LOCUS       NM_018140               2366 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens centrosomal protein 72 (CEP72), transcript variant 1,
            mRNA.
ACCESSION   NM_018140
VERSION     NM_018140.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2366)
  AUTHORS   Klumpers,M.J., Brand,A.C.A.M., Hakobjan,M., Gattuso,G.,
            Schiavello,E., Terenziani,M., Massimino,M., Gidding,C.E.M.,
            Guchelaar,H.J., Te Loo,D.M.W.M. and Coenen,M.J.H.
  TITLE     Contribution of common and rare genetic variants in CEP72 on
            vincristine-induced peripheral neuropathy in brain tumour patients
  JOURNAL   Br J Clin Pharmacol 88 (7), 3463-3473 (2022)
   PUBMED   35150001
  REMARK    GeneRIF: Contribution of common and rare genetic variants in CEP72
            on vincristine-induced peripheral neuropathy in brain tumour
            patients.
REFERENCE   2  (bases 1 to 2366)
  AUTHORS   Goodenough,C.G., Diouf,B., Yang,W., Sapkota,Y., Finch,E.R., Lu,L.,
            Partin,R.E., Wogksch,M.D., Hudson,M.M., Robison,L.L., Wang,Z.,
            Jeha,S., Evans,W.E. and Ness,K.K.
  TITLE     Association between CEP72 genotype and persistent neuropathy in
            survivors of childhood acute lymphoblastic leukemia
  JOURNAL   Leukemia 36 (4), 1160-1163 (2022)
   PUBMED   34980876
  REMARK    GeneRIF: Association between CEP72 genotype and persistent
            neuropathy in survivors of childhood acute lymphoblastic leukemia.
REFERENCE   3  (bases 1 to 2366)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2366)
  AUTHORS   Lin,P.C., Chen,H.O., Lee,C.J., Yeh,Y.M., Shen,M.R. and Chiang,J.H.
  TITLE     Comprehensive assessments of germline deletion structural variants
            reveal the association between prognostic MUC4 and CEP72 deletions
            and immune response gene expression in colorectal cancer patients
  JOURNAL   Hum Genomics 15 (1), 3 (2021)
   PUBMED   33431054
  REMARK    GeneRIF: Comprehensive assessments of germline deletion structural
            variants reveal the association between prognostic MUC4 and CEP72
            deletions and immune response gene expression in colorectal cancer
            patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2366)
  AUTHORS   Kavcic,M., Zeckanovic,A., Jazbec,J. and Debeljak,M.
  TITLE     Association of CEP72 rs924607 TT Genotype with Vincristine-induced
            Peripheral Neuropathy Measured by Motor Nerve Conduction Studies
  JOURNAL   Klin Padiatr 232 (6), 331-333 (2020)
   PUBMED   32877958
  REMARK    GeneRIF: Association of CEP72 rs924607 TT Genotype with
            Vincristine-induced Peripheral Neuropathy Measured by Motor Nerve
            Conduction Studies.', trans 'Assoziation von CEP72
            rs924607TTGenotyp mit Vincristin-induzierter peripherer
            Neuropathie, gemessen durch Untersuchungen der motorischen
            Nervenleitung.
            Erratum:[Klin Padiatr. 2020 Nov;232(6):e12. doi:
            10.1055/a-1313-8762.. PMID: 33242893]
REFERENCE   6  (bases 1 to 2366)
  AUTHORS   Andersen,J.S., Wilkinson,C.J., Mayor,T., Mortensen,P., Nigg,E.A.
            and Mann,M.
  TITLE     Proteomic characterization of the human centrosome by protein
            correlation profiling
  JOURNAL   Nature 426 (6966), 570-574 (2003)
   PUBMED   14654843
REFERENCE   7  (bases 1 to 2366)
  AUTHORS   Casenghi,M., Meraldi,P., Weinhart,U., Duncan,P.I., Korner,R. and
            Nigg,E.A.
  TITLE     Polo-like kinase 1 regulates Nlp, a centrosome protein involved in
            microtubule nucleation
  JOURNAL   Dev Cell 5 (1), 113-125 (2003)
   PUBMED   12852856
REFERENCE   8  (bases 1 to 2366)
  AUTHORS   Takahashi,M., Yamagiwa,A., Nishimura,T., Mukai,H. and Ono,Y.
