LOCUS       NM_032142               7960 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens centrosomal protein 192 (CEP192), mRNA.
ACCESSION   NM_032142
VERSION     NM_032142.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7960)
  AUTHORS   Guo,J., He,W.B., Dai,L., Tian,F., Luo,Z., Shen,F., Tu,M., Zheng,Y.,
            Zhao,L., Tan,C., Guo,Y., Meng,L.L., Liu,W., Deng,M., Wu,X.,
            Peng,Y., Zhang,S., Lu,G.X., Lin,G., Wang,H., Tan,Y.Q. and Yang,Y.
  TITLE     Mosaic variegated aneuploidy syndrome with tetraploid, and
            predisposition to male infertility triggered by mutant CEP192
  JOURNAL   HGG Adv 5 (1), 100256 (2024)
   PUBMED   37981762
  REMARK    GeneRIF: Mosaic variegated aneuploidy syndrome with tetraploid, and
            predisposition to male infertility triggered by mutant CEP192.
REFERENCE   2  (bases 1 to 7960)
  AUTHORS   Liu,Y., Liang,W., Chang,Y., He,Z., Wu,M., Zheng,H., Ke,X., Lv,M.,
            Liu,Q., Liu,Q., Tang,W., Huang,Q., Lu,Y., He,M., Yang,Q., Mo,C.,
            Wang,J., Peng,K., Min,Z., Su,H. and Chen,J.
  TITLE     CEP192 is a novel prognostic marker and correlates with the immune
            microenvironment in hepatocellular carcinoma
  JOURNAL   Front Immunol 13, 950884 (2022)
   PUBMED   36238304
  REMARK    GeneRIF: CEP192 is a novel prognostic marker and correlates with
            the immune microenvironment in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7960)
  AUTHORS   Batman,U., Deretic,J. and Firat-Karalar,E.N.
  TITLE     The ciliopathy protein CCDC66 controls mitotic progression and
            cytokinesis by promoting microtubule nucleation and organization
  JOURNAL   PLoS Biol 20 (7), e3001708 (2022)
   PUBMED   35849559
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7960)
  AUTHORS   O'Neill,A.C., Uzbas,F., Antognolli,G., Merino,F., Draganova,K.,
            Jack,A., Zhang,S., Pedini,G., Schessner,J.P., Cramer,K.,
            Schepers,A., Metzger,F., Esgleas,M., Smialowski,P., Guerrini,R.,
            Falk,S., Feederle,R., Freytag,S., Wang,Z., Bahlo,M., Jungmann,R.,
            Bagni,C., Borner,G.H.H., Robertson,S.P., Hauck,S.M. and Gotz,M.
  TITLE     Spatial centrosome proteome of human neural cells uncovers
            disease-relevant heterogeneity
  JOURNAL   Science 376 (6599), eabf9088 (2022)
   PUBMED   35709258
REFERENCE   5  (bases 1 to 7960)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 7960)
  AUTHORS   Andersen,J.S., Wilkinson,C.J., Mayor,T., Mortensen,P., Nigg,E.A.
            and Mann,M.
  TITLE     Proteomic characterization of the human centrosome by protein
            correlation profiling
  JOURNAL   Nature 426 (6966), 570-574 (2003)
   PUBMED   14654843
REFERENCE   7  (bases 1 to 7960)
  AUTHORS   Casenghi,M., Meraldi,P., Weinhart,U., Duncan,P.I., Korner,R. and
            Nigg,E.A.
  TITLE     Polo-like kinase 1 regulates Nlp, a centrosome protein involved in
            microtubule nucleation
  JOURNAL   Dev Cell 5 (1), 113-125 (2003)
   PUBMED   12852856
REFERENCE   8  (bases 1 to 7960)
  AUTHORS   Takahashi,M., Yamagiwa,A., Nishimura,T., Mukai,H. and Ono,Y.
