LOCUS       NM_001291941            3369 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens centrosomal protein 15 (CEP15), transcript variant 2,
            mRNA.
ACCESSION   NM_001291941 XM_005265338
VERSION     NM_001291941.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3369)
  AUTHORS   Etcheverry,A., Aubry,M., de Tayrac,M., Vauleon,E., Boniface,R.,
            Guenot,F., Saikali,S., Hamlat,A., Riffaud,L., Menei,P., Quillien,V.
            and Mosser,J.
  TITLE     DNA methylation in glioblastoma: impact on gene expression and
            clinical outcome
  JOURNAL   BMC Genomics 11, 701 (2010)
   PUBMED   21156036
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3369)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA783189.1, AF236158.1, AC092502.2 and BE047745.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001291941.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.899445.1,
                                           SRR1803612.38600.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000462069.6/ ENSP00000419977.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DA783189.1         50-63
            15-802              AF236158.1         1-788
            803-2966            AC092502.2         103751-105914
            2967-3349           BE047745.1         9-391
            3350-3369           AC092502.2         106298-106317
FEATURES             Location/Qualifiers
     source          1..3369
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.2"
     gene            1..3369
                     /gene="CEP15"
                     /gene_synonym="C3orf14; HT021"
                     /note="centrosomal protein 15"
                     /db_xref="GeneID:57415"
                     /db_xref="HGNC:HGNC:25024"
     exon            1..34
                     /gene="CEP15"
                     /gene_synonym="C3orf14; HT021"
                     /inference="alignment:Splign:2.1.0"
     exon            35..146
                     /gene="CEP15"
                     /gene_synonym="C3orf14; HT021"
                     /inference="alignment:Splign:2.1.0"
     exon            147..211
                     /gene="CEP15"
                     /gene_synonym="C3orf14; HT021"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..545
                     /gene="CEP15"
                     /gene_synonym="C3orf14; HT021"
                     /note="isoform a is encoded by transcript variant 2;
                     uncharacterized protein C3orf14; centrosomal protein 15
                     kDa"
                     /codon_start=1
                     /product="centrosomal protein 15 isoform a"
                     /protein_id="NP_001278870.1"
                     /db_xref="CCDS:CCDS2896.1"
                     /db_xref="GeneID:57415"
                     /db_xref="HGNC:HGNC:25024"
                     /translation="MTSLFAQEIRLSKRHEEIVSQRLMLLQQMENKLGDQHTEKASQL
                     QTVETAFKRNLSLLKDIEAAEKSLQTRIHPLPRPEVVSLETRYWASVEEYIPKWEQFL
                     LGRAPYPFAVENQNEAENTIQNEAQR"
     exon            212..335
                     /gene="CEP15"
                     /gene_synonym="C3orf14; HT021"
                     /inference="alignment:Splign:2.1.0"
     exon            336..410
                     /gene="CEP15"
                     /gene_synonym="C3orf14; HT021"
                     /inference="alignment:Splign:2.1.0"
     exon            411..3369
                     /gene="CEP15"
                     /gene_synonym="C3orf14; HT021"
                     /inference="alignment:Splign:2.1.0"
     regulatory      797..802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP15"
                     /gene_synonym="C3orf14; HT021"
                     /note="hexamer: ATTAAA"
     polyA_site      802
                     /gene="CEP15"
                     /gene_synonym="C3orf14; HT021"
                     /note="major polyA site"
     regulatory      3310..3315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP15"
                     /gene_synonym="C3orf14; HT021"
                     /note="hexamer: AATAAA"
     regulatory      3349..3354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP15"
                     /gene_synonym="C3orf14; HT021"
                     /note="hexamer: ATTAAA"