  TITLE     Centrosomal proteins CG-NAP and kendrin provide microtubule
            nucleation sites by anchoring gamma-tubulin ring complex
  JOURNAL   Mol Biol Cell 13 (9), 3235-3245 (2002)
   PUBMED   12221128
REFERENCE   9  (bases 1 to 2366)
  AUTHORS   Mayor,T., Stierhof,Y.D., Tanaka,K., Fry,A.M. and Nigg,E.A.
  TITLE     The centrosomal protein C-Nap1 is required for cell cycle-regulated
            centrosome cohesion
  JOURNAL   J Cell Biol 151 (4), 837-846 (2000)
   PUBMED   11076968
REFERENCE   10 (bases 1 to 2366)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG718176.1 and BC000132.2.
            
            On Nov 23, 2018 this sequence version replaced NM_018140.3.
            
            Summary: The product of this gene is a member of the
            leucine-rich-repeat (LRR) superfamily of proteins. The protein is
            localized to the centrosome, a non-membraneous organelle that
            functions as the major microtubule-organizing center in animal
            cells. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000132.2, AK001427.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264935.6/ ENSP00000264935.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BG718176.1         73-83
            12-2366             BC000132.2         1-2355
FEATURES             Location/Qualifiers
     source          1..2366
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.33"
     gene            1..2366
                     /gene="CEP72"
                     /note="centrosomal protein 72"
                     /db_xref="GeneID:55722"
                     /db_xref="HGNC:HGNC:25547"
                     /db_xref="MIM:616475"
     exon            1..104
                     /gene="CEP72"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1966
                     /gene="CEP72"
                     /note="centrosomal protein 72kDa"
                     /codon_start=1
                     /product="centrosomal protein of 72 kDa"
                     /protein_id="NP_060610.2"
                     /db_xref="CCDS:CCDS34126.1"
                     /db_xref="GeneID:55722"
                     /db_xref="HGNC:HGNC:25547"
                     /db_xref="MIM:616475"
                     /translation="MARAGPRLVLSEEAVRAKSGLGPHRDLAELQSLSIPGTYQEKIT
                     HLGHSLMSLTGLKSLDLSRNSLVSLEGIQYLTALESLNLYYNCISSLAEVFRLHALTE
                     LVDVDFRLNPVVKVEPDYRLFVVHLLPKLQQLDDRPVRASERKASRLHFASEDSLDSK
                     ESVPASLKEGRPHHPRAKCTEALAKQSLVMDADDEAVLNLIAECEWDLGRPPGSTSFS
                     QKGREADSRGSQESRHLLSPQLVQYQCGDSGKQGRETRRSSCRGCCLEKMPWSQLCGE
                     LPPLYGAEPEASRAPRPHTYFTPHPDSMDTEDSASSQKLDLSGEMVPGPLPAPGKCRK
                     RRMPVGRFQTFSDQEGLGCPERTHGSSVPKESLSRQDSSESRNGRTLSQPEASETEEQ
                     RSRGVTDTREPSPGSHSALPGKKTALQAALLETLLDLVDRSWGGCRSLHSNEAFLAQA
                     RHILSSVEEFTAAQDSSAMVGEDVGSLALESKSLQSRLAEQQQQHAREMSEVTAELHH
                     THKELDDLRQHLDKSLEENSRLKSLLLSMKKEVKSADTAATLNLQIAGLQTSVKRLCG
                     EIVELKQHLEHYDKIQELTQMLQESHSSLVSTNEHLLQELSQVRAQHRAEVEQMHWSY
                     QELKKTMALFPHSSASHGGCQAC"
     exon            105..232
                     /gene="CEP72"
                     /inference="alignment:Splign:2.1.0"
     exon            233..425
                     /gene="CEP72"
                     /inference="alignment:Splign:2.1.0"
     exon            426..534
                     /gene="CEP72"
                     /inference="alignment:Splign:2.1.0"
     exon            535..713
                     /gene="CEP72"
                     /inference="alignment:Splign:2.1.0"
     exon            714..926
                     /gene="CEP72"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1228
