LOCUS       NM_024491               2636 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens centrosomal protein 70 (CEP70), transcript variant 1,
            mRNA.
ACCESSION   NM_024491
VERSION     NM_024491.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2636)
  AUTHORS   Woerz,F., Hoffmann,F., Antony,S., Bolz,S., Jarboui,M.A., Junger,K.,
            Klose,F., Stehle,I.F., Boldt,K., Ueffing,M. and Beyer,T.
  TITLE     Interactome Analysis Reveals a Link of the Novel ALMS1-CEP70
            Complex to Centrosomal Clusters
  JOURNAL   Mol Cell Proteomics 23 (1), 100701 (2024)
   PUBMED   38122899
  REMARK    GeneRIF: Interactome Analysis Reveals a Link of the Novel
            ALMS1-CEP70 Complex to Centrosomal Clusters.
REFERENCE   2  (bases 1 to 2636)
  AUTHORS   McGray,A.J.R., Chiello,J.L., Tsuji,T., Long,M., Maraszek,K.,
            Gaulin,N., Rosario,S.R., Hess,S.M., Abrams,S.I., Kozbor,D.,
            Odunsi,K. and Zsiros,E.
  TITLE     BiTE secretion by adoptively transferred stem-like T cells improves
            FRalpha+ ovarian cancer control
  JOURNAL   J Immunother Cancer 11 (6) (2023)
   PUBMED   37647218
  REMARK    GeneRIF: BiTE secretion by adoptively transferred stem-like T cells
            improves FRalpha+ ovarian cancer control.
REFERENCE   3  (bases 1 to 2636)
  AUTHORS   Ruan,T., Yang,Y., Jiang,C., Shen,G., Li,D. and Shen,Y.
  TITLE     Identification of biallelic variations of CEP70 in patients with
            male infertility
  JOURNAL   Front Endocrinol (Lausanne) 14, 1133222 (2023)
   PUBMED   36967801
  REMARK    GeneRIF: Identification of biallelic variations of CEP70 in
            patients with male infertility.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2636)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2636)
  AUTHORS   Liu,Q., Guo,Q., Guo,W., Song,S., Wang,N., Chen,X., Sun,A., Yan,L.
            and Qiao,J.
  TITLE     Loss of CEP70 function affects acrosome biogenesis and flagella
            formation during spermiogenesis
  JOURNAL   Cell Death Dis 12 (5), 478 (2021)
   PUBMED   33980814
  REMARK    GeneRIF: Loss of CEP70 function affects acrosome biogenesis and
            flagella formation during spermiogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2636)
  AUTHORS   Andersen,J.S., Wilkinson,C.J., Mayor,T., Mortensen,P., Nigg,E.A.
            and Mann,M.
  TITLE     Proteomic characterization of the human centrosome by protein
            correlation profiling
  JOURNAL   Nature 426 (6966), 570-574 (2003)
   PUBMED   14654843
REFERENCE   7  (bases 1 to 2636)
  AUTHORS   Casenghi,M., Meraldi,P., Weinhart,U., Duncan,P.I., Korner,R. and
            Nigg,E.A.
  TITLE     Polo-like kinase 1 regulates Nlp, a centrosome protein involved in
            microtubule nucleation
  JOURNAL   Dev Cell 5 (1), 113-125 (2003)
   PUBMED   12852856
REFERENCE   8  (bases 1 to 2636)
  AUTHORS   Takahashi,M., Yamagiwa,A., Nishimura,T., Mukai,H. and Ono,Y.
  TITLE     Centrosomal proteins CG-NAP and kendrin provide microtubule
            nucleation sites by anchoring gamma-tubulin ring complex
  JOURNAL   Mol Biol Cell 13 (9), 3235-3245 (2002)
   PUBMED   12221128
REFERENCE   9  (bases 1 to 2636)
  AUTHORS   Mayor,T., Stierhof,Y.D., Tanaka,K., Fry,A.M. and Nigg,E.A.
  TITLE     The centrosomal protein C-Nap1 is required for cell cycle-regulated
            centrosome cohesion
  JOURNAL   J Cell Biol 151 (4), 837-846 (2000)
   PUBMED   11076968
REFERENCE   10 (bases 1 to 2636)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC030598.2, AF202146.1, AK023098.1 and BF435951.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024491.3.
