LOCUS       NM_014895               5155 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens centrosomal protein 162 (CEP162), transcript variant
            1, mRNA.
ACCESSION   NM_014895 XM_376518
VERSION     NM_014895.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5155)
  AUTHORS   Li,H., Ning,M., Li,Q., Wang,T., Li,W., Xiao,J., Wang,L., Wang,K.,
            Zou,R., Hao,F., Yu,M., Shi,Y., Lei,C., Wang,Z., Yang,Z., Xu,H. and
            Gong,B.
  TITLE     The association of five polymorphisms with diabetic retinopathy in
            a Chinese population
  JOURNAL   Ophthalmic Genet 44 (4), 346-351 (2023)
   PUBMED   37066695
  REMARK    GeneRIF: The association of five polymorphisms with diabetic
            retinopathy in a Chinese population.
REFERENCE   2  (bases 1 to 5155)
  AUTHORS   Nuzhat,N., Van Schil,K., Liakopoulos,S., Bauwens,M., Rey,A.D.,
            Kaseberg,S., Jager,M., Willer,J.R., Winter,J., Truong,H.M.,
            Gruartmoner,N., Van Heetvelde,M., Wolf,J., Merget,R.,
            Grasshoff-Derr,S., Van Dorpe,J., Hoorens,A., Stohr,H., Mansard,L.,
            Roux,A.F., Langmann,T., Dannhausen,K., Rosenkranz,D., Wissing,K.M.,
            Van Lint,M., Rossmann,H., Hauser,F., Nurnberg,P., Thiele,H.,
            Zechner,U., Pearring,J.N., De Baere,E. and Bolz,H.J.
  TITLE     CEP162 deficiency causes human retinal degeneration and reveals a
            dual role in ciliogenesis and neurogenesis
  JOURNAL   J Clin Invest 133 (8), e161156 (2023)
   PUBMED   36862503
  REMARK    GeneRIF: CEP162 deficiency causes human retinal degeneration and
            reveals a dual role in ciliogenesis and neurogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5155)
  AUTHORS   Gupta,G.D., Coyaud,E., Goncalves,J., Mojarad,B.A., Liu,Y., Wu,Q.,
            Gheiratmand,L., Comartin,D., Tkach,J.M., Cheung,S.W., Bashkurov,M.,
            Hasegan,M., Knight,J.D., Lin,Z.Y., Schueler,M., Hildebrandt,F.,
            Moffat,J., Gingras,A.C., Raught,B. and Pelletier,L.
  TITLE     A Dynamic Protein Interaction Landscape of the Human
            Centrosome-Cilium Interface
  JOURNAL   Cell 163 (6), 1484-1499 (2015)
   PUBMED   26638075
REFERENCE   4  (bases 1 to 5155)
  AUTHORS   Awata,T., Yamashita,H., Kurihara,S., Morita-Ohkubo,T.,
            Miyashita,Y., Katayama,S., Mori,K., Yoneya,S., Kohda,M.,
            Okazaki,Y., Maruyama,T., Shimada,A., Yasuda,K., Nishida,N.,
            Tokunaga,K. and Koike,A.
  TITLE     A genome-wide association study for diabetic retinopathy in a
            Japanese population: potential association with a long intergenic
            non-coding RNA
  JOURNAL   PLoS One 9 (11), e111715 (2014)
   PUBMED   25364816
  REMARK    Erratum:[PLoS One. 2015 Apr 24;10(4):e0126789. doi:
            10.1371/journal.pone.0126789.. PMID: 25910184]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5155)
  AUTHORS   Wang,W.J., Tay,H.G., Soni,R., Perumal,G.S., Goll,M.G.,
            Macaluso,F.P., Asara,J.M., Amack,J.D. and Tsou,M.F.
  TITLE     CEP162 is an axoneme-recognition protein promoting ciliary
            transition zone assembly at the cilia base
  JOURNAL   Nat Cell Biol 15 (6), 591-601 (2013)
   PUBMED   23644468
  REMARK    GeneRIF: CEP162 is an axoneme-recognition protein pre-tethered at
            centriole distal ends before ciliogenesis to promote and restrict
            transition zone formation specifically at the cilia base.
REFERENCE   6  (bases 1 to 5155)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   7  (bases 1 to 5155)
  AUTHORS   Leon,A., Omri,B., Gely,A., Klein,C. and Crisanti,P.
  TITLE     QN1/KIAA1009: a new essential protein for chromosome segregation
            and mitotic spindle assembly
  JOURNAL   Oncogene 25 (13), 1887-1895 (2006)
   PUBMED   16302001
  REMARK    GeneRIF: QN1/KIAA1009 is a new microtubule-associated ATPase
            involved in cell division
REFERENCE   8  (bases 1 to 5155)
  AUTHORS   Tomsig,J.L., Snyder,S.L. and Creutz,C.E.
