LOCUS       NM_007045              13956 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens centrosomal protein 43 (CEP43), transcript variant 1,
            mRNA.
ACCESSION   NM_007045
VERSION     NM_007045.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13956)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 13956)
  AUTHORS   Steib,E., Laporte,M.H., Gambarotto,D., Olieric,N., Zheng,C.,
            Borgers,S., Olieric,V., Le Guennec,M., Koll,F., Tassin,A.M.,
            Steinmetz,M.O., Guichard,P. and Hamel,V.
  TITLE     WDR90 is a centriolar microtubule wall protein important for
            centriole architecture integrity
  JOURNAL   Elife 9, e57205 (2020)
   PUBMED   32946374
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 13956)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 13956)
  AUTHORS   Simon,M.A., Ecsedi,P., Kovacs,G.M., Poti,A.L., Remenyi,A.,
            Kardos,J., Gogl,G. and Nyitray,L.
  TITLE     High-throughput competitive fluorescence polarization assay reveals
            functional redundancy in the S100 protein family
  JOURNAL   FEBS J 287 (13), 2834-2846 (2020)
   PUBMED   31837246
REFERENCE   5  (bases 1 to 13956)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 13956)
  AUTHORS   Yan,X., Habedanck,R. and Nigg,E.A.
  TITLE     A complex of two centrosomal proteins, CAP350 and FOP, cooperates
            with EB1 in microtubule anchoring
  JOURNAL   Mol Biol Cell 17 (2), 634-644 (2006)
   PUBMED   16314388
  REMARK    GeneRIF: CAP350 interacts directly with FOP (FGFR1 oncogene
            partner) to form a centrosomal complex required for microtubule
            anchoring.
REFERENCE   7  (bases 1 to 13956)
  AUTHORS   Guasch,G., Delaval,B., Arnoulet,C., Xie,M.J., Xerri,L., Sainty,D.,
            Birnbaum,D. and Pebusque,M.J.
  TITLE     FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation,
            induces a fatal myeloproliferative disease in mice
  JOURNAL   Blood 103 (1), 309-312 (2004)
   PUBMED   12969958
REFERENCE   8  (bases 1 to 13956)
  AUTHORS   Andersen,J.S., Wilkinson,C.J., Mayor,T., Mortensen,P., Nigg,E.A.
            and Mann,M.
  TITLE     Proteomic characterization of the human centrosome by protein
            correlation profiling
  JOURNAL   Nature 426 (6966), 570-574 (2003)
   PUBMED   14654843
REFERENCE   9  (bases 1 to 13956)
  AUTHORS   Guasch,G., Ollendorff,V., Borg,J.P., Birnbaum,D. and Pebusque,M.J.
  TITLE     8p12 stem cell myeloproliferative disorder: the FOP-fibroblast
            growth factor receptor 1 fusion protein of the t(6;8) translocation
            induces cell survival mediated by mitogen-activated protein kinase
            and phosphatidylinositol 3-kinase/Akt/mTOR pathways
  JOURNAL   Mol Cell Biol 21 (23), 8129-8142 (2001)
   PUBMED   11689702
REFERENCE   10 (bases 1 to 13956)
  AUTHORS   Popovici,C., Zhang,B., Gregoire,M.J., Jonveaux,P.,
            Lafage-Pochitaloff,M., Birnbaum,D. and Pebusque,M.J.
  TITLE     The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative
            disorder fuses a novel gene, FOP, to fibroblast growth factor
            receptor 1
  JOURNAL   Blood 93 (4), 1381-1389 (1999)
   PUBMED   9949182
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC418208.1, AK312791.1 and
            Z94721.1.
            
            On Nov 23, 2018 this sequence version replaced NM_007045.3.
