LOCUS       NM_001271852           12903 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens centrosomal protein 57 like 1 (CEP57L1), transcript
            variant 3, mRNA.
ACCESSION   NM_001271852
VERSION     NM_001271852.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12903)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   2  (bases 1 to 12903)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   3  (bases 1 to 12903)
  AUTHORS   Ito,K.K., Watanabe,K., Ishida,H., Matsuhashi,K., Chinen,T., Hata,S.
            and Kitagawa,D.
  TITLE     Cep57 and Cep57L1 maintain centriole engagement in interphase to
            ensure centriole duplication cycle
  JOURNAL   J Cell Biol 220 (3) (2021)
   PUBMED   33492359
  REMARK    GeneRIF: Cep57 and Cep57L1 maintain centriole engagement in
            interphase to ensure centriole duplication cycle.
REFERENCE   4  (bases 1 to 12903)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 12903)
  AUTHORS   Liu,Y., Li,Y., March,M.E., Nguyen,K., Xu,K., Wang,F., Guo,Y.,
            Keating,B., Glessner,J., Li,J., Ganley,T.J., Zhang,J.,
            Deardorff,M.A., Xu,X. and Hakonarson,H.
  TITLE     Copy number variation in CEP57L1 predisposes to congenital absence
            of bilateral ACL and PCL ligaments
  JOURNAL   Hum Genomics 9, 31 (2015)
   PUBMED   26561035
  REMARK    Erratum:[Hum Genomics. 2016 Jan 18;10:5. doi:
            10.1186/s40246-016-0060-8.. Kenny, Nguyen [corrected to Nguyen,
            Kenny]. PMID: 26782110]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 12903)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   7  (bases 1 to 12903)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   8  (bases 1 to 12903)
  AUTHORS   Kamatani,Y., Matsuda,K., Okada,Y., Kubo,M., Hosono,N., Daigo,Y.,
            Nakamura,Y. and Kamatani,N.
  TITLE     Genome-wide association study of hematological and biochemical
            traits in a Japanese population
  JOURNAL   Nat Genet 42 (3), 210-215 (2010)
   PUBMED   20139978
REFERENCE   9  (bases 1 to 12903)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355305.9.
            
            On May 20, 2020 this sequence version replaced NM_001271852.2.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, 5, and 6 all encode the same
            isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.4099868.1,
                                           SRR1803611.118404.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000517392.6/ ENSP00000427844.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AL355305.9         59332-59400
            70-232              AL355305.9         109044-109206
            233-412             AL355305.9         110583-110762
            413-534             AL355305.9         113943-114064
            535-651             AL355305.9         117658-117774
            652-729             AL355305.9         119055-119132
            730-816             AL355305.9         119616-119702
            817-894             AL355305.9         122850-122927
            895-1088            AL355305.9         123094-123287
