LOCUS       NM_014810              13414 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens centrosomal protein 350 (CEP350), mRNA.
ACCESSION   NM_014810
VERSION     NM_014810.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13414)
  AUTHORS   Zhu,T., Zhang,Y., Sheng,X., Zhang,X., Chen,Y., Zhu,H., Guo,Y.,
            Qi,Y., Zhao,Y., Zhou,Q., Chen,X., Guo,X. and Zhao,C.
  TITLE     Absence of CEP78 causes photoreceptor and sperm flagella
            impairments in mice and a human individual
  JOURNAL   Elife 12, e76157 (2023)
   PUBMED   36756949
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13414)
  AUTHORS   Goncalves,A.B., Hasselbalch,S.K., Joensen,B.B., Patzke,S.,
            Martens,P., Ohlsen,S.K., Quinodoz,M., Nikopoulos,K., Suleiman,R.,
            Damso Jeppesen,M.P., Weiss,C., Christensen,S.T., Rivolta,C.,
            Andersen,J.S., Farinelli,P. and Pedersen,L.B.
  TITLE     CEP78 functions downstream of CEP350 to control biogenesis of
            primary cilia by negatively regulating CP110 levels
  JOURNAL   Elife 10, e63731 (2021)
   PUBMED   34259627
  REMARK    GeneRIF: CEP78 functions downstream of CEP350 to control biogenesis
            of primary cilia by negatively regulating CP110 levels.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 13414)
  AUTHORS   Kanie,T., Abbott,K.L., Mooney,N.A., Plowey,E.D., Demeter,J. and
            Jackson,P.K.
  TITLE     The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate
            Intraflagellar Transport at the Ciliary Base
  JOURNAL   Dev Cell 42 (1), 22-36 (2017)
   PUBMED   28625565
REFERENCE   4  (bases 1 to 13414)
  AUTHORS   Nishijima,Y., Hagiya,Y., Kubo,T., Takei,R., Katoh,Y. and
            Nakayama,K.
  TITLE     RABL2 interacts with the intraflagellar transport-B complex and
            CEP19 and participates in ciliary assembly
  JOURNAL   Mol Biol Cell 28 (12), 1652-1666 (2017)
   PUBMED   28428259
REFERENCE   5  (bases 1 to 13414)
  AUTHORS   Mojarad,B.A., Gupta,G.D., Hasegan,M., Goudiam,O., Basto,R.,
            Gingras,A.C. and Pelletier,L.
  TITLE     CEP19 cooperates with FOP and CEP350 to drive early steps in the
            ciliogenesis programme
  JOURNAL   Open Biol 7 (6) (2017)
   PUBMED   28659385
REFERENCE   6  (bases 1 to 13414)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   7  (bases 1 to 13414)
  AUTHORS   Yan,X., Habedanck,R. and Nigg,E.A.
  TITLE     A complex of two centrosomal proteins, CAP350 and FOP, cooperates
            with EB1 in microtubule anchoring
  JOURNAL   Mol Biol Cell 17 (2), 634-644 (2006)
   PUBMED   16314388
  REMARK    GeneRIF: CAP350 interacts directly with FOP (FGFR1 oncogene
            partner) to form a centrosomal complex required for microtubule
            anchoring.
REFERENCE   8  (bases 1 to 13414)
  AUTHORS   Patel,H., Truant,R., Rachubinski,R.A. and Capone,J.P.
  TITLE     Activity and subcellular compartmentalization of peroxisome
            proliferator-activated receptor alpha are altered by the
            centrosome-associated protein CAP350
  JOURNAL   J Cell Sci 118 (Pt 1), 175-186 (2005)
   PUBMED   15615782
REFERENCE   9  (bases 1 to 13414)
  AUTHORS   Andersen,J.S., Wilkinson,C.J., Mayor,T., Mortensen,P., Nigg,E.A.
            and Mann,M.
  TITLE     Proteomic characterization of the human centrosome by protein
            correlation profiling
  JOURNAL   Nature 426 (6966), 570-574 (2003)
   PUBMED   14654843
REFERENCE   10 (bases 1 to 13414)
  AUTHORS   Makalowska,I., Sood,R., Faruque,M.U., Hu,P., Robbins,C.M.,
            Eddings,E.M., Mestre,J.D., Baxevanis,A.D. and Carpten,J.D.
  TITLE     Identification of six novel genes by experimental validation of
            GeneMachine predicted genes
  JOURNAL   Gene 284 (1-2), 203-213 (2002)
   PUBMED   11891061
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA716735.1, AF287356.1,
            DB072323.1, AK026986.1, BC033619.1, AL390718.11 and BM675467.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014810.4.