            
            Summary: This gene encodes a largely hydrophilic centrosomal
            protein that is required for anchoring microtubules to subcellular
            structures. A t(6;8)(q27;p11) chromosomal translocation, fusing
            this gene and the fibroblast growth factor receptor 1 (FGFR1) gene,
            has been found in cases of myeloproliferative disorder. The
            resulting chimeric protein contains the N-terminal leucine-rich
            region of this encoded protein fused to the catalytic domain of
            FGFR1. Alterations in this gene may also be associated with Crohn's
            disease, Graves' disease, and vitiligo. Alternatively spliced
            transcript variants that encode different proteins have been
            identified. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.246086.1,
                                           SRR1803615.81276.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366847.9/ ENSP00000355812.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DC418208.1         82-90
            10-1216             AK312791.1         1-1207
            1217-13956          Z94721.1           48282-61021         c
FEATURES             Location/Qualifiers
     source          1..13956
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q27"
     gene            1..13956
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
                     /note="centrosomal protein 43"
                     /db_xref="GeneID:11116"
                     /db_xref="HGNC:HGNC:17012"
                     /db_xref="MIM:605392"
     exon            1..118
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1216
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
                     /note="isoform a is encoded by transcript variant 1;
                     fibroblast growth factor receptor 1 oncogene partner;
                     FGFR1 oncogene partner"
                     /codon_start=1
                     /product="centrosomal protein 43 isoform a"
                     /protein_id="NP_008976.1"
                     /db_xref="CCDS:CCDS5296.1"
                     /db_xref="GeneID:11116"
                     /db_xref="HGNC:HGNC:17012"
                     /db_xref="MIM:605392"
                     /translation="MAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLA
                     LEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFTLAVFQPETSTLQ
                     GLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEGALDLSDVHSPPKS
                     PEGKTSAQTTPSKIPRYKGQGKKKTSGQKAGDKKANDEANQSDTSVSLSEPKSKSSLH
                     LLSHETKIGSFLSNRTLDGKDKAGLCPDEDDMEGDSFFDDPIPKPEKTYGLRKEPRKQ
                     AGSLASLSDAPPLKSGLSSLAGAPSLKDSESKRGNTVLKDLKLISDKIGSLGLGTGED
                     DDYVDDFNSTSHRSEKSEISIGEEIEEDLSVEIDDINTSDKLDDLTQDLTVSQLSDVA
                     DYLEDVA"
     exon            119..172
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
                     /inference="alignment:Splign:2.1.0"
     exon            173..227
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
                     /inference="alignment:Splign:2.1.0"
     exon            228..316
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