            1089-1233           AL355305.9         124397-124541
            1234-12903          AL355305.9         126574-138243
FEATURES             Location/Qualifiers
     source          1..12903
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..12903
                     /gene="CEP57L1"
                     /gene_synonym="bA487F23.2; C6orf182; cep57R"
                     /note="centrosomal protein 57 like 1"
                     /db_xref="GeneID:285753"
                     /db_xref="HGNC:HGNC:21561"
     exon            1..69
                     /gene="CEP57L1"
                     /gene_synonym="bA487F23.2; C6orf182; cep57R"
                     /inference="alignment:Splign:2.1.0"
     exon            70..232
                     /gene="CEP57L1"
                     /gene_synonym="bA487F23.2; C6orf182; cep57R"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1455
                     /gene="CEP57L1"
                     /gene_synonym="bA487F23.2; C6orf182; cep57R"
                     /note="isoform 1 is encoded by transcript variant 3;
                     cep57-related protein; centrosomal protein CEP57L1;
                     centrosomal protein of 57 kDa-related protein; centrosomal
                     protein 57kDa-like protein 1; centrosomal protein
                     57kDa-like 1"
                     /codon_start=1
                     /product="centrosomal protein CEP57L1 isoform 1"
                     /protein_id="NP_001258781.1"
                     /db_xref="CCDS:CCDS5071.1"
                     /db_xref="GeneID:285753"
                     /db_xref="HGNC:HGNC:21561"
                     /translation="MDSELMHSIVGSYHKPPERVFVPSFTQNEPSQNCHPANLEVTSP
                     KILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERN
                     LAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQRE
                     KEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKAS
                     ELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMR
                     QHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDEL
                     DQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQ
                     QKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRKCLTDTNLFQKNSSFHPIRVHNLQMK
                     LRRDDIMWEQ"
     exon            233..412
                     /gene="CEP57L1"
                     /gene_synonym="bA487F23.2; C6orf182; cep57R"
                     /inference="alignment:Splign:2.1.0"
     exon            413..534
                     /gene="CEP57L1"
                     /gene_synonym="bA487F23.2; C6orf182; cep57R"
                     /inference="alignment:Splign:2.1.0"
     exon            535..651
                     /gene="CEP57L1"
                     /gene_synonym="bA487F23.2; C6orf182; cep57R"
                     /inference="alignment:Splign:2.1.0"
     exon            652..729
                     /gene="CEP57L1"
                     /gene_synonym="bA487F23.2; C6orf182; cep57R"
                     /inference="alignment:Splign:2.1.0"
