LOCUS       NM_018718               6292 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens centrosomal protein 41 (CEP41), transcript variant 1,
            mRNA.
ACCESSION   NM_018718
VERSION     NM_018718.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6292)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 6292)
  AUTHORS   Ki,S.M., Kim,J.H., Won,S.Y., Oh,S.J., Lee,I.Y., Bae,Y.K.,
            Chung,K.W., Choi,B.O., Park,B., Choi,E.J. and Lee,J.E.
  TITLE     CEP41-mediated ciliary tubulin glutamylation drives angiogenesis
            through AURKA-dependent deciliation
  JOURNAL   EMBO Rep 21 (2), e48290 (2020)
   PUBMED   31885126
  REMARK    GeneRIF: CEP41-mediated ciliary tubulin glutamylation drives
            angiogenesis through AURKA-dependent deciliation.
REFERENCE   3  (bases 1 to 6292)
  AUTHORS   Patowary,A., Won,S.Y., Oh,S.J., Nesbitt,R.R., Archer,M.,
            Nickerson,D., Raskind,W.H., Bernier,R., Lee,J.E. and Brkanac,Z.
  TITLE     Family-based exome sequencing and case-control analysis implicate
            CEP41 as an ASD gene
  JOURNAL   Transl Psychiatry 9 (1), 4 (2019)
   PUBMED   30664616
  REMARK    GeneRIF: Missense variants in one gene, CEP41, associated
            significantly with Autism Spectrum Disorder (ASD). Homozygous
            gene-disrupting variants in CEP41 were initially found to be
            responsible for recessive Joubert syndrome.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6292)
  AUTHORS   Schneider,E., Mayer,S., El Hajj,N., Jensen,L.R., Kuss,A.W.,
            Zischler,H., Kondova,I., Bontrop,R.E., Navarro,B., Fuchs,E.,
            Zechner,U. and Haaf,T.
  TITLE     Methylation and expression analyses of the 7q autism susceptibility
            locus genes MEST, COPG2, and TSGA14 in human and anthropoid primate
            cortices
  JOURNAL   Cytogenet Genome Res 136 (4), 278-287 (2012)
   PUBMED   22456293
  REMARK    GeneRIF: In cortices, the MEST promoter was hemimethylated, as
            expected for a differentially methylated imprinting control region,
            whereas the COPG2 and TSGA14 promoters were completely
            demethylated, typical for transcriptionally active non-imprinted
            genes.
REFERENCE   5  (bases 1 to 6292)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 6292)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   7  (bases 1 to 6292)
  AUTHORS   Andersen,J.S., Wilkinson,C.J., Mayor,T., Mortensen,P., Nigg,E.A.
            and Mann,M.
  TITLE     Proteomic characterization of the human centrosome by protein
            correlation profiling
  JOURNAL   Nature 426 (6966), 570-574 (2003)
   PUBMED   14654843
REFERENCE   8  (bases 1 to 6292)
  AUTHORS   Yamada,T., Kayashima,T., Yamasaki,K., Ohta,T., Yoshiura,Ki.,
            Matsumoto,N., Fujimoto,S., Niikawa,N. and Kishino,T.
  TITLE     The gene TSGA14, adjacent to the imprinted gene MEST, escapes
            genomic imprinting
  JOURNAL   Gene 288 (1-2), 57-63 (2002)
   PUBMED   12034494
REFERENCE   9  (bases 1 to 6292)
  AUTHORS   Gunay-Aygun,M., Gahl,W.A. and Heller,T.
  TITLE     Congenital Hepatic Fibrosis Overview horizontal line RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301743
REFERENCE   10 (bases 1 to 6292)
  AUTHORS   Parisi,M. and Glass,I.
  TITLE     Joubert Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF429308.1 and AC007938.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_018718.2.
