LOCUS       NM_014812               7059 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens centrosomal protein 170 (CEP170), transcript variant
            alpha, mRNA.
ACCESSION   NM_014812 XM_936267
VERSION     NM_014812.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7059)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 7059)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 7059)
  AUTHORS   Ma,D., Wang,F., Wang,R., Hu,Y., Chen,Z., Huang,N., Tian,Y., Xia,Y.,
            Teng,J. and Chen,J.
  TITLE     alpha-/gamma-Taxilin are required for centriolar subdistal
            appendage assembly and microtubule organization
  JOURNAL   Elife 11, e73252 (2022)
   PUBMED   35119360
  REMARK    GeneRIF: alpha-/gamma-Taxilin are required for centriolar subdistal
            appendage assembly and microtubule organization.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7059)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 7059)
  AUTHORS   Pizon,V., Gaudin,N., Poteau,M., Cifuentes-Diaz,C., Demdou,R.,
            Heyer,V., Reina San Martin,B. and Azimzadeh,J.
  TITLE     hVFL3/CCDC61 is a component of mother centriole subdistal
            appendages required for centrosome cohesion and positioning
  JOURNAL   Biol Cell 112 (1), 22-37 (2020)
   PUBMED   31789463
REFERENCE   6  (bases 1 to 7059)
  AUTHORS   Kim,J.E., Tannenbaum,S.R. and White,F.M.
  TITLE     Global phosphoproteome of HT-29 human colon adenocarcinoma cells
  JOURNAL   J Proteome Res 4 (4), 1339-1346 (2005)
   PUBMED   16083285
REFERENCE   7  (bases 1 to 7059)
  AUTHORS   Guarguaglini,G., Duncan,P.I., Stierhof,Y.D., Holmstrom,T.,
            Duensing,S. and Nigg,E.A.
  TITLE     The forkhead-associated domain protein Cep170 interacts with
            Polo-like kinase 1 and serves as a marker for mature centrioles
  JOURNAL   Mol Biol Cell 16 (3), 1095-1107 (2005)
   PUBMED   15616186
  REMARK    GeneRIF: Cep170 interacts with Polo-like kinase 1 in mature
            centrioles.
REFERENCE   8  (bases 1 to 7059)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   9  (bases 1 to 7059)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   10 (bases 1 to 7059)
  AUTHORS   Andersen,J.S., Wilkinson,C.J., Mayor,T., Mortensen,P., Nigg,E.A.
            and Mann,M.
  TITLE     Proteomic characterization of the human centrosome by protein
            correlation profiling
  JOURNAL   Nature 426 (6966), 570-574 (2003)
   PUBMED   14654843
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP349680.1, BP349206.1,
            AB022657.1, AC092782.2, AL606534.15 and CB410835.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014812.2.
            
            Summary: The product of this gene is a component of the centrosome,
            a non-membraneous organelle that functions as the major
            microtubule-organizing center in animal cells. During interphase,
            the encoded protein localizes to the sub-distal appendages of
            mature centrioles, which are microtubule-based structures thought
            to help organize centrosomes. During mitosis, the protein
            associates with spindle microtubules near the centrosomes. The
            protein interacts with and is phosphorylated by polo-like kinase 1,
            and functions in maintaining microtubule organization and cell
            morphology. The human genome contains a putative transcribed
            pseudogene. Several alternatively spliced transcript variants of
            this gene have been found, but the full-length nature of some of
            these variants has not been determined. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (alpha, also known as 1)
            represents the longest transcript and encodes the longest isoform