     exon            730..816
                     /gene="CEP57L1"
                     /gene_synonym="bA487F23.2; C6orf182; cep57R"
                     /inference="alignment:Splign:2.1.0"
     exon            817..894
                     /gene="CEP57L1"
                     /gene_synonym="bA487F23.2; C6orf182; cep57R"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1088
                     /gene="CEP57L1"
                     /gene_synonym="bA487F23.2; C6orf182; cep57R"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1233
                     /gene="CEP57L1"
                     /gene_synonym="bA487F23.2; C6orf182; cep57R"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..12903
                     /gene="CEP57L1"
                     /gene_synonym="bA487F23.2; C6orf182; cep57R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2367..2372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP57L1"
                     /gene_synonym="bA487F23.2; C6orf182; cep57R"
                     /note="hexamer: AATAAA"
     polyA_site      2397
                     /gene="CEP57L1"
                     /gene_synonym="bA487F23.2; C6orf182; cep57R"
                     /note="major polyA site"
     regulatory      6565..6570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP57L1"
                     /gene_synonym="bA487F23.2; C6orf182; cep57R"
                     /note="hexamer: GATAAA"
     polyA_site      6585
                     /gene="CEP57L1"
                     /gene_synonym="bA487F23.2; C6orf182; cep57R"
                     /note="major polyA site"
     regulatory      9149..9154
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP57L1"
                     /gene_synonym="bA487F23.2; C6orf182; cep57R"
                     /note="hexamer: ATTAAA"
     polyA_site      9171
                     /gene="CEP57L1"
                     /gene_synonym="bA487F23.2; C6orf182; cep57R"
     regulatory      12881..12886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP57L1"
                     /gene_synonym="bA487F23.2; C6orf182; cep57R"
                     /note="hexamer: CATAAA"
     polyA_site      12903
                     /gene="CEP57L1"
                     /gene_synonym="bA487F23.2; C6orf182; cep57R"
ORIGIN      
        1 gacgttgcct gtgggtgccc gcgaaccaac ggttagcggt ggcaggggct gactgagagc
       61 gtctgcttga taatggattc tgaattaatg catagtatag taggaagcta tcataaacct
      121 ccagaaagag tatttgttcc ctcattcacc cagaatgaac catctcagaa ttgccatcct
      181 gcaaacttag aagttacctc tcctaagata cttcatagcc caaatagcca agctcttatt
      241 ttagccttaa aaactcttca ggaaaaaatt catcgtttag agctggagag aacacaagct
      301 gaagataacc tgaacattct ttccagagaa gcagcacagt ataagaaggc cttagagaat
      361 gaaacaaatg agagaaatct ggcacaccag gagctgataa agcagaaaaa agatataagt
      421 atacagttaa gctcagccca gtctcgttgt actcttctag agaagcaact agaatataca
      481 aagagaatgg ttctcaacgt agagcgagaa aagaacatga tcctagaaca acaggcccag
      541 cttcagaggg aaaaagaaca agatcagatg aagctgtatg caaaacttga aaagcttgat
      601 gtcttagaaa aagagtgttt cagacttaca acaactcaga aaactgctga ggacaagatt