                     /inference="alignment:Splign:2.1.0"
     exon            317..454
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
                     /inference="alignment:Splign:2.1.0"
     exon            455..535
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
                     /inference="alignment:Splign:2.1.0"
     exon            536..595
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
                     /inference="alignment:Splign:2.1.0"
     exon            596..822
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
                     /inference="alignment:Splign:2.1.0"
     exon            823..935
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1004
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1044
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1141
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..13956
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1533..1538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
                     /note="hexamer: AATAAA"
     polyA_site      1555
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
                     /note="major polyA site"
     regulatory      1793..1798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
                     /note="hexamer: ATTAAA"
     polyA_site      1816
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
     regulatory      3627..3632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
                     /note="hexamer: AATAAA"
     polyA_site      3656
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
     regulatory      12919..12924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
                     /note="hexamer: AATACA"
     polyA_site      12943
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
     regulatory      13933..13938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
                     /note="hexamer: AATAAA"
     polyA_site      13956
                     /gene="CEP43"
                     /gene_synonym="FGFR1OP; FOP"
ORIGIN      
        1 gtcttggaga agcaagatgg cggcgacggc ggccgcagtg gtggccgagg aggacacgga
       61 gctgcgggac ctgctggtgc agacgctgga gaacagcggg gtcctgaacc gcatcaaggc
      121 tgaactccga gcagctgtgt ttttagcact agaggagcaa gaaaaagtag agaacaaaac
      181 tcctttagtt aatgagagcc tgaaaaagtt tttaaatacc aaagacggtc gtttagtggc
      241 tagtcttgtt gcagaatttc ttcagttttt taaccttgac tttactttgg ctgtttttca
      301 acctgaaact agcacactgc aaggtctcga aggtcgagag aatttagccc gagatttagg
      361 tataattgaa gcagaaggta ctgtgggtgg acccttatta ttagaagtga tcaggcgctg
      421 tcaacagaaa gaaaaagggc caaccactgg ggaaggtgca cttgatctat ctgatgtaca
      481 ttctccacca aagtcaccag agggaaaaac aagtgcacag acaacaccaa gtaagatacc
      541 aaggtataaa ggacaaggta agaagaagac aagcgggcag aaggctggtg acaagaaggc
      601 caatgatgag gccaatcaga gtgatacaag tgtctccttg tcagaaccca agagcaaaag
      661 cagccttcac ttactgtccc atgaaacaaa aattggatct tttctaagca acagaacttt
      721 agatggcaaa gacaaagctg gcctttgtcc agatgaagat gatatggaag gagattcttt
      781 ctttgatgat cccattccta agccagagaa aacttacggt ttgaggaagg aacctaggaa
      841 gcaagcagga agtctggcct cgctctcgga tgcacccccc ttaaaaagtg gactcagctc
      901 cctggcggga gccccttctt taaaagactc tgagagtaaa aggggaaata cagttttgaa
