LOCUS       NM_001040157            4298 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens centrosomal protein 44 (CEP44), transcript variant 1,
            mRNA.
ACCESSION   NM_001040157
VERSION     NM_001040157.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4298)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4298)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4298)
  AUTHORS   Hossain,D., Shih,S.Y., Xiao,X., White,J. and Tsang,W.Y.
  TITLE     Cep44 functions in centrosome cohesion by stabilizing rootletin
  JOURNAL   J Cell Sci 133 (4) (2020)
   PUBMED   31974111
  REMARK    GeneRIF: Cep44 functions in centrosome cohesion by stabilizing
            rootletin.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4298)
  AUTHORS   Atorino,E.S., Hata,S., Funaya,C., Neuner,A. and Schiebel,E.
  TITLE     CEP44 ensures the formation of bona fide centriole wall, a
            requirement for the centriole-to-centrosome conversion
  JOURNAL   Nat Commun 11 (1), 903 (2020)
   PUBMED   32060285
  REMARK    GeneRIF: CEP44 was identified as a luminal centriolar protein that
            binds to A-MTs and the inner centriole protein POC1B.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4298)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4298)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   7  (bases 1 to 4298)
  AUTHORS   Gupta,G.D., Coyaud,E., Goncalves,J., Mojarad,B.A., Liu,Y., Wu,Q.,
            Gheiratmand,L., Comartin,D., Tkach,J.M., Cheung,S.W., Bashkurov,M.,
            Hasegan,M., Knight,J.D., Lin,Z.Y., Schueler,M., Hildebrandt,F.,
            Moffat,J., Gingras,A.C., Raught,B. and Pelletier,L.
  TITLE     A Dynamic Protein Interaction Landscape of the Human
            Centrosome-Cilium Interface
  JOURNAL   Cell 163 (6), 1484-1499 (2015)
   PUBMED   26638075
REFERENCE   8  (bases 1 to 4298)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   9  (bases 1 to 4298)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA347369.1, AY426674.1 and AC097653.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001040157.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript but encodes the shorter isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB051499.1, SRR1803614.87824.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000503780.6/ ENSP00000423153.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-287               DA347369.1         235-521
            288-1353            AY426674.1         108-1173
            1354-4298           AC097653.2         132039-134983
FEATURES             Location/Qualifiers
     source          1..4298
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q34.1"
     gene            1..4298
                     /gene="CEP44"
                     /gene_synonym="KIAA1712; PS1TP3"
                     /note="centrosomal protein 44"
                     /db_xref="GeneID:80817"
                     /db_xref="HGNC:HGNC:29356"
                     /db_xref="MIM:620217"
     exon            1..33
                     /gene="CEP44"
                     /gene_synonym="KIAA1712; PS1TP3"
                     /inference="alignment:Splign:2.1.0"
     exon            34..130
                     /gene="CEP44"
                     /gene_synonym="KIAA1712; PS1TP3"
                     /inference="alignment:Splign:2.1.0"
     exon            131..269
                     /gene="CEP44"
                     /gene_synonym="KIAA1712; PS1TP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..1353
                     /gene="CEP44"
                     /gene_synonym="KIAA1712; PS1TP3"
                     /note="isoform a is encoded by transcript variant 1;
                     centrosomal protein of 44 kDa; HBV PreS1-transactivated
                     protein 3; centrosomal protein 44kDa"
                     /codon_start=1
                     /product="centrosomal protein of 44 kDa isoform a"
                     /protein_id="NP_001035247.1"