  TITLE     Centrosomal proteins CG-NAP and kendrin provide microtubule
            nucleation sites by anchoring gamma-tubulin ring complex
  JOURNAL   Mol Biol Cell 13 (9), 3235-3245 (2002)
   PUBMED   12221128
REFERENCE   9  (bases 1 to 7960)
  AUTHORS   Mayor,T., Stierhof,Y.D., Tanaka,K., Fry,A.M. and Nigg,E.A.
  TITLE     The centrosomal protein C-Nap1 is required for cell cycle-regulated
            centrosome cohesion
  JOURNAL   J Cell Biol 151 (4), 837-846 (2000)
   PUBMED   11076968
REFERENCE   10 (bases 1 to 7960)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK096548.1, DB079620.1, BX648232.1, AL833494.2, BC144481.1 and
            AB046789.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032142.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: KJ567064.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1965299, SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000506447.5/ ENSP00000427550.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AK096548.1         1-21
            22-312              DB079620.1         1-291
            313-556             AK096548.1         313-556
            557-1280            BX648232.1         143-866
            1281-1742           AL833494.2         1-462
            1743-4733           BC144481.1         489-3479
            4734-7342           AB046789.1         1913-4521
            7343-7960           BX648232.1         8002-8619
FEATURES             Location/Qualifiers
     source          1..7960
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.21"
     gene            1..7960
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /note="centrosomal protein 192"
                     /db_xref="GeneID:55125"
                     /db_xref="HGNC:HGNC:25515"
                     /db_xref="MIM:616426"
     exon            1..76
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            77..244
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..7694
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /note="protein phosphatase 1, regulatory subunit 62; 192
                     kDa centrosomal protein; centrosomal protein 192kDa;
                     cep192/SPD-2"
                     /codon_start=1
                     /product="centrosomal protein of 192 kDa"
                     /protein_id="NP_115518.3"
                     /db_xref="CCDS:CCDS32792.2"
                     /db_xref="GeneID:55125"
                     /db_xref="HGNC:HGNC:25515"
                     /db_xref="MIM:616426"
                     /translation="MEDFRGIAEESFPSFLTNSLFGNSGILENVTLSSNLGLPVAVST
                     LARDRSSTDNRYPDIQASYLVEGRFSVPSGSSPGSQSDAEPRERLQLSFQDDDSISRK
                     KSYVESQRLSNALSKQSALQMETAGPEEEPAGATESLQGQDLFNRASPLEQAQDSPID
                     FHLQSWMNNKEPKIVVLDAGKHFEDKTLKSDLSHTSLLENEKLILPTSLEDSSDDDID
                     DEMFYDDHLEAYFEQLAIPGMIYEDLEGPEPPEKGFKLPTNGLRQANENGSLNCKFQS
                     ENNSSLISLDSHSSETTHKESEESQVICLPGTSNSIGTGDSRRYTDGMLPFSSGTWGT
                     EKEIENLKGIVPDLNSECASKDVLVKTLRAIDVKLNSDNFHDANANRGGFDLTDPVKQ
                     GAECPHQNKTVLHMDGCLDTETPTVSIQENVDVASLKPISDSGINFTDAIWSPTCERR
                     TCECHESIEKNKDKTDLPQSVVYQNEEGRWVTDLAYYTSFNSKQNLNVSLSDEMNEDF
