LOCUS       NM_001353122            5407 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens centrosomal protein 63 (CEP63), transcript variant 16,
            mRNA.
ACCESSION   NM_001353122
VERSION     NM_001353122.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5407)
  AUTHORS   Kodani,A., Knopp,K.A., Di Lullo,E., Retallack,H., Kriegstein,A.R.,
            DeRisi,J.L. and Reiter,J.F.
  TITLE     Zika virus alters centrosome organization to suppress the innate
            immune response
  JOURNAL   EMBO Rep 23 (9), e52211 (2022)
   PUBMED   35793002
REFERENCE   2  (bases 1 to 5407)
  AUTHORS   Ling,H., Cao,C.H., Han,K., Lv,Y.R., Ma,X.D., Cao,J.H., Chen,J.W.,
            Li,S., Lin,J.L., Fang,Y.J., Pan,Z.Z., Xie,D. and Wang,F.W.
  TITLE     CEP63 upregulates YAP1 to promote colorectal cancer progression
            through stabilizing RNA binding protein FXR1
  JOURNAL   Oncogene 41 (39), 4433-4445 (2022)
   PUBMED   35989368
  REMARK    GeneRIF: CEP63 upregulates YAP1 to promote colorectal cancer
            progression through stabilizing RNA binding protein FXR1.
REFERENCE   3  (bases 1 to 5407)
  AUTHORS   O'Neill,A.C., Uzbas,F., Antognolli,G., Merino,F., Draganova,K.,
            Jack,A., Zhang,S., Pedini,G., Schessner,J.P., Cramer,K.,
            Schepers,A., Metzger,F., Esgleas,M., Smialowski,P., Guerrini,R.,
            Falk,S., Feederle,R., Freytag,S., Wang,Z., Bahlo,M., Jungmann,R.,
            Bagni,C., Borner,G.H.H., Robertson,S.P., Hauck,S.M. and Gotz,M.
  TITLE     Spatial centrosome proteome of human neural cells uncovers
            disease-relevant heterogeneity
  JOURNAL   Science 376 (6599), eabf9088 (2022)
   PUBMED   35709258
REFERENCE   4  (bases 1 to 5407)
  AUTHORS   Liu,C., Yu,F., Ma,R., Zhang,L., Du,G., Niu,D. and Yin,D.
  TITLE     Cep63 knockout inhibits the malignant phenotypes of papillary
            thyroid cancer cell line TPC-1
  JOURNAL   Oncol Rep 46 (3) (2021)
   PUBMED   34296302
  REMARK    GeneRIF: Cep63 knockout inhibits the malignant phenotypes of
            papillary thyroid cancer cell line TPC1.
REFERENCE   5  (bases 1 to 5407)
  AUTHORS   Mahjabeen,I., Maqsood,Y., Abbasi,R., Ahmed,M.W. and Kayani,M.A.
  TITLE     Polymorphism in miRNA target sites of CEP-63 and CEP-152 ring
            complex influences expression of CEP genes and favors tumorigenesis
            in glioma
  JOURNAL   Future Oncol 17 (25), 3355-3372 (2021)
   PUBMED   34156311
  REMARK    GeneRIF: Polymorphism in miRNA target sites of CEP-63 and CEP-152
            ring complex influences expression of CEP genes and favors
            tumorigenesis in glioma.
REFERENCE   6  (bases 1 to 5407)
  AUTHORS   Morris,J.A., Kandpal,G., Ma,L. and Austin,C.P.
  TITLE     DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated
            protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL:
            regulation and loss of interaction with mutation
  JOURNAL   Hum Mol Genet 12 (13), 1591-1608 (2003)
   PUBMED   12812986
REFERENCE   7  (bases 1 to 5407)
  AUTHORS   Takahashi,M., Yamagiwa,A., Nishimura,T., Mukai,H. and Ono,Y.
  TITLE     Centrosomal proteins CG-NAP and kendrin provide microtubule
            nucleation sites by anchoring gamma-tubulin ring complex
  JOURNAL   Mol Biol Cell 13 (9), 3235-3245 (2002)
   PUBMED   12221128
REFERENCE   8  (bases 1 to 5407)
  AUTHORS   Mayor,T., Stierhof,Y.D., Tanaka,K., Fry,A.M. and Nigg,E.A.