      661 aaacatttag aagaaaaact taaggaagaa gaacatcagc gtaagctatt tcaagacaaa
      721 gcttctgagc ttcaaactgg acttgaaatc agtaaaatta taatgtcttc agtttcaaat
      781 ctaaagcact ccaaggaaaa gaagaaatct tcaaagaaaa ctaaatgtat aaagagacga
      841 ccaccttggc aaatttgttc aaagtttgga gcactgcctt ttgtggctga aaagatgagg
      901 caacatcgtg acccacatat ccttcagaaa ccttttaacg tgactgagac tagatgtctc
      961 cccaagcctt ctagaacaac ttcctggtgt aaagctattc ctcctgactc agaaaagtcc
     1021 atttccattt gtgacaattt atctgaactt ttgatggcaa tgcaagatga gctggaccaa
     1081 atgagcatgg agcaccaaga actactgaaa caaatgaagg aaactgaaag tcattcagtc
     1141 tgtgacgaca tagaatgtga actagagtgt ttactcaaga aaatggaaat taaaggagaa
     1201 caaatctcca aactgaagaa gcatcaagac agtgtctgta aactgcagca aaaagttcaa
     1261 aactcaaaga tgagtgaagc ttcaggtatt cagcaagaag acagctaccc taaaggatca
     1321 aagaacataa aaaatagccc cagaaaatgt ttgactgaca ctaacctttt tcagaaaaac
     1381 agcagctttc atccaatacg agttcataat cttcaaatga aattgagaag agatgatatc
     1441 atgtgggaac agtaacaaaa cagcaaaact gtcaccttaa tgaactttgt cagtgagacc
     1501 ttgaattgtc taaagtggtt ttaatttaat ataactttgt gacattttga atcatgtttc
     1561 tagtttctat aaaacatgaa gttgcagtat ttaaaaatta atgcctaatg acctggtggg
     1621 ttccaaataa taaattaatt gcttttttat ttttcttatt gattgaagcc cgtaacctca
     1681 tcttgtctta gaaacattgt tggctttgca gatatcttaa gctaaattta agaaattgta
     1741 ctagattgac aatattcaaa attgagttaa atccaagcta caagtaccat tcattccact
     1801 tttcatttag taggtttgga accttaaaaa ccaatgttca atgaacagag ttcagaaaga
     1861 tcatttagct ttcctggtgc cttctttcta ttttgtttta gagctgtgaa atgtttttct
     1921 cttttggaaa aggaaaaact taatagttac acagttttgt gaagaagcct ttaatccaag
     1981 ttttatgaga cagtaggaac ctatagctac ttaattttta ggagacagta attcagttgc
     2041 agaagctttc ctctgctatt cccattctct tttacaaaac tagttttttt taaaaaatca
     2101 atgatcaatt ttatcttact actttataac ttttgctgac ttttattctt tgcattgtat
     2161 gtaatgtcca tcagtataaa ttgagactgt gaatttctag gacccacaaa agtggtattt
     2221 tttttttgta caagaaagta tagaggaaga ggaagctggg cattaaatta cctcatccag
     2281 cagaaattca cggtagtatg gtatattttt attttttata ttttaaaatc aataatgtca
     2341 aatgtcattg tgtatgcatg ctttataata aatttacact tgatcatttt tctggaagcc
     2401 tatgggaact agtacaactc ttctgaactc ttggtttctc actcaaatcc tctgaggcaa
     2461 ctggggaact agagtcatga actgaattag aaatagagga cagagagaaa agatataata
     2521 gaatggagga gctcaaatat agggtagcag tttaagagat ggtgattcct aagggacaga
     2581 gttggaagta catatttact gaattctttg aacccacagc tgatggaatg ttcaagctat
     2641 agatgtgaaa gaatttttag gtcaggatct tgggaagcta aggagagcaa tttttaaaag
     2701 acagtttttc tgttttccta ggaaattccc aagaagcttg tgtaggaaaa agttggtaat
     2761 tatggatctt ttggggagga agagaactat aattcattct aatggtgagg agagatacca
     2821 tgttagaata ccttccatac ctggaagtgg ggaagtgact gaagatgggc acattgatgc
     2881 ttgaaattgt ccttgaaagt agttaatggc agagatcaaa atttcctcct gttgtaaata
     2941 gtgcatgtgc cctttgccag ctttcactcc cactcattca cacccttagc tcctcagccc
     3001 tggagatgtt ccatagggtg tttgatctaa actcagttgc atcaccttac ctgtttttct
     3061 actttgcctt tcctccttga ggatatgagt tttatagctt aagcttagct ttttgctaaa