  TITLE     Identification of targets for calcium signaling through the copine
            family of proteins. Characterization of a coiled-coil
            copine-binding motif
  JOURNAL   J Biol Chem 278 (12), 10048-10054 (2003)
   PUBMED   12522145
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL138742.24, CD684914.1, BC063632.1, AK308190.1, AB023226.1 and
            AW069289.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014895.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            CCDS Note: The exon combination of this CCDS representation lacks
            full-length human transcript support, but it is supported by
            partial human transcript alignments and by full-length orthologous
            transcripts, e.g., mouse BC150998.1 or BC151006.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.123804.1,
                                           SRR1803614.55681.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000403245.8/ ENSP00000385215.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AL138742.24        111343-111350       c
            9-155               CD684914.1         42-188
            156-299             BC063632.1         121-264
            300-2246            AK308190.1         259-2205
            2247-5152           AB023226.1         2146-5051
            5153-5155           AW069289.1         27-29               c
FEATURES             Location/Qualifiers
     source          1..5155
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14.2-q14.3"
     gene            1..5155
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /note="centrosomal protein 162"
                     /db_xref="GeneID:22832"
                     /db_xref="HGNC:HGNC:21107"
                     /db_xref="MIM:610201"
     exon            1..64
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            65..180
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..4335
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /note="isoform a is encoded by transcript variant 1;
                     protein QN1 homolog; centrosomal protein of 162 kDa;
                     centrosomal protein 162kDa"
                     /codon_start=1
                     /product="centrosomal protein of 162 kDa isoform a"
                     /protein_id="NP_055710.2"
                     /db_xref="CCDS:CCDS34494.2"
                     /db_xref="GeneID:22832"
                     /db_xref="HGNC:HGNC:21107"
                     /db_xref="MIM:610201"
                     /translation="MANCSQEELDEEFEQFMKELSDDSFENSDKTARQSKKEMKKKDT
                     VPWWITEDDFKDDGLLGTNVSYLKTKKTSQPVMEIEEESAEKIQFLKSSGTSLLSTDS
                     LETNELVVSELNHSSLGVGLDTLEEQEEKEQFFARLEKGLTSSIDYSRLNKELDSNDS
                     THFKALHSNQANAELTDDEHENESKHEELAENYSDDFEDEYVGAPLTTKDEEMPSKEN
                     SKSEKISVPKQEEEKTGMLANVVLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMT
                     GTGVSYGQSSSDVEALHQAYCHIAHSLGDEDKQKIESNTVEDIKSSVKGHPQENEENS
                     KNISTMESDLPTVEELMKPIRIDSFGISGFDLQPVSSEKVAERKETEFFSSLPLKMNP
                     NILSQDSQHVNLFFDKNDENVILQKTTNESMENSCPQVTEVTATEEHVDKMYLNILRK
                     KITVNSSSLSQDDKINKTYRSQLSSEEEGAVMGKQVPYKKARSAPPLLKRKPQSGLYA
                     SVRSSGYGKPSSPLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPA
                     ALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEKKLLMFKRVQEAED
                     KWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSFEET
                     NKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKK
                     NEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEK
                     DSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEIS
                     RLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDK
                     AADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKL
                     EADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKE
                     LDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLV
                     RLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGN
                     ANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQF
                     ENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRH
