LOCUS       NM_015147               5803 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens centrosomal protein 68 (CEP68), transcript variant 1,
            mRNA.
ACCESSION   NM_015147
VERSION     NM_015147.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5803)
  AUTHORS   O'Neill,A.C., Uzbas,F., Antognolli,G., Merino,F., Draganova,K.,
            Jack,A., Zhang,S., Pedini,G., Schessner,J.P., Cramer,K.,
            Schepers,A., Metzger,F., Esgleas,M., Smialowski,P., Guerrini,R.,
            Falk,S., Feederle,R., Freytag,S., Wang,Z., Bahlo,M., Jungmann,R.,
            Bagni,C., Borner,G.H.H., Robertson,S.P., Hauck,S.M. and Gotz,M.
  TITLE     Spatial centrosome proteome of human neural cells uncovers
            disease-relevant heterogeneity
  JOURNAL   Science 376 (6599), eabf9088 (2022)
   PUBMED   35709258
REFERENCE   2  (bases 1 to 5803)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5803)
  AUTHORS   Hossain,D., Shih,S.Y., Xiao,X., White,J. and Tsang,W.Y.
  TITLE     Cep44 functions in centrosome cohesion by stabilizing rootletin
  JOURNAL   J Cell Sci 133 (4) (2020)
   PUBMED   31974111
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5803)
  AUTHORS   Perkins,J.R., Acosta-Herrera,M., Plaza-Seron,M.C.,
            Jurado-Escobar,R., Dona,I., Garcia-Martin,E., Isidoro-Garcia,M.,
            Bartra,J., Ribas-Perez,D., Mayorga,C., Torres,M.J., Flores,C. and
            Cornejo-Garcia,J.A.
  TITLE     Polymorphisms in CEP68 gene associated with risk of immediate
            selective reactions to non-steroidal anti-inflammatory drugs
  JOURNAL   Pharmacogenomics J 19 (2), 191-199 (2019)
   PUBMED   30093714
  REMARK    GeneRIF: Two intronic variants (rs2241160 and rs2241161) were
            significantly associated with an increased risk of
            single-NSAID-induced urticaria/angioedema or anaphylaxis (SNIUAA),
            suggesting CEP68 to be a key player in both types of Non-steroidal
            anti-inflammatory drugs hypersensitivity.
REFERENCE   5  (bases 1 to 5803)
  AUTHORS   Vlijm,R., Li,X., Panic,M., Ruthnick,D., Hata,S.,
            Herrmannsdorfer,F., Kuner,T., Heilemann,M., Engelhardt,J.,
            Hell,S.W. and Schiebel,E.
  TITLE     STED nanoscopy of the centrosome linker reveals a CEP68-organized,
            periodic rootletin network anchored to a C-Nap1 ring at centrioles
  JOURNAL   Proc Natl Acad Sci U S A 115 (10), E2246-E2253 (2018)
   PUBMED   29463719
  REMARK    GeneRIF: CEP68 is important in forming rootletin filaments that
            branch off centrioles and to modulate the thickness of rootletin
            fibers.
REFERENCE   6  (bases 1 to 5803)
  AUTHORS   Graser,S., Stierhof,Y.D. and Nigg,E.A.
  TITLE     Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion
  JOURNAL   J Cell Sci 120 (Pt 24), 4321-4331 (2007)
   PUBMED   18042621
  REMARK    GeneRIF: data suggest that Cep68 cooperates with rootletin and
            C-Nap1 in centrosome cohesion.
REFERENCE   7  (bases 1 to 5803)
  AUTHORS   Chen,Y., Low,T.Y., Choong,L.Y., Ray,R.S., Tan,Y.L., Toy,W., Lin,Q.,
            Ang,B.K., Wong,C.H., Lim,S., Li,B., Hew,C.L., Sze,N.S., Druker,B.J.
            and Lim,Y.P.