                     RSGSEAFDLIAQDEEEFNKEHQFIQEENIDAHNTSVALGDTSWGATINYSLLRKSRST
                     SDLDKDDASYLRLSLGEFFAQRSEALGCLGGGNNVKRPSFGYFIRSPEKREPIALIRK
                     SDVSRGNLEKEMAHLNHDLYSGDLNEQSQAQLSEGSITLQVEAVESTSQVDENDVTLT
                     ADKGKTEDTFFMSNKPQRYKDKLPDSGDSMLRISTIASAIAEASVNTDPSQLAAMIKA
                     LSNKTRDKTFQEDEKQKDYSHVRHFLPNDLEKSNGSNALDMEKYLKKTEVSRYESALE
                     NFSRASMSDTWDLSLPKEQTTQDIHPVDLSATSVSVRAPEENTAAIVYVENGESENQE
                     SFRTINSSNSVTNRENNSAVVDVKTCSIDNKLQDVGNDEKATSISTPSDSYSSVRNPR
                     ITSLCLLKDCEEIRDNRENQRQNECVSEISNSEKHVTFENHRIVSPKNSDLKNTSPEH
                     GGRGSEDEQESFRPSTSPLSHSSPSEISGTSSSGCALESFGSAAQQQQPPCEQELSPL
                     VCSPAGVSRLTYVSEPESSYPTTATDDALEDRKSDITSELSTTIIQGSPAALEERAME
                     KLREKVPFQNRGKGTLSSIIQNNSDTRKATETTSLSSKPEYVKPDFRWSKDPSSKSGN
                     LLETSEVGWTSNPEELDPIRLALLGKSGLSCQVGSATSHPVSCQEPIDEDQRISPKDK
                     STAGREFSGQVSHQTTSENQCTPIPSSTVHSSVADMQNMPAAVHALLTQPSLSAAPFA
                     QRYLGTLPSTGSTTLPQCHAGNATVCGFSGGLPYPAVAGEPVQNSVAVGICLGSNIGS
                     GWMGTSSLCNPYSNTLNQNLLSTTKPFPVPSVGTNCGIEPWDSGVTSGLGSVRVPEEL
                     KLPHACCVGIASQTLLSVLNPTDRWLQVSIGVLSISVNGEKVDLSTYRCLVFKNKAII
                     RPHATEEIKVLFIPSSPGVFRCTFSVASWPCSTDAETIVQAEALASTVTLTAIAESPV
                     IEVETEKKDVLDFGDLTYGGWKALPLKLINRTHATVPIRLIINANAVAWRCFTFSKES
                     VRAPVEVAPCADVVTRLAGPSVVNHMMPASYDGQDPEFLMIWVLFHSPKKQISSSDIL
                     DSAEEFSAKVDIEVDSPNPTPVLRSVSLRARAGIARIHAPRDLQTMHFLAKVASSRKQ
                     HLPLKNAGNIEVYLDIKVPEQGSHFSVDPKNLLLKPGEEHEVIVSFTPKDPEACEERI
                     LKIFVQPFGPQYEVVLKGEVISSGSKPLSPGPCLDIPSILSNKQFLAWGGVPLGRTQL
                     QKLALRNNSASTTQHLRLLIRGQDQDCFQLQNTFGSEQRLTSNCEIRIHPKEDIFISV
                     LFAPTRLSCMLARLEIKQLGNRSQPGIKFTIPLSGYGGTSNLILEGVKKLSDSYMVTV
                     NGLVPGKESKIVFSVRNTGSRAAFVKAVGFKDSQKKVLLDPKVLRIFPDKFVLKERTQ
                     ENVTLIYNPSDRGINNKTATELSTVYLFGGDEISRQQYRRALLHKPEMIKQILPEHSV
                     LQNINFVEAFQDELLVTEVYDLPQRPNDVQLFYGSMCKIILSVIGEFRDCISSREFLQ
                     PSSKASLESTSDLGASGKHGGNVSLDVLPVKGPQGSPLLSRAARPPLDQLASEEPWTV
                     LPEHLILVAPSPCDMAKTGRFQIVNNSVRLLRFELCWPAHCLTVTPQHGCVAPESKLQ
                     ILVSPNSSLSTKQSMFPWSGLIYIHCDDGQKKIVKVQIREDLTQVELLTRLTSKPFGI
                     LSPVSEPSVSHLVKPMTKPPSTKVEIRNKSITFPTTEPGETSESCLELENHGTTDVKW
                     HLSSLAPPYVKGVDESGDVFRATYAAFRCSPISGLLESHGIQKVSITFLPRGRGDYAQ
                     FWDVECHPLKEPHMKHTLRFQLSGQSIEAENEPENACLSTDSLIKIDHLVKPRRQAVS
                     EASARIPEQLDVTARGVYAPEDVYRFRPTSVGESRTLKVNLRNNSFITHSLKFLSPRE
                     PFYVKHSKYSLRAQHYINMPVQFKPKSAGKFEALLVIQTDEGKSIAIRLIGEALGKN"
     exon            245..370
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            371..546
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            547..599
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            600..720
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            721..869
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1005
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1130