            
            Summary: The product of this gene is a large protein with a CAP-Gly
            domain typically found in cytoskeleton-associated proteins. The
            encoded protein primarily localizes to the centrosome, a
            non-membraneous organelle that functions as the major
            microtubule-organizing center in animal cells. The encoded protein
            directly interacts with another large centrosomal protein and is
            required to anchor microtubules at the centrosome. It is also
            implicated in the regulation of a class of nuclear hormone
            receptors in the nucleus. Several alternatively spliced transcript
            variants have been found, but their full-length nature has not been
            determined. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF287356.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367607.8/ ENSP00000356579.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                DA716735.1         38-99
            63-242              DA716735.1         101-280
            243-685             AF287356.1         64-506
            686-1024            DB072323.1         200-538
            1025-1720           AF287356.1         846-1541
            1721-2381           AK026986.1         482-1142
            2382-3178           AF287356.1         2203-2999
            3179-3581           AK026986.1         1938-2340
            3582-6835           AF287356.1         3403-6656
            6836-8529           BC033619.1         1470-3163
            8530-9693           AF287356.1         8351-9514
            9694-12789          AL390718.11        61081-64176
            12790-13414         BM675467.1         23-647              c
FEATURES             Location/Qualifiers
     source          1..13414
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.2"
     gene            1..13414
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /note="centrosomal protein 350"
                     /db_xref="GeneID:9857"
                     /db_xref="HGNC:HGNC:24238"
                     /db_xref="MIM:617870"
     exon            1..333
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            334..419
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..9700
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /note="centrosomal protein 350kDa"
                     /codon_start=1
                     /product="centrosome-associated protein 350"
                     /protein_id="NP_055625.4"
                     /db_xref="CCDS:CCDS1336.1"
                     /db_xref="GeneID:9857"
                     /db_xref="HGNC:HGNC:24238"
                     /db_xref="MIM:617870"
                     /translation="MRSSKSKEVPLPNPRNSQSKDTVQADITTSWDALSQTKAALRHI
                     ENKLEVAPTSTAVCDSVMDTKKSSTSATRKISRKDGRYLDDSWVNAPISKSTKSRKEK
                     SRSPLRATTLESNVKKNNRVEFREPLVSYREIHGAPSNFSSSHLESKHVYCVDVNEEK
                     TESGNWMIGSREERNIRSCDFESSQSSVINDTVVRFLNDRPAIDALQNSECLIRMGAS
                     MRTEEEMPNRTKGSENNLKLSVNNMAHDTDPKALRLTDSSPSSTSTSNSQRLDILKRR
                     QHDVKLEKLKERIRKQWEHSEETNGRGQKLGHIDHPVMVVNVDNSVTAKVRKVATAPP
                     APAYKGFNPSETKIRTPDGKVWQEAEFQNMSRELYRDLALHFADDISIKEKPAEKSKE
                     KKVVKPVRKVQKVAQLSSTECRTGSSHLISTSSWRDGQKLVKKILGPAPRMEPKEQRT
                     ASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQRNSERSRSKSRSENNIKKLASSL
                     PDNKQEENTALNKDFLPIEIRGILDDLQLDSTAHTAKQDTVELQNQKSSAPVHAPRSH
                     SPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRKQNEEKKAQKEATEQ
                     KNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKLLLEKTLLEEPSHQHVTQE
                     TQAKPGYQPSGESDKENKVQERPPSASSSSDMSLSEPPQPLARKDLMESTWMQPERLS
                     PQVHHSQPQPFAGTAGSLLSHLLSLEHVGILHKDFESILPTRKNHNMASRPLTFTPQP
