and 5 encode isoforms that are the same length, but have
            distinct protein sequences. The encoded isoform (c) is shorter and
            has a distinct C-terminus, compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.8235.1,
                                           SRR1803616.34310.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000643273.2/ ENSP00000496423.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-298               DA970400.1         14-311
            299-858             BE267999.1         1-560
            859-1312            DA935092.1         138-591
            1313-1763           BG287960.1         42-492
            1764-2004           BM759819.1         214-454
            2005-2073           AL353705.23        140018-140086
            2074-2121           AL353705.23        140402-140449
            2122-3426           BC091515.1         440-1744
            3427-9979           AL353705.23        146427-152979
            9980-9980           CB241629.1         18-18               c
            9981-11233          AL353705.23        152981-154233
FEATURES             Location/Qualifiers
     source          1..11233
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.2"
     gene            1..11233
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /note="centrosomal protein 78"
                     /db_xref="GeneID:84131"
                     /db_xref="HGNC:HGNC:25740"
                     /db_xref="MIM:617110"
     exon            1..529
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..2394
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /note="isoform c is encoded by transcript variant 3;
                     centrosomal protein of 78 kDa; centrosomal protein 78kDa"
                     /codon_start=1
                     /product="centrosomal protein of 78 kDa isoform c"
                     /protein_id="NP_001317620.1"
                     /db_xref="CCDS:CCDS83376.1"
                     /db_xref="GeneID:84131"
                     /db_xref="HGNC:HGNC:25740"
                     /db_xref="MIM:617110"
                     /translation="MIDSVKLRRDSAADFFSHYEYLCALQNSVPLPAVRACLREGVLD
                     FNADRLRGVDWAPLLSTLKINKDLPLVSIKSFFQPWLGDTGSDMNKFCRSRVPAIRYK
                     DVTFQLCKALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPI
                     GDGGLEIICQGIKSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRY
                     RRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKAL
                     LEALETNTTLVVLDIRKNPLIDHSMMKAVIKKVLQNGRSAKSEYQWITSPSVKEPSKT
                     AKQKRRTIILGSGHKGKATIRIGLATKKPVSSGRKHSLGKEYYAPAPLPPGVSGFLPW
                     RTAERAKRHRGFPLIKTRDICNQLQQPGFPVTVTVESPSSSEVEEVDDSSESVHEVPE
                     KTSIEQEALQEKLEECLKQLKEERVIRLKVDKRVSELEHENAQLRNINFSLSEALHAQ
                     SLTNMILDDEGVLGSIENSFQKFHAFLDLLKDAGLGQLATMAGIDQSDFQLLGHPQMT
                     STVSNPPKEEKKALEDEKPEPKQNALGQMQNIQVSICMQSAYNEGTLMKFQKITGDAR
                     IPLPLDSFPVPVSTPEGLGTSSNNLGVPATEQRQESFEGFIARMCSPSPDATSGTGSQ
                     RKEEELSRNSRSSSEKKTKTESH"
     exon            530..702
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /inference="alignment:Splign:2.1.0"