     3121 ctttttagct ttctgctatc caccaggacc ataatgcaga cctatagttc tgtgcctttg
     3181 ttttctatac atttaggaag gtggctgaat atatttagtt attaataatt cattacttgt
     3241 gaaaaggtat tgctttaaaa attatcatta aaaatttaaa aaccgtccag gcgcggtggc
     3301 tcacacctat aatcccagca ctttgggagg ccgaggcagg cagatcacga ggtcaggaga
     3361 ttgagaccat cctggccaac atgtgaaacc ctgtctctac taaattacaa aaattagccg
     3421 ggtgtggtgg cgcatgcctg taatcccagc tacttgggag actgaggcag gggaatcgct
     3481 tgaacctggg agatggaggt tgcagtgagc tgagatctca ccactgtact ccagcctggt
     3541 gacacagcaa gactctgtct caaaaaaaaa aaaaaaaatt aaaaccattt taggaacatg
     3601 gaatatttca actgagaatt ttcttaaaaa ttagtccagt gtagtagaaa aaaccacaac
     3661 ttcagagcta ggaaacttgg tttcaaattc tgggactcta ccatttaata gcttggacaa
     3721 gtcagataac tttctggagc ctcagtttct catctgtaaa gtgaggatta tactaatatc
     3781 tccctcacag gactatacta atttgttgtg aggagttaat gaaataacat gggaaagcac
     3841 ccagcagaag agttgacact tattaaacac tcaataaata ttttttgaat ctgagtggca
     3901 aaaaaaaaaa aaaaatgtag aacacatgtt tgcatgggtt gaagcctaaa agcaaacacc
     3961 taaatatatt attggtaaaa gtgggaatat tctcacttat tttggttttt atctctttct
     4021 gtgtgcctga agggaaatgg ctttgtcatc tttcctagcc caggtttcta atgggagggg
     4081 gtaaagaaca cagtcctgtc attgtgctga aacatgtaac cacacacagc aaataggttt
     4141 ggagtatggt gtggttgttg aggtgacatt tattattgag agacaatgaa gaatggtgtc
     4201 ttgttgcttc atcacagcta ctgaactcac agactgcctg cttgccagag cctttgactc
     4261 ctcagggggt ggagcaaaag atttctttcc tggatggagc agtcagtcta tggtcagtgt
     4321 aagagttgct gtagcaacct cacagctgtg ctctgtctag cagaaacttg gtatgatttc
     4381 acggattttg ttcacttaag taaaaaacag atttgtttgg tttttatgta attagaaatt
     4441 gaaataatgg aattggaatt ttctagccaa ggcaggtctc aattttgatg aaactgaagc
     4501 cagaaagttc cagtgtttga agcagcaggt attgtgacta tattctgata ctggaaatgg
     4561 gagttggaat cctgaattaa ctgtacttgg gtggatcatt ggcaacccag ccatttttat
     4621 taggttgtag ataaagacag gagggtcaga gggaaatgtt cagttttcaa caatgtaaga
     4681 ttaaagtggg agatacttag tacatagtaa gttaactggc tgggataatg tagataatgt
     4741 acttgaaaat tatttttgag cttttttggt agctttctta ctttattcct ttttttctat
     4801 acctgccagt agatgtgaga gcttttctta ctttaaaagt gtaattttaa ctataaatgt
     4861 atattctttt tttttttttt ttggtgggca tggagtctcg ctgtgtcacc caggctagag
     4921 tgcagtggca cgatctcagc tcactgcaac ctccacctct caggttcaag ctattctcct
     4981 gcctcagcct cccgagtagc tggaattaca ggcacctgcc atacacccag ctaatttttg
     5041 tatttttagt agagatgggg tttcactgtg ttagccagga tggtctggat ctcctgacct
     5101 caggtgatcc gcccacctca gcctcccaaa gtgctgggat tacaggcatg agccactgcg
     5161 cccagcctaa atgtgtattc ttatccatga taagagatca aaaattaaat aaaaatttta
     5221 cttgtaatgt gagaaatcaa tctaaggggg gaagaggcca gttggttatg cacaatggaa
     5281 ggagtgcatt gtggacagaa atgcaacagc tgccattatt ggtgtagagt aaataatgaa
     5341 actcctaatg gggtttcctg gaacaatatt cagctgtaac taaagcttta tctactgaga
     5401 acatttaatt gtaggtgacg tgtagataag tataagctga cactcagaca tatgacaaga
     5461 caaccttcac taaggcataa tagcaactgt gagattttta aaaaactatg cgtgccattg
     5521 caccttttaa ttaaagtgag atgaggataa ataaaaataa tattgactgt cactcatctg