      961 agatctgaaa ttgatcagtg ataaaattgg atcacttgga ttaggaactg gagaagatga
     1021 tgactatgtt gatgatttta atagtaccag ccatcgctca gagaaaagtg agataagtat
     1081 tggtgaagag atagaagaag acctttctgt ggaaatagat gacatcaata ccagtgataa
     1141 gcttgatgac ctcacacaag atctgactgt atcccagctc agtgatgttg cggattatct
     1201 ggaagatgtt gcatagacac gaagaaggaa gtattctaat taacaaggac agaggactga
     1261 ccggttccat tttttttttt tccagacaat cactcagctg gaatgtctgc tctctattgg
     1321 tgccttgcat ttcaaaaaca ctgcagatat tttttaaaag taattttcat tttactaaac
     1381 aaaatacttc ctatttgagc ccatgtgtgg aagatttaat attcttaatt taactgtaca
     1441 tttctttatg gaaattgatt atctacactc agtttcatta cagggaagga acccatgaaa
     1501 acatcagtgt taagagcatg atgaaaggtg tcaataaagc cgtaggatcg cgcaaccctt
     1561 tgtgtgtgtg gctgctggta cgtgtgatct ttgaaaacct tggctttagc cctctggaat
     1621 cagagcttac ccaccatagt atattttgat attaggtggt tctacacata gttggcaaaa
     1681 tgacttggta aatttgtaat gctgaagtat attagtataa gttaaatttg atgtgtcaac
     1741 tttattttgt atttccttcc atttggaagg tttgttagac cattaaggtt atattaaagt
     1801 actcttgtgt gtgctattta gttttgcttg ttttaaagaa atctagaagt ggttatgagt
     1861 tttaattcat agaattgtca ataacataac atttgcaatc gtcattcctc ctgttatcca
     1921 tgtaagcagc tttagtcgta ggttctcttc attataattt attatctgta aagattcctt
     1981 gaaacttaaa tgcatctgaa accattaagc agtgctttta tttcagatct gtaagttaat
     2041 tgtattaaaa tccaaattgg aatgaaatag tagtaatggc ctaagaccat gttcagtttg
     2101 acaagcttta tatactgtac ataatttcat tgtaaccctt aaaaatagag ccaataatag
     2161 aatttccaca gtctcattta tacggttaaa gcattattgc tattatgtag gtcacggatg
     2221 tttataatac taaagtattt taaaatgtgc aagtagaaaa aacagtagaa agtgatgcat
     2281 gcatatttat atataagtaa agcaggattg tgctgttttt gcactttata atttcaatta
     2341 agttgcggct ttttactaca agttaacttt attagtaaaa ggagcaaatt agacctaatt
     2401 cattgatctc ggttaagtga gcagactgca tgacttgtgt aatgccagtt tctcatttca
     2461 tattagccta aatattacag aaattactcc ttgggctcta aaatgtagag gaaatgaaaa
     2521 tgtaaggatt aaggctgtgt aacagaatct ggctttttaa aatttaagtg aaactaagct
     2581 gtaaacatca agaggaagta ggacataaac tgggccggta cagcctggga gccctgtgta
     2641 tttctgccct ccgtctgtga gctgctatct cagtctcctt cagctcttca tgtcttagta
     2701 aacagcacca cgtgcagatg taatcttgtt gcagtccccc agtgtggttg ttataaaatg
     2761 catttctttg taagtcatct ctgtaaacag tcactttcta aaagcactat agttctggtc
     2821 ccctggaatc tggatcacat gtatgattta tttttaatat ttgataggaa ctaggtttca
     2881 gtgaaatgat ttgaaagcat agcaggatgt ggctttttaa atttatgaaa ctttcgaaca
     2941 gtagcaactg aaatttgtca cttttctgtt acgcagagaa tcagaccttt tgataatatt
     3001 tgggagggta aaagaaatat gccaaatatg aaactttttt gtcagcacta catacatctt
     3061 ttttttgcgg ggggcggggg ggacagagtc tcactgtgtc actcagactg gagtacagtg
     3121 atgcgatctc ggctcactgc aacctccgcc tcctgggttc aagcgattct cctgcttcag
     3181 cctcctgagt agctgggatt acaggtgcac accaccacgc ccggctaatt tttgtatttt
     3241 tagtagagat ggggtttcac catgttggtc aggctggtct tgaactcctg acctcgttcc
     3301 tgccttagcc tcctaaagtg ccgggattac aggcgtgaac caccgcacct ggccagtact
     3361 acatccattt tattgaatga ttttgaatga cttaaagttc aactatgaaa aagctttctt
     3421 ttcacatgta ctttttgatt aggtattatc aacttatgaa acttgaagat gtgaagtgac
     3481 aggttttgca tgtgatgagt gttttctgtt aaaaaataaa tattgaaata ttaacccatt
     3541 aaatacattt ttatggtaac ctatgtttta cagtggagtt ttaaaaatgc taggtctttc