            
            Transcript Variant: This variant (1) encodes isoform (1). Variants
            1 and 6 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030598.2, SRR1803613.270993.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264982.8/ ENSP00000264982.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-574               BC030598.2         26-599
            575-633             AF202146.1         552-610
            634-2112            BC030598.2         659-2137
            2113-2633           AK023098.1         1946-2466
            2634-2636           BF435951.1         19-21               c
FEATURES             Location/Qualifiers
     source          1..2636
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.3"
     gene            1..2636
                     /gene="CEP70"
                     /gene_synonym="BITE"
                     /note="centrosomal protein 70"
                     /db_xref="GeneID:80321"
                     /db_xref="HGNC:HGNC:29972"
                     /db_xref="MIM:614310"
     exon            1..63
                     /gene="CEP70"
                     /gene_synonym="BITE"
                     /inference="alignment:Splign:2.1.0"
     exon            64..166
                     /gene="CEP70"
                     /gene_synonym="BITE"
                     /inference="alignment:Splign:2.1.0"
     exon            167..240
                     /gene="CEP70"
                     /gene_synonym="BITE"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1965
                     /gene="CEP70"
                     /gene_synonym="BITE"
                     /note="isoform 1 is encoded by transcript variant 1;
                     p10-binding protein; centrosomal protein of 70 kDa;
                     centrosomal protein 70kDa; testicular tissue protein Li
                     36"
                     /codon_start=1
                     /product="centrosomal protein of 70 kDa isoform 1"
                     /protein_id="NP_077817.2"
                     /db_xref="CCDS:CCDS3102.1"
                     /db_xref="GeneID:80321"
                     /db_xref="HGNC:HGNC:29972"
                     /db_xref="MIM:614310"
                     /translation="MFPVAPKPQDSSQPSDRLMTEKQQEEAEWESINVLLMMHGLKPL
                     SLVKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQ
                     SRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQH
                     YKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLID
                     YYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDAL
                     SSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEP
                     SKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHL
                     VPVIEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEE
                     VENKEKDSNMPHFQTLQAIVSHFQKLFDVPSLNGVYPRMNEVYTRLGEMNNAVRNLQE
                     LLELDSSSSLCVLVSTVGKLCRLINEDVNEQVMQVLGPEDLQSIIYKLEEHEEFFPAF
                     QAFTNDLLEILEIDDLDAIVPAVKKLKVLSY"
     exon            241..331
                     /gene="CEP70"
                     /gene_synonym="BITE"
                     /inference="alignment:Splign:2.1.0"
     exon            332..455
                     /gene="CEP70"
                     /gene_synonym="BITE"
                     /inference="alignment:Splign:2.1.0"
     exon            456..636
                     /gene="CEP70"
                     /gene_synonym="BITE"
                     /inference="alignment:Splign:2.1.0"
     exon            637..806
                     /gene="CEP70"
                     /gene_synonym="BITE"
                     /inference="alignment:Splign:2.1.0"
     exon            807..863
                     /gene="CEP70"
                     /gene_synonym="BITE"
                     /inference="alignment:Splign:2.1.0"
     exon            864..951
                     /gene="CEP70"
                     /gene_synonym="BITE"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1040
                     /gene="CEP70"
                     /gene_synonym="BITE"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1115
                     /gene="CEP70"
                     /gene_synonym="BITE"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1221
                     /gene="CEP70"
                     /gene_synonym="BITE"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1392
