LOCUS       NM_001194998            5560 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens centrosomal protein 152 (CEP152), transcript variant
            1, mRNA.
ACCESSION   NM_001194998
VERSION     NM_001194998.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5560)
  AUTHORS   Sullenberger,C., Kong,D., Avazpour,P., Luvsanjav,D. and Loncarek,J.
  TITLE     Centrosomal organization of Cep152 provides flexibility in Plk4 and
            procentriole positioning
  JOURNAL   J Cell Biol 222 (12) (2023)
   PUBMED   37707473
  REMARK    GeneRIF: Centrosomal organization of Cep152 provides flexibility in
            Plk4 and procentriole positioning.
REFERENCE   2  (bases 1 to 5560)
  AUTHORS   Batman,U., Deretic,J. and Firat-Karalar,E.N.
  TITLE     The ciliopathy protein CCDC66 controls mitotic progression and
            cytokinesis by promoting microtubule nucleation and organization
  JOURNAL   PLoS Biol 20 (7), e3001708 (2022)
   PUBMED   35849559
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5560)
  AUTHORS   O'Neill,A.C., Uzbas,F., Antognolli,G., Merino,F., Draganova,K.,
            Jack,A., Zhang,S., Pedini,G., Schessner,J.P., Cramer,K.,
            Schepers,A., Metzger,F., Esgleas,M., Smialowski,P., Guerrini,R.,
            Falk,S., Feederle,R., Freytag,S., Wang,Z., Bahlo,M., Jungmann,R.,
            Bagni,C., Borner,G.H.H., Robertson,S.P., Hauck,S.M. and Gotz,M.
  TITLE     Spatial centrosome proteome of human neural cells uncovers
            disease-relevant heterogeneity
  JOURNAL   Science 376 (6599), eabf9088 (2022)
   PUBMED   35709258
REFERENCE   4  (bases 1 to 5560)
  AUTHORS   Mahjabeen,I., Maqsood,Y., Abbasi,R., Ahmed,M.W. and Kayani,M.A.
  TITLE     Polymorphism in miRNA target sites of CEP-63 and CEP-152 ring
            complex influences expression of CEP genes and favors tumorigenesis
            in glioma
  JOURNAL   Future Oncol 17 (25), 3355-3372 (2021)
   PUBMED   34156311
  REMARK    GeneRIF: Polymorphism in miRNA target sites of CEP-63 and CEP-152
            ring complex influences expression of CEP genes and favors
            tumorigenesis in glioma.
REFERENCE   5  (bases 1 to 5560)
  AUTHORS   Dzhindzhev,N.S., Yu,Q.D., Weiskopf,K., Tzolovsky,G.,
            Cunha-Ferreira,I., Riparbelli,M., Rodrigues-Martins,A.,
            Bettencourt-Dias,M., Callaini,G. and Glover,D.M.
  TITLE     Asterless is a scaffold for the onset of centriole assembly
  JOURNAL   Nature 467 (7316), 714-718 (2010)
   PUBMED   20852615
  REMARK    GeneRIF: Drosophila Asl and human CEP152 are required for the
            centrosomal loading of Plk4 in Drosophila and CPAP in human cells,
            respectively
REFERENCE   6  (bases 1 to 5560)
  AUTHORS   Guernsey,D.L., Jiang,H., Hussin,J., Arnold,M., Bouyakdan,K.,
            Perry,S., Babineau-Sturk,T., Beis,J., Dumas,N., Evans,S.C.,
            Ferguson,M., Matsuoka,M., Macgillivray,C., Nightingale,M.,
            Patry,L., Rideout,A.L., Thomas,A., Orr,A., Hoffmann,I.,
            Michaud,J.L., Awadalla,P., Meek,D.C., Ludman,M. and Samuels,M.E.