     5581 aaaataaatt tacttcttgg taattaaata gaccttctca atgcctcagc ctttttcttc
     5641 atattccatc tacttgtttt catgtaactt tgtctttcaa ttcgtttttg tttttttttt
     5701 cctgtaagga gaattagaca tagaaaaatt ataaatttaa gccttaaaat aatgtctggg
     5761 ccagagtttg ttgttacttt tgctgtagat tgtttactta aagaattagg tgaatttttt
     5821 ttttcctggt aggtttattg ggagtgttct ccatattgat atagatggat ccatttccca
     5881 tttggggctg agcactgtgt cttacgcctg taatcccagc actgtgagag gccgaggcag
     5941 gcggatcacc taagtcagga gttcaacacc agcctggcca atgtagtgaa accctgtctc
     6001 tactaaaaat aaaaaaaaat tagctgggtg tggtagcatg cagtccagct actcgggagg
     6061 ctgaggcagg ataattgctt gaacctggga ggcagaggtt gcggtgagcc gagattgtgc
     6121 cactgcactc cagcctgggc aacagagcaa gactctgcct caaagcaaaa aaaaaaagaa
     6181 aagaaaagaa aaaaggaata gcccagtatt gtttgtttgg ggaggggcag ggtgtggttc
     6241 caccaactgt gggcaccaga atggtgcttt ctttgatact atgctaagag gaagaggttt
     6301 gagagccaag agttctttat ttggatattg gtatgtttga cttgttcatc agtgagtatt
     6361 tattgatctc taattattga tctcaaaata ctgtattagc tactatggaa ttccgttttc
     6421 aagttgctta tagtcttgag gagagataag atgtatatat atttaaaagg aagaaaacag
     6481 taagtgacat gaaaggcata atgacaacca cagagcagat gctcaaatat ttatttgcct
     6541 actaaatgtt tgttctcatc tatcgataaa gtgcttaaga agttggcctg tttgtaattt
     6601 cttcattttc tatctatctt gatttatata ccttcacctt tttaaatttt ttgcctggta
     6661 gcagtattgg tctaggattt tcactcttta ttaggcttct tgattgaaga taccagttcc
     6721 tttagtaatt tcaaaatgcc ggccatagcc agtctataat ccaattcaaa ggcatgagtg
     6781 gaaaaagtgg gtatgaaaca atgaagtaaa tggagaagtg ggggaaaatc aagcaataat
     6841 cacttagact aaaacagaac aataagaatt atacagaaag gttatattct agaggccaag
     6901 tattgacttg cacagaattg tgtaaatgat tgccattcac ttcccttatg aacttaagcc
     6961 actcaatttc tgcatacttc agcctcctca ttggttggat ccagtcagtg tttttcatag
     7021 tacatacagt cataccggtg gattgtcaaa tcaatttagc gggtcactac cagcattttt
     7081 tttttttttt tttttttgag attggagtct cgctccttca cccaggctgg agtgcaatgg
     7141 tacaatctcg tctcactgca acctccacct cccaggttca agcaattctc ctgcctcagc
     7201 ctcccaagta gctgggatta taggtgtgca ccaccatgcc ctgctaattt tttgtatttt
     7261 agtagagatg gggtttcact gtattgccca ggctggtcac gaactcctga gctcaggcaa
     7321 tctgcccgcc tcagtgtccc aaagtgctgg gattacaggc gtgagccacc atgcctggcc
     7381 agcatttttt aaatgatata aaatagtatt gaaaatatca gaatgtggcc aggtgcgatg
     7441 gctcacgcct gtaaaatctt aacactttag gaggccgagg cgggcagatt gcctgagctc
     7501 aggagttcaa gaccaccctg ggcgacatgg tgaaatccca tctctactaa aaatacaaaa
     7561 attagccggg catggtggta tgtgcctgta atcccgggta ctcgggaggc taaggccaga
     7621 ggattgcttg aaccagggag gcggaggttg cagtaagctg agattgtgcc actgcactct
     7681 agcctgagca gcagagtgag gctccatcag caaaaaaaaa aaaaaaaaaa aagatcagag
     7741 tgcatcacac ataattaagg tagcttatgt tttgtgaaac tttgtgagta cgggttgtca
     7801 tttttaatgt agccctaaat gttttttagg gaagaaaaag ttggctttta ataagtattc
     7861 agtgagaatg aatttgaagg gtgtggagaa aagtggaata gccaatttaa aataggaata
     7921 ctcccaagtc ccctgttatg gatgtgccaa tctattgttt atcccagaaa tattgtttca
     7981 tgtgttttac agataacaag tctcatttta atcaatactg ttgcatttcc tggtctatag
