LOCUS       NM_018131               2658 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens centrosomal protein 55 (CEP55), transcript variant 1,
            mRNA.
ACCESSION   NM_018131
VERSION     NM_018131.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2658)
  AUTHORS   Liu,Y., Dong,M., Jia,Y., Yang,D., Hui,Y. and Yang,X.
  TITLE     SPI1-mediated transcriptional activation of CEP55 promotes the
            malignant growth of triple-negative breast cancer and M2 macrophage
            polarization
  JOURNAL   Pathol Res Pract 262, 155544 (2024)
   PUBMED   39197215
  REMARK    GeneRIF: SPI1-mediated transcriptional activation of CEP55 promotes
            the malignant growth of triple-negative breast cancer and M2
            macrophage polarization.
REFERENCE   2  (bases 1 to 2658)
  AUTHORS   Muhs,S., Paraschiakos,T., Schafer,P., Joosse,S.A. and Windhorst,S.
  TITLE     Centrosomal Protein 55 Regulates Chromosomal Instability in Cancer
            Cells by Controlling Microtubule Dynamics
  JOURNAL   Cells 13 (16), 1382 (2024)
   PUBMED   39195269
  REMARK    GeneRIF: Centrosomal Protein 55 Regulates Chromosomal Instability
            in Cancer Cells by Controlling Microtubule Dynamics.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2658)
  AUTHORS   Zhang,X., Xu,Q., Li,E., Shi,T. and Chen,H.
  TITLE     CEP55 predicts the poor prognosis and promotes tumorigenesis in
            endometrial cancer by regulating the Foxo1 signaling
  JOURNAL   Mol Cell Biochem 478 (7), 1561-1571 (2023)
   PUBMED   36434144
  REMARK    GeneRIF: CEP55 predicts the poor prognosis and promotes
            tumorigenesis in endometrial cancer by regulating the Foxo1
            signaling.
REFERENCE   4  (bases 1 to 2658)
  AUTHORS   Mihalic,F., Simonetti,L., Giudice,G., Sander,M.R., Lindqvist,R.,
            Peters,M.B.A., Benz,C., Kassa,E., Badgujar,D., Inturi,R., Ali,M.,
            Krystkowiak,I., Sayadi,A., Andersson,E., Aronsson,H., Soderberg,O.,
            Dobritzsch,D., Petsalaki,E., Overby,A.K., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Large-scale phage-based screening reveals extensive pan-viral
            mimicry of host short linear motifs
  JOURNAL   Nat Commun 14 (1), 2409 (2023)
   PUBMED   37100772
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2658)
  AUTHORS   Chen,C.H., Lu,P.J., Chen,Y.C., Fu,S.L., Wu,K.J., Tsou,A.P.,
            Lee,Y.C., Lin,T.C., Hsu,S.L., Lin,W.J., Huang,C.Y. and Chou,C.K.
  TITLE     FLJ10540-elicited cell transformation is through the activation of
            PI3-kinase/AKT pathway
  JOURNAL   Oncogene 26 (29), 4272-4283 (2007)
   PUBMED   17237822
  REMARK    GeneRIF: By forming a complex with phosphatidylinositol 3'-kinase,
            FLJ10540 activates the PI3-kinase/AKT proto-oncogene protein
            pathways, providing a mechanistic basis for FLJ10540-mediated
            oncogenesis.
REFERENCE   6  (bases 1 to 2658)
  AUTHORS   Zhao,W.M., Seki,A. and Fang,G.
  TITLE     Cep55, a microtubule-bundling protein, associates with
            centralspindlin to control the midbody integrity and cell
            abscission during cytokinesis
  JOURNAL   Mol Biol Cell 17 (9), 3881-3896 (2006)
   PUBMED   16790497
  REMARK    GeneRIF: This study defines a cellular mechanism that links
            centralspindlin to Cep55, which, in turn, controls the midbody
            structure and membrane fusion at the terminal stage of cytokinesis.
REFERENCE   7  (bases 1 to 2658)
  AUTHORS   Martinez-Garay,I., Rustom,A., Gerdes,H.H. and Kutsche,K.
  TITLE     The novel centrosomal associated protein CEP55 is present in the
            spindle midzone and the midbody
  JOURNAL   Genomics 87 (2), 243-253 (2006)
   PUBMED   16406728
  REMARK    GeneRIF: data suggest a possible involvement of CEP55 in
            centrosome-dependent cellular functions, such as centrosome
            duplication and/or cell cycle progression, or in the regulation of
            cytokinesis
REFERENCE   8  (bases 1 to 2658)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 2658)
  AUTHORS   Fabbro,M., Zhou,B.B., Takahashi,M., Sarcevic,B., Lal,P.,
            Graham,M.E., Gabrielli,B.G., Robinson,P.J., Nigg,E.A., Ono,Y. and
            Khanna,K.K.
