LOCUS       NM_014956               5629 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens centrosomal protein 164 (CEP164), transcript variant
            1, mRNA.
ACCESSION   NM_014956 XM_374936
VERSION     NM_014956.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5629)
  AUTHORS   Devlin,L.A., Coles,J., Jackson,C.L., Barroso-Gil,M., Green,B.,
            Walker,W.T., Thomas,N.S., Thompson,J., Rock,S.A., Neatu,R.,
            Powell,L., Molinari,E., Wilson,I.J., Cordell,H.J., Olinger,E.,
            Miles,C.G., Sayer,J.A., Wheway,G. and Lucas,J.S.
  CONSRTM   Genomics England Research Consortium
  TITLE     Biallelic variants in CEP164 cause a motile ciliopathy-like
            syndrome
  JOURNAL   Clin Genet 103 (3), 330-334 (2023)
   PUBMED   36273371
  REMARK    GeneRIF: Biallelic variants in CEP164 cause a motile
            ciliopathy-like syndrome.
REFERENCE   2  (bases 1 to 5629)
  AUTHORS   Rosa E Silva,I., Bino,L., Johnson,C.M., Rutherford,T.J.,
            Neuhaus,D., Andreeva,A., Cajanek,L. and van Breugel,M.
  TITLE     Molecular mechanisms underlying the role of the centriolar
            CEP164-TTBK2 complex in ciliopathies
  JOURNAL   Structure 30 (1), 114-128 (2022)
   PUBMED   34499853
  REMARK    GeneRIF: Molecular mechanisms underlying the role of the centriolar
            CEP164-TTBK2 complex in ciliopathies.
REFERENCE   3  (bases 1 to 5629)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5629)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5629)
  AUTHORS   Takahashi,M., Yamagiwa,A., Nishimura,T., Mukai,H. and Ono,Y.
  TITLE     Centrosomal proteins CG-NAP and kendrin provide microtubule
            nucleation sites by anchoring gamma-tubulin ring complex
  JOURNAL   Mol Biol Cell 13 (9), 3235-3245 (2002)
   PUBMED   12221128
REFERENCE   6  (bases 1 to 5629)
  AUTHORS   Mayor,T., Stierhof,Y.D., Tanaka,K., Fry,A.M. and Nigg,E.A.
  TITLE     The centrosomal protein C-Nap1 is required for cell cycle-regulated
            centrosome cohesion
  JOURNAL   J Cell Biol 151 (4), 837-846 (2000)
   PUBMED   11076968
REFERENCE   7  (bases 1 to 5629)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
REFERENCE   8  (bases 1 to 5629)
  AUTHORS   Stokman,M., Lilien,M. and Knoers,N.
  TITLE     Nephronophthisis-Related Ciliopathies
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   27336129
REFERENCE   9  (bases 1 to 5629)
  AUTHORS   Gunay-Aygun,M., Gahl,W.A. and Heller,T.
  TITLE     Congenital Hepatic Fibrosis Overview horizontal line RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301743
REFERENCE   10 (bases 1 to 5629)
  AUTHORS   Forsyth,R. and Gunay-Aygun,M.
  TITLE     Bardet-Biedl Syndrome Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301537
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000892.4, BX648682.1,
            AP001822.4, AB028975.1 and AL833532.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014956.4.
