LOCUS       NM_144600               2264 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens centrosomal protein 20 (CEP20), transcript variant 1,
            mRNA.
ACCESSION   NM_144600
VERSION     NM_144600.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2264)
  AUTHORS   Simon,M.A., Ecsedi,P., Kovacs,G.M., Poti,A.L., Remenyi,A.,
            Kardos,J., Gogl,G. and Nyitray,L.
  TITLE     High-throughput competitive fluorescence polarization assay reveals
            functional redundancy in the S100 protein family
  JOURNAL   FEBS J 287 (13), 2834-2846 (2020)
   PUBMED   31837246
REFERENCE   2  (bases 1 to 2264)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2264)
  AUTHORS   Ali,M., Lemonakis,K., Wihlborg,A.K., Veskovski,L., Turesson,I.,
            Mellqvist,U.H., Gullberg,U., Hansson,M. and Nilsson,B.
  TITLE     Sequence variation at the MTHFD1L-AKAP12 and FOPNL loci does not
            influence multiple myeloma survival in Sweden
  JOURNAL   Blood Cancer J 9 (8), 57 (2019)
   PUBMED   31363079
  REMARK    GeneRIF: Results together with the limitations of the original
            studies indicate that the reported associations between the MTHFD1L
            and FOPNL loci and MM survival are false positives due to a
            winner's curse effect.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2264)
  AUTHORS   Kiss,K.P., Varga,G., Mikala,G., Balassa,K., Bors,A., Kovy,P.,
            Meggyesi,N., Kozma,A., Csacsovszki,O., Remenyi,P., Valyi-Nagy,I.,
            Tordai,A., Masszi,T. and Andrikovics,H.
  TITLE     The adverse effect of FOPNL genomic variant is reversed by
            bortezomib-based treatment protocols in multiple myeloma
  JOURNAL   Leuk Lymphoma 59 (3), 710-716 (2018)
   PUBMED   28691553
  REMARK    GeneRIF: FOPNL genomic variant is associated with multiple myeloma.
REFERENCE   5  (bases 1 to 2264)
  AUTHORS   Sakane,K., Nishiguchi,M., Denda,M., Yamagchi,F., Magari,M.,
            Kanayama,N., Morishita,R. and Tokumitsu,H.
  TITLE     Identification and characterization of a centrosomal protein, FOR20
            as a novel S100A6 target
  JOURNAL   Biochem Biophys Res Commun 491 (4), 980-985 (2017)
   PUBMED   28765046
  REMARK    GeneRIF: The S100A6 interacts with FOR20 and related centrosomal
            proteins through a conserved N-terminal domain, suggesting a novel
            Ca(2+)-dependent regulation of centrosomal function.
REFERENCE   6  (bases 1 to 2264)
  AUTHORS   Srivastava,S. and Panda,D.
  TITLE     A centrosomal protein FOR20 regulates microtubule assembly dynamics
            and plays a role in cell migration
  JOURNAL   Biochem J 474 (16), 2841-2859 (2017)
   PUBMED   28694353
  REMARK    GeneRIF: The results suggested that the centrosomal protein FOR20
            is a new member of the microtubule-associated protein family and
            that it regulates the assembly and dynamics of microtubules while
            interacting with tubulin.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2264)
  AUTHORS   Shen,M., Cai,Y., Yang,Y., Yan,X., Liu,X. and Zhou,T.
  TITLE     Centrosomal protein FOR20 is essential for S-phase progression by
            recruiting Plk1 to centrosomes
  JOURNAL   Cell Res 23 (11), 1284-1295 (2013)
   PUBMED   24018379
  REMARK    GeneRIF: The depletion of FOR20 (FOP-related protein of 20 kDa), a
            conserved centrosomal protein, inhibits S-phase progression and
            prevents targeting of Plk1 (polo-like kinase 1) to centrosomes,
            where FOR20 interacts with Plk1.
REFERENCE   8  (bases 1 to 2264)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   9  (bases 1 to 2264)
  AUTHORS   Sedjai,F., Acquaviva,C., Chevrier,V., Chauvin,J.P., Coppin,E.,
            Aouane,A., Coulier,F., Tolun,A., Pierres,M., Birnbaum,D. and
            Rosnet,O.
