LOCUS       NM_001353108            5779 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens centrosomal protein 63 (CEP63), transcript variant 5,
            mRNA.
ACCESSION   NM_001353108
VERSION     NM_001353108.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5779)
  AUTHORS   Kodani,A., Knopp,K.A., Di Lullo,E., Retallack,H., Kriegstein,A.R.,
            DeRisi,J.L. and Reiter,J.F.
  TITLE     Zika virus alters centrosome organization to suppress the innate
            immune response
  JOURNAL   EMBO Rep 23 (9), e52211 (2022)
   PUBMED   35793002
REFERENCE   2  (bases 1 to 5779)
  AUTHORS   Ling,H., Cao,C.H., Han,K., Lv,Y.R., Ma,X.D., Cao,J.H., Chen,J.W.,
            Li,S., Lin,J.L., Fang,Y.J., Pan,Z.Z., Xie,D. and Wang,F.W.
  TITLE     CEP63 upregulates YAP1 to promote colorectal cancer progression
            through stabilizing RNA binding protein FXR1
  JOURNAL   Oncogene 41 (39), 4433-4445 (2022)
   PUBMED   35989368
  REMARK    GeneRIF: CEP63 upregulates YAP1 to promote colorectal cancer
            progression through stabilizing RNA binding protein FXR1.
REFERENCE   3  (bases 1 to 5779)
  AUTHORS   O'Neill,A.C., Uzbas,F., Antognolli,G., Merino,F., Draganova,K.,
            Jack,A., Zhang,S., Pedini,G., Schessner,J.P., Cramer,K.,
            Schepers,A., Metzger,F., Esgleas,M., Smialowski,P., Guerrini,R.,
            Falk,S., Feederle,R., Freytag,S., Wang,Z., Bahlo,M., Jungmann,R.,
            Bagni,C., Borner,G.H.H., Robertson,S.P., Hauck,S.M. and Gotz,M.
  TITLE     Spatial centrosome proteome of human neural cells uncovers
            disease-relevant heterogeneity
  JOURNAL   Science 376 (6599), eabf9088 (2022)
   PUBMED   35709258
REFERENCE   4  (bases 1 to 5779)
  AUTHORS   Liu,C., Yu,F., Ma,R., Zhang,L., Du,G., Niu,D. and Yin,D.
  TITLE     Cep63 knockout inhibits the malignant phenotypes of papillary
            thyroid cancer cell line TPC-1
  JOURNAL   Oncol Rep 46 (3) (2021)
   PUBMED   34296302
  REMARK    GeneRIF: Cep63 knockout inhibits the malignant phenotypes of
            papillary thyroid cancer cell line TPC1.
REFERENCE   5  (bases 1 to 5779)
  AUTHORS   Mahjabeen,I., Maqsood,Y., Abbasi,R., Ahmed,M.W. and Kayani,M.A.
  TITLE     Polymorphism in miRNA target sites of CEP-63 and CEP-152 ring
            complex influences expression of CEP genes and favors tumorigenesis
            in glioma
  JOURNAL   Future Oncol 17 (25), 3355-3372 (2021)
   PUBMED   34156311
  REMARK    GeneRIF: Polymorphism in miRNA target sites of CEP-63 and CEP-152
            ring complex influences expression of CEP genes and favors
            tumorigenesis in glioma.
REFERENCE   6  (bases 1 to 5779)
  AUTHORS   Morris,J.A., Kandpal,G., Ma,L. and Austin,C.P.
  TITLE     DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated
            protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL:
            regulation and loss of interaction with mutation
  JOURNAL   Hum Mol Genet 12 (13), 1591-1608 (2003)
   PUBMED   12812986
REFERENCE   7  (bases 1 to 5779)
  AUTHORS   Takahashi,M., Yamagiwa,A., Nishimura,T., Mukai,H. and Ono,Y.
  TITLE     Centrosomal proteins CG-NAP and kendrin provide microtubule
            nucleation sites by anchoring gamma-tubulin ring complex
  JOURNAL   Mol Biol Cell 13 (9), 3235-3245 (2002)
   PUBMED   12221128
REFERENCE   8  (bases 1 to 5779)
  AUTHORS   Mayor,T., Stierhof,Y.D., Tanaka,K., Fry,A.M. and Nigg,E.A.
  TITLE     The centrosomal protein C-Nap1 is required for cell cycle-regulated
            centrosome cohesion
  JOURNAL   J Cell Biol 151 (4), 837-846 (2000)
   PUBMED   11076968
REFERENCE   9  (bases 1 to 5779)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
REFERENCE   10 (bases 1 to 5779)
  AUTHORS   Verloes,A., Drunat,S., Gressens,P. and Passemard,S.