            
            Summary: This gene encodes a centrosomal protein involved in
            microtubule organization, DNA damage response, and chromosome
            segregation. The encoded protein is required for assembly of
            primary cilia and localizes to mature centrioles. Defects in this
            gene are a cause of nephronophthisis-related ciliopathies. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648682.1, SRR14038195.2800136.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278935.8/ ENSP00000278935.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AP000892.4         126337-126337
            2-1629              BX648682.1         1-1628
            1630-1630           AP001822.4         95929-95929
            1631-2547           BX648682.1         1630-2546
            2548-3872           AB028975.1         2761-4085
            3873-4266           BX648682.1         3872-4265
            4267-4446           AB028975.1         4456-4635
            4447-4872           AP001822.4         126240-126665
            4873-5039           BX648682.1         4872-5038
            5040-5629           AL833532.1         2568-3157
FEATURES             Location/Qualifiers
     source          1..5629
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..5629
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /note="centrosomal protein 164"
                     /db_xref="GeneID:22897"
                     /db_xref="HGNC:HGNC:29182"
                     /db_xref="MIM:614848"
     exon            1..51
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            52..127
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            128..230
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..4531
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /note="isoform 1 is encoded by transcript variant 1;
                     centrosomal protein 164kDa"
                     /codon_start=1
                     /product="centrosomal protein of 164 kDa isoform 1"
                     /protein_id="NP_055771.4"
                     /db_xref="CCDS:CCDS31683.1"
                     /db_xref="GeneID:22897"
                     /db_xref="HGNC:HGNC:29182"
                     /db_xref="MIM:614848"
                     /translation="MAGRPLRIGDQLVLEEDYDETYIPSEQEILEFAREIGIDPIKEP
                     ELMWLAREGIVAPLPGEWKPCQDITGDIYYFNFANGQSMWDHPCDEHYRSLVIQERAK
                     LSTSGAIKKKKKKKEKKDKKDRDPPKSSLALGSSLAPVHVPLGGLAPLRGLVDTPPSA
                     LRGSQSVSLGSSVESGRQLGELMLPSQGLKTSAYTKGLLGSIYEDKTALSLLGLGEET
                     NEEDEEESDNQSVHSSSEPLRNLHLDIGALGGDFEYEESLRTSQPEEKKDVSLDSDAA
                     GPPTPCKPSSPGADSSLSSAVGKGRQGSGARPGLPEKEENEKSEPKICRNLVTPKADP
                     TGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELEISEHM
                     KEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKD
                     DSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAE
                     ELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVS
                     PTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREK
                     LCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQ
                     ADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAAL
                     NAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQE
                     AQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKE
                     EHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLR
                     RRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEE
                     ATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFS
                     SLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKED
                     LYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQ
                     EVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEA
                     SDEGTLGGSPTKKAVTFDLSDMDSLSSESSESFSPPHREWWRQQRIDSTPSLTSRKIH
                     GLSHSLRQISSQLSSVLSILDSLNPQSPPPLLASMPAQLPPRDPKSTPTPTYYGSLAR
                     FSALSSATPTSTQWAWDSGQGPRLPSSVAQTVDDFLLEKWRKYFPSGIPLLSNSPTPL
                     ESRLGYMSASEQLRLLQHSHSQVPEAGSTTFQGIIEANRRWLERVKNDPRLPLFSSTP
                     KPKATLSLLQLGLDEHNRVKVYRF"
     exon            231..342
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            343..541
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            542..700
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            701..835