  TITLE     Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel
            tyrosine phosphorylation targets of EGF signaling and Iressa in
            human cancer cells
  JOURNAL   Proteomics 7 (14), 2384-2397 (2007)
   PUBMED   17570516
  REMARK    GeneRIF: our study is the first to identify and validate Endofin,
            DCBLD2, and KIAA0582 as part of a complex EGF phosphotyrosine
            signaling network
REFERENCE   8  (bases 1 to 5803)
  AUTHORS   Wang,H.Y., Chien,H.C., Osada,N., Hashimoto,K., Sugano,S.,
            Gojobori,T., Chou,C.K., Tsai,S.F., Wu,C.I. and Shen,C.K.
  TITLE     Rate of evolution in brain-expressed genes in humans and other
            primates
  JOURNAL   PLoS Biol 5 (2), e13 (2007)
   PUBMED   17194215
REFERENCE   9  (bases 1 to 5803)
  AUTHORS   Andersen,J.S., Wilkinson,C.J., Mayor,T., Mortensen,P., Nigg,E.A.
            and Mann,M.
  TITLE     Proteomic characterization of the human centrosome by protein
            correlation profiling
  JOURNAL   Nature 426 (6966), 570-574 (2003)
   PUBMED   14654843
REFERENCE   10 (bases 1 to 5803)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB011154.2, AC007318.4 and CA398160.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015147.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.31745.1, AB011154.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377990.7/ ENSP00000367229.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2494              AB011154.2         56-2549
            2495-5261           AC007318.4         5340-8106
            5262-5803           CA398160.1         21-562              c
FEATURES             Location/Qualifiers
     source          1..5803
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p14"
     gene            1..5803
                     /gene="CEP68"
                     /gene_synonym="KIAA0582"
                     /note="centrosomal protein 68"
                     /db_xref="GeneID:23177"
                     /db_xref="HGNC:HGNC:29076"
                     /db_xref="MIM:616889"
     exon            1..113
                     /gene="CEP68"
                     /gene_synonym="KIAA0582"
                     /inference="alignment:Splign:2.1.0"
     exon            114..516
                     /gene="CEP68"
                     /gene_synonym="KIAA0582"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..2433
                     /gene="CEP68"
                     /gene_synonym="KIAA0582"
                     /note="isoform a is encoded by transcript variant 1;
                     centrosomal protein of 68 kDa; centrosomal protein 68kDa"
                     /codon_start=1
                     /product="centrosomal protein of 68 kDa isoform a"
                     /protein_id="NP_055962.2"
                     /db_xref="CCDS:CCDS1880.2"
                     /db_xref="GeneID:23177"
                     /db_xref="HGNC:HGNC:29076"
                     /db_xref="MIM:616889"
                     /translation="MALGEEKAEAEASEDTKAQSYGRGSCRERELDIPGPMSGEQPPR
                     LEAEGGLISPVWGAEGIPAPTCWIGTDPGGPSRAHQPQASDANREPVAERSEPALSGL