                     YVTSPAAYTDALLKPSASQYKSKLDRIEALKATAASLSSRIESEAKKLAGASINYGSA
                     WNTEYDVQQAPQEDGPWTKAVTPPVKDDNEDVFSARIQKMLGSCVSHATFDDDLPGVG
                     NLSEFKKLPEMIRPQSAISSFRVRSPGPKPEGLLAQLCKRQTDSSSSDMQACSQDKAK
                     ISLGSSIDSVSEGPLLSEGSLSEEEGDQDGQPLLKVAEILKEKEFCPGERNSYEPIKE
                     FQKEAEKFLPLFGHIGGTQSKGPWEELAKGSPHSVINIFTKSYQLYGKGFEDKLDRGT
                     STSRPLNATATPLSGVSYEDDFVSSPGTGTSTEKKSTLEPHSTLSPQEDHSNRKSAYD
                     PSSVDVTSQHSSGAQSAASSRSSTSSKGKKGKKEKTEWLDSFTGNVQNSLLDEEKAER
                     GSHQGKKSGTSSKLSVKDFEQTLDTDSTLEDLSGHSVSVSSDKGRSQKTPTSPLSPSS
                     QKSLQFDVAGTSSERSKSSVMPPTITGFKPNAPLTDLNPAASRTTTENMAPIPGSKRF
                     SPAGLHHRMAAELSYLNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHER
                     DLALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAA
                     QQSETARLTTDAARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRT
                     RTETDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESP
                     SVPSCKENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKF
                     DESMTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMP
                     FSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKH
                     LRDKGEDDKMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKI
                     RQTTIKLQEKLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSI
                     MQKLKKMRSRMDEKFLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAW
                     DKELIKPKTPKKELEDQRTEQKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPS
                     ESIGQEQPGSPDHSILTEEMICSQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGG
                     QCHLPIKSHQHCYSWSDESLSMTQSETTSDQSDIEGRIRALKDELRKRKSVVNQLKKE
                     QKKRQKERLKAQEASLIKQLESYDEFIKKTEAELSQDLETSPTAKPQIKTLSSASEKP
                     KIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHVDASLSGSERSVSERSLSAYAK
                     RVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPALHLLKELNATSRILDMSDGK
                     VGESSKKSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVLEQGDSSEILSKKDLPLD
                     SENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQKNTKEKDLSWS
                     EHLFAPKEIPYSEDFEVSSFKKEISAELYKDDFEVSSLLSLRKDSQSCRDKPQPMRSS
                     TSGATSFGSNEEISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQQVT
                     ESPSLASVPTADELFDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNN
                     NGTYDGIAYFECKEKHGIFAPPQKISHIPENFDDYVDINEDEDCYSDERYQCYNQEQN
                     DTEGPKDREKDVSEYFYEKSLPSVNDIEASVNRSRSLKIETDNVQDISGVLEAHVHQQ
                     SSVDSQISSKENKDLISDATEKVSIAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEAS
                     EKLCTPLLDLLTREKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQL
                     QQIKKTRDEKIQLSNQELLGDDQKKVTPQDLSQNVEEQSPSISGCFLSSELEDEKEEI
                     SSPDMCPRPESPVFGASGQEELAKRLAELELSREFLSALGDDQDWFDEDFGLSSSHKI
                     QKNKAEETIVPLMAEPKRVTQQPCETLLAVPHTAEEVEILVHNAAEELWKWKELGHDL
                     HSISIPTKLLGCASKGLDIESTSKRVYKQAVFDLTKEIFEEIFAEDPNLNQPVWMKPC
                     RINSSYFRRVKNPNNLDEIKSFIASEVLKLFSLKKEPNHKTDWQKMMKFGRKKRDRVD
                     HILVQELHEEEAQWVNYDEDELCVKMQLADGIFETLIKDTIDVLNQISEKQGRMLLV"
     exon            420..466
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            467..581
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            582..741
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            742..1364
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1478
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1592
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1739
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..2398