     3601 tttcatttta ttgataacta caaatgaata aaaagcattt attctctttg ttgatattcg
     3661 gttgtgcttt tatactttat gttggataac aacctgtggg cagttgtgta gatgccatta
     3721 gtccctgcct catgcttgcc cacagctctt cctcccctcc ttacttccct ctcctgccca
     3781 tgcaccagag ctgtgccagc ccactgctgc acagcctctg cacctgagct tgccaaagcc
     3841 cttcctgtct caaggtgtga tatttgcccc tccttgtctg gaatgtcctt cccctagaac
     3901 tgcatgaagc tggtttattt cagtctcatg ttcaaagacg cttccagacc taagggagat
     3961 gtccattctc ctccctgtcc ctgccccacc acttgcattt acccctttta ttttattcat
     4021 ctcagcatac tctgaaatgg tcttgcttat tttgtgtgtg tgtgtgtgtg tgtgtgttta
     4081 actatgagct cgtgagaaca gggattttct tttaaactgc tgtgtacctg gcacaacatt
     4141 tgtcccctag tatgagcttg gcatctttgg ggctgtaaac aggcttgagc actgacatgg
     4201 ggcctggaga atgtggtttc tggctaggca gctggaacaa tctacaaaat ctgaggggaa
     4261 agctgtcctt accctaaacc tggggaggtc cctaggttca agtctgcagg aaggggatct
     4321 ggttcaggag aaggccgtcc tgtgaatttg ccccacccac caagctcagc tggagcaggg
     4381 cctctgaagg aggtgccctc tgtgtggctc tgctgtggtg ttggttcatg aaggacatgg
     4441 gaggggggca ggacaggaga ggcagctctt cctggagaaa aacacaccca gcccaagttg
     4501 gagccctcct gtggcattgg gtggggagga ttcccgccat cagttctctg tccatgggtg
     4561 ctagtctcac ccctgccctc cgagcagtcc gtgctcccag tgtccctgtc ctcttttttt
     4621 tttttttttt tttttgaggt ggagttttgt tcttgttgcc caggctggag tgccatgggg
     4681 cgacctcggc tcactgcaac ccctgccttc tgggttcaag tgattctcct gcctcagcct
     4741 cccaagtagc tgagattaca ggtgcctgcc accatgccca gctaattttt ataatttttt
     4801 tgtagagacg ggatttcacc atgttggcca ggctggtctc aaactcctga cctcaggtga
     4861 tccacccgcc tcagcctccc aaagtgctgg gaatacaggt gtgagtcacg gtgcccggcc
     4921 tagtcttcct gctctaggaa gggacgtgtt tggggaggaa atccagggca gctacctttg
     4981 tgagttgtcc taatgctgcg ttcagagttc cacacgttca acaagcatct gacatttaag
     5041 gaaagtgaat gtatgtcatg aaagacagat gaacaaagaa ctgatcttga agaaaatgta
     5101 atcaggaaac gagataattc aagaacaaaa acctgtgaag gactgaatgt gtcccccaaa
     5161 atgtgtatgt cgaaacctaa tcccacatag gatggaatta ggtagggcct ctggaagttg
     5221 atgagatcat tagcgccctt ataggaggcc cgggagagct gctttgcccc ttccagcgtg
     5281 tgaggacaca gtgaggaggt gttgcctatg aggaaacagg ccctcccaga tggtgaacct
     5341 gccggtacct tgatcttgga cttaagccat ctgagctgtg agccctacac ttccattctt
     5401 tataaattat ccagtccaag gtactttagg aacctgaatg gattaagaca aacctgatta
     5461 tgccactccg agatttgagg taacatttga atctaaaaga ggctatatga aagaggttat
     5521 aataaaaatg atttttgact aaaaaattgt tggcctaaga taattcagta gcagggctga
     5581 ataatgggat gactcaaaat cagtaagctc aaaggcaatt tcaaagaaat ctttatgttt
     5641 agcaagaaga ccaagatgac aagatgcgcc aggagacttg gccagaggac ctccaggctg
     5701 acaaagtttc cccgaggaag tcagattgga aaagtgtcct caggttcaag gaaacctggg
     5761 tgtgcaccgg gtgaatgaga gtggcagaca gaaggaaaca gcaaggcctc tgaggtagga
     5821 gggacagcgt ttttgaatgt gaaatttatt ccctgataca tgtttttaaa aatgaatctt
     5881 gctgccctta gaaaatgaac ccccgaacaa ggtaaggtcg agctggcccc tcgtgtcatc
     5941 cgactttgcg ttgtggccct gcctgcagaa acgtgtgctc tgctacagcc ctgggaggag
     6001 gggccgggct cccaactcct gccccgcttc tagcacatgc tgtgcttggc cacttctctg
     6061 cctcttagtt taacagcagc actgggcaag gtttgccctc tgcacaccag accggcttcc
     6121 caagaaccgg ggaagaggag agggcatgcc tggggcctga gcttagtggg ccgggtggag