     8041 aatacaattt tcaaacacta gccaacttac cttagagaaa tactggtttt ctaatgtggg
     8101 caaataaata cattcagtat gaatccctta acaaaatgac ctcattatgc tacctcttgg
     8161 taaaatctaa ccaagcatga gtcttatgat taagaaagaa atttgctctg taggtgcttc
     8221 agacagtttt acaaccaata agaatgtgag atttgtcgga gaaaaactat ctgcatgtct
     8281 ccaatctgaa gagagcaaag atctgttatt tgacaaaccc tatttttccg agcatcaaca
     8341 gtcagtggca ccatgaaaat taaaaacctg ataataccac caatgtagta ctctttaaaa
     8401 acatgtcatc ttactcagca atcaacctga ttgaatattt taaaatgaat aagtggataa
     8461 atatcttacc tgaaagatag cttcattaaa taaactaact cctgagagga tttctttggc
     8521 ctttaatatc ctatttaata gatttcttat aaccatatca gcaaagccac tctgctctgg
     8581 acaatggtca gaaggtagga agaagtgtta tagggtaatg agcaataata aggccaccaa
     8641 atataatccc attgtaatgg gattctaccc acttgtagaa gtttattcac cactacaaat
     8701 tactaaagtt aacctaaaca attaaagaaa gaaatcttag tctttaagaa cagaggattg
     8761 taaagtgagc cagaccttcc aatcagctaa aataatgtaa aataatgtac ttttcaacct
     8821 gacttggctt aatgtagtta agtaaatttt aggataggtt ctaaaaaacc ttgagaggca
     8881 ttttgttgtt gttgttgttg ttgttagttt gccttaaagt taaatgtaca ttgacctttg
     8941 gtatttctta gaaaaacctg ttactgaacc tagtacagaa tgtgaatcat ttcatgcctg
     9001 aaatacaaga ttgatgttta cagggcaatt gtccagaatc ttgctgaatt ggaaagtatt
     9061 tcactcttca tcactgtaga tccgtttaac tttacaaatg tgttatttaa aacataaacc
     9121 attttggtgc acaggaaacc cacttaaaat taaattttaa aaagctctcg agaagtctgt
     9181 ggaacattta tggttttata acttacaatt tctagcaaaa gtatctttaa tatcttacaa
     9241 aatattttca gagatagctt atccaaaata tgtaatacat gtgagagaat agcactgttg
     9301 aaatgcttga acacataaaa agcattattg ccttcatttt ccctgaaatg aaccaagcta
     9361 ccaatttaaa gctgggaaag tcagtaccag agttaaaaac aagttacttt aaagatatct
     9421 gcttttactt taatctaaaa aataattgat tttttaaaaa acttattcta ttttatgtat
     9481 ataacttctc ctttataagc ttagaaaaat ttatatcagt attacattct tgattctctc
     9541 aaggtatgat ttaaatggtg gacacttaag ccaaaatttc aaacaggttc ttttttcttt
     9601 gttcttttac agaatggctc tcaagtcgaa agagggctgt gcctttggtg tttgggtatg
     9661 atatatttgc ctgtgatttc tcattctcag agcattccca taaataatgc cacaaagtag
     9721 agtttgattt tttttttttt gagacggagt ttcgctcttg ttgcccaagc tggagtgcaa
     9781 tggcgcgatc tcagctcact gcaacctccg cctcccaggt tcaagcgatt cttctgcctc
     9841 agcctcccaa gtagctggga ttacaggcat gcgtcaccac acccggctgt tttttttttt
     9901 cgcattttta atagaaacgg ggtttcaccg tgttagccag gctggtctcg aactcctgac
     9961 cttaggtgaa ctgcccgcct cagcctccca aagtgctggg attacaggtg tgagccaccg
    10021 cgccctgcct agagtttgat tctcttaaac cgttctacta aaatactatc agtttaaact
    10081 accatctaca gaaataaaaa acataaacca ctaaaagatt aaagcattta ggagtttata
    10141 tgcaaagaag tcttgcaagg gagtacaagc tttaggagga caggcttatc aaattaaaaa
    10201 atgaaaaaac ctacaaaatt accaaagtca ccaagtttag ttattctttt catggtggaa
    10261 aacagtttcc tcagataatc atcatatcag aggtcatcat gtatccttag atatcagcat
    10321 tgccaagacc agggatatag ttattagtaa tttacaggaa aggctcaagg tttcatttac
    10381 atgggaaatg agaactagac agtgtggtga ctgtttttgt tgttaacctt acctcagtgt