     exon            703..775
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /inference="alignment:Splign:2.1.0"
     exon            776..879
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1054
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1168
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1233
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1345
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1481
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1527
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1656
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1734
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1901
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2073
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2121
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2383
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..11233
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3207..3212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /note="hexamer: AATGAA"
     polyA_site      3227
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /note="major polyA site"
     regulatory      9950..9955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /note="hexamer: AATGAA"
     polyA_site      9974
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /note="major polyA site"
     polyA_site      10038
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
     regulatory      10093..10098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /note="hexamer: AAGAAA"
     polyA_site      10115
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
     regulatory      11209..11214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
                     /note="hexamer: AATAAA"
     polyA_site      11233
                     /gene="CEP78"
                     /gene_synonym="C9orf81; CRDHL; IP63"
ORIGIN      
        1 ggcttgaatc ccggcgcctc agaggactat gaggcgggcg ccaactgctt gggccgcagg
       61 gcgggaggca gcgcgggagt ggggcgttga ggggccggcc tagcttgggg ctctggcctt
      121 gcgtcttccg accgaatcac cgctcctgag cccggtgcgg ggctgccgct atcgcctggc
      181 cgtgggtgcc ggagcggccg ggttgcgact cagcgttctt gggtgggcgc gggcggcgtc
      241 tccgcggcgg gcatcccccg aggccgccct cgggccatga tcgactccgt gaagctgcgc
      301 cgcgacagcg cggcggactt cttctcccac tacgagtacc tgtgcgcgct gcagaactcg
      361 gtgccgctgc ccgccgtgcg cgcctgtctc cgggagggcg tgctggattt caacgccgac
      421 cgcctccgcg gggtggactg ggcgcctctg ctgagcaccc tcaagatcaa taaagacctg
      481 cccttggtct ccatcaagag cttcttccag ccctggctgg gggacacagg ttctgacatg
      541 aataaatttt gcagaagtcg tgttcctgcg ataagataca aagatgtgac cttccagttg
      601 tgtaaagctc ttaaaggctg tttaagtata tcaagtgtgc taaagaacct ggagctaaat
      661 ggactaattc tgagagagag ggatttaact attctagcaa agggattgaa taaatcggct
      721 tctttggtgc acctgtctct tgcaaattgt ccaattggag atggaggttt agaaattatt
      781 tgtcaaggta taaagagctc tatcactctt aagacagtca acttcacagg atgtaatctg
      841 acatggcagg gagcagatca catggccaag atcttaaagt atcagaccat gagaaggcat
      901 gaagaaacct gggctgagag tcttcgctat aggagacctg atcttgactg tatggctggc
      961 ttaagacgta tcacactgaa ttgcaacaca cttattggtg acctaggtgc atgtgctttt