            (alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.121338.1,
                                           SRR1660803.43701.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366542.6/ ENSP00000355500.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               BP349680.1         126-274
            150-509             BP349206.1         222-581
            510-919             AB022657.1         280-689
            920-920             AC092782.2         81447-81447         c
            921-5742            AB022657.1         691-5512
            5743-6809           AL606534.15        138785-139851       c
            6810-7059           CB410835.1         1-250
FEATURES             Location/Qualifiers
     source          1..7059
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q43"
     gene            1..7059
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /note="centrosomal protein 170"
                     /db_xref="GeneID:9859"
                     /db_xref="HGNC:HGNC:28920"
                     /db_xref="MIM:613023"
     exon            1..242
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /inference="alignment:Splign:2.1.0"
     exon            243..388
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..5038
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /note="isoform alpha is encoded by transcript variant
                     alpha; XRCC5 binding protein; KARP-1-binding protein;
                     centrosomal protein 170kDa"
                     /codon_start=1
                     /product="centrosomal protein of 170 kDa isoform alpha"
                     /protein_id="NP_055627.2"
                     /db_xref="CCDS:CCDS44339.1"
                     /db_xref="GeneID:9859"
                     /db_xref="HGNC:HGNC:28920"
                     /db_xref="MIM:613023"
                     /translation="MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHA
                     VINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFGYDTNLFTVVQGE
                     MRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKS
                     EEKAMDISAMPRGTPLYGQPSWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQ
                     VEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSSHITGAG
                     HASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVA
                     DWLAQNNPPQMLWERTEEDSKSIKSDVPVYLKRLKGNKHDDGTQSDSENAGAHRRCSK
                     RATLEEHLRRHHSEHKKLQKVQATEKHQDQAVTSSAHHRGGHGVPHGKLLKQKSEEPS
                     VSIPFLQTALLRSSGSLGHRPSQEMDKMLKNQATSATSEKDNDDDQSDKGTYTIELEN
                     PNSEEVEARKMIDKVFGVDDNQDYNRPVINEKHKDLIKDWALSSAAAVMEERKPLTTS
                     GFHHSEEGTSSSGSKRWVSQWASLAANHTRHDQEERIMEFSAPLPLENETEISESGMT
                     VRSTGSATSLASQGERRRRTLPQLPNEEKSLESHRAKVVTQRSEIGEKQDTELQEKET
                     PTQVYQKDKQDADRPLSKMNRAVNGETLKTGGDNKTLLHLGSSAPGKEKSETDKETSL
                     VKQTLAKLQQQEQREEAQWTPTKLSSKNVSGQTDKCREETFKQESQPPEKNSGHSTSK
                     GDRVAQSESKRRKAEEILKSQTPKGGDKKESSKSLVRQGSFTIEKPSPNIPIELIPHI
                     NKQTSSTPSSLALTSASRIRERSESLDPDSSMDTTLILKDTEAVMAFLEAKLREDNKT
                     DEGPDTPSYNRDNSISPESDVDTASTISLVTGETERKSTQKRKSFTSLYKDRCSTGSP
                     SKDVTKSSSSGAREKMEKKTKSRSTDVGSRADGRKFVQSSGRIRQPSVDLTDDDQTSS
                     VPHSAISDIMSSDQETYSCKPHGRTPLTSADEHVHSKLEGSKVTKSKTSPVVSGSSSK
                     STTLPRPRPTRTSLLRRARLGEASDSELADADKASVASEVSTTSSTSKPPTGRRNISR
                     IDLLAQPRRTRLGSLSARSDSEATISRSSASSRTAEAIIRSGARLVPSDKFSPRIRAN
                     SISRLSDSKVKSMTSAHGSASVNSRWRRFPTDYASTSEDEFGSNRNSPKHTRLRTSPA
                     LKTTRLQSAGSAMPTSSSFKHRIKEQEDYIRDWTAHREEIARISQDLALIAREINDVA