  TITLE     Mutations in centrosomal protein CEP152 in primary microcephaly
            families linked to MCPH4
  JOURNAL   Am J Hum Genet 87 (1), 40-51 (2010)
   PUBMED   20598275
  REMARK    GeneRIF: CEP152 is a strong candidate for the causal gene
            underlying MCPH4 and may be an important gene in the evolution of
            human brain size.
REFERENCE   7  (bases 1 to 5560)
  AUTHORS   Yuasa,I., Umetsu,K., Matsusue,A., Nishimukai,H., Harihara,S.,
            Fukumori,Y., Saitou,N., Jin,F., Chattopadhyay,P.K., Henke,L. and
            Henke,J.
  TITLE     A Japanese-specific allele in the GALNT11 gene
  JOURNAL   Leg Med (Tokyo) 12 (4), 208-211 (2010)
   PUBMED   20547088
  REMARK    GeneRIF: Observational study of genotype prevalence. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5560)
  AUTHORS   Andersen,J.S., Wilkinson,C.J., Mayor,T., Mortensen,P., Nigg,E.A.
            and Mann,M.
  TITLE     Proteomic characterization of the human centrosome by protein
            correlation profiling
  JOURNAL   Nature 426 (6966), 570-574 (2003)
   PUBMED   14654843
REFERENCE   9  (bases 1 to 5560)
  AUTHORS   Jamieson,C.R., Govaerts,C. and Abramowicz,M.J.
  TITLE     Primary autosomal recessive microcephaly: homozygosity mapping of
            MCPH4 to chromosome 15
  JOURNAL   Am J Hum Genet 65 (5), 1465-1469 (1999)
   PUBMED   10521316
REFERENCE   10 (bases 1 to 5560)
  AUTHORS   Verloes,A., Drunat,S., Gressens,P. and Passemard,S.
  TITLE     Primary Autosomal Recessive Microcephalies and Seckel Syndrome
            Spectrum Disorders - RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301772
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG941609.1, BX648822.1 and
            CN394613.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001194998.1.
            
            Summary: This gene encodes a protein that is thought to be involved
            with centrosome function. Mutations in this gene have been
            associated with primary microcephaly (MCPH4). Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Aug
            2010].
            
            Transcript Variant: This variant (1) represents the longer variant
            and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648822.1, SRR1803613.56021.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380950.7/ ENSP00000370337.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                BG941609.1         2-98
            98-2849             BX648822.1         102-2853
            2850-2858           CN394613.1         207-215
            2859-5560           BX648822.1         2863-5564
FEATURES             Location/Qualifiers
     source          1..5560
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.1"
     gene            1..5560
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /note="centrosomal protein 152"
                     /db_xref="GeneID:22995"
                     /db_xref="HGNC:HGNC:29298"
                     /db_xref="MIM:613529"
     exon            1..109
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            110..203
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..5249
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     asterless; microcephaly, primary autosomal recessive 4;
                     centrosomal protein 152kDa"
                     /codon_start=1
                     /product="centrosomal protein of 152 kDa isoform 1"
                     /protein_id="NP_001181927.1"
                     /db_xref="CCDS:CCDS58361.1"
                     /db_xref="GeneID:22995"
                     /db_xref="HGNC:HGNC:29298"
                     /db_xref="MIM:613529"
                     /translation="MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDD
                     DLSSPELQYSDCSEDGTDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCG
                     NVWEENRSKTEDRHPVYHPEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQE
                     FNNQATNVIKFSDPQWNHFQGPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTF
                     EGLQQQFLGANENSAENMQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVII
                     KDEKDGLTLSLRESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEM
                     ALESLKQQLVDLHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQE
                     DICSRLKDHVKQLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQ
                     FQLQQAQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTES
                     YVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQ
                     LQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLL
                     KNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHH
                     EAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREK
                     DNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQV
                     TTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVE
                     IAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSEL
                     ENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQ
                     EQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQSRREWTMQ
                     EAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSKWMSVQYFE
                     KLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQPL
                     ALQATEAEADKKKVLEIKDLCCGHCFQELEKAKQECQDLKGKLEKCCRHLQHLERKHK
                     AVVEKIGEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSGGA
                     LEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ
                     QILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKK
                     SKRNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGS
                     KETHLEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSA
                     AYPFLGTLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKS
                     QGLDVQEPPVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQ
                     FSPSGYLSDTEESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLK
                     SDFKKLSSTLPSSVCQQPSRKLIVPLSSQQDSGFDSPFVNLD"
     exon            204..307
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            308..377
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            378..656
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            657..807
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            808..948
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1088
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1289
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1437
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1529
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1693
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1898
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2024
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2134
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2263
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2396
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2678
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2810
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..3461
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            3462..3582
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            3583..3750
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            3751..3847
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            3848..3951