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            836..913
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1300
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1381
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1465
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1557
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1725
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1872
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2082
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2214
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2431
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2509
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2641
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2764
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2908
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..2992
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3061
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..3237
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            3238..3364
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..3426
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            3427..3649
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            3650..3757
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            3758..3896
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            3897..4244
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            4245..4311
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            4312..4434
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     exon            4435..5629
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5594..5599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /note="hexamer: AATAAA"
     polyA_site      5629
                     /gene="CEP164"
                     /gene_synonym="NPHP15"
                     /note="major polyA site"
ORIGIN      
        1 gttgcgcgct gcagggcaac accccggcgt ccctggaagc tgggggagcg ggagaaataa
       61 ctttatttgg actgagagct ggagaatgag aataggacct gagagtatat tgggctaagg
      121 aggagaggtg tttgagccca gatgagtcat ggctggacga cccctccgca taggagatca
      181 gctggttctg gaagaagatt atgatgagac ctacattcct agtgagcaag aaattcttga
      241 atttgcccgg gagattggta ttgatcccat caaggaacca gaactgatgt ggctggcgcg
      301 agagggcatc gtggccccac tgcctggaga gtggaaacca tgccaggaca tcacaggtga
      361 catttactat ttcaacttcg ccaacgggca gtctatgtgg gaccatccat gtgacgaaca
      421 ctatcggagc ttggtgatcc aagagcgggc aaagctgtca acttctgggg ccattaagaa
      481 gaagaaaaaa aaaaaggaaa agaaagacaa gaaggacaga gaccccccca aaagttcgct
      541 ggccttgggt tcctcattag ccccagttca tgttcctctt gggggcctgg ctcctttacg
      601 aggtcttgtg gataccccac cctctgctct tcgtggatct caaagcgtga gcctggggag
      661 ctcagtggag tctggacgtc agcttggaga actcatgctg ccttcacagg gtctcaagac
      721 ctctgcttat acaaagggtc tcttgggctc catatatgag gacaagactg ctctcagcct
      781 cttgggttta ggagaagaaa ccaatgagga ggatgaggag gaaagtgaca accagagtgt
      841 ccacagctca agtgagcctc ttaggaacct acacctggac attggggcac tggggggtga
      901 ctttgagtat gaggagtctc tgagaacaag ccagccagag gagaagaagg atgtttctct
      961 ggattcagat gctgccggtc cccctactcc ctgcaagccc tccagcccag gtgcagacag
     1021 cagtctgagc agtgctgttg gcaaagggcg acagggaagt ggagcaagac ctggtcttcc
     1081 agaaaaagag gaaaatgaga agagtgaacc taagatttgc aggaatctgg tgacccccaa
     1141 ggcagaccct acaggcagtg agcctgccaa agcctctgaa aaggaagcac cagaggacac
     1201 agtagatgca ggagaggagg gttccaggag ggaagaggca gccaaggagc caaagaagaa
     1261 ggcttctgct ctggaagagg gcagttcaga cgccagccaa gaactggaaa ttagtgaaca
     1321 catgaaggaa ccacagctct cagactccat agcttctgac cccaagtcct tccatggcct
     1381 ggacttcggt tttcgcagcc ggatctcgga gcacctgctg gatgttgatg tgctttcccc
     1441 agtcctgggt ggagcttgtc ggcaggccca gcaaccactg ggaatagaag acaaggatga
     1501 cagccagtcc agccaagatg agctgcagag caagcagtcc aaaggcctgg aggagaggtt
     1561 atctcctcca cttccacacg aggagcgggc ccagagtccc cctcgcagcc tggccactga
     1621 agaagagcct ccccagggcc ccgaggggca gcccgagtgg aaggaggcag aggagcttgg
     1681 ggaggactct gcagccagcc tcagcctgca gctgtccctc cagagggagc aggccccaag
     1741 cccacctgct gcctgtgaga agggcaagga gcagcattcc caggccgagg agctgggccc
     1801 tgggcaggaa gaggcagagg atcctgagga gaaggtggcg gtcagcccca ccccgccagt
     1861 ctctccagag gtgcgatcca cagagcctgt ggctccccca gagcagctct cagaggctgc
     1921 actaaaggcc atggaagagg cagtggccca agtactcgag caagaccaga ggcacctgct
     1981 ggaatccaag caagagaaga tgcagcaact gcgggagaag ctgtgccaag aggaggaaga