                     FQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIK
                     QMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTELDSILD
                     VLRELHRQGVVVPVAFADEMNAPEY"
     exon            181..295
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            296..442
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..626
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..694
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..810
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..841
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            842..958
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1150
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1232
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1524
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1786
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1920
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2148
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2289
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2402
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2508
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2635
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2799
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2904
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..3117
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..3752
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3753..3894
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3895..3993
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3994..4128
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     exon            4129..5155
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5134..5139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /note="hexamer: AATAAA"
     polyA_site      5155
                     /gene="CEP162"
                     /gene_synonym="C6orf84; KIAA1009; QN1"
                     /note="major polyA site"
ORIGIN      
        1 gttaccctga caactggtgg acccgcacag accttccggg aaagcgcgga attcagaggc
       61 agagtgtttc caatgtttga ggtactttag aatgtttact ttgggaggtc aaaattgttg
      121 actatggcta actgttccca agaagagcta gatgaagagt ttgaacagtt tatgaaagag
      181 ctttcagatg attcttttga aaattcagac aaaacagcta gacaatctaa aaaagagatg
      241 aagaagaaag atacagtgcc ttggtggata actgaagatg attttaaaga tgatggactt
      301 cttggaacaa atgtgagcta tttgaaaaca aagaagactt ctcagcctgt tatggaaata
      361 gaagaggagt ctgctgaaaa gattcaattt cttaagagca gtggaacctc tctcttaagt
      421 actgatagct tagaaacaaa tgaactagta gtttctgagc tcaaccatag tagtctcgga
      481 gtgggattgg acacattaga agaacaagag gagaaagaac aattttttgc caggcttgag
      541 aaaggcttga catcttccat tgattattcg agattaaata aggaattgga ttctaatgac
      601 tctacacatt ttaaagcttt acatagtaat caagccaacg cagaactaac tgatgacgaa
      661 catgagaatg aatcgaaaca tgaagaactg gcagaaaatt acagtgatga ttttgaagat
      721 gagtatgttg gtgcaccgtt gactactaaa gatgaagaga tgccttccaa agagaattcc
      781 aaatcagaaa aaataagtgt gcccaaacag gaagaagaaa aaactggcat gcttgctaat
      841 gttgtgctgc ttgattcatt agactctgtt gcagaggtca atcttgatga acaagataaa
      901 ataacaccta agccaaggtg cctaccagaa atgactgaga atgaaatgac aggaacaggt
      961 gtttcttatg gacaaagcag tagtgacgtt gaagccctac atcaagctta ttgtcatata
     1021 gcccattcat tgggagatga agacaaacaa aaaattgaga gtaacacagt ggaagatatc
     1081 aagagctcag tgaaaggtca tcctcaagaa aatgaagaga attcaaaaaa catctctact
     1141 atggaatctg atctgcccac agtagaggag ctgatgaaac ctatcagaat agattccttt
     1201 gggatcagtg gttttgattt acaacctgtc agctctgaga aagtggccga aagaaaagaa
     1261 actgaatttt ttagctcttt acccctgaag atgaacccaa atattttgtc tcaagactca
     1321 caacatgtga accttttttt tgacaaaaat gatgagaatg tgattttaca aaagaccaca
     1381 aatgagagta tggaaaacag ctgtccacaa gtaactgaag taactgccac agaagaacat
     1441 gttgataaaa tgtaccttaa tattttgagg aaaaaaataa ctgttaattc ttcatcatta
     1501 tctcaggatg acaaaattaa taaaacttac agatctcaac ttagttctga agaagaaggg
     1561 gctgtaatgg gtaaacaggt accatacaag aaggccagaa gtgcacctcc tttacttaaa
     1621 aggaaacccc agagtggatt atatgcgtca gttaggagct caggctatgg caaacccagt
     1681 tcaccactca agatgttttc tactcttgaa aagaaaactt cagaggacat tataaaaagc