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1470
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1614
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1679
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1889
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2016
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2147
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2970
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            2971..3097
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            3098..3269
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            3270..4188
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            4189..4337
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            4338..4568
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            4569..4694
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            4695..4838
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            4839..4902
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            4903..5042
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            5043..5135
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            5136..5254
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            5255..5428
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            5429..5519
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            5520..5696
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            5697..5957
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            5958..6073
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            6074..6183
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            6184..6334
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            6335..6513
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            6514..6637
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            6638..6743
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            6744..6951
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            6952..7031
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            7032..7127
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            7128..7247
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            7248..7369
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            7370..7496
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            7497..7555
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     exon            7556..7960
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7938..7943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /note="hexamer: AATAAA"
     polyA_site      7960
                     /gene="CEP192"
                     /gene_synonym="PPP1R62"
                     /note="major polyA site"
ORIGIN      
        1 agtgccctgg gacacctctt cagtccgtgg actttcccgc tgcacactgc cctccgaagt
       61 cggggacgcg ggctcgtgag atggaagatt ttcgaggtat agcagaagaa tcatttccaa
      121 gctttctcac caattcatta tttggtaaca gtgggatttt ggaaaatgtc actctttctt
      181 caaatcttgg cttgcctgtt gctgtttcta cacttgctag ggatagatcc agcactgata
      241 acaggtatcc tgatatccag gcatcttact tagtagaagg gagattttca gttccatccg