                     GEIDSVTSSGTAPSTTVSTAATTPGSAIDTREELVDRVFDESLNFRKIPPLVHSKTPE
                     GNNGRSGDPRPQAAEPPDHLTITRRRTWSRDEVMGDNLLLSSVFQFSKKIRQSIDKTA
                     GKIRILFKDKDRNWDDIESKLRAESEVPIVKTSSMEISSILQELKRVEKQLQAINAMI
                     DPDGTLEALNNMGFPSAMLPSPPKQKSSPVNNHHSPGQTPTLGQPEARALHPAAVSAA
                     AEFENAESEADFSIHFNRFNPDGEEEDVTVQE"
     exon            389..478
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /inference="alignment:Splign:2.1.0"
     exon            479..557
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /inference="alignment:Splign:2.1.0"
     exon            558..616
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /inference="alignment:Splign:2.1.0"
     exon            617..779
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /inference="alignment:Splign:2.1.0"
     exon            780..914
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1391
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1555
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1849
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1999
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2126
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..3959
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /inference="alignment:Splign:2.1.0"
     exon            3960..4194
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /inference="alignment:Splign:2.1.0"
     exon            4195..4342
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /inference="alignment:Splign:2.1.0"
     exon            4343..4513
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /inference="alignment:Splign:2.1.0"
     exon            4514..4602
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /inference="alignment:Splign:2.1.0"
     exon            4603..4696
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /inference="alignment:Splign:2.1.0"
     exon            4697..4748
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /inference="alignment:Splign:2.1.0"
     exon            4749..7059
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7037..7042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /note="hexamer: AATAAA"
     polyA_site      7059
                     /gene="CEP170"
                     /gene_synonym="FAM68A; KAB; KIAA0470"
                     /note="major polyA site"
ORIGIN      
        1 ctttcccgag gcgcctgcgc actaggcagt cggtctttgc cgttaccgct atgtgtgggg
       61 cgtgtgtgga ataacgttat tgcccagcgg agctgagggc cccggagctc gaccgcagcg
      121 gcagcgacga caacagcggc gacgacgacg acgacgaggt ggggggagga cggcgtgcga
      181 gagactcacg ggacgcgacg cgccccgcct cccccgtccg gtccctctct ccacggtaag
      241 gggatgacgt agctttgcca aagacttaga agctaagcag aaaatgagct taacatcctg
      301 gtttttggtg agcagtggag gcactcgcca caggctgcca cgagaaatga tttttgttgg
      361 aagagatgac tgtgagctca tgttgcagtc tcgtagtgtg gataagcaac acgctgtcat
      421 caactatgat gcgtctacgg atgagcattt agtgaaggat ttgggcagcc tcaatgggac
      481 ttttgtgaat gatgtaagga ttccggaaca gacttatatc accttgaaac ttgaagataa
      541 gctgagattt ggatatgata caaatctttt cactgtagta caaggagaaa tgagggtccc
      601 tgaagaagct cttaagcatg agaagtttac cattcagctt cagttgtccc aaaaatcttc
      661 agaatcagaa ttatccaaat ctgcaagtgc caaaagcata gattcaaagg tagcagacgc
      721 tgctactgaa gtgcagcaca aaactactga agcactgaaa tccgaggaaa aagccatgga
      781 tatttctgct atgccccgtg gtactccatt atatgggcag ccgtcatggt ggggggatga
      841 tgaggtggat gaaaaaagag ctttcaagac aaatggcaaa cctgaagaaa aaaaccatga
      901 agctggaaca tcagggtgcg gcatagatgc caagcaagtt gaggaacaat ctgcagctgc
      961 aaatgaagaa gtactttttc ctttctgtag ggaaccaagt tattttgaaa tccctacaaa
     1021 agaattccag caaccatcac aaataacaga aagcactatt catgaaatcc caacaaaaga