                     /gene="CEP70"
                     /gene_synonym="BITE"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1539
                     /gene="CEP70"
                     /gene_synonym="BITE"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1708
                     /gene="CEP70"
                     /gene_synonym="BITE"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1823
                     /gene="CEP70"
                     /gene_synonym="BITE"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1903
                     /gene="CEP70"
                     /gene_synonym="BITE"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2636
                     /gene="CEP70"
                     /gene_synonym="BITE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2609..2614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP70"
                     /gene_synonym="BITE"
                     /note="hexamer: AATAAA"
     polyA_site      2636
                     /gene="CEP70"
                     /gene_synonym="BITE"
                     /note="major polyA site"
ORIGIN      
        1 gtagctgatc ccagcctaac ctggcccggc tggctgctgg tgggaggccg gcgactgagt
       61 aagatgaaga tccagtttca gacatgagac tcgttgggtg atcatttcat tgagatcaac
      121 ctgaatgacc aggtgtaaag tgcaagagta atatgctatg actgagtaac tatgtttccg
      181 gtagccccta aaccccagga ttccagtcaa ccatcagaca gactcatgac tgaaaaacag
      241 caggaagaag cagaatggga aagcataaat gtgctattga tgatgcatgg cttaaaacct
      301 ttgtctctag tcaaaagaac agatctcaaa gatctcatca tttttgacaa acagtcatca
      361 caaaggatga gacagaattt gaaattgttg gtggaagaaa catcatgtca acagaacatg
      421 atacaggagc ttatagaaac taatcaacag cttagaaatg aacttcagct agagcaaagc
      481 cgagcagcca atcaagaaca acgagctaat gacttggaac aaattatgga aagtgtgaaa
      541 tccaaaattg gtgaattgga ggatgaatca ctaagtaggg cttgccacca acagaataaa
      601 ataaaagatc ttcaaaagga gcagaaaact ttacaggtga agtgccagca ttataagaaa
      661 aaacgaacgg agcaagaaga aactattgct tctttgcaaa tggaagtctg tagattaaaa
      721 aaggaggaag aagatcgcat tgtcactcaa aacagagtgt ttgcctatct gtgcaaaaga
      781 gttcctcata ccgtcttgga tagacagttg ctttgtctaa ttgattacta tgaatctaaa
      841 attagaaaaa ttcatacaca aaggcaatat aaagaagatg aaagtcagtc agaagaagaa
      901 aacgactaca gaaatctgga tgcctcacca acttataaag gccttttaat gtcattacag
      961 aatcaactca aggaatcaaa atctaagatt gatgcacttt caagtgaaaa gctgaacctc
     1021 caaaaagatt tggaaaccag gcctacgcag catgaattaa gactttataa acagcaggtg
     1081 aagaagctgg aaaaagccct taagaaaaac gtcaaattac aggagcttat taatcataag
     1141 aaggctgagg acacagagaa gaaagatgag cccagcaaat ataatcagca acaggcccta
     1201 attgaccaga gatactttca ggtgctgtgt agcatcaatt caattatcca caatccaaga
     1261 gctccagtaa taatttataa acagaccaaa gggggagtcc aaaattttaa taaagatctt
     1321 gttcaagatt gtggatttga gcatcttgtt cctgtaatag aaatgtgggc agatcaactg
     1381 acatccttaa aggatttgta taagtccttg aaaacactat ctgcagaact ggtaccttgg
     1441 cttaatttga agaagcagga tgaaaatgaa ggtatcaaag ttgaagattt gttgtttata
     1501 gtagatacta tgctggaaga agttgaaaat aaggaaaagg acagcaatat gccacacttt
     1561 caaactttgc aagctattgt ttctcacttc caaaagttat ttgatgtgcc ttctttaaat
     1621 ggagtctatc cccgaatgaa tgaagtttat actaggcttg gagaaatgaa caatgctgtg
     1681 agaaacctcc aagaactctt agaattagat agttcatcct cattgtgtgt gctagtaagc
     1741 actgttggaa aactctgtag gctgattaat gaagatgtga atgagcaggt tatgcaggta
     1801 ttaggacctg aagacctcca gagcattatc tacaaattgg aagaacacga ggaatttttc
     1861 ccagcatttc aggcatttac taatgatcta cttgaaatct tagaaattga tgacttggat
     1921 gccattgtac ctgcagtaaa gaaattaaaa gtactttcat actgaaaaca aatcaaatca
     1981 tttttactgt gtaaattgta ttcttaacat tttgtatttt gtaggattga tcttattttg
     2041 agacaagggt tgtaaaatgt atttgctctc agaattcatc cccttcttag tattaggtca
     2101 ttcttcatct gtataatttt tattaacttt gagattctta tacagaaaat agttgcaagg
     2161 gtaaggtaat taactttaga tcccttcatt tctaaagcaa ttattgagtg cttaaaattt
     2221 aaggttgttt tagagtggag tttgtgagta aaagaggagc ccagggagac agattgcaag
     2281 tagtaggttg caatctttta gattcagctt gtaataatct ttgagccaca ccaaaaggaa
     2341 tgccaagggc tctctaaatt tagccagtag gaagctactg ctctcctggc aaggattaat
     2401 tggcacattc tgttaagata tccctcatga cagttgccct ttcaaagcag gaggaagaaa
     2461 aggaagaaag aaaaactgtt tcatcatttc tgttagggta ggaaatgaat catagggtaa
     2521 aatggatgag tagatagaag tctctcattt aaaaagtgtc ttttgcaatc ttgatgtaat
     2581 gcacttttta taaggacttg agatctcaaa taaaatttct gtaaagaatt tccaaa
//