  TITLE     Primary Autosomal Recessive Microcephalies and Seckel Syndrome
            Spectrum Disorders - RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301772
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010207.18, AC026117.15,
            AC139764.5 and AC109912.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 30, 2020 this sequence version replaced NM_001353108.2.
            
            Summary: This gene encodes a protein with six coiled-coil domains.
            The protein is localized to the centrosome, a non-membraneous
            organelle that functions as the major microtubule-organizing center
            in animal cells. Several alternatively spliced transcript variants
            have been found, but their biological validity has not been
            determined. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2057279.1,
                                           SRR1803612.273315.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000675561.1/ ENSP00000502085.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               AC010207.18        165549-165694
            147-215             AC010207.18        174788-174856
            216-393             AC026117.15        4024-4201
            394-489             AC139764.5         22081-22176
            490-612             AC139764.5         23014-23136
            613-726             AC139764.5         27391-27504
            727-960             AC139764.5         35822-36055
            961-1100            AC139764.5         36385-36524
            1101-1238           AC139764.5         37571-37708
            1239-1353           AC139764.5         39298-39412
            1354-1551           AC139764.5         40299-40496
            1552-1638           AC139764.5         42162-42248
            1639-1844           AC139764.5         48378-48583
            1845-2124           AC139764.5         49386-49665
            2125-5779           AC109912.10        3400-7054
FEATURES             Location/Qualifiers
     source          1..5779
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.2"
     gene            1..5779
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /note="centrosomal protein 63"
                     /db_xref="GeneID:80254"
                     /db_xref="HGNC:HGNC:25815"
                     /db_xref="MIM:614724"
     exon            1..146
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            147..215
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2283
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /note="isoform a is encoded by transcript variant 5;
                     centrosome protein CEP63; centrosomal protein 63kDa"
                     /codon_start=1
                     /product="centrosomal protein of 63 kDa isoform a"
                     /protein_id="NP_001340037.1"
                     /db_xref="CCDS:CCDS3086.1"
                     /db_xref="GeneID:80254"
                     /db_xref="HGNC:HGNC:25815"
                     /db_xref="MIM:614724"
                     /translation="MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWE
                     GRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKK
                     LHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQR
                     LIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERAND
                     TICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAAL
                     QSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLS
                     QLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEI
                     KKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQ
                     KAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNK
                     LVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFKNTEFKPTHGQHRH
                     DGIKTEHYKTDLHSPRGQASDSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLP
                     SALDTNEANFSDTMSESMNDQEEFISSCSLPVSPLGSIATRFLEEEELRSHHILERLD
                     AHIEELKRESEKTVRQFTALK"
     exon            216..393
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            394..489
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            490..612