     2041 ggagatcctc cggcttcacc agcagaaaga gcaatctctc agttccttga gggagcggct
     2101 gcagaaagcc attgaggagg aggaggcccg gatgagagag gaggaaagcc agaggctatc
     2161 ctggctccga gctcaggtcc agtccagcac acaagcagat gaggaccaaa tcagggctga
     2221 gcaagaggct tccctgcaga aactgagaga agagttggag tctcaacaga aggctgagag
     2281 ggccagcttg gaacagaaaa ataggcaaat gctggagcag ctcaaggaag agatagaggc
     2341 ttcggagaag agcgagcagg ctgccctgaa tgctgcaaag gagaaggctc tgcagcagct
     2401 gagggagcag ctggaagggg agaggaaaga agctgtggca acgctggaga aggagcacag
     2461 tgctgagctg gagcggctct gctcctcatt ggaggccaag caccgggagg tggtctccag
     2521 cctccagaag aagatacagg aagctcaaca gaaagaggag gcccagctgc agaagtgcct
     2581 tgggcaagtg gagcacagag ttcaccagaa gtcttatcac gtggctgggt atgagcacga
     2641 gctcagcagt ctcctgcgag agaagcgcca ggaagtggaa ggggagcatg agaggaggtt
     2701 ggacaagatg aaggaggagc accagcaagt gatggctaag gccagagagc agtatgaagc
     2761 tgaggagagg aagcagcggg ctgagcttct ggggcacctg accggagagc tggagcgcct
     2821 gcagagggcc catgaacgag aactggagac tgtgaggcag gagcaacaca agcgtcttga
     2881 ggacttgcgg cgccggcaca gggagcagga aaggaagctc caggatttag agttggacct
     2941 tgaaaccaga gctaaagatg tcaaggccag attggctctg ctggaggtcc aggaggagac
     3001 cgcccggagg gagaagcagc agctgcttga tgtgcagagg caggttgctc tgaagagtga
     3061 ggaagccaca gccacccatc agcagctgga ggaggcacag aaggagcaca cccacctgtt
     3121 gcagtcaaac cagcagctcc gagaaattct tgatgagctg caggcccgca agctgaagct
     3181 ggagtcccaa gtggatctgc tgcaggctca gagccagcaa ctgcagaaac acttcagcag
     3241 cctggaggct gaagctcaaa agaagcagca cctgttgaga gaagtgacag ttgaggaaaa
     3301 taatgcttcc ccacattttg agccagatct ccatattgag gacctgagga aatcccttgg
     3361 aacaaaccag accaaagagg tgtcttcttc tctctcccag agcaaggagg acttatactt
     3421 ggacagcctg tcctcccaca atgtctggca cctcctctct gctgaggggg tagccctccg
     3481 tagtgccaag gagttccttg tgcagcagac acgctccatg cggaggcggc agacagctct
     3541 gaaagctgcc cagcagcatt ggcgccatga gctggccagt gcgcaggagg tggccaaaga
     3601 cccaccaggc atcaaggccc tggaagatat gcgcaagaac ctggagaagg agaccaggca
     3661 cctggatgag atgaagtcgg ccatgcggaa aggccacaac ctgctgaaga agaaagagga
     3721 gaagctgaat cagttggagt cctctctttg ggaagaggcc tcagatgagg gcactctggg
     3781 aggatccccc accaagaagg cagtaacctt cgacctcagt gacatggaca gcctgagcag
     3841 tgaaagttct gaatcttttt ccccgcctca ccgtgagtgg tggcggcagc agaggatcga
     3901 ctcaaccccg agtctcacct cccgcaagat ccacgggctt agccactccc tccggcagat
     3961 cagcagccag ctgagcagtg tcctcagcat cctggacagc ctcaaccctc agtcgccgcc
     4021 gccgctcctc gcctccatgc cagcccagct ccctccccgg gaccctaaga gcacccccac
     4081 ccccacctac tatggctccc tggccaggtt ctcagcctta tcatctgcta cacccacgtc
     4141 cacccaatgg gcctgggatt cagggcaggg gcccaggctc ccctcctctg tggctcaaac
     4201 ggtggacgac ttcctgttgg agaagtggcg caagtatttt ccatctggca tcccgctgct
     4261 cagcaacagc cccaccccgc tggagagcag gctgggttac atgtctgcca gtgagcagct
     4321 ccggctccta cagcactccc attcgcaagt ccctgaggcg ggcagcacca cctttcaggg
     4381 cataattgag gccaaccgga ggtggctgga acgtgtcaag aatgacccca ggttacctct
     4441 cttctcgtca acacccaagc caaaagctac tttgagcctc ctgcagctgg gccttgatga
     4501 gcacaacaga gtgaaggtgt atcgcttctg aggccctgag caggggcttg gggcagccca
     4561 gcctctcctc cacccagacc aagtgcctga ggagctgcct gccttcttcc atctgagaaa
     4621 gcaccctcct tccccctttg acttgcagga gccaccaggg accagggggt tgagtggaac
     4681 agtaaagcca cacattctgt gactatataa cctatctcag gctaaaatgt gtggactcgt
     4741 acgagctctt gtcattgaca tggcaagctg atggcgtgcg gtggctgcgg ggtatcaggg
     4801 ccgggagccc tttgggagga agggaggcgt tagaggagct gccttcggag gctcagggag
     4861 tccctttgga gctggttgtt tccttggccc tgcagcgcac tgctcggggc tcccaaggag
     4921 gttgtgtgta tggttcttaa ttcatcagga caaagacccc cagcatgtgt gtaccctggg
     4981 acccgatttc tctgggccca catctatctc caatacctca gcctcagatc agaccctttc
     5041 ttttttgtct ttcttctctt aatttttaaa tgcctctttt cttgagcatt ccatctctct
     5101 ttttgaccct ctcaggactg ggcttagctg tccagagccc tgccggaggg tgctgggggc
     5161 tgtccctctg caggcactgt gttttcctca ggggctgtcc tcagaacacc cctcctgctc
     5221 cctggggctc ctcagggagc catttcagct ggagtctcag gtctcaaaaa caacttctcc
     5281 aggaggccaa aaaaagactg ggttggcttc tggtcctcat gatggctttt atcctcctgg
     5341 gacactttgg gtatattcat gggcattgtt tccatctgtc ttttctacct gtgccacccc
     5401 tgccctgatt ccacggctgc ctcaggcagg caggcaagga gctaggccgg tgcccggccc
     5461 tggcagcaag gggtctttgt gcagttggag atgctgccgt tgtggcagag cgtcctgcag
     5521 ccccgcttcc atcagcaggc tctggggtgg gggctttgca ggggatgctc tctgatgttt
     5581 gttccgttgt ttaaataaaa tgcacttatt tttgtttttt tttttgcaa
//