  TITLE     Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome
            protein, Cep55, is required for its recruitment to midbody and
            cytokinesis
  JOURNAL   Dev Cell 9 (4), 477-488 (2005)
   PUBMED   16198290
REFERENCE   10 (bases 1 to 2658)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356214.20.
            
            On May 17, 2019 this sequence version replaced NM_018131.4.
            
            Transcript Variant: This variant (1) results from use of an
            alternate splice donor site for exon 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008947.2, AB091343.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371485.8/ ENSP00000360540.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-312               AL356214.20        12762-13073
            313-507             AL356214.20        16190-16384
            508-783             AL356214.20        19263-19538
            784-852             AL356214.20        23138-23206
            853-1003            AL356214.20        31555-31705
            1004-1317           AL356214.20        33085-33398
            1318-1389           AL356214.20        35027-35098
            1390-1515           AL356214.20        35832-35957
            1516-2658           AL356214.20        44100-45242
FEATURES             Location/Qualifiers
     source          1..2658
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.33"
     gene            1..2658
                     /gene="CEP55"
                     /gene_synonym="C10orf3; CT111; MARCH; URCC6"
                     /note="centrosomal protein 55"
                     /db_xref="GeneID:55165"
                     /db_xref="HGNC:HGNC:1161"
                     /db_xref="MIM:610000"
     exon            1..312
                     /gene="CEP55"
                     /gene_synonym="C10orf3; CT111; MARCH; URCC6"
                     /inference="alignment:Splign:2.1.0"
     exon            313..507
                     /gene="CEP55"
                     /gene_synonym="C10orf3; CT111; MARCH; URCC6"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..1719
                     /gene="CEP55"
                     /gene_synonym="C10orf3; CT111; MARCH; URCC6"
                     /note="cancer/testis antigen 111; up-regulated in colon
                     cancer 6; centrosomal protein 55kDa"
                     /codon_start=1
                     /product="centrosomal protein of 55 kDa"
                     /protein_id="NP_060601.4"
                     /db_xref="CCDS:CCDS7428.1"
                     /db_xref="GeneID:55165"
                     /db_xref="HGNC:HGNC:1161"
                     /db_xref="MIM:610000"
                     /translation="MSSRSTKDLIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEI
                     TSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTTLLE
                     QLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCF
                     NSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQ
                     QTKKPESEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEV
                     HNLNQLLYSQRRADVQHLEDDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQF
                     LYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQIT
                     QLESLKQLHEFAITEPLVTFQGETENREKVAASPKSPTAALNESLVECPKCNIQYPAT
                     EHRDLLVHVEYCSK"
     exon            508..783
                     /gene="CEP55"
                     /gene_synonym="C10orf3; CT111; MARCH; URCC6"
                     /inference="alignment:Splign:2.1.0"
     exon            784..852
                     /gene="CEP55"
                     /gene_synonym="C10orf3; CT111; MARCH; URCC6"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1003
                     /gene="CEP55"
                     /gene_synonym="C10orf3; CT111; MARCH; URCC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1317
                     /gene="CEP55"
                     /gene_synonym="C10orf3; CT111; MARCH; URCC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1389
                     /gene="CEP55"