            
            Summary: This gene encodes a centrosomal and microtubule-binding
            protein which is predicted to have two coiled-coil domains and a
            rhodanese domain. In human retinal pigment epithelial cells the
            protein localized to centrioles and cilia. Mutations in this gene
            have been associated with Joubert Syndrome 15; an autosomal
            recessive ciliopathy and neurological disorder. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Mar 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1; also known as long
            (L) type).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF429308.1, AJ278890.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000223208.10/ ENSP00000223208.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3529              AF429308.1         41-3569
            3530-6292           AC007938.1         49189-51951         c
FEATURES             Location/Qualifiers
     source          1..6292
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.2"
     gene            1..6292
                     /gene="CEP41"
                     /gene_synonym="JBTS15; TSGA14"
                     /note="centrosomal protein 41"
                     /db_xref="GeneID:95681"
                     /db_xref="HGNC:HGNC:12370"
                     /db_xref="MIM:610523"
     exon            1..83
                     /gene="CEP41"
                     /gene_synonym="JBTS15; TSGA14"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1172
                     /gene="CEP41"
                     /gene_synonym="JBTS15; TSGA14"
                     /note="isoform 1 is encoded by transcript variant 1;
                     centrosomal protein 41 kDa; centrosomal protein of 41 kDa;
                     testis specific protein A14; testis-specific gene A14
                     protein; testis specific, 14; centrosomal protein 41kDa"
                     /codon_start=1
                     /product="centrosomal protein of 41 kDa isoform 1"
                     /protein_id="NP_061188.1"
                     /db_xref="CCDS:CCDS5821.1"
                     /db_xref="GeneID:95681"
                     /db_xref="HGNC:HGNC:12370"
                     /db_xref="MIM:610523"
                     /translation="MSLRRHIGNPEYLMKRIPQNPRYQHIKSRLDTGNSMTKYTEKLE
                     EIKKNYRYKKDELFKRLKVTTFAQLIIQVASLSDQTLEVTAEEIQRLEDNDSAASDPD
                     AETTARTNGKGNPGEQSPSPEQFINNAGAGDSSRSTLQSVISGVGELDLDKGPVKKAE
                     PHTKDKPYPDCPFLLLDVRDRDSYQQCHIVGAYSYPIATLSRTMNPYSNDILEYKNAH
                     GKIIILYDDDERLASQAATTMCERGFENLFMLSGGLKVLAQKFPEGLITGSLPASCQQ
                     ALPPGSARKRSSPKGPPLPAENKWRFTPEDLKKIEYYLEEEQGPADHPSRLNQANSSG
                     RESKVPGARSAQNLPGGGPASHSNPRSLSSGHLQGKPWK"
     exon            84..147
                     /gene="CEP41"
                     /gene_synonym="JBTS15; TSGA14"
                     /inference="alignment:Splign:2.1.0"
     exon            148..195
                     /gene="CEP41"
                     /gene_synonym="JBTS15; TSGA14"
                     /inference="alignment:Splign:2.1.0"
     exon            196..257
                     /gene="CEP41"
                     /gene_synonym="JBTS15; TSGA14"
                     /inference="alignment:Splign:2.1.0"
     exon            258..327
                     /gene="CEP41"
                     /gene_synonym="JBTS15; TSGA14"