     6181 gcaggaggta ctgcatggag gagcgtggac agtggcatgc aggaggccag tcattctgcg
     6241 gttttagctg gaggtttgtt tttggtagtt tgtagaatca tcagatttga tgatgaaact
     6301 ttttttccat aaatgttaaa ttttcagaca cttgtatttt ttttttcctt tttttttttt
     6361 gagactgagt cactgtcgcc caggctggag tgcagtggta ctagctcggc tcactgcaac
     6421 ctctgcctcc caggttcaag cgattctcct gcctcagcct cctgagtagc tgggattaca
     6481 gatgtgtttc accatgcccg gcgaattttt tttgtatttt tagtagacac gggatctcac
     6541 cgtgttggcc aggctggtct tgaactcctg acctatggtg atccgcaccc ctccccgccc
     6601 cccccgcggc ccagcctccc aaagtgctgg gattacaggc atgagccact gtacccagcc
     6661 ctgtattttc tttaaaaacc aattttgggc cgggcacggt ggctcacgcc tgtaatccca
     6721 gcactttggg aggccgaggc aggcggatca cgaggtcagg agatcgagac catcctggct
     6781 aacatggtga aaacccatct ctactaaaaa tacagaaaaa aaatgagctg ggtgcgatgg
     6841 tgggtgcctg cagtcccagc tactcgggag gctgaggcag gagaatggcg tgaacccagg
     6901 aggcggagct tgcagtgagc ccagatcacg cccctgcact ccagcctggg tgacagagcg
     6961 agactccgtc tcaaaaacaa caacaacaac gaaaaaacga ttttggcatg ttttgtaagt
     7021 tgccagacta ttggatatac ctcttaatca tactttgttt gaaatccttt gtggtttcta
     7081 aagcactagt agctttctga aaggaaaatt tttaatgaat gaagcatgct tcatcctgca
     7141 catcccctcc tgccccagca cccctactgc ccatgcgcct ctcctgcccc agcaccccta
     7201 ctgccccagt gccaggcctt ttctagcagc tctcatgggt tcatccctgc tgcgggcatt
     7261 gctccaccaa ggggcagtgc tctccctgcc ggtaagtgtt ggaacttcac gtttccctct
     7321 agttttctct ttacatttta acatacacta ttatgtgtca atatattaat tatatattaa
     7381 ttacatttat agaggttagg tatatatggc agatcatatc tgagcgtgaa ttacattctc
     7441 caatattttt atttgtcatg atttattgca gggttcactt atttgatcta ccccaactta
     7501 acacacattt ccaagaaaat atccatcaca ctagaaagaa agaaagagga aggaaggaag
     7561 ggagggaggg agagaaggag aaaggaagaa agggaaggaa aatggaatgg aggaagggaa
     7621 aaatggaagg aggaaggaag gaagggaaag aatgaagaaa gccatttgtt cctgcaaacc
     7681 taaacctctt tgtagtaagt tctggcagaa ggtgtgtttc tggagttaaa ctacaggctt
     7741 ggaaatggaa tttcttagcc taatttctaa attagaactg cttatgcaaa ttaacactcc
     7801 gtacatttca acaagcagtt ggctgatttc ttctgtccac tccacctgca gatgcagagg
     7861 tggccccatc ctgtgatgtg ccaccacatc ccttttcagt gaagggcttt gttggctgct
     7921 gtgggcattc tcatggcctc tccagggatg gcctccactg tagagaccta tgtcaccaag
     7981 gccaggccct ctcagggggc tccatccaac gaccattctg cctcagggta agaggcccgg
     8041 ccctctcagc ctgagtccat tctggctcca gagctccctg agagcttgcc tggcaagtta
     8101 ctcttgcaat tctagcttcc agcaggcgtt gatttctggg gcacttttga taaactcctg
     8161 gcaggaaact caatctctgg gggtcagagt ccacttcctg gggagcccaa tctgtgaccc
     8221 ctaggagtgg ggaccatgga agcacttggc tctccagcat gtgctgaata gggggcgctg
     8281 cctgcaatgt ccacgtggaa acctggctgg gagaatgcct gtgtgctctg catggggatg
     8341 taaaggtgtg agcaaacctt cttcagagag gggatgttca atgcgaaatt tgaacattgg
     8401 gacctgaaaa actgatgggc tgatggggtc tgcccatgat tggcagcctt catagaatca
     8461 cgagggagga gcacaggcca ccctagacag gaggggtccc ctactgacag ggaggtgctg
     8521 tcggggcagc aggcacgtgc aggaaaacgg aaaagcagag taattgaatg taaatcatgc
     8581 aactccacta cagtggctag aagcctggat gggcaacttg gctgagtgat gttgggcaag
     8641 ttatttaata tcagtattct cagttttctc atctgtaaag gggattaaat acttccttcc
     8701 cttacagggc tgccctggtc ttaagtaatg cccacagaga gcttagcatt gttcttggca