  TITLE     Control of ciliogenesis by FOR20, a novel centrosome and
            pericentriolar satellite protein
  JOURNAL   J Cell Sci 123 (Pt 14), 2391-2401 (2010)
   PUBMED   20551181
  REMARK    Erratum:[J Cell Sci. 2010 Jul 15;123(Pt 14):2521]
REFERENCE   10 (bases 1 to 2264)
  AUTHORS   de Kovel,C.G., Trucks,H., Helbig,I., Mefford,H.C., Baker,C.,
            Leu,C., Kluck,C., Muhle,H., von Spiczak,S., Ostertag,P.,
            Obermeier,T., Kleefuss-Lie,A.A., Hallmann,K., Steffens,M., Gaus,V.,
            Klein,K.M., Hamer,H.M., Rosenow,F., Brilstra,E.H., Trenite,D.K.,
            Swinkels,M.E., Weber,Y.G., Unterberger,I., Zimprich,F., Urak,L.,
            Feucht,M., Fuchs,K., Moller,R.S., Hjalgrim,H., De Jonghe,P.,
            Suls,A., Ruckert,I.M., Wichmann,H.E., Franke,A., Schreiber,S.,
            Nurnberg,P., Elger,C.E., Lerche,H., Stephani,U., Koeleman,B.P.,
            Lindhout,D., Eichler,E.E. and Sander,T.
  TITLE     Recurrent microdeletions at 15q11.2 and 16p13.11 predispose to
            idiopathic generalized epilepsies
  JOURNAL   Brain 133 (Pt 1), 23-32 (2010)
   PUBMED   19843651
  REMARK    GeneRIF: Microdeletions at 16p13.11 are associated with a
            predisposition to idiopathic generalized epilepsy.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY004717.1, AK055715.1 and AL832498.1.
            
            On Nov 22, 2018 this sequence version replaced NM_144600.3.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832498.1, AY507846.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255759.11/ ENSP00000255759.6
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                HY004717.1         48-60
            14-1613             AK055715.1         3-1602
            1614-2264           AL832498.1         1624-2274
FEATURES             Location/Qualifiers
     source          1..2264
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.11"
     gene            1..2264
                     /gene="CEP20"
                     /gene_synonym="C16orf63; FOPNL; FOR20; PHSECRG2"
                     /note="centrosomal protein 20"
                     /db_xref="GeneID:123811"
                     /db_xref="HGNC:HGNC:26435"
                     /db_xref="MIM:617149"
     exon            1..46
                     /gene="CEP20"
                     /gene_synonym="C16orf63; FOPNL; FOR20; PHSECRG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..543
                     /gene="CEP20"
                     /gene_synonym="C16orf63; FOPNL; FOR20; PHSECRG2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pluripotent embryonic stem cell-related protein;
                     FOP-related protein of 20 kDa; lisH domain-containing
                     protein C16orf63; lisH domain-containing protein FOPNL;
                     FGFR1OP N-terminal like"
                     /codon_start=1
                     /product="centrosomal protein 20 isoform 1"
                     /protein_id="NP_653201.1"
                     /db_xref="CCDS:CCDS10567.1"
                     /db_xref="GeneID:123811"
                     /db_xref="HGNC:HGNC:26435"
                     /db_xref="MIM:617149"
                     /translation="MATVAELKAVLKDTLEKKGVLGHLKARIRAEVFNALDDDREPRP
                     SLSHENLLINELIREYLEFNKYKYTASVLIAESGQPVVPLDRQFLIHELNAFEESKDN
                     TIPLLYGILAHFLRGTKDGIQNAFLKGPSLQPSDPSLGRQPSRRKPMDDHLRKEEQKS
                     TNIEDLHVSQAVNR"
     exon            47..244
                     /gene="CEP20"
                     /gene_synonym="C16orf63; FOPNL; FOR20; PHSECRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            245..329
                     /gene="CEP20"
                     /gene_synonym="C16orf63; FOPNL; FOR20; PHSECRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            330..466
                     /gene="CEP20"