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            3952..4105
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            4106..4209
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     exon            4210..5560
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5538..5543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /note="hexamer: AATAAA"
     polyA_site      5560
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /note="major polyA site"
ORIGIN      
        1 gtgactagga aggagctagt ggactagagc cagggtaagg ggatctgcta gaagttggtc
       61 ttccgccagg actagagttt cctcgcggta acagcctccg tggcctccgg aggaccatgt
      121 cattagactt tggcagtgtg gcactaccag tgcaaaatga agatgaagag tatgacgaag
      181 aggactatga aagagagaaa gagttgcagc agttactcac agaccttccc catgacatgc
      241 tggatgacga cctctcctct ccagagctcc agtattcgga ctgcagcgag gatggcacag
      301 acggacaacc acatcatcct gagcaattgg agatgagctg gaatgagcaa atgctgccca
      361 aatctcaaag tgtaaatggc tataatgaaa ttcagagttt atatgctgga gaaaaatgtg
      421 gtaatgtctg ggaagaaaat agaagtaaaa ctgaagaccg acatcctgtg taccatcctg
      481 aagaaggtgg agatgaaggt ggaagtggtt atagtcctcc aagtaaatgt gaacagactg
      541 atttatatca ccttcctgaa aactttaggc catataccaa tggtcagaag caggaattta
      601 ataaccaagc aaccaatgta attaaatttt cagatcctca atggaaccat tttcagggtc
      661 ccagttgtca aggtttggaa ccgtataata aagtgacata taaaccttat cagtcttctg
      721 cccagaataa tggctcacca gcccaggaga taacaggaag tgacacattc gaaggcctgc
      781 aacaacaatt tttaggagct aatgagaact ctgcagaaaa tatgcagatt attcaacttc
      841 aggttcttaa caaagcaaaa gagagacaac tggagaactt aattgaaaag ttaaatgaaa
      901 gtgaacgtca aattcgatat ctgaatcacc agcttgtaat aataaaagat gaaaaggatg
      961 gtttgactct cagccttcga gaatcacaga aactctttca gaatggaaaa gaaagagaga
     1021 tacagcttga agctcaaata aaagcactgg agactcagat acaagcatta aaagtcaatg
     1081 aagaacagat gatcaagaag tccagaacaa ctgaaatggc tctggaaagc ttgaagcagc
     1141 agctggtgga ccttcatcat tctgaatcac ttcaacgagc tagagaacag catgagagca
     1201 ttgttatggg cctcacaaag aagtacgaag agcaagtatt gtccttacaa aagaatttgg
     1261 atgccacagt caccgcactt aaagaacagg aagacatttg ctctcgtctg aaagatcacg
     1321 tgaaacaact ggaaaggaat caagaagcaa tcaagttaga aaagactgag atcattaata
     1381 agttgacaag aagtctagag gagagtcaaa agcagtgtgc ccacttgttg cagtccgggt
     1441 cagtacaaga ggtggctcag ctacagttcc agctgcagca agcacagaag gcacatgcta
     1501 tgagtgcaaa catgaacaag gctttgcaag aagaattaac agaactaaaa gatgaaattt
     1561 ctctctatga atctgctgca aaactaggaa tacatccaag tgactcagaa ggagaattaa
     1621 atatagaact cactgaatcg tatgtggatt tgggtattaa aaaggtcaac tggaaaaaat
     1681 ccaaagttac cagcattgta caagaagaag acccaaatga agagctttca aaagatgagt
     1741 tcattctgaa gttaaaggca gaagtacagc gtttgctggg tagcaactca atgaagcgtc
     1801 atctggtgtc tcagttacaa aatgacctca aagactgtca taagaaaatt gaagatctcc
     1861 accaagtgaa gaaggatgaa aaaagcattg aggttgagac taaaacagat acctcagaaa
     1921 aaccaaagaa tcaattatgg cctgagtctt ctacttctga tgttgtcaga gatgatattc
     1981 tgctgcttaa aaatgaaatt caagttttac aacaacaaaa tcaggaactt aaagaaactg
     2041 aaggaaaact gagaaataca aatcaagact tatgtaatca aatgagacaa atggtacaag
     2101 attttgacca tgacaaacaa gaagctgtgg ataggtgtga aaggacttat cagcagcacc
     2161 atgaagccat gaaaactcaa atacgtgaaa gcctattagc aaagcatgct ttggagaagc
     2221 agcagctctt tgaggcttat gagagaactc atttgcaact gaggtctgag ttggataagt
     2281 tgaataagga ggtgactgct gtgcaggaat gttacctaga agtgtgcaga gagaaggata
     2341 atctagaatt gactctcagg aagaccactg aaaaggagca acagactcag gagaagatca
     2401 aagaaaaact cattcaacag cttgaaaagg agtggcagtc taagctggat caaactataa
     2461 aggcaatgaa aaagaagacc ttagattgtg gcagccaaac tgaccaagta accaccagtg
     2521 atgttatttc caagaaagag atggcaatta tgatagaaga gcagaagtgc acaatccagc