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            613..726
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            727..960
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1100
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1238
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1353
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1551
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1638
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1844
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..2124
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..5779
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2497..2502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /note="hexamer: AATAAA"
     polyA_site      2515
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /note="major polyA site"
     regulatory      5758..5763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /note="hexamer: ATTAAA"
     polyA_site      5779
                     /gene="CEP63"
                     /gene_synonym="SCKL6"
                     /note="major polyA site"
ORIGIN      
        1 gttcatttgc tcgcgtgcag gggaagtctg gagaaggcat tgtttcaatt attaaaagtg
       61 tgggggcagt gggcggaaca aacgcgccga ctacagaggc tggacgtaag cttagcggtg
      121 gcgcgcgtgc gcagcgccgg cccgagttgc caaaacaaag gggatttggt gatggaggct
      181 ttgttagaag gaatacaaaa tcgagggcat ggtgggggat ttttgacatc ttgtgaagca
      241 gaactacagg agctcatgaa acagattgac ataatggtgg ctcataaaaa atctgaatgg
      301 gaaggacgta cacatgctct agaaacttgc ttgaaaatcc gtgaacagga acttaagagt
      361 cttaggagtc agttggatgt gacacataag gaggttggaa tgttgcatca gcaggtagaa
      421 gaacatgaaa aaatcaagca agagatgacc atggaatata agcaggagtt gaagaaacta
      481 catgaagaat tatgcatact gaagagaagc tatgaaaagc ttcagaaaaa gcaaatgagg
      541 gaattcagag gaaataccaa aaatcacagg gaagatcggt ctgaaattga gaggttaact
      601 gcaaaaatag aggaattccg tcagaaatcg ctggactggg agaagcaacg cttgatttat
      661 cagcaacagg tatcttcact ggaggcacaa aggaaggctc tggctgaaca atcagagata
      721 attcaggctc agcttgtcaa tcggaaacag aaattagagt ctgtggaact ttctagccaa
      781 tcagaaattc aacacttaag cagtaaactg gagcgggcta atgacactat ctgtgccaat
      841 gagttggaaa tagagcgcct caccatgagg gtcaatgact tggttggaac cagtatgact
      901 gtcctacagg agcagcagca aaaagaagaa aaattgaggg aatctgaaaa actattagag
      961 gctctgcagg aagaaaagag agaattgaag gcagctcttc agtctcaaga aaatctcata
     1021 catgaggcca gaatacaaaa ggagaagtta caagaaaaag taaaggcaac taacactcaa
     1081 catgctgtag aagctataag gccacgggaa gaatctctgg cagaaaagaa gtacacctct
     1141 caagggcagg gggacttaga cagtgtgctc tcccagttga attttaccca tactagtgag
     1201 gaccttctgc aggcagaggt gacttgtctt gaaggcagtt tggaatctgt gagtgcaacg
     1261 tgtaaacagc tgagccaaga actaatggaa aaatatgaag aactgaagag gatggaagca
     1321 cataacaatg aatacaaagc agagattaag aagttgaaag aacagatttt acagggtgaa
     1381 caaagttaca gttctgcact agaaggaatg aagatggaaa tctcccatct aactcaggag
     1441 ttacatcagc gagatatcac tattgcttcc accaaaggtt cttcctcaga catggaaaag
     1501 cgactcagag cagagatgca aaaggcagaa gacaaagcag tagagcataa ggagattttg
     1561 gatcagctgg agtcactcaa attagaaaat cgtcatcttt ctgaaatggt gatgaaattg
     1621 gaattgggtt tacatgaggc aaaagagatt tcactagcag acctccagga gaattatatt
     1681 gaggcattaa ataaattagt gtctgaaaat caacaactac agaaagattt gatgaatacc
     1741 aaatctcagc tggagatttc tactcagatg tgcaaaaaac aaaatgacag gatctttaaa
     1801 ccaacacaca gcagaacaac tgagttcaag aatacagagt tcaagccaac ccatggccag
     1861 cacagacatg atggaataaa gactgagcac tacaaaacag atcttcattc tccaagagga
     1921 caagcgtcgg atagtataaa ccccatgtct agggtgctaa gccccctgag tcctcaaatc
     1981 agcccttgca gctccaccag gtctttgact tcctactctc tatgtaaaac tcattctttg
     2041 ccttcagcgc tagatacaaa tgaagccaat ttttctgaca ctatgtctga gagtatgaat
     2101 gaccaagaag agtttatatc ttcgtgttcc ttgcctgtat ctccccttgg ttcaatagct
     2161 accagatttt tggaagagga ggaactgagg tctcatcaca ttctagagcg cttggatgcc
     2221 catattgaag aactaaaaag agagagtgaa aagacagtga gacaattcac agccttaaag
     2281 tagcctctta aaaaaatcac tatcttggaa ataaaaataa acaccaaaga gttactgtca
     2341 tctgaagtag cagctcttta aaaacatgaa gagataaaat tataaaaatg atacatctaa
     2401 agcagtggtg aagaaagctg aaaaactgat acttttgata ggcattttct ctgcactggt