                     /db_xref="CCDS:CCDS34106.1"
                     /db_xref="GeneID:80817"
                     /db_xref="HGNC:HGNC:29356"
                     /db_xref="MIM:620217"
                     /translation="MATGDLKRSLRNLEQVLRLLNYPEEVDCVGLIKGDPAASLPIIS
                     YSFTSYSPYVTELIMESNVELIAKNDLRFIDAVYKLLRDQFNYKPILTKKQFIQCGFA
                     EWKIQIVCDILNCVMKKHKELSSLQKIPSQQRKKISSGKSEPPLGNEKISAEAVGVDI
                     SGRFMTSGKKKAVVIRHLYNEDNVDISEDTLSPITDVNEAVDVSDLNATEIKMPEVKV
                     PEIKAEQQDVNVNPEITALQTMLAECQENLKKLTSIEKRLDCLEQKMKGKVMVDENTW
                     TNLLSRVTLLETEMLLSKKNDEFIEFNEVSEDYASCSDMDLLNPHRKSEVERPASIPL
                     SSGYSTASSDSTPRASTVNYCGLNEISEETTIQKMERMKKMFEETAELLKCPNHYL"
     exon            270..417
                     /gene="CEP44"
                     /gene_synonym="KIAA1712; PS1TP3"
                     /inference="alignment:Splign:2.1.0"
     exon            418..564
                     /gene="CEP44"
                     /gene_synonym="KIAA1712; PS1TP3"
                     /inference="alignment:Splign:2.1.0"
     exon            565..687
                     /gene="CEP44"
                     /gene_synonym="KIAA1712; PS1TP3"
                     /inference="alignment:Splign:2.1.0"
     exon            688..858
                     /gene="CEP44"
                     /gene_synonym="KIAA1712; PS1TP3"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1065
                     /gene="CEP44"
                     /gene_synonym="KIAA1712; PS1TP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1141
                     /gene="CEP44"
                     /gene_synonym="KIAA1712; PS1TP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1266
                     /gene="CEP44"
                     /gene_synonym="KIAA1712; PS1TP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1304
                     /gene="CEP44"
                     /gene_synonym="KIAA1712; PS1TP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..4298
                     /gene="CEP44"
                     /gene_synonym="KIAA1712; PS1TP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4279..4284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP44"
                     /gene_synonym="KIAA1712; PS1TP3"
                     /note="hexamer: AATAAA"
     polyA_site      4298
                     /gene="CEP44"
                     /gene_synonym="KIAA1712; PS1TP3"
                     /note="major polyA site"
ORIGIN      
        1 agagaagctc ccagctttga aggtcttgcg gtgaagcatc aagtgtacct gatttgtgaa
       61 cctatcttgc ttcagttggt ttcctcctaa atattaggca gatgggattg gctggtctgt
      121 gctctgctag gtgaaaaatt agacgatttc aagaattgga gctgaatctg atgttaagta
      181 atggcaacag gtgacttaaa aagaagctta cggaacctag aacaggtgct ccgcttgcta
      241 aattatcctg aagaggtgga ctgtgtaggt ttgataaagg gagacccagc agcatctttg
      301 cccatcatca gctattcttt tacctcatac tcaccttatg taacagaact tataatggaa
      361 tccaatgtag agctcatagc aaaaaatgac ttgcgcttta tagatgctgt ctataagctt
      421 cttcgtgatc aatttaatta taaaccaatt ttgacaaaaa agcagtttat ccaatgtggg
      481 tttgcagaat ggaaaatcca aattgtttgt gatattttga attgtgtgat gaaaaagcac
      541 aaggaattaa gcagtcttca gaagattcca tcacaacaaa gaaagaaaat cagttctggt
      601 aagtcagaac ctcctttggg caatgagaaa atatctgcag aggctgttgg cgttgatatc
      661 agtggcaggt ttatgacctc aggaaagaag aaagctgtgg tgattcgtca cttgtataat
      721 gaagataatg ttgacatttc tgaggataca ttaagtccaa taacagatgt taatgaagca
      781 gttgatgtgt ctgacttaaa tgctactgaa ataaagatgc ctgaagtaaa ggttcctgaa
      841 atcaaggctg agcaacagga tgtaaatgtt aatcctgaga ttactgcact acaaactatg
      901 cttgctgaat gccaagaaaa tcttaagaaa ctgacttcga tagagaaaag gttagactgt
      961 ttggaacaaa aaatgaaagg aaaagtgatg gtagatgaaa acacctggac taatcttctt
     1021 agtcgtgtca ctcttcttga aacagaaatg cttttgtcta aaaagaatga tgaatttata
     1081 gagtttaatg aagttagtga agactacgct tcttgtagtg acatggacct tctgaatcct