     2581 aaaacttaga acaagagaag gacatagcca tcaagggggc tatgaagaaa ctcgaaattg
     2641 aattggaact caaacattgt gaaaatatta ccaaacaggt agaaatagct gtgcaaaatg
     2701 ctcatcagcg atggctggga gaactaccag agctggcaga gtatcaagca cttgtgaagg
     2761 cagaacagaa aaagtgggaa gaacagcatg aggtctctgt gaacaaaagg atatcatttg
     2821 ctgtttctga agctaaagag aaatggaaga gtgagcttga aaatatgagg aaaaatatac
     2881 ttcctggaaa ggaattggaa gagaagattc attctcttca gaaggaactt gagttaaaga
     2941 acgaagaagt ccctgtggtc atcagggctg agttagctaa ggctcggagt gaatggaaca
     3001 aagaaaagca agaagaaatc cacagaatcc aagaacaaaa tgagcaagat taccggcaat
     3061 ttttagatga tcaccgaaat aaaattaatg aggtgcttgc ggcagctaaa gaagacttta
     3121 tgaaacaaaa aactgaacta cttcttcaga aggagacaga attacaaact tgtctagacc
     3181 agagtcgtag agaatggact atgcaggaag ccaagcggat ccaactggaa atctatcagt
     3241 atgaggaaga catcctgact gtacttgggg ttcttttaag tgatacccaa aaggagcaca
     3301 tcagtgattc tgaggacaag cagcttttgg aaatcatgtc gacttgttct tcaaaatgga
     3361 tgtctgtgca atattttgaa aaactaaagg gctgcataca gaaagcattt caagatacac
     3421 ttcctctgct tgtagaaaac gctgacccag aatggaaaaa gagaaatatg gccgagctct
     3481 ctaaggattc tgccagccag ggcactggcc aaggagaccc tggacctgct gctggacacc
     3541 atgctcagcc cttggcctta caagcaacag aagcagaagc tgataagaaa aaggtccttg
     3601 aaattaagga tttatgctgt ggacactgct tccaagaact tgaaaaggca aagcaggaat
     3661 gtcaagatct gaaaggaaaa ctggagaaat gctgtaggca tcttcagcat ttagaaagga
     3721 agcacaaagc tgtagtggaa aaaattggag aagagaataa taaagttgtt gaagaattaa
     3781 tagaagaaaa caacgacatg aagaataaat tggaagaatt gcaaacactt tgtaaaacac
     3841 caccaaggtc attgtcagca ggggccattg aaaatgcttg cctgccatgc agtgggggag
     3901 ccttggaaga acttcgtggg cagtacatta aagctgtaaa aaaaattaaa tgtgacatgc
     3961 ttcgttatat tcaggagagt aaggaacgag ctgcagaaat ggtaaaagca gaggtactgc
     4021 gagaacgtca agaaaccgcc cgaaagatgc gcaaatatta tttgatttgc ctccaacaga
     4081 ttttgcagga tgatggaaaa gaaggggctg agaaaaagat tatgaatgct gctagcaaac
     4141 ttgctacaat ggcaaaatta ctggaaacac ctatttctag taagtcccaa agcaaaacta
     4201 cacagtcagc actgccccta acttcagaga tgctgattgc agttaaaaaa tcaaaaagaa
     4261 atgatgtgaa tcagaaaata ccatgttgta ttgaaagcaa atcaaatagt gtaaacacca
     4321 tcaccagaac tctgtgcgaa caagctccca agaggagggc agcttgtaac ttacaaaggc
     4381 tgttagagaa ctcagagcat cagagcataa agcatgtggg atccaaagag acacatttgg
     4441 aattccagtt tggggatggt agttgcaagc acctaaacag tttgccaagg aatgtttctc
     4501 ctgagtttgt tccttgtgaa ggtgaaggag gctttggttt gcacaagaag aaagacctac
     4561 tcagtgataa tggttctgaa tcacttccgc attcagctgc ataccccttt cttggaacct
     4621 taggaaataa accctcacct agatgtaccc ctggtccttc tgaatcagga tgcatgcata
     4681 taacctttcg cgattctaat gaaagacttg gtttaaaagt atataaatgc aatccactaa
     4741 tggaaagtga aaatgctgca tctgagaaaa gtcaaggttt ggatgttcag gaacctccag
     4801 taaaagatgg aggggacctt agtgactgct tgggctggcc ttccagcagt gcaaccttat
     4861 cctttgacag tcgtgaagca tcatttgtac atggtaggcc acaaggaact ttggaaatac
     4921 caagtgaatc tgttaaatcc aaacagtttt caccatccgg ttatctttca gatacagagg
     4981 aaagtaatat gatttgtcaa acaatgaaat gtcagcgtta tcaaactcca tacctgtcag
     5041 aagaaaccac gtatttggag ccaggaaaga tcagtgtgaa ttgtggacac ccatctcgtc
     5101 ataaggctga tagattaaag tcagatttca aaaaactgag cagtacatta ccatcttcag
     5161 tgtgtcagca gccttcaaga aaattaattg ttccgctatc tagccaacaa gatagtggct
     5221 ttgatagccc atttgttaat ctagactaat tatggtacag tatttaagaa gaatcattaa
     5281 tatattaaca aaaatggaag ggaagacctc atactgaaaa aaattgtgag ccctgcctct
     5341 tttgagatgt tttaataaca tctgttatat aagtaaagca ttcttctaaa attgcttgag
     5401 atatttatgt tgccttaata ttccaaaggc ctgatggtgt atgtataatc tgcttttgtg
     5461 tggtgcttat ttttggtttc taaaccatct atttttatac ttataaattg actcactctg
     5521 cagtgttaac ttatttaaat aaacttgcat atggtctgta
//