     1081 cacgccaagt tcccatataa caggtgcagg gcatgcttca tttaccattg aatttgatga
     1141 cagtacccca gggaaggtaa ctattagaga ccatgtgaca aagtttactt ctgatcagcg
     1201 ccacaagtcc aagaagtctt ctcctggaac tcaagacttg ctggggattc aaacaggaat
     1261 gatggcaccc gaaaacaaag ttgctgactg gctagcacaa aacaaccctc ctcaaatgct
     1321 atgggaaaga acagaagagg attctaaaag cattaaaagt gatgttccag tgtacttgaa
     1381 aaggttgaaa ggaaataaac atgatgatgg tacgcaaagt gattcagaga acgctggggc
     1441 tcacaggcgc tgtagcaaac gtgcaactct tgaggaacac ttaagacgcc accattcaga
     1501 acacaaaaag ctacagaagg tccaggctac tgaaaagcat caagaccaag ctgttactag
     1561 ctctgcgcat cacagagggg ggcatggtgt tccacatggg aaattgttaa aacagaaatc
     1621 agaggagcca tcggtgtcaa tacccttcct acaaactgca ttattaagaa gttcagggag
     1681 tcttgggcac agaccaagcc aggagatgga taaaatgtta aaaaatcaag caacttctgc
     1741 tacttctgaa aaggataatg atgatgacca aagtgacaag ggtacttata ccattgagtt
     1801 agagaatccc aacagtgagg aagtggaagc aagaaaaatg attgacaagg tgtttggagt
     1861 agatgacaat caggattata ataggcctgt tatcaacgaa aaacataaag atctaataaa
     1921 agattgggct ctcagttctg ctgcagcagt aatggaagaa agaaaaccac tgactacatc
     1981 tggatttcac cactcagagg aaggcacatc ttcatctgga agcaaacgtt gggtttcaca
     2041 gtgggctagt ttggctgcca atcatacaag gcatgatcaa gaagaaagga taatggaatt
     2101 ttctgcacct cttcctttag agaatgagac agagatcagt gagtctggca tgacagtgag
     2161 aagtactggc tctgcaactt ccttggctag ccagggagag agaaggagac gaactcttcc
     2221 ccagcttcca aatgaagaaa agtctcttga gagccacaga gcaaaggttg taacacagag
     2281 gtcagagata ggagaaaaac aagacacaga acttcaggag aaagaaacac ctacacaggt
     2341 ataccagaaa gataaacaag atgctgacag acccttgagt aaaatgaaca gggcagtaaa
     2401 tggagagact ctcaaaactg gtggagataa taaaacccta cttcacttag gcagctctgc
     2461 tcctggaaaa gagaaaagtg aaactgataa ggaaacttct ttggtaaagc aaacattagc
     2521 aaaacttcaa caacaagaac aaagggagga ggctcagtgg acacctacta aattgtcttc
     2581 caaaaatgtt tcaggtcaga cagataaatg tagggaggaa acttttaaac aagaatcaca
     2641 acctccagaa aaaaattcag gacattctac aagcaaagga gacagagtgg cacaaagtga
     2701 gagcaagaga agaaaagctg aggaaattct gaaaagtcag actccaaagg gaggagacaa
     2761 gaaggaatcc tccaagtcat tagtgcgaca agggagcttc actatagaaa aacccagccc
     2821 aaacataccc atagaactta ttccccatat aaataaacag acttcctcta ctccttcttc
     2881 tttagcatta acatctgcaa gtagaatacg agaaagaagt gagtctttgg atcctgattc
     2941 tagtatggac acaaccctta ttctaaaaga cacagaagca gtaatggctt ttctagaagc
     3001 taaactacgt gaagataata aaactgatga aggaccagat actcccagtt ataatagaga
     3061 caattctatt tcaccagaat ctgatgtaga tacagctagt acaatcagtc tggttactgg
     3121 agaaactgaa agaaagtcaa cccaaaagcg aaagagtttc actagcctct ataaagatag
     3181 gtgttccaca ggttctcctt ccaaagatgt tacaaaatca tcatcttcag gtgctaggga
     3241 aaaaatggaa aagaaaacaa aaagtcgttc cacagatgtg ggttcaagag cagatggtcg
     3301 taaatttgtt cagtccagtg ggagaataag acagccctca gtagacttaa cagatgatga
     3361 ccaaacctct agtgtacctc attctgccat ctctgatatt atgtcatctg atcaagaaac
     3421 ttactcttgt aaacctcatg gacggactcc acttacctca gctgatgagc atgtacattc
     3481 caaactggaa ggaagtaaag taacgaaatc taagacttct ccggtggtat ctggttcatc
     3541 tagtaaatca accacccttc caaggccacg acctaccagg acttccctct tgcgcagagc
     3601 acgacttggt gaagcttcag acagtgaact tgctgatgct gacaaagcat ctgttgcttc
     3661 tgaagtatcc acaacaagtt ctacatcaaa acctcccaca ggaaggcgta acatctctcg
     3721 gattgattta ttggctcagc ctcgtagaac acgacttggc tcactgtcag ctcgtagtga
     3781 ctctgaagca acaatttcta gaagtagtgc ctcttcgagg accgcagaag ccatcattag
     3841 aagtggagcc agactagtac catcagataa attttctcct agaattagag ctaacagtat
     3901 ctctcgactc tcagactcca aggtcaaaag tatgacctca gctcatggct ctgcttcagt
     3961 aaattcaaga tggaggcgct ttcctactga ttatgcttcc acctcagaag atgaatttgg
     4021 atcaaaccgt aattccccta aacatacccg tctacgtact tctccagccc tgaaaaccac