                     PPATMGSGDLLLSGESQVEKTKLSSSEEFPQTLSLPRTTTICSGHDADTEDDPSLADL
                     PQALDLSQQPHSSGLSCLSQWKSVLSPGSAAQPSSCSISASSTGSSLQGHQERAEPRG
                     GSLAKVSSSLEPVVPQEPSSVVGLGPRPQWSPQPVFSGGDASGLGRRRLSFQAEYWAC
                     VLPDSLPPSPDRHSPLWNPNKEYEDLLDYTYPLRPGPQLPKHLDSRVPADPVLQDSGV
                     DLDSFSVSPASTLKSPTNVSPNCPPAEATALPFSGPREPSLKQWPSRVPQKQGGMGLA
                     SWSQLASTPRAPGSRDARWERREPALRGAKDRLTIGKHLDMGSPQLRTRDRGWPSPRP
                     EREKRTSQSARRPTCTESRWKSEEEVESDDEYLALPARLTQVSSLVSYLGSISTLVTL
                     PTGDIKGQSPLEVSDSDGPASFPSSSSQSQLPPGAALQGSGDPEGQNPCFLRSFVRAH
                     DSAGEGSLGSSQALGVSSGLLKTRPSLPARLDRWPFSDPDVEGQLPRKGGEQGKESLV
                     QCVKTFCCQLEELICWLYNVADVTDHGTAARSNLTSLKSSLQLYRQFKKDIDEHQSLT
                     ESVLQKGEILLQCLLENTPVLEDVLGRIAKQSGELESHADRLYDSILASLDMLAGCTL
                     IPDKKPMAAMEHPCEGV"
     exon            517..2043
                     /gene="CEP68"
                     /gene_synonym="KIAA0582"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2166
                     /gene="CEP68"
                     /gene_synonym="KIAA0582"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2263
                     /gene="CEP68"
                     /gene_synonym="KIAA0582"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2437
                     /gene="CEP68"
                     /gene_synonym="KIAA0582"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..5803
                     /gene="CEP68"
                     /gene_synonym="KIAA0582"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5783..5788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP68"
                     /gene_synonym="KIAA0582"
                     /note="hexamer: AATAAA"
     polyA_site      5803
                     /gene="CEP68"
                     /gene_synonym="KIAA0582"
                     /note="major polyA site"
ORIGIN      
        1 gttttgggct gcggttggag ggccgcagtt gcagtcaggg tccgccagct cggggccagc
       61 gcatggggct gctgagaccg ctccggacgt gcgaagcgtt cgcggtgcgg taggaagctg
      121 aagtcttcag cagaaccctg acctaggtag ggagtctcaa tggccctggg tgaagaaaag
      181 gcagaagcgg aagcatctga agacacaaag gcccagtcct atgggagagg gagctgcagg
      241 gagcgggagc tggacatccc agggcccatg agtggggagc agcccccacg cctggaagct
      301 gagggagggc tcatctcccc tgtatggggg gcagaaggga tacctgcccc tacttgctgg
      361 attgggactg accctggcgg cccctctaga gcccaccagc cacaggccag tgatgccaac
      421 agagagcccg tagctgagag gtctgagcct gcactcagtg gcctgcctcc tgccaccatg
      481 gggtctggag accttctgct ctccggggaa agccaggtgg agaagaccaa gctttcttcc
      541 tccgaggagt tccctcagac tctgagcctt cccagaacaa caactatttg ctcaggacat
      601 gatgctgata ccgaagatga tccatcccta gcagatttgc cccaggcact ggacctcagc
      661 cagcagcctc acagctcagg tctctcttgc ctgtcacagt ggaagtccgt gctgagccca
      721 ggttccgcag ctcagccttc cagctgcagc atctctgctt cctccacagg cagcagtctc
      781 cagggtcacc aggagagggc ggagcctcgt ggtggttctc tggccaaggt ctcctcctcc
      841 ctggagccgg tcgtccccca ggaaccttcc tctgtggtgg ggctaggacc tcggccccag