  TITLE     The centrosomal protein C-Nap1 is required for cell cycle-regulated
            centrosome cohesion
  JOURNAL   J Cell Biol 151 (4), 837-846 (2000)
   PUBMED   11076968
REFERENCE   9  (bases 1 to 5407)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
REFERENCE   10 (bases 1 to 5407)
  AUTHORS   Verloes,A., Drunat,S., Gressens,P. and Passemard,S.
  TITLE     Primary Autosomal Recessive Microcephalies and Seckel Syndrome
            Spectrum Disorders - RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301772
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010207.18, AC026117.15,
            AC139764.5, AC109912.10 and BC014050.2.
            
            Summary: This gene encodes a protein with six coiled-coil domains.
            The protein is localized to the centrosome, a non-membraneous
            organelle that functions as the major microtubule-organizing center
            in animal cells. Several alternatively spliced transcript variants
            have been found, but their biological validity has not been
            determined. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1803614.148122.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2148093, SAMEA2151119 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-329               AC010207.18        165216-165544
            330-401             AC010207.18        167511-167582
            402-470             AC010207.18        174788-174856
            471-648             AC026117.15        4024-4201
            649-744             AC139764.5         22081-22176
            745-867             AC139764.5         23014-23136
            868-981             AC139764.5         27391-27504
            982-1215            AC139764.5         35822-36055
            1216-1355           AC139764.5         36385-36524
            1356-1470           AC139764.5         39298-39412
            1471-1668           AC139764.5         40299-40496
            1669-1755           AC139764.5         42162-42248
            1756-1931           AC109912.10        3400-3575
            1932-1932           BC014050.2         1840-1840
            1933-5407           AC109912.10        3577-7051
FEATURES             Location/Qualifiers
     source          1..5407
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.2"
     gene            1..5407
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /note="centrosomal protein 63"
                     /db_xref="GeneID:80254"
                     /db_xref="HGNC:HGNC:25815"
                     /db_xref="MIM:614724"
     exon            1..329
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            330..401
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            402..470
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     CDS             427..1914
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /note="isoform c is encoded by transcript variant 16;
                     centrosome protein CEP63; centrosomal protein 63kDa"
                     /codon_start=1
                     /product="centrosomal protein of 63 kDa isoform c"
                     /protein_id="NP_001340051.1"
                     /db_xref="CCDS:CCDS43154.1"
                     /db_xref="GeneID:80254"
                     /db_xref="HGNC:HGNC:25815"
                     /db_xref="MIM:614724"
                     /translation="MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWE
                     GRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKK
                     LHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQR
                     LIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERAND
                     TICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAAL
                     QSQENLIHEARIQKEKLQEKVKATNTQHAVEAISLESVSATCKQLSQELMEKYEELKR
                     MEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSS