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2520
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..3581
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            3582..3732
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            3733..3896
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            3897..4071
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            4072..4292
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            4293..4456
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            4457..4567
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            4568..4708
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            4709..4845
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            4846..4968
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            4969..5138
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            5139..5335
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            5336..5520
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            5521..5608
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            5609..5755
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            5756..5913
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            5914..6113
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            6114..6325
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            6326..6470
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            6471..6631
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            6632..6771
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            6772..6854
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            6855..8857
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            8858..9265
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            9266..9412
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            9413..9535
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     exon            9536..13414
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /inference="alignment:Splign:2.1.0"
     regulatory      13393..13398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /note="hexamer: AATAAA"
     polyA_site      13414
                     /gene="CEP350"
                     /gene_synonym="CAP350; GM133"
                     /note="major polyA site"
ORIGIN      
        1 agttgttggg ctgtaatggc gactgggccg cccctgacga agtgactccc gggccgggga
       61 gcggggccag acctgcgcca gagagaactg cagggagccg cagctcgggg ggtggcttgc
      121 cctgagggag gggaggcagc ctttccgcct tgtcttcctt cccagcggac cggcggatcc
      181 ccggagccgg tgcgaggagg gcacccggtg cgtccccgga gcggggaggc caggccgggc
      241 agccctgggg ccggtcgggg cggcgtcact gcaccctccg ccaggctccg cgggatgcac
      301 cgtggtagcc gagggcggag gcgacactct caggtaaatt ggcaggatga ggagcagcaa
      361 atcaaaagag gtgcctttac caaatccaag gaactctcaa agcaaggata ctgttcaagc
      421 agatataacc acatcgtggg atgcactttc tcaaaccaag gctgctctga gacacattga
      481 aaataaatta gaagtagccc ctacaagtac agctgtgtgt gattctgtca tggataccaa
      541 gaagtcttct acaagtgcta ctcgaaaaat aagtagaaaa gatggtagat acctggatga
      601 ttcttgggtt aatgctccaa tctccaaatc cactaaatca cgaaaagaga aatctcgtag
      661 tcctctcagg gccaccaccc tggagagtaa tgtgaagaaa aataatcgtg tggaatttcg
      721 tgaacctttg gtttcttata gggaaatcca tggtgcacct tccaatttca gttccagcca
      781 tctggaatca aagcacgtat actgtgtaga tgttaatgaa gaaaagactg agagcggtaa
      841 ctggatgata ggcagtcgag aagaacggaa tatacggagc tgtgattttg agagctccca
      901 atcatctgtc atcaatgata cagttgttag gtttttaaat gatcgaccag caattgatgc
      961 attgcaaaat tctgaatgtt tgattaggat gggagcttct atgagaactg aggaagaaat
     1021 gcctaacaga acaaaaggaa gtgagaataa tttgaagctt tctgtgaata acatggccca