     1021 gcagactctc tcagtgagga tttatggctg agagctcttg acctgcaaca gtgcggcctc
     1081 accaatgaag gagcaaaggc tttgctagag gcccttgaaa ccaatacaac tctggtcgtt
     1141 ctggatataa gaaaaaatcc actcattgat cattctatga tgaaagcagt tatcaaaaaa
     1201 gtcctccaga atggaaggag tgccaaatca gagtaccagt ggataacttc tccatcagtg
     1261 aaggaaccat ccaaaactgc taaacagaaa aggagaacta taattctagg aagtggtcac
     1321 aaaggaaaag ctactattag aattggattg gctacaaaga aacctgtaag tagtggcaga
     1381 aaacactccc ttggtaaaga atattatgcg cccgcacctc ttccacctgg tgtgtctggt
     1441 ttcttgccgt ggcgtactgc agaacgtgca aaaagacaca ggggtttccc attaatcaaa
     1501 acacgtgata tatgtaatca gttgcagcaa ccaggttttc ctgtgactgt gacagtagag
     1561 agtccttcat cctctgaagt tgaagaggtt gatgattctt cagagagtgt tcatgaagtg
     1621 cctgagaaaa ctagtataga acaagaagca ttacaggaaa aactggagga gtgcctaaag
     1681 cagttaaagg aagaaagagt gataaggctt aaggttgata aacgagtcag tgagctggaa
     1741 catgaaaatg cccagttaag aaatataaat ttctctttgt ctgaagccct tcatgcacag
     1801 tcattgacaa atatgatcct ggatgatgaa ggtgttttgg gcagcattga gaattctttt
     1861 cagaagtttc atgctttctt ggatctcctt aaagatgctg ggcttgggca gcttgccaca
     1921 atggctggga tagatcagtc agattttcaa ttactaggtc atccccagat gacttctact
     1981 gttagtaatc cacctaaaga agaaaagaag gcgcttgaag atgaaaaacc agaaccgaag
     2041 cagaatgccc tagggcaaat gcaaaatatc caggtttcta tttgtatgca gtcagcttac
     2101 aatgaaggaa cactaatgaa gtttcagaaa attacaggtg atgctagaat tcctttgcct
     2161 ctcgactcct ttcctgtccc agtttctact ccagagggct taggaacttc cagcaacaac
     2221 ctaggagtcc cagctactga gcagcggcag gagtcttttg aaggattcat tgctagaatg
     2281 tgttctcctt caccagatgc gacttctgga actggaagtc aaagaaaaga agaggagttg
     2341 tccagaaata gcagatcttc ttcagagaaa aagaccaaaa cagaatccca ttgaaatgac
     2401 tggagaaata ttaaaataaa aataatagca gagttggaaa accagaaatt tgaacagtga
     2461 aatttctgga agataagaag cagatgattt aagtaccagt taattaaagg atggaacagc
     2521 taagccattc cactcatctt tggagcatct gattctggag tttgccacca ggctaagaaa
     2581 gcagctatct gaagtgggag ctctgaccca agaaatgctg ggatcggaga ataagggaat
     2641 tatccaaaat ggctccgaag aggaactgaa gttaagctgc ccacatgatc tctctaacta
     2701 tgatgacctg ccacttccgt ttataatcac catataagtg cctgtaatca tttgtgttca
     2761 ttaaaagtga accagaattc ccatttggat gaaaaaataa cacttccaac tttaatctta
     2821 ggccctcatt tataaatatg gacaaccaag aatcatcaaa tttgaagaaa accagtaaca
     2881 taaaaggagg catgaaatta aaattaacct gttcaagaag atagttacta ggagaaacat
     2941 gaaattttta aattaatgaa tcaaaatctt cagcaattca taaagatact gtgttcataa
     3001 agaataggat gccatgaaaa aaatatttag agtttctgga aattaaaaat ttgattatga
     3061 aactgaaaca ctcagaagat ggactacaca gcagaatgga ttcatttgaa gcttaaattc
     3121 atgaaatgga aggtattaat tggtcttaga cgtttcatca gcaacttaat tacttagaaa
     3181 aaatctttct cagagtaact aagcaaaatg aacaatgaac ccattaacgt gtggttttgt
     3241 tttttgggtt tttttttttt gagtcaaggt ctcactcatg tcacccaggc tggggtgtag
     3301 tgatgggatc acagcttatt gtaaccatga accattgggc ttaaattatc ttcccacctc
     3361 agcctcccaa gtagctgcaa tgtaccacca tgccgaagtt ttaaaaaatt attgtagagt
     3421 tgggttcttt ctttcttttc tttttttctt tttttctttt ttttttgaga cggagtctcg
     3481 ctctattgcc caggctggag tgcagtggta caatctcagc tcactgcaac ctcctcgatc
     3541 tcagctcact gcaaccgtga agtgatcttc ctgcctcagc ccccctagta actgggatta