                     SDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSP
                     LGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALK"
     exon            471..648
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            649..744
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            745..867
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            868..981
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1215
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1355
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1470
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1668
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1755
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..5407
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2128..2133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /note="hexamer: AATAAA"
     polyA_site      2146
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /note="major polyA site"
ORIGIN      
        1 tgcggcttcc tgcctcaggc aggatgtacc aaacgtggaa gcggagacgg ggaggtctgg
       61 gggtgccacg caagtccctt tcctcccgac acgagtgcag taaagaaaaa cggttatgag
      121 cgtaaagtga cagcctcggc cgatgggaat agggggaagt ccgacactga gcaacgaacg
      181 cattcccgcg cctccaaaac ctaggccggg ggcgctggaa acccttaccg gcacccggcc
      241 accgcggcag acgcttgctc ctgccacgcc ccccccccct cccccgcatc acgtgtctgc
      301 actcgctttc ctcggattcc cggatgtggg ggcccccaaa cccggggccg cagagcagta
      361 ccagtccgtg gcctgttagg aaccaggcta cagagcagga gttgccaaaa caaaggggat
      421 ttggtgatgg aggctttgtt agaaggaata caaaatcgag ggcatggtgg gggatttttg
      481 acatcttgtg aagcagaact acaggagctc atgaaacaga ttgacataat ggtggctcat
      541 aaaaaatctg aatgggaagg acgtacacat gctctagaaa cttgcttgaa aatccgtgaa
      601 caggaactta agagtcttag gagtcagttg gatgtgacac ataaggaggt tggaatgttg
      661 catcagcagg tagaagaaca tgaaaaaatc aagcaagaga tgaccatgga atataagcag
      721 gagttgaaga aactacatga agaattatgc atactgaaga gaagctatga aaagcttcag
      781 aaaaagcaaa tgagggaatt cagaggaaat accaaaaatc acagggaaga tcggtctgaa
      841 attgagaggt taactgcaaa aatagaggaa ttccgtcaga aatcgctgga ctgggagaag
      901 caacgcttga tttatcagca acaggtatct tcactggagg cacaaaggaa ggctctggct
      961 gaacaatcag agataattca ggctcagctt gtcaatcgga aacagaaatt agagtctgtg
     1021 gaactttcta gccaatcaga aattcaacac ttaagcagta aactggagcg ggctaatgac
     1081 actatctgtg ccaatgagtt ggaaatagag cgcctcacca tgagggtcaa tgacttggtt
     1141 ggaaccagta tgactgtcct acaggagcag cagcaaaaag aagaaaaatt gagggaatct
     1201 gaaaaactat tagaggctct gcaggaagaa aagagagaat tgaaggcagc tcttcagtct
     1261 caagaaaatc tcatacatga ggccagaata caaaaggaga agttacaaga aaaagtaaag
     1321 gcaactaaca ctcaacatgc tgtagaagct ataagtttgg aatctgtgag tgcaacgtgt
     1381 aaacagctga gccaagaact aatggaaaaa tatgaagaac tgaagaggat ggaagcacat
     1441 aacaatgaat acaaagcaga gattaagaag ttgaaagaac agattttaca gggtgaacaa
     1501 agttacagtt ctgcactaga aggaatgaag atggaaatct cccatctaac tcaggagtta
     1561 catcagcgag atatcactat tgcttccacc aaaggttctt cctcagacat ggaaaagcga
     1621 ctcagagcag agatgcaaaa ggcagaagac aaagcagtag agcataagga gattttggat
     1681 cagctggagt cactcaaatt agaaaatcgt catctttctg aaatggtgat gaaattggaa
     1741 ttgggtttac atgagtgttc cttgcctgta tctccccttg gttcaatagc taccagattt
     1801 ttggaagagg aggaactgag gtctcatcac attctagagc gcttggatgc ccatattgaa
     1861 gaactaaaaa gagagagtga aaagacagtg agacaattca cagccttaaa gtagcctctt
     1921 aaaaaaatca caatcttgga aataaaaata aacaccaaag agttactgtc atctgaagta
     1981 gcagctcttt aaaaacatga agagataaaa ttataaaaat gatacatcta aagcagtggt
     2041 gaagaaagct gaaaaactga tacttttgat aggcattttc tctgcactgg tttgtttaaa
     2101 ggacttcttc cagcaataag ttgaaagaat aaaccacttt gctagacttt tttctcatac
     2161 gaatatttat tatcataaag tgatacttac cttgctgact taaatgtgaa tagctatgta
     2221 ctaattgaaa taaggatttt atgatacatg ttgaaaataa agtaactgca ggaactttct