     1741 aaaaacttga gatcgatttc tacctccaat caacctagga aaaaagaaat cttatctgga
     1801 acaaaactca tcaagcctgc agctttggat aaaccagctc acaaaactga aagttgcctg
     1861 tctactcgta agaagtctga aaatcccaca gaaactgatt cctgtattca gtttcagact
     1921 gattccttag gatactgtgg tgagaacaag gagaagaaat tacttatgtt taaaagagtt
     1981 caggaagcag aggataaatg gaggggtgcg caagccctaa ttgagcaaat taaagccaca
     2041 ttctcagaaa aggagaaaga actagaaaat aagttggaag aactaaagaa acaacaggaa
     2101 aaagaactct tcaaattgaa tcaagataat tatattcttc aagccaagtt aagcagcttt
     2161 gaagaaacaa acaaaaaaca aaggtggtta cattttggag aagcagctga tcctgtcact
     2221 ggagaaaagt tgaagcaaat ccaaaaagaa atacaagaac aagagacact tcttcaagga
     2281 tatcaacagg aaaatgaacg attatataat caagtaaaag atctccaaga acaaaacaag
     2341 aaaaatgagg agcgaatgtt taaggaaaac caaagtttat tcagtgaggt agcttcctta
     2401 aaagaacaga tgcacaaaag tcgttttctg tctcaagtag ttgaagattc agagcccaca
     2461 agaaatcaga attttacaga tctgttagca gaactacgga tggcacagaa agaaaaagac
     2521 agtttattgg aagacatcaa aagactgaaa caagacaaac aagctcttga agtagacttc
     2581 gaaaaaatga agaaagagag ggaccaagcc aaagatcaga ttgcttatgt cacaggtgag
     2641 aaattatatg aaataaaaat tttagaagaa acacataaac aagaaatcag tcgtctgcaa
     2701 aaaagattac agtggtatgc tgaaaatcag gaacttctgg ataaagatgc acttcggctt
     2761 agagaagcaa atgaggaaat tgagaagctc aaacttgaga ttgagaaact gaaagctgaa
     2821 tctgggaatc catctattcg gcagaagata cgcttaaaag ataaagcagc agatgccaaa
     2881 aaaattcagg atctggagcg acaagttaag gaaatggaag ggattctgaa gagaagatat
     2941 cccaattctt tacctgcttt aatattggct gcatcagcag ctggtgatac agtggataaa
     3001 aatacagtgg aatttatgga gaaaaggata aaaaagctag aagctgatct ggagggcaaa
     3061 gatgaagatg caaagaaaag ccttcgtacc atggaacaac agtttcagaa aatgaagatt
     3121 cagtatgaac aaagactaga gcagcaggag cagctacttg cctgcaaatt gaatcaacat
     3181 gactctccca gaattaaagc cctagagaag gaacttgatg acatcaagga agcccatcag
     3241 atcactgtaa gaaaccttga agccgaaata gacgttctta aacatcagaa tgctgaatta
     3301 gacgtcaaga aaaatgataa agatgatgaa gattttcagt ctatagaatt ccaggtggaa
     3361 caggctcatg ctaaagctaa attagtaaga ctcaatgaag aactggctgc aaaaaagaga
     3421 gaaatacaag acctctcaaa aactgtggag aggcttcaga aagacagaag aatgatgcta
     3481 tcaaatcaga actcaaaggg cagagaggaa atgtctgcca aaagggcaaa gaaagatgtt
     3541 ttgcactcaa gtaaaggaaa tgctaactcc ttccctggaa ccctggacag caagctgtac
     3601 caaccacata ctttcactga ttcccatgtt tcagaagttt tacaagaaaa ctacagatta
     3661 aaaaatgagc tagaaggatt aatttcagag aagaatgaac tgaagatgaa atctgaagca
     3721 gtgatgaatc aatttgaaaa ctccatgaga agggtcaagg aagatactgc agcacacatt
     3781 gcatccctca aagcatctca tcagagagaa atagagaaac tcctttgcca aaatgcagta
     3841 gaaaattctt cttccaaagt agctgaacta aatcgtaaaa tagcaactca agaggtactt
     3901 ataagacatt tccaaagtca agttaatgag ctgcagagta aacaagagtc tctcgtagtt
     3961 tctgaagttc gagaagaaat tctacagaaa gagattacaa aactcttaga agaattgaga
     4021 gaagccaaag aaaaccatac accagagatg aaacatttcg tgggcttaga aaagaaaatt
     4081 aagcagatgg aaatgagaca tgcacaaaga gaacaggaac ttcaacagat aatacagcaa
     4141 acacaccaag tagtagaaac tgagcaaaac aaagaagttg aaaaatggaa aagactggca
     4201 cagttaaaga atcgtgagct ggagaagttc cgcacagaac tagactcaat attagatgtt
     4261 ctccgagagc tgcaccggca aggagtggtt gtgccagttg cttttgcaga tgaaatgaat
     4321 gcaccagagt attaatagaa attcagattt cataatgacc ttattaaaag gcctgaagat
     4381 ggatgggatt gtgccactgt caggacagct tatgaaaaac aagtgttcca atatgtttcc
     4441 agaaagcaaa caaccaaagc aacatttcaa aataaattgc ctttaaccaa taagaaaaaa
     4501 aacatataat ggtgtatttt actaaaaatc attaaccagt ctcattttaa gtgatttatg
     4561 gacagtttcc tttatagcag agaagggctc acttgtatgc tagaaataga aagaaaagaa
     4621 aattgaacat actccgccac atttttattg ataatgtgag gtttttaaaa tttttatttt
     4681 agatccaggg ggtacatgtg cttgttgtaa catgggtgta ttgaataatg gtgggaattg
     4741 ggcttctagt gtacccatca tccaaatatt aaacactgta cccaacaggt aatttttcaa
     4801 cgcttactgc cgctcacact ctttccccta ttggagtccc cagtgtctgt tatctccatc
     4861 tttatgtctc tgtgtaccca ttgtttagct cctactttta agtgagaata tatgcaatat
     4921 tttatttttt atgtctgatt tagttcacat aggataatgg cctccagctc tatccatgtt
     4981 gctgcaaatg acatgatttc attctttttt atagttgcat aatactccat ttatatatct
     5041 ctctctatat atatctcacg ttttctttat ccagtcaatt gttggtagat acttaggttg
     5101 gttccatgaa tttgctattg taaatattgc tgcaataaac atacatgtac agata
//