     1141 cacagaaaaa gcgaagtaga gaggccagca agtattcctc tgtcctctgg ctatagtaca
     1201 gcatcatcag attcaactcc cagagcctct actgttaatt actgtggttt gaatgagatt
     1261 tcagaggaaa caacaatcca gaaaatggaa aggatgaaaa aaatgtttga agaaactgca
     1321 gagttactga aatgtccaaa tcactacttg taggattttc tacatgaact tttttctagg
     1381 actttggtta ctatacatat tgtatatttt aagaattctt tatacaattt taatatactg
     1441 caatactgca gtttttgaca atttggattc catttggtat atgaattttt gcattcatta
     1501 ttgaataact cttttaatat ttttgagcaa tgattatact gctttacctt gtgtcacttt
     1561 tttttttttt aggaaaaact catgttccag tatatttctc ttacagagtg aagtcattac
     1621 agcactgtat ttctgtgttg acatttgttg gcagtgtgct aagtaatgtt ttttaaagca
     1681 caggcttgag gactatggtt tacatcctgt tggaaacatt ccaaatggga cttgtgtatt
     1741 atacccagga ggctctcata tataccatct tggcatctgt actgatgaat aagttataat
     1801 gaacagttaa aaatgctcat tgaaaattaa ataaaacaaa aaggcagtta tttcatgctt
     1861 ggtcaaaaac atcaatacct ttccaattaa cactgagaaa ttaaggttaa gattctcctt
     1921 ttgtactggg aaacaggctg gaggactatg gtcctcaagt ttagaccaag aggactatgg
     1981 tctcaaggtt caccatgaga aatgtgttga acattttagt atgctctatt gtataatttt
     2041 tttggagggg gggatggagt ttcgctgttg ttgcccaggc tggagtgcaa tagcacgatc
     2101 ttggctcacc gcaacctctg cctaccgggt tcaagtgatt cttgtgcctc agcctcctga
     2161 gtagctggga ttataggcat gcaccaccat gcccagctaa ttttgtattt ttattagaga
     2221 cagggtttct ccgtgttggt caggctggtc tcaaactcct gacctcaggt gatctgcctg
     2281 tcttggcctc cggcgtaaca ctttttaaga ccagtgtaac agaaagagaa tgtagccatt
     2341 ctagccaccg ttaaaagata cacagtgagg tgttgtgttt tgttttttta atgatgaaaa
     2401 gttacacatt ttttggagag aaaagtctta gctgaaggta aatcaatgga aaaatgaaat
     2461 ttatttttaa tattactact atatgaatta tcttttttta aacttgtaga taaaagtgtt
     2521 ccagtaatca gaaaatcctc aagaaaattg acttcattat ttggaaggaa aattagtatt
     2581 ttttttaata ttatatggac catctgatta tattttattt attcatctat ttatggtatg
     2641 tatgtataat tctatattac actgtcaaat ataaaatatt gttatatgag tagaaatcac
     2701 ttaaattttt tttgtgtttg tgaatttgaa acagtgtaag aaatcacttt taagaaaaca
     2761 tttttagaat tcctttgttt tttttttttt tctttttgaa acagggtctc actctattgc
     2821 ccaggctgga gtgcactggc gtgatctcgg ctcactgcac cttctgccta ccgagttcaa
     2881 gcgattcttg tgcttcagcc tcctgagtag ctgggactat aggcctgtac cgtcatgcct
     2941 ggctaatttt tgtatttttg tagagacagg gtttcaccat gttgcccagt ctgttctcaa
     3001 actcgtgagc taaagctact cgcccacctg gatgtcccaa agtgctagat tccatgggtg
     3061 agtcaccatg cttggccaca tttttagtat tctaataaac agttggtcat cagaacttta
     3121 aaatggtagc ctacagaaac atacaatttt gaatttaaca gagtttcagt aaatatttcc
     3181 agaattaatg aagcatgtta gctttaattt tttcaattgt gagagaagta catttataaa
     3241 aattaagagg ttaagaggtt atagttataa gggaaaaaac ttctgtatcg attaactcct
     3301 aaaatatcag taccagcatg gaattatagc accaccttgt ggttaacatg ccagtatttt
     3361 accttttgtt aaaacaagtg atttcccatc aaacaggata atattttttc ccttttgaaa
     3421 aattcaattt taaaaagaaa catttttgaa gttttcttat ggaagataga aaaaaagtta
     3481 agtctctttc taccctttct ttttttcttt atatagtgca gatatacaca cagagaaggg
     3541 acttaaaaca tttctaatct cctagtttat atacagtgtg caaaatataa gtaagtatat
     3601 attgaaaata taaaatattt catatatgtt atcaggtgga aatttagaat ccaaattttc
     3661 ttaaacttta ataacttgtc taacaactct ctaataggga ctaaaaatca actcaatata
     3721 tcatacattt acacttacaa agagtcttta tctagacaac ataatttttg gaaaaataaa
     3781 gcaaattcaa ctttattgga gttattggac agatcagcaa attgttattt taaaaagttt
     3841 tcttgtttag gcaatttggt aagtggtttc tagttataaa ctagccactg ttgattaact
     3901 tgagaaggtg aagcagggga gttctgaaga gattacctag agctacataa ccctaagtta
     3961 agtaaaattt tcactttcat tcttttcatt ctctcataaa ctggttgaaa aaacactgta
     4021 ctaccaacaa aggtgtcagt tgcttgtgct gccctgtcta tgttatgctc tgaataggtc
     4081 tcggtaaaga ttatatggaa atactataaa gaatacataa ggtaaaatac tagtcagaaa
     4141 gggttcagaa gaagttagca tcaactgtat gaaaattcta ggtaaagcta agtactattg
     4201 agttggaaaa aagtaattct atcatgtttg cttgttttcc tctactgttt ttaatgtgat
     4261 gttgtaatat attttaaaaa taaaacttga aaacgttg
//