                     /gene_synonym="C10orf3; CT111; MARCH; URCC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1515
                     /gene="CEP55"
                     /gene_synonym="C10orf3; CT111; MARCH; URCC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..2658
                     /gene="CEP55"
                     /gene_synonym="C10orf3; CT111; MARCH; URCC6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2636..2641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP55"
                     /gene_synonym="C10orf3; CT111; MARCH; URCC6"
                     /note="hexamer: AATAAA"
     polyA_site      2658
                     /gene="CEP55"
                     /gene_synonym="C10orf3; CT111; MARCH; URCC6"
                     /note="major polyA site"
ORIGIN      
        1 aaactcccgg aagcggcatc cacacctgat ggtgtgactc ggccgacgcg agcgccgcgc
       61 ttcgcttcag ctgctagctg gcccaaggga ggcgaccgcg gagggtggcg aggggcggcc
      121 aggacccgca gccccggggc cgggccggtc cggaccgcca gggagggcag gtcagtgggc
      181 agatcgcgtc cgcgggattc aatctctgcc cgctctgata acagtccttt tccctggcgc
      241 tcacttcgtg cctggcaccc ggctgggcgc ctcaagaccg ttgtctcttc gatcgcttct
      301 ttggacttgg cgaccatttc agagatgtct tccagaagta ccaaagattt aattaaaagt
      361 aagtggggat cgaagcctag taactccaaa tccgaaacta cattagaaaa attaaaggga
      421 gaaattgcac acttaaagac atcagtggat gaaatcacaa gtgggaaagg aaagctgact
      481 gataaagaga gacacagact tttggagaaa attcgagtcc ttgaggctga gaaggagaag
      541 aatgcttatc aactcacaga gaaggacaaa gaaatacagc gactgagaga ccaactgaag
      601 gccagatata gtactaccac attgcttgaa cagctggaag agacaacgag agaaggagaa
      661 aggagggagc aggtgttgaa agccttatct gaagagaaag acgtattgaa acaacagttg
      721 tctgctgcaa cctcacgaat tgctgaactt gaaagcaaaa ccaatacact ccgtttatca
      781 cagactgtgg ctccaaactg cttcaactca tcaataaata atattcatga aatggaaata
      841 cagctgaaag atgctctgga gaaaaatcag cagtggctcg tgtatgatca gcagcgggaa
      901 gtctatgtaa aaggactttt agcaaagatc tttgagttgg aaaagaaaac ggaaacagct
      961 gctcattcac tcccacagca gacaaaaaag cctgaatcag aaggttatct tcaagaagag
     1021 aagcagaaat gttacaacga tctcttggca agtgcaaaaa aagatcttga ggttgaacga
     1081 caaaccataa ctcagctgag ttttgaactg agtgaatttc gaagaaaata tgaagaaacc
     1141 caaaaagaag ttcacaattt aaatcagctg ttgtattcac aaagaagggc agatgtgcaa
     1201 catctggaag atgataggca taaaacagag aagatacaaa aactcaggga agagaatgat
     1261 attgctaggg gaaaacttga agaagagaag aagagatccg aagagctctt atctcaggtc
     1321 cagtttcttt acacatctct gctaaagcag caagaagaac aaacaagggt agctctgttg
     1381 gaacaacaga tgcaggcatg tactttagac tttgaaaatg aaaaactcga ccgtcaacat
     1441 gtgcagcatc aattgcatgt aattcttaag gagctccgaa aagcaagaaa tcaaataaca
     1501 cagttggaat ccttgaaaca gcttcatgag tttgccatca cagagccatt agtcactttc
     1561 caaggagaga ctgaaaacag agaaaaagtt gccgcctcac caaaaagtcc cactgctgca
     1621 ctcaatgaaa gcctggtgga atgtcccaag tgcaatatac agtatccagc cactgagcat
     1681 cgcgatctgc ttgtccatgt ggaatactgt tcaaagtagc aaaataagta tttgttttga
     1741 tattaaaaga ttcaatactg tattttctgt tagcttgtgg gcattttgaa ttatatattt
     1801 cacattttgc ataaaactgc ctatctacct ttgacactcc agcatgctag tgaatcatgt
     1861 atcttttagg ctgctgtgca tttctcttgg cagtgatacc tccctgacat ggttcatcat
     1921 caggctgcaa tgacagaatg tggtgagcag cgtctactga gactactaac attttgcact
     1981 gtcaaaatac ttggtgagga aaagatagct caggttattg ctaatgggtt aatgcaccag
     2041 caagcaaaat attttatgtt ttgggggttt tgaaaaatca aagataatta accaaggatc
     2101 ttaactgtgt tcgcattttt tatccaagca cttagaaaac ctacaatcct aattttgatg
     2161 tccattgtta agaggtggtg atagatacta tttttttttt catattgtat agcggttatt
     2221 agaaaagttg gggattttct tgatctttat tgctgcttac cattgaaact taacccagct
     2281 gtgttcccca actctgttct gcgcacgaaa cagtatctgt ttgaggcata atcttaagtg
     2341 gccacacaca atgttttctc ttatgttatc tggcagtaac tgtaacttga attacattag
     2401 cacattctgc ttagctaaaa ttgttaaaat aaactttaat aaacccatgt agccctctca
     2461 tttgattgac agtattttag ttatttttgg cattcttaaa gctgggcaat gtaatgatca
     2521 gatctttgtt tgtctgaaca ggtattttta tacatgcttt ttgtaaacca aaaactttta
     2581 aatttcttca ggttttctaa catgcttacc actgggctac tgtaaatgag aaaagaataa
     2641 aattatttaa tgttttaa
//