                     /inference="alignment:Splign:2.1.0"
     exon            328..472
                     /gene="CEP41"
                     /gene_synonym="JBTS15; TSGA14"
                     /inference="alignment:Splign:2.1.0"
     exon            473..624
                     /gene="CEP41"
                     /gene_synonym="JBTS15; TSGA14"
                     /inference="alignment:Splign:2.1.0"
     exon            625..692
                     /gene="CEP41"
                     /gene_synonym="JBTS15; TSGA14"
                     /inference="alignment:Splign:2.1.0"
     exon            693..807
                     /gene="CEP41"
                     /gene_synonym="JBTS15; TSGA14"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1023
                     /gene="CEP41"
                     /gene_synonym="JBTS15; TSGA14"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..6292
                     /gene="CEP41"
                     /gene_synonym="JBTS15; TSGA14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3509..3514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP41"
                     /gene_synonym="JBTS15; TSGA14"
                     /note="hexamer: ATTAAA"
     polyA_site      3529
                     /gene="CEP41"
                     /gene_synonym="JBTS15; TSGA14"
                     /note="major polyA site"
     regulatory      5301..5306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP41"
                     /gene_synonym="JBTS15; TSGA14"
                     /note="hexamer: AATAAA"
     regulatory      5305..5310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP41"
                     /gene_synonym="JBTS15; TSGA14"
                     /note="hexamer: AATGAA"
     polyA_site      5320
                     /gene="CEP41"
                     /gene_synonym="JBTS15; TSGA14"
     polyA_site      5323
                     /gene="CEP41"
                     /gene_synonym="JBTS15; TSGA14"
     regulatory      6273..6278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP41"
                     /gene_synonym="JBTS15; TSGA14"
                     /note="hexamer: AGTAAA"
     polyA_site      6292
                     /gene="CEP41"
                     /gene_synonym="JBTS15; TSGA14"
ORIGIN      
        1 agaggcaacc cgtgaggcta gaaccccgaa cgtggtcggt tggagaaaat atgtccctcc
       61 ggaggcacat tgggaaccct gagtatctga tgaaaaggat accacagaac ccaagatacc
      121 agcatatcaa atcaagactg gacactggta acagtatgac taaatatact gagaagctcg
      181 aagagattaa gaaaaattat agatacaaaa aagatgagct tttcaagaga ctaaaagtta
      241 caacttttgc ccagctgatc atccaagttg cttccctctc tgatcaaaca ctggaagtga
      301 cagctgagga gattcaaagg ctggaagaca atgattctgc agcttcagac cctgatgctg
      361 aaaccactgc caggaccaat gggaaaggaa atccaggtga gcagtcgccg agccctgagc
      421 agttcataaa caacgcagga gcaggggact ccagccgctc aactcttcag agtgtcatca
      481 gtggtgttgg ggaactggat ctagacaaag ggccagtgaa gaaagcagag ccccatacca
      541 aagacaaacc ttatcctgac tgccccttcc tgctgctaga tgtgcgtgat agagattctt
      601 accagcagtg ccacattgtt ggagcttaca gttacccaat tgcaactctg tctagaacaa
      661 tgaaccctta ttcaaatgat attcttgaat ataaaaatgc ccatggcaag atcatcattc
      721 tgtatgacga tgatgaaagg ctggccagtc aggcggccac caccatgtgc gagcgtggat
      781 ttgaaaacct cttcatgctt tccggaggtc taaaagtctt agctcagaaa ttcccggaag
      841 gactgattac tggttccctg ccagcatctt gccagcaggc ccttcctcct gggtctgccc