    10441 tttatctcgg gtggtcccca agaccacctt caggatcagt gattcactgg agggactcac
    10501 agaactcaga aaagctgtta agttatggtt atggtatatt atagcaaaag aatatatatt
    10561 aaaatcagca gctgaaaaaa ggcacatagg gcaaagtctg ggggacacca ggcacaagct
    10621 tccagttgtc cttcacctgt gaagtcatgt agacagacca taattctctc agcagacaga
    10681 ccataattct ctcagcaaca atgtgtgaca acattcttgg agaattgcta accagggaag
    10741 ctccaccaag ccttggtgtc cagatttttt cttgagggtt ggtcacgtag gcatagcatg
    10801 actgatagcc catgtggctg accttcagtt ttcagcccct ccaaagatgg agctgatact
    10861 acatggccta aggacttcac cattaatcac attgttagct tagactacct ggtatggcct
    10921 aaggccccca agtaaattaa aacattcata tcaggcagga tagtccaagg acttagaggt
    10981 tatcttgaat ctggacacag gacaaacatt tctttggaat gtgaaaagtt tacacaatca
    11041 agacttgcta tgttgatcct ttactgcggt attgtttttt gttttctgac ccaaaagtga
    11101 tgtgcattgc ttacctatca tggcctctgg ttaaggtgtc agtcttgcct ccaaatttcc
    11161 tcctaaagca tggaattggc cataaatttg cttagtgatt ttctgattta gtatcattag
    11221 tttgatgact agttttatta tgtgagtgtg ataaaaggtt acgcttagta tacaaagacc
    11281 ttcttataag tctagttaat aaaactaggg ccatgtgtta ctacaacata ggagttaact
    11341 ttgtctggag gctttttcaa gcccaagagg ttgtcatttc tttatgtgta agatactgcc
    11401 cacatactat actgaagtca ggaaccaaga accggtcaat ttacctcagc caagttgctt
    11461 ggactgcttt gcttaataat gggtttgcca tatctacttt aatgagatgt gtggcatggt
    11521 gatggttaca aaagtgattt gttaattatt gcctggtagg aaggagaaca tgtttttttt
    11581 gaacctatgc aaatagccac atgtctgtga aaagtaaagg gatacttttg tgtaatattt
    11641 aaccatgtat accattgttt gtgtactttt taattgtgtc attttctaca gtattatttt
    11701 tgcattttcc tgacactgta ttacttacaa gttatattaa taatttttat taattttttt
    11761 cctgaatcct aaaaggtcag ttggaacatg agaccattta aagaatatta tttccttcca
    11821 gtttattcaa gggtggccta ttgagagttt gagataaaga agaaaggaat ctttcctttc
    11881 cttccccctc agcccgcccc ctacctttct tttttttttt tttttctttt cagggtcttg
    11941 ttctgtcacc caggctggag tggagtgaat gcaatcaaag ctcactgcaa cctcaaactc
    12001 ttgggcttaa gcagtcctcc tgcctctgcc tcccaagtag ctgggactac aggtgcatgc
    12061 caccacacct ggctaattaa aaaaaaaaaa aaattttttt ttttgaggag acgcggtctc
    12121 actttgctgc ccaggctggt ctcaaactct gggctcaagc aatccttcca cctcagcctc
    12181 ccaaagctct gggattacag gcatgagcca ctgtgcccgg cagaattttt ctgtgtccat
    12241 tagaaataga aatcagtcac atgctatgat ttcaatatgt cactcaaaag ccatgtgttg
    12301 gggctgaacg tagtggctca cgcctataat cccagcactt tgggaggcaa aggaaggtgg
    12361 atcacttgag gtcaggagtt tgagaccagc ctccaacatg gtgaaacccc gtctctacta
    12421 aaaaaaaaaa aaaaattagc tgggtgtggt ggcatgcacc tgtagtctca gctactcatc
    12481 aggctgaggc aggagaatcg cttgaaccca ggagacagag ggtgcagtga gccgagatca
    12541 tgccattgca ctccagcctg agccatagag tgagtcttgg tctcaaaaaa aaaaaaaaac
    12601 cttgtgttgg aaaccatctc caatgaagca gtgttaggag atagggccta atggatataa
    12661 attacagtgt ctaagatgga tactttactc ttttcttttg agaagggaga gagtatgtta
    12721 tgcactgaga acttttcaga tttcttgcag aggtcataat gttccagaca agctggcagc
    12781 aatcattccc atcccatcac agatccaggc ttatttgtag aatggttaca caaaccaagc
    12841 aaaaccttct gtaaagtttc taccctttgc tctaaagtta cataaaaaca atttccaagt
    12901 ttg
//