     1081 tgatactgat ccaaaagcgt tacgactaac tgactcttct ccatcctcta ctagtacttc
     1141 taattcccaa agattagata ttctaaagcg gcgacaacat gatgtcaaac tggaaaaact
     1201 taaggaacgg attagaaaac agtgggaaca ctcagaagaa acaaatggcc ggggccagaa
     1261 gctgggtcat attgaccatc cagtaatggt tgttaatgtt gataactcag taacagcaaa
     1321 agtcagaaaa gtggcaacag caccacctgc tccagcatat aaaggtttca acccttcaga
     1381 gaccaagatt cgaacacctg atgggaaagt gtggcaggag gctgagtttc aaaacatgag
     1441 tagagaactg tatcgagatt tagcacttca ctttgcagat gatatttcta taaaggagaa
     1501 acctgctgaa aaaagtaaag agaagaaagt agtcaagcca gtacgaaaag tccaaaaagt
     1561 agcacagtta tcaagtacag aatgcagaac aggtagtagt catcttataa gtacatcttc
     1621 ttggcgagat ggacaaaaat tagtaaagaa gattctggga cctgctccca gaatggagcc
     1681 aaaagagcaa agaacagcat caagtgacag aggtggaaga gaaagaactg ctaaatctgg
     1741 gggtcacatt ggaagagcag aatctgatcc caggttggac gttttacata gacatcttca
     1801 aagaaactca gaacgttcga gaagtaaatc tcggtctgaa aataatataa agaaactagc
     1861 ttcatctctt ccagataata agcaggagga aaatactgcc ttaaataagg actttttacc
     1921 tattgaaatt cgtggcattc ttgatgacct acagctggat tctacagctc acactgcaaa
     1981 gcaagatact gtagagttac agaaccagaa gtcatcagca ccagtacatg ctcctaggag
     2041 tcacagccca gtaaaaagaa aacctgacaa aataacagct aatgaagatc cccctgttat
     2101 ttccaaaagg cgccactatg acacagatga ggtacgacag tacattgtta ggcagcagga
     2161 ggaaaggaag agaaagcaaa atgaagagaa gaaggctcaa aaggaggcta cagaacagaa
     2221 aaacaaacga ttacaagagc tctaccggaa gcagaaggaa gcctttacta aagtaaaaaa
     2281 tgtccctcct tctgagccat cagcaactag gcgactacag gaaacttact ccaaattgct
     2341 actagaaaag accttgcttg aagagccatc tcatcaacat gttacgcagg aaacacaggc
     2401 caaaccaggg tatcagccat ctggagaatc tgacaaagaa aacaaagtac aggaacgtcc
     2461 cccaagtgca tcttccagta gtgacatgtc tctctcagaa cctccacagc ctcttgcaag
     2521 aaaagacttg atggaatcta catggatgca gcctgaaaga ttgagcccac aagttcacca
     2581 ttctcaacca cagccttttg ctggaacagc tggaagttta ctctcccatc tcttgagttt
     2641 agagcatgta ggaattttgc ataaggattt tgaatctatt ttaccaacca ggaagaatca
     2701 taatatggct tcaaggccat taacttttac acctcaacca tatgtgacct caccagctgc
     2761 ttatacagat gccttgttaa aacctagtgc cagccaatat aagagtaaac tggatcgtat
     2821 tgaagccttg aaagcaacag ctgcttcttt gtccagcaga attgaaagtg aagccaagaa
     2881 attagctggg gccagcatta actatgggtc agcatggaac actgagtatg atgtgcagca
     2941 ggcacctcaa gaagatggac cttggaccaa ggctgtaact ccacctgtga aagatgataa
     3001 tgaagatgtt ttctctgcca gaattcagaa gatgctggga agctgtgtat ctcatgcaac
     3061 ttttgatgat gatcttcctg gtgtaggcaa tcttagtgaa tttaaaaagc ttcctgagat
     3121 gataagacca cagagtgcca tatcaagctt tagagtgaga tcccctggtc ccaaaccaga
     3181 agggctactg gcacagttat gtaaaaggca gactgactct tctagctctg atatgcaagc
     3241 ctgttctcaa gacaaagcca aaatatctct tggttccagc atagattcag tcagtgaagg
     3301 gcctcttctt agtgagggga gtctctctga agaagaggga gaccaggatg gacagcccct
     3361 tttgaaagta gcagaaattt taaaagaaaa ggaattttgt cctggagaaa gaaatagtta
     3421 tgaacccatc aaagagtttc agaaagaagc tgaaaaattc ttgccacttt ttgggcacat
     3481 aggtggtaca caaagcaaag gaccatggga agaattggca aagggaagtc cacatagcgt
     3541 cattaatatt tttacaaaat cctatcagtt atatggaaaa gggtttgaag acaagttgga
     3601 cagaggaaca tcaacatcac ggcctttgaa tgccaccgca actcctctaa gtggtgtttc
     3661 atatgaagat gattttgtct cctctccagg gactgggact tcgacagaaa aaaaatcaac
     3721 tcttgaacct catagcactt taagccctca ggaggaccat tctaacagaa agtctgccta
     3781 tgatccttcc tctgtggatg ttacctccca gcattcatca ggagcccagt ctgctgcatc
     3841 gtctcgttca tctacttctt ctaaaggaaa gaaaggaaaa aaggaaaaga cagaatggtt
     3901 ggattcattc actggaaatg ttcagaactc acttcttgat gaggaaaaag cagaacgtgg
     3961 ctcccatcaa ggaaagaaat ctgggaccag cagcaaactt tctgttaaag attttgagca
     4021 gactcttgat acagatagca ctttggagga tctttctgga cattctgtga gtgtctcatc
     4081 agataaggga agatctcaga aaactccaac ttctcccctg tcaccaagtt cccagaaatc
     4141 attgcagttt gacgttgcag gaacttcttc agaaagatct aagtcgtcag taatgcctcc