     2281 ttaggggaaa tgtgtagaag catggattta ggggtcaaac atacctggat cgatagactg
     2341 gttttgccac ttaccagcca acggggcttg ttatttactg ggctggtagc ccctcctagc
     2401 caaggggctg gtagtgtgta aagtcaggct ggtagtgaat aagggggggg tgtgctaaag
     2461 aaccttatca agcagtcctc tcttgctcaa cactcatgca gaggagagag gcagggaggg
     2521 caagggactg gctgtcatgc acggtgccca tggaatatcc attggaaata aatgttcatc
     2581 gtctgcactg ctgaggacaa gtttagatgg gagacaaaga tctggatgtt gatgtgccgc
     2641 aggcatttga aacgatggga gttgataaga tccaccaggg aggctgtgga gagagagagg
     2701 agcaggaggc tgggtttggg gccctgaaag atgccagcat ctgaggatca caggaaatag
     2761 atctagcaaa ggaactagaa tgtgcagtta cagatgagaa aggtcagtgt agtgtacttg
     2821 ccagctcaag ggtgtggcct ctgtgaaccc tctttctgta gtggatcttt cccatcagcg
     2881 taaaacatcc tgttatttcc cctttttaaa taaaacctca gtttttttta atgcctctct
     2941 tttactgctc tgtatgtttg cttcccttca cccaaacact tctggaaaga gttgtctgca
     3001 gtgactcttt ccagttcctc accccgcccc accgtagttc tcttcctaac cctctccaac
     3061 accacttcca tccccagact gctttcttgc tcttgagttc accagtgacc taatcagtgt
     3121 ctgagcatca ttcagcacag ttggactctc tcttggcttc tgtgacctgg aacttctggt
     3181 ttcctctcta cctcatcctc cactccatct catggctttt cctcttctaa cctctaagtc
     3241 agagggcccc ctagagctct gtcatgggtt ttctccctca gcattctctt ccctagaagt
     3301 ttccattcca ttctcaagct cttaatacca cctataggcc agtgaccctt acatttatta
     3361 ctaatcttga cctctcccca gagctgctgt cttagatacc tagctgctta tgcgatgtct
     3421 tcacttggat atctgacaaa catcttgttt ccaagagaga actctttatt ctccctcttg
     3481 ctaagattcc atatcaggac atagcattat gtttgccagt tcctaggagt tacttataat
     3541 tccttcctta cccacatccg catatccagt catttgggag gtcctgtcat ttcttccccc
     3601 agaatcttat ctcagaccca accgtttccc tcctgcactt ctaccacctg atccagacta
     3661 cttctctctc accctgattc tggcagtagc ctcctaactg atagtactca caccagtaat
     3721 tcagggagct tctggagtta tcctttagaa atgtaaatga aacagtgtca ccactgcttc
     3781 ccttcagact cttccaaggc ttctcttttt ttttttattg agacagagtc tcactctgtc
     3841 gcccaagctg cagtacagtg gcaggatctc ggctctctgc aacctccacc tcccgggctc
     3901 aagtgattct cctgccttag cttcccgagt agctgggatt acaggcgcat gccaccaggc
     3961 ccagctaatt tttgtatttt tagtaggaac agggtttcac catgttggtc aggctgatct
     4021 cgaactcctg acctcaagtg atccacccgc ctgagcttcc caaagtgctg ggttataagc
     4081 gtgagccact gcacccagcc ccaaggcttc ttactgcact cagaataaaa tccaaatgaa
     4141 ttagtatagc ctacagagtg tcaataatct gggcctaatc acccattgca tcatccttta
     4201 ctgtgctcca cccatgctgg cgtcctttct gtttattgag tgcagcaagc tttaacctgt
     4261 tcgggtcttt catttgcagt ttaccctgaa tattcccttt ctcttacctc acctttgatt
     4321 ggcgttttcc cccttgcaga cctgcactct ggcatcctct cctgagcaag ccttctttga
     4381 ttgctgcctc ccaaacctgt ttctccccat ttctctagct cattggcctg tgttacttgc
     4441 ttcatagtgc tcactactat ctgaaatcat ttcattactt gatttatgtt tgtactgtct
     4501 atttctgtct ttagaattaa aactccttga gggcaaggac tttgcttctc tggttcatgg
     4561 tgggatcctc atcacccagc acaagcccaa cacttaggag aggctcagct agtttgaacc
     4621 aatggaaaat gccattcctg aggtgcacca catcgtttct tttgtgttgg tgtgcatgct
     4681 gtccttcagt ttgtctcctc ttcccacacc ctgtcatgtg ctcctaaaac tcccccttta
     4741 cttggctact ttatctggct tggcaaagct ttcccatatc ccctgaccca tgtcagggaa
     4801 cgtttctcct cattgctgtc atggcaccct gtgtgtggct ctgaccagac tttgctatcc
     4861 gctttgattt ctgtctttca ggggctaagt cctgcctaca tcctcagtca gcatgctgcc
     4921 taacacataa cagatcctaa gcaaatattg ggtggatgaa aatcactacc attcaaggct
     4981 tcattgtatt tatcagtaaa actgaaataa tatctaatgg ggtcgagaag atttactgaa
     5041 aatatatatt tgaaagggct ttgcagtttt aagtactgta cctatgtgca ttgctgttac
     5101 attcaggaga tttctgagtt ttagacagtc ccaagcttca gcttaaaatc tgtagactgc
     5161 agcccgtttc tgaaacgttt gtactacgtg ttgactagga ggaacaatga cagactctgt
     5221 agtcaccgga aatacttaag gaatcatgag gtactatgta tttccttaaa ttatactgtt
     5281 ttttaaagct gaagtatcta atagttaatg ggttgtccaa atttgtcaga acatttgact
     5341 gtaatttaat gtctcaccat ttttcaaaaa gatatattaa taccaaatat taaaatgtgt
     5401 caagact
//