      901 ggaaacgatc cagccccaaa gggccacccc taccagctga gaataaatgg agatttaccc
      961 cagaagactt aaaaaagata gaatattatc tggaagagga gcaagggcct gcagatcatc
     1021 ctagccgact gaaccaagct aactcctccg gaagagagtc caaggtgcct ggtgcccgaa
     1081 gcgctcagaa tctgccaggt ggcggccccg ccagccactc aaacccccgc tccctcagca
     1141 gtggtcacct gcaaggcaaa ccctggaagt aaagactttg tctcacttag gcaaataaat
     1201 gttcttcctc ttttcagaac ccctgagcat ttcccaagtt gggtcatttc cagaaacttc
     1261 tgcagaggaa agaccatgac atatgtatgg gataggcctc ttccctgtcc ctgtctccag
     1321 ttcctctccc ctcaggaggc cacctcagga aggattttga caggtgacca taaaaaccag
     1381 aggtgtgaca ggctctagtc tcctccctgt tgtttacagc atatttaagt cttgtgaaac
     1441 tgtataggaa aaaagtatct acgtttttag tttttttgtt ttgttttttt ttaataaggt
     1501 ccagcttgtt gggtctctct gtgttgtttt gtaaatactt cagtcacatc tgcccgtgtg
     1561 cctgtccctg ccaccttttc attcactgtt cttgacttca tgaaggcttc tccgggcagt
     1621 cttggtgtga gaagctgttt ccaagggtgc agatgagcct taggttccag ccgcctgcag
     1681 accccacccc agcaggctca ctcagcaagg agctctctgc ccagcatatt gcaggccctg
     1741 ttttgagtat ggaagccagt gcctgtgtac tcactgaaat tgaagatgag gaaagtagct
     1801 gtacactcac tgaatgctcc cccttactag atatttcctg gagccagaaa ggtatgcatg
     1861 tgggtgtctt cacaccgggg aggagggcct ctcatgggaa agccctggcc accacaccgg
     1921 cctgtgcccc ttgaagccca ccaaagcggc cctcacttgt ggtcagtata tcagttatga
     1981 cgcccattgc ccagcttcag tccatccatg ttagatggac agaaattatg gccagttgaa
     2041 aataccagct ttggttggac aactgtggac acacaaggtg aagaggactc cgaagtcctt
     2101 tgtcagggct gacaacctcg taagcccttg cttagaaata cagtattagt ctaattgagt
     2161 aattagtgca atttcctgct tacttttcat tctcatgact gaactgtgat taggaagttg
     2221 tgattataga ttctggtttt ggccggaatt ttgaatcagc attaattgaa ttgctaaatg
     2281 actgacattc attccattta attgggggaa caaaaggcct caggtaagga tgaggaactc
     2341 tgaaatcaga tggaaaagag cggtgttaat ttttatggtc tgtgatcgta gctgtgataa
     2401 gggactgagg aataaattgt gctctttgtc atggcaacca gcttctgaaa agcccactga
     2461 aaattgcctg tcctgctggt aactgctacg gggtaagatt tgccttaaca gtactatttt
     2521 ctcgccacca aaaaaaaaaa aaaaaaaaaa aaaaaatgca ccacagtatt tctagcatgg
     2581 gggctgtgtt tgtatgagaa ataaacgtaa taaatatctc atagagacat atggaaaaat
     2641 aactttcaga ttcagcccag ttctgtttta gagtgtgttt attcttctct acttgatttc
     2701 caaagtgcaa cattttccga tgctttagaa atcaaacaaa ccagggacat tgttcagatg
     2761 tcaagccatg cccaattttc cacaagattc aagaatcttg tataaaattc agccaacgta
     2821 cacatagctt taatgaggag cctgtcatgt ttccccataa atttattgcc tgagaactta
     2881 gttcagcctt tgctaatgcc aaaatgctct ggctttgtat tttctttaca gcatagatag
     2941 aaaaatgcac atttttccac actcagcttt cccctagcat ggacaagatt ttcagccatt
     3001 tttgccacat atacattttt aaggaaaaaa gatttttctc tgtaagaaag ttctggttat
     3061 gctgttttaa aggtgacttg tcaggagttg agacttccct gccggattct attttgaaag
     3121 taaatggtct tccctccttg ttccgattct gcgttcccat cgtcagacaa ctttggagta
     3181 ttagaaacca ctgtatatat gtggaaagcc aggtcagcca gacctgttag aattggtgtg
     3241 cactcacctg agagatctgg caggttggat atatttatgt gtatttctcc acagtgcttg
     3301 ctttgccctg ttggtaagga ttttaaataa ccatgctcaa aagagctgtt ctaatctgcg
     3361 ttttgcatgt taagtgttaa tatcaaacat tctttacgtg ctcgaggtat tgcttttaac
     3421 attctacttt gccagtttct tcattagatt aattgacatg tattatttaa atgaccagtg
     3481 atgctttgtg caattatgaa tgttgaagat taaagtacat agttactaat ttgtcgtttg
     3541 ctattaatat gctgaaaact gccaacttct ctcttctttt ctgtcgagat gatttggggg