      301 ggtcatctcc cggaagccag agtgatgctg aaccaagaga gaggttacag cttagcttcc
      361 aggatgatga ttctatctct aggaaaaaga gctatgtgga aagtcaacgt ttgtcaaatg
      421 ctctcagcaa acagtcagct ttacaaatgg agacagcagg accagaagag gagccagccg
      481 gagctacaga atccttgcag ggccaagatc tcttcaacag ggcttcacca ctggaacaag
      541 cacaagactc acctattgat tttcatttac agtcatggat gaataataag gaacccaaga
      601 ttgttgtgct tgatgctgga aaacattttg aagacaagac tctaaagagt gacctaagcc
      661 acactagctt attagaaaat gagaaactta tcttaccgac aagcttggaa gattcttctg
      721 atgatgatat tgatgatgaa atgttttatg atgatcattt ggaggcttat tttgaacaac
      781 tggcaattcc aggaatgata tatgaagacc tagaaggacc agaacctcca gaaaaaggtt
      841 ttaagttacc tacaaatggt cttagacagg caaatgaaaa cggtagctta aactgcaagt
      901 ttcaatcaga aaataacagc tctctgattt ccctcgactc acactcttct gaaacaactc
      961 acaaagagtc tgaggaaagc caagttattt gtctacctgg gactagtaat tctataggta
     1021 ctggagatag tagaaggtac acagatggta tgttaccatt ttcctctggt acttggggaa
     1081 ctgagaaaga aatagaaaat ttgaagggta ttgttccaga tcttaacagt gaatgtgcaa
     1141 gtaaagatgt tctggtgaag accctcaggg ctattgatgt gaaacttaac tctgataatt
     1201 ttcatgatgc aaatgccaat agaggtggtt ttgatctgac tgaccctgta aaacaggggg
     1261 cagagtgtcc tcaccaaaat aagacagttt tgcacatgga tggatgttta gacactgaga
     1321 ctcctacggt gtccattcaa gaaaatgtgg atgtagcctc tttgaagccc attagtgaca
     1381 gtggaattaa tttcactgat gccatttggt caccaacttg tgaaaggcga acatgtgaat
     1441 gtcacgagtc catcgaaaag aataaagaca aaacagatct cccacagagt gtggtctatc
     1501 aaaatgaaga gggtaggtgg gtcacagacc ttgcctatta cacatctttt aatagcaaac
     1561 aaaatttaaa tgtgtctcta agtgatgaga tgaatgaaga cttcagatct ggttctgaag
     1621 catttgattt gattgcacaa gatgaagaag aatttaataa agagcatcaa tttatacagg
     1681 aagaaaacat agatgctcat aatacttcgg ttgcactggg cgatacgtcc tggggagcta
     1741 caattaatta cagtctgttg aggaaatcac gtagcacatc agatttggat aaagatgatg
     1801 ccagttattt acgtctgtct ttaggagagt tctttgctca aagatctgaa gctcttggtt
     1861 gccttggtgg tggtaacaat gtgaaaagac catcatttgg ctattttatt agatcaccag
     1921 agaagagaga acctattgcc ttaataagaa aatctgatgt atcaagaggt aatttggaaa
     1981 aagaaatggc tcatcttaac catgatctat attcaggaga tttaaatgaa cagtcccagg
     2041 cacagctaag tgaaggatca attacacttc aggttgaagc agtagagagt acttcacaag
     2101 tggatgaaaa tgatgtgacg ttaacggctg ataaaggcaa aacagaggac actttcttca
     2161 tgagcaacaa accccaaaga tacaaagaca agctaccaga tagtggtgat tctatgctta
     2221 ggatcagcac cattgcttca gccattgcag aggcatcagt taatactgat ccttcccaac
     2281 ttgctgcaat gatcaaggca ctttcaaata aaaccagaga caagactttt caggaagatg
     2341 agaaacaaaa ggactattct catgtgcgtc atttcttacc taatgattta gaaaaaagta
     2401 atggatccaa tgcacttgat atggagaaat accttaaaaa aacagaagtt agtagatatg
     2461 aaagtgcatt ggaaaacttt tcaagggcta gtatgtctga tacttgggat ttatctttgc
     2521 ccaaagaaca aactactcaa gacattcatc cggtggactt aagtgctact agtgtaagtg
     2581 tgagggcacc agaagaaaac acagcagcta ttgtttatgt tgaaaatgga gagagtgaga
     2641 atcaagagtc atttagaacc ataaactcct caaattcagt tacaaataga gagaataaca
     2701 gtgcagtagt tgatgtgaag acatgttcca ttgacaacaa attacaagat gttggtaacg
     2761 atgaaaaagc tacctcaatt tccactccat ctgatagtta ttcatcagtg aggaacccca