     3601 caggcacaca ccaccatgcc tggctaattt ttgtattttt agtaaagacg gggtttcacc
     3661 atgttggcca ggctggtctc gaactcctaa cctcaggtga ttcacccacc tcggcctccc
     3721 aaagtgctgg gattacaggc atgagccact gcatccggcc aagatgggtt ctttcttagg
     3781 ctggtcttga actcctggcc tcaaatgatc ctcccacctt ggcctcccaa agtgctgaga
     3841 ctacagacct gagccactgt gcccagcccc atgaaagatg tttagatcaa ataaactgat
     3901 aaagatattg ataaagatat gagacaaact acttcagctt tgtgacctgc aaatcccctt
     3961 ttataatcac cagaggtgcc tgtagtcaga aaaagtctaa ataaatacta atgacatatg
     4021 aaaacaaagt ccaaccaaag ttctaggttt gaacatgaat ggaggcatgg caggacacag
     4081 aaagtgaaag cttgtcctag atattgtctt attcatggga aggatacagg tagtgtttga
     4141 ttctaggtat tgattgaaaa aatatattaa aatatatata aagttaaggg tatgttagta
     4201 aggataggtt aggtgatgtt gcattaacag ctcccaaatt ttaattactt tcaacaacat
     4261 aggtttattt gtgcccatgc agtttgcctt tggcagattg gctagaggcc cctattcaac
     4321 atcaacctca atctggaagc gaggctggtg gaacgtcact atttggaaca ttgctggttg
     4381 cagtgtccaa ggaaagacag tatgatgcag catatattgt gacttaaagc ttctgtctag
     4441 atgtgacata tgtcacttct gttcacattt ctttggccaa agaaagtcac atggttatgc
     4501 ctgagttcag cagaccaggg aagtgcagaa ttgccatttg ccatgagaag agagggaagc
     4561 aaatgtatgt caacaacttt aatagctaca aaactacctg gaaagaggga atggaatttt
     4621 taggtccaac aagacgggaa agaaaaagaa acaagctaca tagaaataaa aaatccacaa
     4681 tatagcaaga tcaagttttt tactcataat aaacatgaac aggttaaatt ctggaatcct
     4741 taggcttgag taaaaacatg aaatcccact gtgtgctatt tgcaaaatct aaaacgctgt
     4801 catagattat aaagagatga acaaaaatat accaggcaga tgctaaagag taaatgtggc
     4861 tgtgttagct gcagactaaa tagaacccaa ggtgaaaatt ggtaaagggg acaaaagctt
     4921 cttttggctg ataagtacag tgttgcagaa gattttttaa aaaaatatat ctgcaattta
     4981 aaaacttgat gttaggccgg gcgcagcggc tcacgcctgt aatcctagca ctttgggagg
     5041 ccgaggtggg tggatcacct gaggtcagaa gttcaagacc agcctggcca acatggcaaa
     5101 actccgtctc tactaaaaat acaaaaaaaa aaaaaaaaaa ttagctgggt gtcatggcgc
     5161 atgcctgtaa tcccagctac tcgggaggct gaggcaggag aatcgcttga acctgggagg
     5221 cggagtttgc agtgagctga gatggcaccg ctgcactcca gcctgggcca tagaggagac
     5281 tccgtctcaa acaaacaaaa accttcatct taaaattata gggtaagaat ttagaaatac
     5341 aaggaaaaat ggccagccag ttataacaag aagctttaag acatctcttt tcagaatcag
     5401 tggatcgact gctgcacaca cactagaatg gctaacattt tgaaatgctg ataaatatgc
     5461 agagcaactg gagttcctca cagctggtag gaatgcaaaa tgactcagtc actcaaaaca
     5521 gtttggcaga ttctttaaat gctaacatac acataccata tgaccaagca gtcccactcc
     5581 tgggtattta gagagatgaa aacttagttc acacaaaacc tgtgcgtgga tatttatagc
     5641 agctccattc atagtgacca agatgtcttc caacaggtga atggatagcg atgtatccat
     5701 atggtggcaa acatgccaca attcggatga atctcaacat catatgctga gtgaaaaagc
     5761 cagtctcgga aggctacatt ctgtatgatt ccatttatat ggcattcttg aaaagacaaa
     5821 actatagtga cagaacagat tggagattgc caggtgttgg ggttgggagg agttgattac
     5881 aaagaggctg tacaagggag tttgtttgtt tgtttgtttt ggtgatgaac agttctgtat
     5941 cctgattgcg gtggtggtaa cgtgagtcta tacatatgtt aaaatttata gaactgcata
     6001 ctctcaaaaa aattagtttt actctataat aatattagag cttaaaaaat tcatccctct
     6061 tgcccatcag tagatcagga tatgaaggat accattgaac ataaatattt tgtatccatg