     4201 aactataaca ggatttaagc ctaatgcacc tctcactgat ctgaacccgg cagccagcag
     4261 aacaacgaca gagaacatgg ctccaatacc aggttctaag cgcttttctc ctgctggcct
     4321 ccatcatcgt atggcagcag aactcagtta tctgaacgcc attgaggagt cggtgcgcca
     4381 actgtcagat gtagaaagag ttagaggcat ttcacttgct cagcaggaga gtgtgtctct
     4441 agctcagata ataaaggcac aacagcaacg ccatgaaaga gacttggccc tcttgaaact
     4501 aaaggctgaa caagaggctc tggagagtca gagacaatta gaagaaaccc gaaacaaagc
     4561 agctcaggtc catgcagaat cattacagca ggtggttcaa tcacaacggg aagtaactga
     4621 agtcctgcag gaagcaacgt gtaaaatagc agctcagcag tcagaaactg ctcgcctcac
     4681 cacagacgca gcacgtcaaa tctgtgagat ggcagagttg actagaactc atatctcaga
     4741 tgctgtcgtg gcttcaggag ctccccttgc aatactgtat gaccaccaac ggcagcacct
     4801 tccagacttt gtgaaacagc tgaggaccag aactgaaaca gataggaaaa gtccatctgt
     4861 ttcactctct cagagtaaag aagggaccct tgactcaaag catcagaagt attctgcttc
     4921 atatgatagt tattctgagt cttcaggata caagaatcat gatagaagaa gtagcagtgg
     4981 tagcagccgc caagaaagtc cttcagttcc atcttgtaag gaaaatgaga agaaacttaa
     5041 tggtgaaaag atagagagtt ccattgatga acaggttcag actgctgcag atgattctct
     5101 acgaagtgat agtgttccat ctcttcctga tgaaaaagac tcaacgtcta ttgcaacaga
     5161 atattctctg aaatttgatg aatccatgac agaagatgaa atagaagaac aatcatttcg
     5221 atcattacta ccttcagaga gtcaccgcag atttaacatg gaaaagagaa gaggtcatca
     5281 tgatgactct gatgaagaag cttctccaga aaaaactaca ctgtctactg ccaaggaact
     5341 gaacatgcca ttctcaggag gacaagatag cttttctaaa tttactatgg agatggttcg
     5401 acagtatatg aaagaggaag aaatgagggc agctcaccag tcttcactcc tgcgtctccg
     5461 tgaaaaggcc ttgaaggaga agactaaggc tgaattggcc tggttagagc atcaaaaaaa
     5521 acatctacga gacaaaggag aggatgataa aatgcccccg ctccggaaga aacagcgtgg
     5581 tttgctttta aggttgcagc aagaaaaggc agaaataaaa cgtcttcaag aagccaataa
     5641 ggcagctcgg aaggaaagac agctgattct taaacagcag gaggagatag aaaagatccg
     5701 acagaccacc ataaaactac aggagaaatt gaagtctgca ggggagagta aattggactc
     5761 tcatagtgat gatgatacaa aggataataa ggcaaccagt cctggtccaa ctgacttgga
     5821 gacccgcagt ccttctccca tttcaatctc cagcagtgaa actagcagca ttatgcagaa
     5881 actgaagaaa atgagaagcc gcatggatga aaagtttctg acaaagcggg agcaaaaatt
     5941 aatgcaacgg cgacaacatg cagaggagct cctagagtgg aagcgacgtt tagatgcaga
     6001 agaagcagaa attcgtcaaa tggaaaaaca agctttggct gcctgggaca aagaattaat
     6061 aaaacccaaa actcctaaga aagaactgga ggaccagaga acagaacaga aagaaatagc
     6121 aagtgaagag gaatctccag tacctctgta ctctcatcta aacagtgaaa gctccattcc
     6181 agaagaatta ggcagccctg ctgttgaata tgtaccatcc gagtctatag gacaggagca
     6241 gccagggagt ccagatcaca gtatacttac tgaagaaatg atttgttcac aggaactaga
     6301 atcttctacc tctcctagta aacattcact tcccaaaagc tgcacatctg tgtcaaagca
     6361 ggagtctagc aaaggaagtc ataggactgg aggacaatgt cacctgccta tcaagtccca
     6421 tcagcactgt tatagttggt cagatgagtc attatctatg acacagtcag aaactacatc
     6481 tgaccagagt gatattgaag gtaggatcag agctctgaag gatgagttgc ggaaaagaaa
     6541 atcagttgtg aaccagctga agaaggaaca gaaaaaaagg caaaaggaaa gactgaaagc
     6601 ccaagaagcc agtctgatca agcagttaga gtcatatgat gaatttatta agaaaactga
     6661 agccgagctt agccaagatt tggaaacatc accaacagcc aagcctcaga ttaaaacgct
     6721 ctcctcagct tctgaaaaac ccaagatcaa acccctcaca ccactacaca gatctgaaac
     6781 ggcaaagaat tggaaatcac taacagagtc agaacgttcc agaggatccc tggagtctat
     6841 tgctgaacat gttgatgctt cactgtctgg ttctgagaga tcagtatcag aaaggtcttt
     6901 atctgcatat gcaaagagag taaatgaatg ggacagtcga acagaagatt ttcagacccc
     6961 atctccagtt ctcagatcat caaggaaaat cagagaagaa tctggagatt ctctagaaaa
     7021 tgtacctgca ttacatcttc tcaaagaatt aaatgccact agtagaattc ttgatatgtc
     7081 agatggcaag gttggagaat ctagtaaaaa atcagaaata aaagaaatag agtatacaaa
     7141 attgaagaag agtaagattg aagatgcctt ttctaaagaa ggtaaatctg atgtcttact
     7201 gaaattagtc ctagaacagg gagattcatc tgaaattctt tcaaagaaag atcttccttt