     8761 agtcactagt actcagtaaa tactattttt attaagaagg taagattcac aggacttagt
     8821 gtcttaacta gatgttgaga gtaaggagaa gagagaatac ttctcggatg attgttcagt
     8881 ttctgatgaa tgtctgttcc cctttcaaaa cctaattcag atgtcacttc ctcctcaaag
     8941 ctctcgcccc gcgccgagct actgtgatgt atttttatga cctggcagct tttttctcat
     9001 atccctgtta gcggtatgtg gtaagaacat gagacacaga atcagaaacc atggatttct
     9061 ggtcttgact ccactaccac tcagaggaac ctcacggtgg atgccgtaag tgtttacact
     9121 gaaaaggatt ttcacgaaaa cctgcatttt catttcgttc acaagagaat tatgagacta
     9181 gaaaaacaac aattcttagt ataccacaga ctgtggtgcc taggaataac agacaagctt
     9241 taactcacac gatgagcatc tttatttagc tctgctttta gatatctgca tgataaagat
     9301 gagtgatcca acgttagaaa tcatctggac attaaaactg aattgtaggc aggcgtggtg
     9361 gctcacacct gtaatcccag cacttacgga gaccaaggcg ggcagattgc ttgagctcag
     9421 gagtttgtga gactagcctg ggcaacatag taagacccct atctctacaa aaaatataaa
     9481 aattagctag gcatcatggc ctgtgcctgt agtcctagct attgaggaaa ctgatgcagg
     9541 aggatcattt gagctcagga gtttgagacc attctgggca atacggtgaa accctgtctc
     9601 tacaaaaaaa tgcaaagatt agctaggcat gatggcacat gcctgtggtc ccagctactc
     9661 gggaggctga ggcaggagga ttgcaggagg tttgcttgag ccggggaggt cgagtctgca
     9721 gtgaactgag attgcatcac tgcactacag cctgggtgac agagtaagac cctatctcaa
     9781 aaaaaagaac taattgtaac aaactatctt tcaaattata tcaaaacagt gattcataaa
     9841 ttccatgttg cccagagatc atgaggagct cttctatgat ttgacagtgc aattactgaa
     9901 ggggaagaca ccatgcaaat acatggtaaa aatattcaaa ttattactga tttgacacaa
     9961 aatattgatg taaataacat aaaactgtaa tatgccatta tgatgacatt aatgaaaaat
    10021 tggttaatga atgtcattga aagagcatgt acatcactaa atgttcttag tcactgaaag
    10081 tgtgaaatag cctctaaact catatgtgga aaaagaactt gaaaaaggtt tccagaaatg
    10141 tgacaattct agtactttca tgacatttta aaaaagggat tgtaaagact gatgaaaccc
    10201 ttaaaacctc tcaagaatta aaaatcattt ttgatcaaca gagtaaactg attttttatc
    10261 tctgttgaaa gatattttta aaatcattgt cctatggaaa agtcatatag aacgtttgct
    10321 gtttaatgta gcacagatgt atcaaaaagc catgccaggc agttatagat atcttagttt
    10381 tctggatttt gtgacgtttg tggtatttgt cagattttta aaatttgtga tttgttggga
    10441 tttgttcctc attcacaggt aattttatat acttttgtat tcactttcga aaagaaggca
    10501 actctaaatt ttatgaactt caagtgctat aaaacaatta ccacagtaaa ttttgaaaaa
    10561 ttcaccccaa aaagaaacct tgtatccatt ggcagtaact ccctatgctc cgccattcct
    10621 ctcagctccc tgtctggcaa ccacttcctg tctcttcaga gttgcctctt ctggacatta
    10681 catataaacg gaattataca ctatgtggcc ttttatgact ggcttctttc acttagcata
    10741 atgttttcaa gagtcatctg tgttgtagca tttgtcagta cttcatttat ttttgtttcc
    10801 taacaatact ccattgtagg gattgaccac actttatcca ttcattggtt gatggacatt
    10861 tgggttgttt ccactttttc tgctgttgtg aataacagtg ctaagcacat tcatatgcag
    10921 tgtttgtgta gatatataat atgctttatt ttctcttgag tacataaaag tggagcctct
    10981 gagtaatata ataactctat gtttggtgtt ttgaagaatt gctaaattgt tttccaaagc
    11041 agctgcacca ttttatatcc ctaccagcaa tgcatgaagc ttccagtttc tccacatcat
    11101 cacgaatact ccttattctc tctcttttta gatatagaca ttctggcagg tgtgacattg
    11161 tatctcttgt ggtttagatt tgcatttgga gcatgtctta tgtgcactta aaaatattaa
    11221 tatctattct gctgttgttg ggtaaactgt tctatagatg ttgatatggc ttcgctgtgt
    11281 ccccactcaa aatctcatct tgacttgtaa tccccataat ctccatgtgt caagggtggg