     6121 atgaatacaa agtatattct cctggaaaac caatagaaca ttcatataaa tgattcctat
     6181 gaaggtaaaa aacttacaaa attcaaagat catacagatc atgtgctctg tataatgtaa
     6241 taatagtaac aaaaggcctg tccacttgga aatttttaaa tgatcttcta aataactcat
     6301 ttaaaggaga aatcaaaata aattgcaaat tatttagaat taataaaaac ttctctaaag
     6361 ctgaggaatt ctaccaaaga ggtgttagag gaaattgtat agattttgat ttactttcca
     6421 ggaagaaaga agacaaaaga gatgaattaa acatttaaag ctaagaaaga gataaaccaa
     6481 aagaaaggtg aggaattggt aaaagcagaa atgaataaaa tagcaaattt tgatcagtga
     6541 aacacaggtt tttaaaaatg aaagataaac ctttgtaaaa tatgataaag aaaaaaaagc
     6601 aagaagtaat taacaaaaat tgccagcatt aggaataatt ttagaaggat acctacaact
     6661 agaagagata tttttaatta tgagcacttt tataatttac tataaataat tgtgtagtgt
     6721 taaaccaata aatttgaaag actagatgaa atgtgactgt ttaaaaatat ggattgtaaa
     6781 aattgataaa aaatagaaaa tgtaaataaa cgaaacatct taggagaaat tgaaaaaata
     6841 ggacaagaac ttatttttaa aaagaggcca ggtgcggtgg cccatgcctg taataccagt
     6901 actttgggag gccgaggtgg gcggatcacc tgagatgagg agttcaagac cagcctggcc
     6961 aacatggtga aaccccgtct ctactaaaaa tacaaaaatt agccgggctt ggtggcgggc
     7021 acttgtaatc ccaactactc aggagtctga ggcatgagtg tcgcttgaac ctgggaggca
     7081 gaggttgcag tgagctgagg tcacaccgtt gcactctagc ctgggagaca agagggaaac
     7141 tctgtctcca aaaaaaaaaa aaaaaaaata cagttagaaa aactttaaag gggccaggtg
     7201 tggtggctca tgtctgtaat cccagcactt tgggacacca aagtgggaac attgctgaga
     7261 ccagcagttt gagaccagcc tgggcaagac ctcatctcta caaaaattaa aaaacaaaac
     7321 aaaacaaaaa aacccaaaac ttagccaggc atggtggtgc gtgcatgtag tcccagccac
     7381 tcaggaggct gaagtgggag gatcgcttga ggccgggatt cgaggctgca gtgagctgtg
     7441 atcatgccac cactgctctc tagcctgggc aagagtgaga ctccgactca agaagagaaa
     7501 aagaaaaacc ttccaggggc acatttattt gtaaaccatt ccagaggata gaaaagagat
     7561 gtaaggctcc ctaattcatt ccatacggtt agcgtaatcc ttatagcaaa ctgcacaaat
     7621 aaaacacaag gaaaactaaa ccaaattcaa ttaatgtagg tgcaaaaaat ccaaaataaa
     7681 actagcagtt tgaattcagc attgtagcaa aagatatatc attttcaagg aagatttgta
     7741 ccaaaacatg caagattgag tgaagagtaa ctcactgtag ctcactaaat taacagatta
     7801 aagaagtata gtcatcttca caagctgaaa gagtatgtga taaattcaac atcctctggt
     7861 attcttaaca atctcgaaat agaaggaaac ttccttagct tagcttcttg gcttcattaa
     7921 atatacctaa cagaaatcca caggaaacaa acttggtgaa aagtttttgc taagataaaa
     7981 acggtactaa aaagtacaca ttttgggaaa tgagacaagg ctctcgttat ttgtaaatat
     8041 ggggtctttt tttttttgga caaaaaaccc cctgtgatga tctactggca tgctattaca
     8101 gctaataaag ctgaataagg aggctgtgca caacaccaac acaccggtat gaaaagtgtg
     8161 tacaccagca ataaccaatt agaaaatgta tgaggaaata gactctcatc cacaatagct
     8221 gcgagaagta aatattatct agaaataaga ttaacaagag aaatgtaagg cctatataaa
     8281 taaaaggata aatctatgct agagggtata aaagaaacac aaaaatagag gtatgccatg
     8341 tataagaccc aacataataa atagttctac caaattaatt tataaattca aagcaatttc
     8401 atataaccac agtaaagctt tttaaatgga tgtaataacc tgattataac attaatctga
     8461 aagtcatcag gcataaagca attttgatta catctcaaaa caatccatgg agttagggta
     8521 aatgtgctgt tcacacagga ataatcacag gtatagaacc gagaacctag gaacagagca
     8581 atgtatatat atatgtattt aaaaaatggc atcacaagtc agtagagaag ggtttgaact
     8641 attcagtaaa tgatgttgag gttatttact actttttctt atttcatatc atggatgaaa