     7261 agattctgaa aatgttcaga aagacctagt tggattagct attgaaaatc tccataaaag
     7321 tgaggaaatg ttgaaagaga gacagtcaga tcaagatatg aatcatagtc caaacatcca
     7381 atcaggaaaa gacattcacg aacaaaagaa cacaaaggaa aaagatttgt cttggtcaga
     7441 acatcttttt gctcctaaag agataccata ctctgaagat tttgaagtgt cttctttcaa
     7501 gaaagaaatt tcagctgaat tgtacaaaga tgattttgag gtgtcatctt tgctgtcact
     7561 caggaaagac tctcagtctt gcagagataa gccacagcca atgaggagct ctacaagtgg
     7621 agccactagc tttggtagta atgaggaaat cagtgagtgc ctaagtgaga aaagcctttc
     7681 tatccatagc aatgttcatt ctgacaggct gttggaactc aagtccccta ctgagctgat
     7741 gaaaagtaag gagcgcagtg atgtggagca tgaacagcaa gttactgaat ccccttcctt
     7801 ggcttcagtt cctactgcag acgagttatt tgatttccac attggtgata gggtgttgat
     7861 tggaaatgtt cagccaggaa ttcttcgatt caaaggtgag actagttttg ctaaaggatt
     7921 ttgggccgga gtggagttag ataaacctga aggaaataac aatggaacat atgatggtat
     7981 tgcatatttt gagtgcaaag aaaagcatgg tatttttgct cctcctcaaa aaatatctca
     8041 cattccagaa aactttgatg actatgtaga cattaatgaa gatgaagact gttactcaga
     8101 tgaacgatat cagtgctata atcaagagca aaatgataca gagggtccaa aagacagaga
     8161 aaaggatgtc agtgaatatt tttatgagaa atccctacct agtgtgaatg atatagaagc
     8221 ctcagttaat agaagtagaa gccttaaaat agaaacagac aatgtacagg acatttctgg
     8281 ggtacttgaa gcccatgttc accagcagtc ttcagtggat tcacagattt cttcaaagga
     8341 aaacaaagac ctcatttctg atgccacaga aaaggtttcc atcgctgcag aagatgacac
     8401 tttagacaat accttttccg aagaattgga gaagcaacag cagtttacag aagaggaaga
     8461 caacctatat gctgaagctt cagaaaagct ttgtacacca cttctggatc ttttaacaag
     8521 agaaaaaaac caactggaag cccagctgaa gtcatcacta aatgaggaaa aaaagtcaaa
     8581 acaacaactg gaaaaaatca gcttactgac agacagttta ctaaaagtct ttgtaaagga
     8641 cacagtcaat caactacaac aaatcaaaaa aaccagggat gagaaaatcc agcttagcaa
     8701 tcaggagctt cttggtgatg accaaaagaa agtaacaccc caagacctat cccaaaatgt
     8761 tgaggaacag tcgccaagta tttcaggttg cttcttaagt tctgaattgg aagatgaaaa
     8821 agaagagatt tcctctccag atatgtgtcc cagaccggag agcccagtat ttggtgccag
     8881 tgggcaggaa gaacttgcta agagacttgc tgaacttgaa ctcagccggg agttcctgag
     8941 cgcgttagga gatgatcaag actggtttga tgaagacttt ggtttgagct cttctcacaa
     9001 gatccaaaaa aataaggcag aagaaaccat tgtacctcta atggcagaac ctaaaagagt
     9061 aacccaacaa ccatgtgaaa cattattggc agtcccccat actgcagaag aagtagagat
     9121 tcttgtacat aatgcagcag aagaactttg gaaatggaaa gaattaggcc acgatcttca
     9181 tagcatcagt attcctacaa aactgcttgg ctgtgccagt aaaggtctag atatagaaag
     9241 cactagtaaa agggtctaca aacaggcggt ttttgattta acaaaagaga tttttgagga
     9301 aatatttgct gaggatccca acttaaatca acctgtctgg atgaagccat gtagaatcaa
     9361 ctctagttat ttccgacgag tgaaaaatcc aaataacctt gatgaaatca agagcttcat
     9421 agcaagtgaa gtactcaagt tgttcagtct taaaaaggag ccaaaccaca aaacagattg
     9481 gcagaaaatg atgaaatttg gaagaaagaa aagagaccga gtggatcata tcctggttca
     9541 ggagctccat gaggaggagg cacagtgggt gaactatgat gaggatgagt tgtgtgtgaa
     9601 aatgcagcta gccgacggga tctttgagac cctgatcaaa gatactattg atgttctgaa
     9661 tcagatcagt gaaaagcagg ggagaatgct acttgtgtga catcttgcaa ataaatcgaa
     9721 cgctgagtgc taatgtgagt cctgggcctt tctgcctcct gatgtacacc catcgccatc
     9781 atagcaagag tgcttctgga ccttgtactt attcttaaag actaccagta tggagttcat
     9841 aggacaatgt ggtacacctg gtattacagc ctttgccttt cgagactatc cactggatta
     9901 atgggttatt ttcagtgggc agggttgcac agtgtaatcc tacacctttt gctaacaccc
     9961 ctactaggtc ccagagggcc agaaacacct gacttacctc tgagtttaga ctagggtatc
    10021 acttctttga gtctgaagtc aagtgagaga ggtatagata aatgcatcac atcacttttg
    10081 aaatgtaatt ctggtctata ccatggaagt cataaatgga cattatagtc tctaaacagt
    10141 attaaaccct taaccacttc taaaataggc aagctcaata atgtctgcca acttcacatt
    10201 ctggagttta tttcatttct ttttgaagac cattttcttc cattattgta gttgagcagc
    10261 accaagtgga ctgtcaggct aacaggaata agtggtagcc ttgctttctg agcaccatct