     4081 tcgcttgcag agcgctggat cagcaatgcc tactagttct tcattcaaac accggattaa
     4141 agagcaggaa gactacatcc gagattggac tgctcatcga gaagagatag ccaggatcag
     4201 ccaagatctt gctctcattg ctcgggagat caacgatgta gcaggagaga tagattcagt
     4261 gacttcatca ggcactgccc ctagtaccac agtaagcact gctgccacca cccctggctc
     4321 tgccatagac actagagaag agttggttga tcgtgttttt gatgaaagcc tcaacttccg
     4381 aaagattcct ccattagttc attccaaaac accagaagga aacaacggtc gatctggtga
     4441 tccaagacct caagcagcag agcctcccga tcacttaaca attacaaggc ggagaacctg
     4501 gagcagggat gaagtcatgg gagataatct gctgctgtca tccgtctttc agttctctaa
     4561 gaagataaga caatctatag ataagacagc tggaaagatc agaatattat ttaaagacaa
     4621 agatcggaat tgggatgaca tagaaagcaa attaagagcc gaaagtgaag tccctattgt
     4681 gaaaacctca agcatggaga tttcttctat cttacaggaa ctgaaaagag tagaaaagca
     4741 gctgcaagca atcaatgcta tgattgatcc tgatggaact ttggaggctc tgaacaacat
     4801 gggatttccc agtgctatgt tgccatctcc accgaaacag aagtccagcc ctgtgaataa
     4861 ccaccacagc ccgggtcaga caccaacact tggccaacca gaagctaggg ctcttcatcc
     4921 tgctgctgtt tcagccgcag ctgaatttga gaatgctgaa tctgaggctg atttcagtat
     4981 acatttcaat agattcaacc ccgatgggga agaggaagat gttacagtac aagaatgact
     5041 ttctcttgat tgttgaaaaa tcattacctg tggaatggct aggaatattg gaagcagcat
     5101 agtgttgatg tacgcaaaac aagacagctt ggtcagctac aatcttggaa tccctgtctt
     5161 cttaatttta tttatttatt tttgacgtat aatgtagtat atcaatcctt tcaaactatt
     5221 tagataacca cttgatgcac aaataggaaa aagcagattg tggcagtgtc gccttttgtg
     5281 gttttatgat tttcaaattg aatttaatga ttacaccctt tcccttcata gatctttttt
     5341 ctttttttta agccatgctg tgacctacaa gcaaactaaa tagccaacat ttctgaaccc
     5401 ctaagtctcc tgtgccaagc tgctccctga aatggacttc ttcatctgta cagatttgtt
     5461 aaaccattct atttgcttct taataatagg atttatatta gtactcatta ccattggaca
     5521 caatgacata agtactctcc acagtaaagc agacctttca caacagtcac tctgtgtcct
     5581 aaaattttcc aacatagatg tgatttatat aactttgttg atacgtaaat tgtcttgggg
     5641 tttacggaaa ttaactatta tgtttgcact aagatttgct gggagtggta ggtggacata
     5701 tctatatatc aataaggact aaccgtcttt tttgtacata ggagattgat aatactgtat
     5761 ttgttttaag cccacagtgt tttactccac tttcaaaaag atcaatttgg cacttttttt
     5821 catttttttt aatggaaata agatttggtc tctcatttta ggttaaatga taactagaaa
     5881 gattaaacta gacagatagt ttaggtggag tatattttta aaactcagaa catgtatatt
     5941 ggtcctgtgt taccaagttt atatgtgaca gttgaaaaag aaattccctt gaaatgatca
     6001 tgaggttaaa attttcttca ttaggggact tggagaacca gtagtcgtaa gattagttga
     6061 tagtttcact cccaagcaat gaattgcttc tgtgtgtttc cctgtaggac tcaatagtaa
     6121 atgctgtctg tcttacacat ttataaggac cctgcaagac gacgacaaag gcctttggcc
     6181 tgtgctacta aacaagaagc ctatgaaaaa tttcttcttt aaacttgttt tttctctttc
     6241 cagtaagttc acatttggat aattttaaaa agaaaagtaa ttacctttgt gtttccagaa
     6301 cactataatt ggggtgtatc ttaattcagt taaatattat tagtagacct ggattttccc
     6361 ccttgacccc atcagtctat aaaggttaaa ctgcaacttt tatgaaatgg tctttaatat
     6421 ttccacaata atcctgtgct atatttgttt taagaaacaa agtaactcta tacacttcaa
     6481 gactttacag gattttttaa atcctgtatt gttggatcaa ttaataaaga tgcaaaaaaa
     6541 ctttatagag atgtaaaaac aaaactataa tggatctcct atttttcttt aaatacaaaa
     6601 aaaaaaaggt aaatgaacta ttctccttgt aaagctaaat tccccattct gtctaataaa
     6661 ggaagactga aaaaaggttt taaagaacat aaatggaaag atacaaatgc tttgaaggaa
     6721 taaacgaaat gttaaaacag ggtcaatcca tttgaagaaa aagttggaca aaataatcag
     6781 cattgctccc tcttttattt aatatttggg tactgattat atccacatgg aagtagaagg
     6841 taaggagttt aggaaaatac tagaatctac tctgcttaca ttcttgttta agtgtttaca
     6901 cagtttggtt caattataaa catttggcct tttactatgt tatttttatt ttgtatgaat
     6961 acattatcct ccttatttat ttttgttaca tttattactt atgttatttt gttatgcatt
     7021 tacaactcca tttttaaata aagtgtttct ggaacttta
//