     8701 aaaatcaaga tgaattaaac atggaaatta aaaataacta gaagaaaata ctggaaaaaa
     8761 attgtaataa atgtgtaaga aaggcattcc caaccaagac acaaaaccca gtagccatga
     8821 aaaaaaagat agatttgact acatttttaa aaagtaaaac ctttcacttt ttacaaaact
     8881 ttgataaaat tagatttcat aaataaagga gtgggaaaat acatgtaata gaacagaaga
     8941 tttaagataa tataaagagc acctacaaac aacaaaaatt ggacaaaggc tataaaaata
     9001 ttttataaat aagaaataca gactataaac ataaactttc aacctcgtaa gcaatcagga
     9061 aaattaaagt taaaatgaga tactattttt caatacattg aaatggcaga ttattaaaga
     9121 ttggtgatag tgctggagat aatgtgagga aaggagtatt ctcagtcatt gtagaaattg
     9181 atacagcttt tggatggaca gtttgacagt gtgtatcaac atgtgaaatg tctccagcct
     9241 ttgatctaat gactaatttt aggcatccag cctgaagaaa tattcacaca agtgcccaaa
     9301 gagtcagata caagactgtg tgaagtgttt tttgagataa taaaaaacta gaaacagcat
     9361 aaatgtacag aaatgcagaa attgttgaat tagtacatac caatttctga catataacac
     9421 tctgcagcag ataaagacaa tagctctcta gtgtggacat gaaaatattt ctaagacatt
     9481 gacaggacga agaagttgca cagtaaccac gcactcctgt ttacatttgt atagttaaaa
     9541 cttgtttacc tatacgtagc atatatgcgt gtgtgcaccc tagaaaagag tctgtgataa
     9601 cacatatcaa gctattgaca gcggttttgt ctgctgaagg aggaaaaaag gggggcttct
     9661 cacattttac tccatttaat tctaggttgt ttggtttaaa aaaaaagttt ttatgtacaa
     9721 cagacaattt ttaaaattcc ttttcatcat agaaaatgaa aatgtgtact ctgttatcct
     9781 ttacgctctg tccatttttt tcttcaaaaa tgtgtctgac ctattatcaa tgtgaatgaa
     9841 aatgagcttt gctacataac ctcttttcag agctttgtat tcctgaagtg ttggagtcgc
     9901 ctacatggca tagtcaaatg tttttaactt aaccacaacc cacagtaaaa atgaagcttt
     9961 ctgcaaagtt aaaagtagta gtcctggccc caccttcctt gtgtgcacgt ataattaatg
    10021 gaaaattgca tcaaacaact ctgattgtac ttctagtgac taattcatgt tctgttctat
    10081 tccttgcctt taaagaaaat tatgttggca actcacgaag tatgtttcac aatccactaa
    10141 tgggtaatgt cctactgttt ggaaacactg gctagagtgt ttcaaacatc tgctctgttt
    10201 acccctgaca aaactgctac tcgtggggca atgcaagtct ttcccacatt tgttttattt
    10261 tatggctaaa agtcatttct gcatttgcaa attacttcca aagcctacct tccttgagct
    10321 ctttaactct ctatagtctt ctggtaattt tctttagatt tcccttttca gaaccctttt
    10381 gtgacactga aaacctgagt tttcaaactg atacatctac ctgagaattt tcacatataa
    10441 tttggtcaaa aagttaaaaa ataagaagac tttgccctgt gactgaggtg ctcagaaggt
    10501 atggctggct gctcacaaag gcacatagtg agtgataggg gctgaaaggg ctcagagaat
    10561 gcccgagttc tcttagtaca gtttgtacat tttaaaccac tgtgaactga aaaaaaaaaa
    10621 aaaggcaacc ttggtagttt agaaatagat aaggacccac ttatagatta aataataatt
    10681 agcttgttcc agagagacca gtgaagatta gttggtttat ttaatgtgtt agaaagatgg
    10741 tcctcaaagt ccttgaaatg tgaaggcggc ttttatctcc ttaagaaaac aagaaaactc
    10801 cacaaaatct tgaaagctag ataatcctag cttaaatgat aaaatttgag tagagtttga
    10861 aaacactaaa atcagtttgc caaataacca gctctaattt ctttatacca aagccaaact
    10921 tcacctaaat cttacctaag aattgagttc cttattgtaa ccagatagga gacacttttg
    10981 tatattattc caaatattgc aaacctacaa ggagtaaaag gtgttattat tttaaagaag
    11041 aaggaatgag gcctgagagg tattgattca cttggttgag ggcttcaagt agcacaaggc
    11101 aaaagcagga tttgttgact tccaaacctg ttttcttcct tcaccatgtg gcctttgcat
    11161 ctttcccaca caaatattat tccacaaata tttattgtca ccaactataa taaaagaaca
    11221 gaactatgta tca
//