     2821 gaataacatc cctttgtctg ttaaaagact gtgaagaaat acgagataac agagaaaatc
     2881 agaggcaaaa tgagtgtgtc agtgaaataa gcaacagtga gaagcatgtg acttttgaaa
     2941 accatcgcat agtctcacct aaaaatagtg atttgaaaaa tacctctcct gagcatggtg
     3001 gacgtggctc agaggatgag caggagagct tcagaccttc cacgtcacca ctgagtcatt
     3061 cttctcctag tgaaatttct ggaacgagtt catcagggtg tgcgttagag tcctttggtt
     3121 cagcagctca gcagcagcag cctccctgtg agcaggagtt gtctcccttg gtgtgctcgc
     3181 ctgctggggt gagcaggctg acgtatgtgt ctgaaccaga gagctcctat cctaccacag
     3241 ccacagatga tgccctggag gaccgcaaga gtgatatcac cagcgagttg agtaccacaa
     3301 ttattcaagg cagtccagcc gcattggagg aacgggctat ggaaaaattg agagaaaaag
     3361 ttccatttca gaatagagga aaaggaacat tatcatctat tatccagaat aactctgata
     3421 caagaaaagc aactgaaact acttctctga gtagcaagcc tgaatatgta aaacctgact
     3481 ttagatggag taaagatcct tcctccaaaa gtggaaatct gttggaaacc agtgaggtag
     3541 gttggacatc aaaccctgag gaattggacc cgatcaggct ggctctcctg ggcaagtcag
     3601 gtctgagctg tcaggtgggg tcagccacat cacaccctgt gtcctgccag gagcctatag
     3661 atgaagatca aagaataagt cctaaagata agtcaactgc tggccgtgag ttcagtggcc
     3721 aggtttctca tcagaccacc tctgaaaacc agtgtactcc tattcccagc agcacagttc
     3781 acagctctgt ggctgacatg cagaacatgc ctgctgctgt gcacgcactc ttgacacaac
     3841 cctctctcag cgctgctcct tttgctcagc ggtatttggg aacactccct tcaactggaa
     3901 gcaccacctt gcctcagtgc catgctggca atgccacagt ctgtggcttc tcaggaggcc
     3961 ttccctatcc agctgttgca ggagagcctg tgcagaactc tgtggctgtg ggaatttgtc
     4021 taggatcaaa tatcggctct ggatggatgg gtacctcttc cctctgtaac ccatattcta
     4081 ataccttaaa tcagaacctg ctaagcacaa caaaaccttt tcctgtgccg tctgttggta
     4141 caaactgtgg aattgaacca tgggattcag gagtgacatc aggattgggg agtgtccgag
     4201 tgcccgagga gttgaagctt cctcatgctt gctgtgtcgg gatcgcttcc cagaccctcc
     4261 tcagtgtgct taatccaact gaccgctggc tgcaagtcag cattggggtc ctcagcatta
     4321 gtgttaatgg tgaaaaggtg gatctttcaa catatcgttg tttagttttc aagaataaag
     4381 ccatcataag acctcatgcc acagaagaga taaaagtgct ttttatacca tccagtcctg
     4441 gggttttcag atgcacattc agtgttgctt cttggccatg ttcgacagat gctgagacca
     4501 tcgtacaggc agaagctttg gccagcaccg tcactctcac tgccattgcc gagagtcctg
     4561 ttattgaggt agaaacagaa aagaaagacg ttcttgattt tggtgacttg acttatggag
     4621 gctggaaagc cctcccacta aaattgataa accgaacgca tgccactgtg ccaattagac
     4681 tgattattaa tgctaacgct gtagcctggc gctgtttcac gttttccaag gaatccgtcc
     4741 gagctcctgt ggaagttgct ccttgcgctg atgtggtcac tcggctagca ggcccttctg
     4801 tggtcaacca catgatgcct gctagttatg atggacagga tccagaattt ctgatgattt
     4861 gggttctttt ccatagtcca aagaaacaga tcagctcttc agatattctg gactcagcag
     4921 aagaattctc ggcaaaagtt gatatcgaag ttgacagccc aaaccctacg cccgttctta
     4981 gaagtgtgag tctccgagca agagcaggaa tagctaggat ccatgctccc agggacttgc
     5041 agacgatgca tttcttggcc aaagtggctt cctcaagaaa gcagcactta cctttgaaaa
     5101 atgctgggaa cattgaagtt tatttggata tcaaggtccc agaacaagga agtcactttt
     5161 cagtggatcc aaagaatcta ctccttaaac ctggagaaga acatgaggtt attgtttcat
     5221 ttactccaaa ggatcctgaa gcctgcgagg aaaggatctt gaaaatattt gtgcagccat
     5281 ttggacctca gtatgaggta gtgttaaaag gcgaagtcat ttcttcagga agtaaacctc
     5341 tgtcacctgg accttgctta gatattccat cgattttgtc caacaaacaa tttctggctt