                     /gene_synonym="C16orf63; FOPNL; FOR20; PHSECRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            467..2264
                     /gene="CEP20"
                     /gene_synonym="C16orf63; FOPNL; FOR20; PHSECRG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      690..695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP20"
                     /gene_synonym="C16orf63; FOPNL; FOR20; PHSECRG2"
                     /note="hexamer: AATAAA"
     polyA_site      714
                     /gene="CEP20"
                     /gene_synonym="C16orf63; FOPNL; FOR20; PHSECRG2"
     regulatory      2243..2248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP20"
                     /gene_synonym="C16orf63; FOPNL; FOR20; PHSECRG2"
                     /note="hexamer: AATAAA"
     polyA_site      2264
                     /gene="CEP20"
                     /gene_synonym="C16orf63; FOPNL; FOR20; PHSECRG2"
                     /note="major polyA site"
ORIGIN      
        1 cctggcggcc gttgaaaaat ggcgactgtg gcagagttga aggctgtttt aaaggacacc
       61 ttggaaaaaa agggggtatt agggcattta aaagcaagga tccgagctga agttttcaat
      121 gccctagatg atgaccgtga accccgacca tcattgtctc atgaaaacct tctaattaat
      181 gaattaattc gagagtattt agaattcaac aaatataagt atacagcatc tgtcctcata
      241 gcagaatctg gtcaacctgt agttccgttg gacagacagt ttctcatcca tgaactaaat
      301 gcatttgaag aatcaaagga taatacaata cctcttttat atgggatttt agcccatttc
      361 ttgcgtggaa ctaaggatgg catccagaat gcatttctga aagggccttc acttcagcct
      421 tcagacccaa gtcttggcag acaacctagt agaagaaagc caatggatga ccacctaaga
      481 aaggaggaac agaaaagtac taacattgaa gatcttcatg tttctcaggc agtcaacaga
      541 taatgctttg tttggggtat cttttgtctt aaaattgtat tattaattaa ataacttatt
      601 tattgtccca atgttaccaa aatgcaccac taatgtttgt agaaattgga gtttctacaa
      661 aacacccctc atgtttaact acatttgtga ataaaagcta actcttgtca tctagcttat
      721 tggatttgac ttgaaaaaaa aagtattgtt tttacgaagt attttttgtt tttttgagat
      781 ggagtctcgc tctgtcaccc agactggagt gcagtggcac gatctcggct cactgcaatc
      841 tctgcctccc ggattcaagt gattctcctg cctcagcctc ccaagtagct gggaaaacag
      901 gcctgtgcca ccacaccgga gtagtttttg tatttttagt agagatgggg tttcaccatg
      961 ctggccaggc tggtcttgaa ctcctgacct caggtgatct gtgtgcccca gcctcccaaa
     1021 gcgctgggat tacaggtgtg agccactgag cccagccatt taggaagtat tataaaggcc
     1081 cttaaagttt gtaaggaaat gaaagggctt tgtattacct tttcaatagg caacaatgta
     1141 ctttttcttt ccttagactt tggcttactg gaagatttaa ttaaaaggta gaggagaagt
     1201 aaatttgctg taataatttt gctgtaaata aaacaaagag tttattttat tagataaaga
     1261 atgtgaagta agcatgaaga gacaggcttt gggagaaata ccagaaaggg atttttcaaa
     1321 gatggcattg tttaatctcc gtgtggccct cggttgtgca atcacagatg agccagaaga
     1381 gggccagccc cctacttgtt tgggctccga aactcttacc aaacatcaat ttttattctt
     1441 gggatagaaa aatagtatgt gctatctcta atacgctact tcgatattta ttaaagaagt
     1501 atttttaatg tagtgtccac aggctcattt cattgaaaac aactgactat gatgatagac
     1561 agctcctgat tggcaaaagt tcgatggtat attcagaatt aaattttgcc tgcacaccta
     1621 aacactgaca acatttagct taaaggtttt ccatggagaa gagtggtaag agctgtagtt
     1681 agcaaaattg gcatcctctt tagggtgtca attctgtgct gctttgcaaa ttgttgaaac
     1741 ttttgatttt ctgtttggca atgctagtca gtgttcactt cttacagatt agccaagaat
     1801 ttttatctaa atgcagaaac ttattaatga aatccattta aactatactt acacaacatt
     1861 ttgggaggcc ctgctggtaa aattatatat ggatgcagaa gtattgcaag agtccatttt
     1921 ccatttttaa atctgcaata tctgattaca ttgatgaatt ccgttgtatt gtatgtgtga
     1981 atataaatat ctgaattctc ccgggggact tggttttcgt ccaaggatgt tggcagtgga
     2041 cacttagttt acctcaggaa ttgcaatcat gtaagactat attcggaaaa aatgctggag
     2101 tatataattt tggatactga tataaaatca tcaagatgga agttaagcag aattgtcacg
     2161 tgtagtccat agcgctttta tatgcattat tctgtaattt gtttgtactg cggcaacttt
     2221 ttatactttc aatgtatcat ttaataaaaa aaataagcaa gtca
//