    11341 accaggtgga ggtaattgga tcatgagggt ggttttccct actctgtttt catgatagtg
    11401 agtctcacaa ggtctgatgg ttttataagc atctggcatt tcccctgctt gcactcaggc
    11461 tgtcctgcca cactgtgaag aaggtgcctt gcttctcctt tgccttctgc catgagtgta
    11521 agtttcatga ggcctcccca gccatgctga actgtgagtc aattaaacct ctttccttta
    11581 taaattacca agctgcggct atttcttcat agcagtgtga gaacggacta atacaggtgt
    11641 tttttaggtc ttgttattgt gtcgttcacg tcttttattt ccttgttgat cttactctta
    11701 gttgttctat ccatcattga aaatggggca ttggccaggc gtggtggctc acgcctgtaa
    11761 tcccagcact ttgggaggcc aagaccagca gatcacttga ggtcaggggt tcgagaccag
    11821 cgtggctaac atggagaact cctgtctcta ctaaaaatac aaaaattagt caggtgtggc
    11881 agtgcgtgcc cgcctatagt cccatctact tgggaggctg aggcagggga attgcttgaa
    11941 ccctggagtc agagtttgca gtgagctgag atcatgccac tgcgctccag tctgggtgac
    12001 agagtgagac tcaaaaaaga aaaaaaaaaa aaaaaaaaaa aagaaagaaa atgagacatt
    12061 ggatttgtaa gtttctgaca ggttcatttt gcctgctgcc cagatagagc cgatttatga
    12121 ggacagggaa attgcaatag agaaagagtt taatacatgt agaactggct aaacaagaga
    12181 ctggagtttt attattactc aaatcagcct ccacaaaaat ttggaggcta ggtcttttca
    12241 aagatagttt ggtgggcagg ggtttgtgta ctaagaaact aaatgtttct tgtgtactaa
    12301 gtcagcttct gggtgggggc cagaggacca gttgagccaa gaattcaaga ggtacaggtt
    12361 caagtagggc catctggttg tcagaaatgc aaaagcctgg aaagtcatct caaatgttag
    12421 gttctacaat agtcaagtta tttatagtaa ttgggaaagt tgcaaatctt gtgacctctg
    12481 tagaaaatag gtggtaatct ttacacctat atcttagtag aattcaggcc cctcacttcc
    12541 tcctaacctg gtagcctttc attagtttta caaaggcagt ttaattttgg ggggcagggc
    12601 tattatcatc taaactataa actataatcg tttgtcccaa agttagcttg gcccatgccc
    12661 aggaatgacc aagggcaatt tggagattaa agtcaagatg gagttggtta gatcagatct
    12721 ctttcactgt tataattttc tcactgttaa aatttacaaa ggcagtttca aaatctgaaa
    12781 cttttattgt taaattatgt atttattcct ttagttctgt catgttctgc ttcttatatt
    12841 ttggaactct gttgttaggt gcatacatat ttataattgt tatatcttcc tgatggattg
    12901 gtattgtaat cactgtaaaa tacactatta tcattgtaaa atattccttt ttatctctag
    12961 tattttttgt ctgtttgact taaagtctat tttgtttgat attagcatag ctattcttgc
    13021 tcttactgtg gcaatttgta tgataccttt ttcttttagc ctatttatat ctttgaatca
    13081 aaagtttgtc tcctgtagat agcatatagt tggataattt ttagttcttt tgattggatt
    13141 gtttaattca ttcattttta gtgttactat tgatatggct ggatttgtgt ctgcaatttt
    13201 aatttttgtt ttctatatgt ctcgtgtttt tgtggctttg cttcttcttc tttgctttct
    13261 tttgcattaa gtattttcta gtttaacaac ttaatttctt aaattatttt taactatatt
    13321 tttacgtatt tccttaatga atgcttgatg gctcacaatc tccttctcag tttatcagaa
    13381 tctacttaag tttatactaa cttatgtcca gtgagataga aacacatttc ttctttatag
    13441 ctctaggtcc tcttcacttg tttttgtgct attattgtta tacttactac ctctgtatat
    13501 gttacaagcc caagaatact attctactta tttatataat tttatgtttt ttaaagaacc
    13561 tgagactgga agtgagggaa atagggcgtg caggaaggaa ggaagaggaa ggaaaagtgt
    13621 gtgaaagggg gctccacctc ctttagtgga taccctgagc ttatttccag gggcctttgt
    13681 aaattcccag tgacaactct ttggaagatg aaatccccct cttccctgca tcttattaga
    13741 acagtgtatc ctggaggaca tcccttgcct ttcaccaagt gaccctatac tggcggcaga
    13801 acttctcgat tttgcggatt tcaaaatggc tccacgtact catagttttc atgacagact
    13861 tcattgcgat agtcaaatac tgttccactt actgcagttg cctacagtct gggttttgtt
    13921 cagttgaaat taaataaatt ttatgcacaa accttt
//