     2461 ttgtttaaag gacttcttcc agcaataagt tgaaagaata aaccactttg ctagactttt
     2521 ttctcatacg aatatttatt atcataaagt gatacttacc ttgctgactt aaatgtgaat
     2581 agctatgtac taattgaaat aaggatttta tgatacatgt tgaaaataaa gtaactgcag
     2641 gaactttctt taggggaaat gtgtagaagc atggatttag gggtcaaaca tacctggatc
     2701 gatagactgg ttttgccact taccagccaa cggggcttgt tatttactgg gctggtagcc
     2761 cctcctagcc aaggggctgg tagtgtgtaa agtcaggctg gtagtgaata aggggggggt
     2821 gtgctaaaga accttatcaa gcagtcctct cttgctcaac actcatgcag aggagagagg
     2881 cagggagggc aagggactgg ctgtcatgca cggtgcccat ggaatatcca ttggaaataa
     2941 atgttcatcg tctgcactgc tgaggacaag tttagatggg agacaaagat ctggatgttg
     3001 atgtgccgca ggcatttgaa acgatgggag ttgataagat ccaccaggga ggctgtggag
     3061 agagagagga gcaggaggct gggtttgggg ccctgaaaga tgccagcatc tgaggatcac
     3121 aggaaataga tctagcaaag gaactagaat gtgcagttac agatgagaaa ggtcagtgta
     3181 gtgtacttgc cagctcaagg gtgtggcctc tgtgaaccct ctttctgtag tggatctttc
     3241 ccatcagcgt aaaacatcct gttatttccc ctttttaaat aaaacctcag ttttttttaa
     3301 tgcctctctt ttactgctct gtatgtttgc ttcccttcac ccaaacactt ctggaaagag
     3361 ttgtctgcag tgactctttc cagttcctca ccccgcccca ccgtagttct cttcctaacc
     3421 ctctccaaca ccacttccat ccccagactg ctttcttgct cttgagttca ccagtgacct
     3481 aatcagtgtc tgagcatcat tcagcacagt tggactctct cttggcttct gtgacctgga
     3541 acttctggtt tcctctctac ctcatcctcc actccatctc atggcttttc ctcttctaac
     3601 ctctaagtca gagggccccc tagagctctg tcatgggttt tctccctcag cattctcttc
     3661 cctagaagtt tccattccat tctcaagctc ttaataccac ctataggcca gtgaccctta
     3721 catttattac taatcttgac ctctccccag agctgctgtc ttagatacct agctgcttat
     3781 gcgatgtctt cacttggata tctgacaaac atcttgtttc caagagagaa ctctttattc
     3841 tccctcttgc taagattcca tatcaggaca tagcattatg tttgccagtt cctaggagtt
     3901 acttataatt ccttccttac ccacatccgc atatccagtc atttgggagg tcctgtcatt
     3961 tcttccccca gaatcttatc tcagacccaa ccgtttccct cctgcacttc taccacctga
     4021 tccagactac ttctctctca ccctgattct ggcagtagcc tcctaactga tagtactcac
     4081 accagtaatt cagggagctt ctggagttat cctttagaaa tgtaaatgaa acagtgtcac
     4141 cactgcttcc cttcagactc ttccaaggct tctctttttt tttttattga gacagagtct
     4201 cactctgtcg cccaagctgc agtacagtgg caggatctcg gctctctgca acctccacct
     4261 cccgggctca agtgattctc ctgccttagc ttcccgagta gctgggatta caggcgcatg
     4321 ccaccaggcc cagctaattt ttgtattttt agtaggaaca gggtttcacc atgttggtca
     4381 ggctgatctc gaactcctga cctcaagtga tccacccgcc tgagcttccc aaagtgctgg
     4441 gttataagcg tgagccactg cacccagccc caaggcttct tactgcactc agaataaaat
     4501 ccaaatgaat tagtatagcc tacagagtgt caataatctg ggcctaatca cccattgcat
     4561 catcctttac tgtgctccac ccatgctggc gtcctttctg tttattgagt gcagcaagct
     4621 ttaacctgtt cgggtctttc atttgcagtt taccctgaat attccctttc tcttacctca
     4681 cctttgattg gcgttttccc ccttgcagac ctgcactctg gcatcctctc ctgagcaagc
     4741 cttctttgat tgctgcctcc caaacctgtt tctccccatt tctctagctc attggcctgt
     4801 gttacttgct tcatagtgct cactactatc tgaaatcatt tcattacttg atttatgttt
     4861 gtactgtcta tttctgtctt tagaattaaa actccttgag ggcaaggact ttgcttctct
     4921 ggttcatggt gggatcctca tcacccagca caagcccaac acttaggaga ggctcagcta
     4981 gtttgaacca atggaaaatg ccattcctga ggtgcaccac atcgtttctt ttgtgttggt
     5041 gtgcatgctg tccttcagtt tgtctcctct tcccacaccc tgtcatgtgc tcctaaaact
     5101 ccccctttac ttggctactt tatctggctt ggcaaagctt tcccatatcc cctgacccat
     5161 gtcagggaac gtttctcctc attgctgtca tggcaccctg tgtgtggctc tgaccagact
     5221 ttgctatccg ctttgatttc tgtctttcag gggctaagtc ctgcctacat cctcagtcag
     5281 catgctgcct aacacataac agatcctaag caaatattgg gtggatgaaa atcactacca
     5341 ttcaaggctt cattgtattt atcagtaaaa ctgaaataat atctaatggg gtcgagaaga
     5401 tttactgaaa atatatattt gaaagggctt tgcagtttta agtactgtac ctatgtgcat
     5461 tgctgttaca ttcaggagat ttctgagttt tagacagtcc caagcttcag cttaaaatct
     5521 gtagactgca gcccgtttct gaaacgtttg tactacgtgt tgactaggag gaacaatgac
     5581 agactctgta gtcaccggaa atacttaagg aatcatgagg tactatgtat ttccttaaat
     5641 tatactgttt tttaaagctg aagtatctaa tagttaatgg gttgtccaaa tttgtcagaa
     5701 catttgactg taatttaatg tctcaccatt tttcaaaaag atatattaat accaaatatt
     5761 aaaatgtgtc aagactaaa
//