    10321 aaagaatttt aaacctctgc attatgttta gtgttctctg tgtgggcatg aaaacaaaga
    10381 aatgccccta ctgaagactg ggctcaaagg accaatgcag ggctggttct tttacccctt
    10441 ggtttactcc tgcacttgtc ttactcattc tgaatctcta ccagctgctc ccagaatcac
    10501 agatactcag gaccatctca ggcatccagg catggcaaag tggaaataat tcattttggc
    10561 ctgcaaacct tcaactccca tctttcccca agaagtcaga gatgctgtta cttgaatgat
    10621 ttaggaaatg agtgtgtgca ccaaagacaa aaagatattg tctattgttt gtgtgcttgt
    10681 tttgcgctat ggaacatttt ttaatttatt ttaagataaa ttattaagtt gaaaatgtgt
    10741 gtccctattc agaagtgaaa gattcatctt gtaatagtta aacctccatc ttgaagcttc
    10801 tatggttcat agtctttgca caggaacctg tggttttaac aaaccaatac acatattgaa
    10861 gaagtcattt taattcagtg aaacgaagat gggcttttcc agatcacctg caatagcagc
    10921 agtgggataa aatgatttaa aaacactgta caatttaact ctgcctctct tgcagcattg
    10981 cttctcacaa ctattacctg catctgaaaa aaaatctata gactccagct gctacattag
    11041 agcataagag atgctctcct gggacctcag taccctgcct tcttgactgg tttccgttca
    11101 tcagtcctgt ccctcttcaa gtaatctaga agaatgtgga tactcttagg cgtgaatgta
    11161 aatgccttaa tattgaaggt cctggttaga agcatgatac aagacatcta ctggattcat
    11221 atttacaaat atcctggaat gttatagctt caaagtatat tagaaaaacc ccaaagatgg
    11281 tataatcttt aagtgtgcac gttcgtttat ttctgcatct tccctccaaa cttgcctttg
    11341 catcttaaat atttcactat gcacactccc attcctcttg ggtttcatct tgtcgtttaa
    11401 gaaatgtact gaaataatca ttggaatatt tgcattttgc acaatgactg gtatgatagc
    11461 tcttgacaaa taaggaaagc actgaaatgt tgtgattggg tctcgggaaa tgctcagatt
    11521 gatgtcttac cagcatttct tctgggcttg tgatgttgag ctgtagtctt gtagccataa
    11581 tgagcaaatt gactaagaga agcaaaggtt tcttggggtt attaaccagt agtgtggaaa
    11641 tactagtttt atgtggccaa ggaaaagcaa aggcttttct tttcagtttg tgttatttgg
    11701 aagacagaaa aacatcttgt ctacatcctt tggctgtttg taggatcacg ttgtccttac
    11761 gatactgaaa ctttacagct gctgtaaatt ttttataaat gaatttcaaa atgttataat
    11821 gggactgtag gttgtttttc tacatcttca ttatttggac ctaaaaccag tttttaataa
    11881 gaaagtttat ctttactctt tctgaaatta tgactccaga aaaagaaaaa aaaaatacaa
    11941 gtcatggaat cagcaatctg gtaagaaatg ctgccaagaa tgtggcagta gctgtcctga
    12001 cagactccaa ctgtctttac tatctgaaga atcctaggct ccacatgaga ggcagaaatg
    12061 gatcagtctt attcttttct agaaatggtt atctgtagtt tggtagcaaa aaaaaagaaa
    12121 aaagaatcca taattagcag atttcttatt aactatttgg atctaattga aatggcttta
    12181 ttcttaggat taagaaagat agatgtggat acccagccac tcgttccata ttggtatctt
    12241 tttaaatcag ctctgcctct taatcaagaa cctaaatatt ccctctttct aatctttgtt
    12301 ccttctccct acaccctcat cctctttcac tcttccttca taattcctct aagaaaaata
    12361 tctttgcatc agcagtaata tcttttagaa tagcactatc agaatttagc agtaaaccaa
    12421 catacaggct tcagatttac ttctgagtcc aaaacaattt gtgctatcca gggtagttaa
    12481 ctctgggtta aacaagtaca gggtatagat tccctcttca ggtctacaca ggaattttta
    12541 ccatagggaa aagtggggag agctcaaacg tagttaataa ggaaggtaat ttgtttttct
    12601 tttacctaaa agaaaagaaa attccttctg tgactacagg tctctgagaa attatctttc
    12661 aaaagagatt tcattgctca taagagtgtt gtggcctatt gataaaaaca attttgttca
    12721 gtttcttgtc ttgaaaaaaa agtggcctta gctttttgca atacttgaat aaagtgtgta
    12781 ctcgcaaaag aatttctgta gcacagcatt agagactcat aacttttctg caagaaatac
    12841 aaacttacat cttcctttta ctaccttaag aatactagtg aataaaacat taattcaaag
    12901 agcaaattat agaaactaca atgacattta atgcaaattg taggaattta catgtttaca
    12961 aatcatcttc aactggttgt gcagcaattc aataaaatat ctttgtatta taaaaatgtg
    13021 aagaaaaaat gtaaactgat gtaaaggagg tactgtcatt ttaattaacc tatgtttaat
    13081 agcttttcct tctggacttt gcaaagcctt cttggcaaac acattgcaaa gcattctctg
    13141 ggaggttcag cctccttgtg tgtactgtac tgtgcagaca tgaaaaaata aacccgttta
    13201 ctgtgtgcgt gtaaatagcc tggtcatcag gccattttca gccaatagtc acatccagtg
    13261 caattttgca ccgaacactt aagggtgtgg tttgtaagta cgatctgtaa aataactggg
    13321 atgaattccc atgtatacct gtgtaaatag atttgttaac tgaaatatac tttaagaaag
    13381 ataaaatctg taaataaact gatttataaa ttaa
//