     5401 ggggaggagt ccctctaggt agaacacagc ttcagaaact agctttaaga aataattctg
     5461 catctacaac tcaacattta cgactgctta ttagaggaca agatcaggac tgctttcagc
     5521 ttcagaacac ttttggttca gaacagcgat tgaccagtaa ctgtgagatc agaattcacc
     5581 caaaggaaga cattttcatc tctgtattat ttgcacctac tcgattatct tgcatgttgg
     5641 ctagactaga aatcaaacaa cttggaaatc gatcacaacc aggcattaag ttcacaatac
     5701 ctttgtctgg atatggagga acaagcaatc ttattttgga aggcgttaaa aaattatctg
     5761 acagttacat ggtaacagtg aatggcttag tacctggcaa agaaagtaaa attgtttttt
     5821 ctgtccgcaa cactggctcc cgagcagctt ttgttaaagc agtaggtttt aaggattctc
     5881 agaaaaaagt tttgctggat cctaaagtat tgaggatttt tccagataaa tttgtactca
     5941 aggaaagaac acaagaaaat gttactttaa tatataatcc atcagacaga ggaatcaata
     6001 ataaaactgc aacagaacta tcaactgtat acttatttgg tggagatgaa atttcaagac
     6061 agcagtatcg cagggccctg ttacataaac cagagatgat aaaacagata cttccagaac
     6121 atagtgtgct tcaaaacatt aattttgttg aagcatttca agatgagcta ttagtaactg
     6181 aagtatatga tcttccccaa cgacctaatg atgttcagct cttttatgga agcatgtgta
     6241 aaattatact ttcagtaatt ggagaattca gagattgcat ttctagcaga gaattccttc
     6301 agccttcttc caaagctagc ttggaatcta caagcgactt gggagcttct gggaaacatg
     6361 gtggcaacgt ctctttggat gttttaccag tcaaaggtcc tcagggttct cctcttctct
     6421 cacgggcggc tcgcccgcct ctggatcagc tggcctccga agagccgtgg actgtcctac
     6481 ccgagcactt gattctggta gctccttctc cttgtgacat ggcaaaaact ggacgtttcc
     6541 agattgtgaa taactctgtg aggttactga gatttgagct gtgctggcca gcgcattgcc
     6601 tcacagtcac gccgcagcat ggatgtgtcg cgccagagag taaactacaa attcttgtga
     6661 gtcctaattc ctccttatcc acaaaacagt caatgttccc gtggagtggt ttgatctata
     6721 tacactgtga cgatggacag aagaaaattg tgaaagttca aattcgagaa gatttaactc
     6781 aagtggaact tttaactcgt ttgacctcca aaccatttgg aattctttcc ccagtatctg
     6841 agccttcagt tagtcatttg gtcaaaccaa tgacaaaacc gccttccaca aaagttgaaa
     6901 taagaaacaa gagtattact tttcctacaa cagaacctgg tgaaacttca gagagctgtc
     6961 tagaactcga gaatcatggc accacagacg tgaaatggca tctgtcatct ttagcgccac
     7021 cttatgtcaa gggagttgat gaaagtggag atgtttttag agctacctat gcagcattca
     7081 gatgttctcc tatttctggt ctgctggaaa gccatgggat ccaaaaagtc tccatcacat
     7141 ttttgcccag aggtaggggg gattatgccc agttttggga tgttgaatgt caccctctta
     7201 aggagcctca catgaaacac acgttgagat tccaactctc tggacaaagc atcgaagcag
     7261 aaaatgagcc tgaaaacgca tgcctttcca cggattccct cattaaaata gatcatttag
     7321 ttaagccccg aagacaagct gtgtcagagg cttctgctcg catacctgag cagcttgatg
     7381 tgactgctcg tggagtttat gccccagagg atgtgtacag gttccggccg actagtgtgg
     7441 gggaatcacg gacacttaaa gtcaatctgc gaaataattc ttttattaca cactcactga
     7501 agtttttgag tcccagagag ccattctatg tcaaacattc caagtactct ttgagagccc
     7561 agcattacat caacatgccc gtgcagttca aaccgaagtc cgcaggcaaa tttgaagctt
     7621 tgcttgtcat tcaaacagat gaaggcaaga gtattgctat tcgactaatt ggtgaagctc
     7681 ttggaaaaaa ttaactagaa tacatttttg tgtaaagtaa attacataag ttgtattttg
     7741 ttaactttat ctttctacac tacaattatg cttttgtata tatattttgt atgatggata
     7801 tctataattg tagattttgt ttttacaagc taatactgaa gactcgactg aaatattatg
     7861 tatctagccc atagtattgt acttaacttt tacaggtgag aagagagttc tgtgtttgca
     7921 ttgattatga tattctgaat aaatatggaa tatattttaa
//