                     /gene="CEP72"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1364
                     /gene="CEP72"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1561
                     /gene="CEP72"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1688
                     /gene="CEP72"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1800
                     /gene="CEP72"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..2366
                     /gene="CEP72"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2349..2354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP72"
                     /note="hexamer: AATACA"
     polyA_site      2366
                     /gene="CEP72"
                     /note="major polyA site"
ORIGIN      
        1 gtccgagggc tccgtttgaa acatggcgcg ggctggccct cggctggtgc tgagcgagga
       61 ggcggttcgg gcgaagagcg gcttagggcc tcaccgcgac ctggctgagc ttcagtcatt
      121 gtctattcct ggaacttacc aagagaagat cacccacctg ggacattctc tgatgagttt
      181 aacaggtctg aaatctttgg atctctcgcg caactccttg gttagtctgg agggcattca
      241 gtacctgact gcattggaga gtctcaatct ctactacaac tgcatctcct cgttggcaga
      301 agtgtttcgg ctccacgcct taaccgagct cgtggatgtg gacttccggc tgaaccccgt
      361 ggtgaaggtt gagcctgact accgcctttt tgttgtgcac ctgctcccca agctccagca
      421 gctggacgat cgccccgtga gagcaagcga gcggaaggct tcccgactgc attttgcatc
      481 agaggactca ctcgactcca aagagagcgt cccagcttct ttgaaagagg gcagaccaca
      541 ccaccccaga gccaagtgca ccgaggcctt ggccaagcag agcctggtca tggatgcgga
      601 tgacgaggca gtcctgaacc tcattgcaga gtgcgagtgg gacctcggca ggcctcccgg
      661 gagcacgagc ttcagccaga aggggcgtga ggccgactct cgtggttccc aagaatccag
      721 acatctgttg agcccgcagt tggtacagta ccagtgtggg gactctggga agcagggccg
      781 tgagacgagg aggagcagct gcagagggtg ctgtctggag aagatgcctt ggagccagct
      841 ctgtggagag cttccgccac tgtacggagc ggagccagag gcctcccgtg cccccaggcc
      901 acacacgtac ttcaccccac acccagactc catggatacc gaggactcgg cctcttctca
      961 gaagttggat ttgtcaggag aaatggtgcc tggtcccctg ccagcccccg gaaagtgcag
     1021 gaagcgaaga atgcctgttg gaagattcca gacgttttcg gaccaggagg gtttgggctg
     1081 cccggagaga actcatgggt cctccgtgcc caaggagagc ctgagcagac aggacagctc
     1141 agaaagcagg aacgggagga ccttgtctca gcctgaggcc tcggagactg aggagcagag
     1201 gtctcggggt gtgaccgaca ccagagagcc gtctcccggg tcacactcgg ctctacccgg
     1261 gaagaagacg gccctgcagg cggcgctcct ggagacgctc ttggacctgg tggacaggag
     1321 ctggggcggc tgcaggtccc tgcacagcaa cgaggcattc cttgctcagg caagacacat
     1381 cttgtcatct gttgaagaat tcacagcagc tcaggacagc tctgcgatgg tgggtgaaga
     1441 tgtcggctcc ctggctctgg agagtaagtc cctgcaaagc cgccttgctg agcagcagca
     1501 gcagcacgcc cgggagatga gcgaggtgac ggcggagctg caccacacac acaaggagct
     1561 ggatgatttg agacaacatt tagataaatc tttggaagag aacagtaggt taaaatcgct
     1621 tttgttgagt atgaaaaagg aagtgaagag tgcagacact gcagccacgt taaatttgca
     1681 gatcgctgga cttcaaacaa gtgtgaagag gctgtgtggc gagattgtgg aactgaagca
     1741 gcacctggag cactacgaca agatccagga gctcacgcag atgctgcagg agagccacag
     1801 ctccctggtc agcaccaatg aacacctgct gcaggagctg agccaggtgc gggcgcagca
     1861 cagagccgag gtggagcaga tgcactggag ctaccaggag ctcaagaaga ccatggccct
     1921 gtttccacac agcagcgcca gccatggagg ctgccaggcc tgctgactcc tgccgagaag
     1981 ctgggccacc ccttaagctt cctggtaaag ttacattgtc tgcacctttg tacttcttta
     2041 ttgagtgtac tggctggcaa gagttctctc ttctgttggt aattatttag gatttttgga
     2101 atgtattcag gacctgtagc ttggttttct aaagcacctc gtaaaatgat atgattactc
     2161 caagccctct gcatgttttc agacagaaca cattgacata ttttgagaca aactgactat
     2221 taatcttgta tccagtatcc tgagatgaag taaatgcagt gttctactgc ctgatgtgaa
     2281 agagagctat gtatgataat taaagaaaat aattttctgt gtaacaagca atctttattt
     2341 aataaacaaa tacattgttc tgaaaa
//