     3601 agccacagga gactggtgtg atttttgctg catctcctag gaaagcattt tttaaaaaaa
     3661 ataaatgaat caggaaatca gtccaattag ggcagggggc ctcagctctc cagtcagaaa
     3721 gcctggattt cttttcctgc tcaggctggg actgaagcca ccttcaacaa ctggatcatg
     3781 gcttcctacc agcgtctcag gggttgacta gctgcccttg tctggggctt gtgaaccctg
     3841 agacagaagg tgcttcatcg atgtacaact acagcaccct gaacagcagt gatggccaaa
     3901 gtttaaataa taccttaaat gctttaaagg ggtttgtgtt taaggaaggg agaaaagaaa
     3961 aaaagaaagg aagggagaaa gaagcaagga aatgggaaga agggagggca gagagaagaa
     4021 aagaagcaga aagcgagaga gaaaggagaa agctacatta cttatttgaa aacaaaagga
     4081 acaccctggg ctgtaataat gtcaggctca atctcttgaa aaagtatgga atgatttaaa
     4141 tggcctgcat tcattttatc ttttatcttt tttttttttt ttaaccttta gtggttagcc
     4201 aggaccagca cgatcatatt gggcttggta taaatccgaa tgaaaagaga ccaaataaca
     4261 ttcattagtt gctcagggat ttttcctgtg gtgctattta aattatacaa aaattcttaa
     4321 gactttaggc tactcgacca agaaaacaga acaaaacaaa aaatcgtgtt ttctctaatt
     4381 cccttgtgga atgtaagtga aatcagagtc ctaggctagg aagaaatacg taggtaattt
     4441 ttcttgtgtt ggttttggtt tctgtcatgt tgtttattgg ctatagattc tgtcttttat
     4501 gttatctgac ttttttagag cgaataatta gtttctgtcc acctggattt aaatccatga
     4561 ccaccttctt gctctactct gaagataatc agtaagaacc tttctttctc cagttctaaa
     4621 acgttctcag tgtctttaat gtgtgtttat tttcttccca attctttcaa agatttaact
     4681 cccacgatac ttttttttcc ccaggaaaca ccgcaaatgt gtggaatata attcaccagt
     4741 ttaattatgt gagcatgttg agtacttaca tgcaggtcca ttaatttttc actaacaatt
     4801 attttttcat gcaaaagcaa taaataacat tgtgcttcca aaatgttcag aatacatttg
     4861 ggtagtaata ctttcctaga tttacaataa ttattgaaat tattattatg acatctttaa
     4921 atggatacac aggtcagtta caacataaaa aatgtaatgg tggaaatttg tcagccttga
     4981 attcaggcag aacaggattc ggtgcatgat tttatgtgtt ttcgaaacgg tgtctgtcac
     5041 attgtgatcc cctgatggct cccctctctg ttgctgatcc tctttgttct gtacagaagc
     5101 aaattctcac ctgtgtaaca tcctgaagca cctggtaaaa tgtgaggcaa agagaggcca
     5161 cttctcaaat gctgtggacg gatgggctgc atcttttaaa ggatatcaat atgtcttcct
     5221 gttgcaatta ttttgactat aagctcccag agagtgaaaa tcaccaaccc tgtgacagtg
     5281 gcccttaata agtgttcatg aataaatgaa ttgaacctgt caagattgaa gtttggatgt
     5341 gatgcccact gtggtggcca ctcagtgcta gtctgtcatt ctggagaccc agaaagctcg
     5401 ttatcttctg tcccccttgt gtatcctgcc tttgtgggcg aggcattcaa aaccctgagg
     5461 tttttagatc tccctctaca ggaagtaccc agagagctgc tgggggtgtt attaccctgt
     5521 ctctgccagg cttaaagtat cctcccaaat tcagcacgca aaggtcacac accaccccca
     5581 tcttaagagt aggttttctc ttttgtttca aatcttgaag atttccagaa aataataata
     5641 ctagccaatg tttgtggaga gcttactttg ctcctagatt cttcattata tgttttgacc
     5701 catttaattt ccacaacagt ctgatgaggc aggcaccccc attttcagat gaggagactg
     5761 aggttcgggt agaaattaag tgactcaggt ttgccttcag tctctgacca agggtttgaa
     5821 aagccaggag ccagcctgag aactgtggct ccagagggtg ttctttcagc cactccgctc
     5881 tatgcttctc actctgggtg ggcacaacca tgttctcctt tggtgatgcc tctaacttac
     5941 cgtgaaaatg tacctttccc ttcgctattg gcttcccttc cctcctagtc agccgagatt
     6001 cttttgaaaa ctttcctccg cttgcctgca caaaaggcga tggaaattca ggaactgaaa
     6061 catctgctct ggggaatgcg tatttccaca tttccaccgc ctgtgtctgc tgtcttatct
     6121 tgaagacagg tgctccaggg cttccgaggt tattttgtct gttaatggac accttgcaaa
     6181 gtaccactta aggaatgaga attacaaact tttaattata ttgtaggggg aaaaaagtag
     6241 gctgttttcc tgataggtct agccattcat tcagtaaacc atattgatat ga
//