      901 tggtcaccac agcctgtgtt ctctgggggt gatgcttctg ggctaggcag gagacgcctc
      961 tccttccagg ctgagtactg ggcctgtgtg ctgccagatt ccctgcctcc atcacccgac
     1021 cgccactccc ctctctggaa cccaaataaa gagtatgaag atctgcttga ctatacttac
     1081 ccactgaggc ccgggcctca gctcccaaag caccttgata gccgtgtgcc agctgaccct
     1141 gtcctgcagg actccggggt agacctggat agcttctctg tctctccagc aagcaccctc
     1201 aaatcaccta ctaatgtctc ccccaactgc ccaccagcag aggccactgc cctgccattt
     1261 tctgggccca gagagccaag ccttaagcag tggccctcca gagtacccca gaaacagggt
     1321 ggcatgggct tggcatcttg gagccaactt gcatctaccc ccagagcccc aggcagtagg
     1381 gatgctcgtt gggagcgcag agagccagcc ctgaggggtg cgaaggaccg gctgactata
     1441 ggcaagcacc ttgatatggg ctctccccag ctaaggacac gggacagagg gtggccctcg
     1501 cccaggccag agagggagaa gaggaccagc cagagtgccc ggcgccctac ctgcacagag
     1561 tctaggtgga aatcagaaga ggaagtggaa agtgatgacg agtatcttgc cctccccgct
     1621 cggctgacac aggtttctag cctggtttcg tatctaggat ccatttctac cttggttacc
     1681 ctgcccactg gggatatcaa agggcagagc cccttggaag tgtcagacag tgatgggcca
     1741 gcttccttcc cttcaagctc cagccaaagc cagcttcccc ctggagctgc cctccaagga
     1801 tctggggatc ctgagggcca gaatccctgt ttcctgcgct ccttcgtccg tgcccacgac
     1861 tccgcagggg aaggcagtct ggggagcagc caggccctcg gggtctcctc tggactgctg
     1921 aaaacacgcc cctccttgcc agctaggttg gaccggtggc cattctcaga cccagatgtt
     1981 gaagggcagc ttcccaggaa aggaggagaa cagggaaaag aatcactggt gcaatgtgtg
     2041 aagacatttt gctgtcagct ggaagagctg atctgctggc tgtataatgt tgcagatgtt
     2101 actgaccacg ggactgcagc caggtccaat cttacaagtc tcaagtcttc tctgcagctt
     2161 taccggcaat ttaagaaaga tatagatgaa catcagtctc tgacggagag tgtcttacag
     2221 aagggggaga ttcttcttca gtgcctgttg gagaacaccc cagttttaga ggatgtcctt
     2281 gggaggatcg caaagcagtc tggtgagctg gagagccacg cagatcgcct gtatgactct
     2341 atcttggcct ctctggacat gctggctggc tgcaccctta tccctgacaa aaagcccatg
     2401 gcggcaatgg agcacccatg tgaaggggtt taacctggca tcttctcagg cagaggtgca
     2461 acctgtcggc caaacactgg ctagtgagaa aaaaaacctt caagaagtcc ttgcaagagc
     2521 cattcaacac tgaagtcaag ggggaaacct tcaatatact agctttaaaa tgcctttctc
     2581 ctccctgaat ggagggctga gttactattt ttatttacaa tgaatccttc caaactaagg
     2641 ttttcctttt ggtgcttctc cacaaagagc gtgtagcttt gcaatttttg ataaaataag
     2701 acgtgttgcc ttcccctcta tcccattaaa aaagagcaga taaagctcaa actattccac
     2761 ctggtagggt catttaccaa gggctggtag gagattccga atactcaata ttctcaggca
     2821 tgcaagagga cctaagagac tgaaaaaagt gaattgttgg ccagaaacct tgggtctttt
     2881 cataaaagga aatttgggct tgtcaatccc tctttaaaga tataggtaga aagaagagat
     2941 ttttaaccct ttgtctgcaa aagaaaaagg gttaaatgaa gcatctatac agatgacttt
     3001 gggagattat gacacctttt gccatcttca gggcttacgt ctttactttc ttggctaacc
     3061 agtttcttag aagaaaatgt gtcagggact tggggatcta cagtcatgct ttagcatggc
     3121 tatggagcta attatcaagc ttaaagggta actttgggag gactcctccc ttcactccta
     3181 gtctcccttg gaagagcagt ccaggctcag ggaagggaac ggataggatg acacagtaag
     3241 tacagaaact gaagctgtca atagtgaagg aaaaagggga attcttcgtt gctttggcat
     3301 tgacacataa gtactttgat taaaaaaaaa aaaaactatg gatcaaccat tcaaagcatc
     3361 aattctatag ctttttgcag caagatgatc agttattgct ggtaactgca gattctacag
     3421 aaaagcactt ttaaagttct gttgggccat gaatgaacct ggaaggagga aagcacagta
     3481 acaatggaaa ctaaagtcct attattaatg tgacttttct gcttcagaat ttctgagact
     3541 ttatagtcac tggaaaatag ccattaaatt ctttaaagat tagctcttca acagtagcta
     3601 cacataaaat gcagtatttc aagtgcctga tgctgctgtg gtatgcttta tcataatgct
     3661 taagggcatg atcaaaatta aaatggctta tgagtttgcc atattaatca tcttagttcc
     3721 atacacactg agactttaaa agggaaaaac cactctagca aataattgtc aattataaac
     3781 ctgtatgtaa aacattcttg aaaacctaga gttggttaaa aaggtagaga tgtctgacgg
     3841 cctcttctta aattgatata ttttaccttc tcttagatgt acatttataa gtaggaacat
     3901 gtccttccac tgagtatgtt actgaatagc ccttaggaaa ttaaacccat ttatttacta
     3961 atatttgaca ggcatagaag tgtattaatt agcataaaag ttggagatga aaaccctata
     4021 gaaacaaatt ggccaatatt atactaattg aatgcagaat gtggcattct attcccattc
     4081 aactaataat cagcttcaac tgacaggaat ttgcacagaa tgttacacaa taccctgttt
     4141 cccaagaaag tactacctta cctagagatg atctaagata tttttgttca tcctctgaat
     4201 aaggtgagac taaagggtgc taactccctg gacctggctg tgaatgctac tgaagagtat
     4261 caacacaact gttaattata ccgccgtgct ttaagtttaa gacttacctt aaaactcaag
     4321 ctgaaggctg ggcacggtgg ctcatgcctg taatcccagc actttgggag gccgaggcgg
     4381 gtggatcaca aggtcaggag atcgagacca tcctggctaa cacggtgaaa ccccatctct
     4441 actaaaaata caaaaagaaa ttagccaggc gtggtgatgg gcgcctgtag tcccagctac
     4501 ttgggaggct gaggcatgag aatggcatga acccgggagg cggagcttgc agtgagctga
     4561 gatggcacca ctgcactcca gcctgggcaa cagagtgaga ctcttgtctc aaaaaaaaaa
     4621 aatcaagctg aaattgtttc agcctagtaa gatgctgcca gcagcatttc tatgagcaaa
     4681 catggccaaa ttagagtcaa gtagctgagc ttgctaactg cactgtgatg ccacactgga
     4741 ataacttagt agtcccttaa aattaatgga agttaaatcc acagggaagt gatgatactc
     4801 aaagctggat cagcagtttc aagatctggg ttcttggaga tccataggta agctcagcaa
     4861 atggaagacg acgtcaacac ggctattttg aagcttaggt gggaatggaa cacaaagaag
     4921 gtttgaggta agatatgctg gaaaggcaag atgtaggcta agggaaattc aatccaaggt
     4981 cgaagaatag gaaattactg ctcagaccac aatgactatc attctgaaag gatttcacag
     5041 agtgtgcagc tgcttagatt taagaacact cttcttcact atgtaaacta atttatggca
     5101 gcaccttata tttagaacaa gtggtaattc cctttactaa gtgaacagat tattaaaacc
     5161 tgtagtagct ttgaaccgtt tgtacttgaa aatgggggta taaaggggta tatatttttt
     5221 ccagaaccac atttattggc gtatacatag aagcaaatct taaggcatgc tgaaatttgt
     5281 tgtaaatccc aatctttact gccatgggga aaagaacgct ggaattttcc aaacttaagt
     5341 ctgtaaatat gctcatctta agttcatgta atgtttccgc taactcacca agaataagct
     5401 gacaatttaa acaactttta ctgtgtaaaa atgaagtgca cggcatggca tcacagtatc
     5461 ttgacatttg ttttgtgtca tttagctact ttagaaaata gtttctgaac tctttccccc
     5521 tttatactgt attaaggcaa aaacaaaact tctgaagcat taaagatctt caccaaaata
     5581 actattggta acttcaggaa tttgtcagtt gccttatgtg aggatgaata gatccaccaa
     5641 gcacgcctat aatacaaagt aaactatgat ttttattgtg aaattttcat agatggaaaa
     5701 ttgaatattc tgtccatttc attttacaat tatcttacca cttatttttg taccatgtat
     5761 ttcaattgcc tgtttagtga aaaataaaaa ttaaaaaaac cta
//