     polyA_site      3349
                     /gene="CEP15"
                     /gene_synonym="C3orf14; HT021"
     polyA_site      3369
                     /gene="CEP15"
                     /gene_synonym="C3orf14; HT021"
ORIGIN      
        1 ggtgccttcc cggaagggct cagaggcggg ctcgggcaag cactttaacc ttttaagccc
       61 aaccagatga gttgcctgca gttttggagg ccttcagagc atttcactag acctctgtct
      121 gtgtcggtcc agtgtcttta gccaagcttt gattaaagat gacttccttg tttgctcaag
      181 aaattcgcct ttctaaaaga catgaagaaa tagtatcaca aagattaatg ttacttcaac
      241 aaatggagaa taaattgggt gatcaacaca cagaaaaggc atctcaactc caaactgttg
      301 agactgcttt taaaaggaac cttagtcttt taaaggatat agaagcagca gaaaagtcac
      361 tacagaccag gattcaccca cttccacggc ctgaggtggt ttctcttgag actcgttact
      421 gggcatcagt agaagaatat attcccaaat gggaacagtt tcttttagga agagcaccat
      481 atccttttgc tgttgaaaat caaaatgaag cagaaaatac cattcaaaat gaggcacagc
      541 gataacttct tcacatgcta tttcaaaaag cctgtttaat aaagctgaat gttaaggtgt
      601 atgtaggtta ttgcaggaac tttaggaatt aaatatgttc atattcttcg attatctcct
      661 aagtgacagt gaagatatga gaatttactg gcaagtcaca tgttatcacc tactactatt
      721 tcaaggtcat gaatttgctt tctaccaaac ccatagatgt gttaaacacg aatattaaaa
      781 ggtggactct ttattaatta aattattgtc agtgttgtga gtgtgttgct ttaaaaaaaa
      841 aaaaatttac aatcattctc ctctaagcag gtatcttggt tctggtttta agttaagttt
      901 tttagaatcc ttacttttta gggacaaggt ataggatcaa catggttctt tttttttttt
      961 aaaccattat tgtttctttt aacaaattaa aagacaatga cacctaaact gctctagcaa
     1021 aataacttat gagaaaataa attcatagga ttttgtccct cacagatagc caaagctctg
     1081 caagttctgg agacagaaag aactgaacta taaagcagtc aataagtagc cagtttcagg
     1141 aagactcaga cttggttttg aaaaaggatg ccttttagag ctgggaaagg ttattggatt
     1201 ttgacttggt tatttaaaga ttgccaacct tgtgaatgca aataacccca ctcttgtctt
     1261 ttcatcttta aacttcccct tcccgcttcc ttctaatttc attattcctg aaaaaactgt
     1321 cagtcagaaa gcgttgggtc acaaccctaa acagctttga gattcctcag tccaccactg
     1381 cttgagcact taaaaaaaaa aaagaaaaaa aaaatatgta tatataactt tccagctata
     1441 gaggcagcct ctgctagtaa agggtaccta tgctatatta caatgaaatg ttttaaattt
     1501 caaactggtt tatgttttta aaagaagaca ataggaaaag ctaaatacac agcaacaaca
     1561 acaactatat tgaaacgtcc gttgtgccga taagttcctt taaactacca tcttggaaat
     1621 atcctgttga gtgggtgttg gtgtgggtaa caataatgtt gttttcataa tatgtgctgg
     1681 cagattagca cacttctcta cagtgttaac agttgtaatt aaggaataaa cagcacaggg
     1741 tgtcagtccg atgacaattt catctatagt gtcacaatac aaaatgtcac aaaatattag
     1801 aactgttata taactataaa aagtatcagc ttaaaagcta aaagcctttg aaaaaagaag
     1861 acagaggaag gaagaaaaaa gaaaactggc atagcaacca gaacaatttt ataccttctc
     1921 aagaatgttc tgtcatgaaa ataaattgat aatttttttc tgttacatta cagtttggtt
     1981 tctagccatc cagttgattt agcaggagaa tgcaggtttt tttagcagct ttgaattggt
     2041 aaacagattt agatgtagta gaaaggaaca tgaggaagtt gttttttttt ttaacatcca
     2101 atctttccca gcatatgcac ataagaaggt gaatgaagca atgtgaaact tacttctctt
     2161 tagtcaagtg aaaaaaaggc taaacatttg ttagatggta aaatattgtg tcaagcgagt
     2221 aggcaaattc caaaattaca cagtggttga tacattaaca tcctcaaata tttgagcatg
     2281 cacttccttt gagatctgta aattaaatca ccagtgggtt agataaaaat acaaaacaaa
     2341 tggcaatcta accatctcag aaaaggttca ggtttttttc tccctaaaac tgagaacttg
     2401 ctaaataatt tttgaaaagc ataaacgtaa tacaccctgg gttacgatcg agggcagaag
     2461 ggaaggcatt tccaaggctc ctgctgtagt gtttttccca tttttgttaa tacctcaaaa
     2521 actcccagag atgactttat tcctggcccc tgcagagctc ccctccccac ccccaccttg
     2581 tagactgtaa cagattgcac cacatggtgt ctgtttaaaa aaaaaaaaaa aattcccata
     2641 gggacctgga tatcccatta atgggcttta tgttcctcat ggcaaattag ctttacacag
     2701 gaatttccaa acattgtttt ctgttaagaa gggaggaata ccatatataa tgtatatttt
     2761 ttctacaatt agtaggaatc agacaaggaa aaggaaatgt catctattca tacctttctc
     2821 tccaaattca gtgttctttc catatgctcc attgtactcc accactcttc tccatgaaaa
     2881 ctatgaattt atggtttttt tttagaaaaa tggagttttc aaaatgaaag tcaaataatt
     2941 ttttccaaag ccgtttgtgg actgttgcaa atgcataaat attcaaagct cattttctgc
     3001 agaaacactt ctggtatatg aaattattaa actgtagaat gctaaagatc agaagaagct
     3061 acagtttttc tttaaacttg aaaaaaaatt aagaagtatt aaggaaaaag cttaatactc
     3121 tggaaaccag acatctggtc tttctcatgc gtagggagca gtgtgaatga aagtgaagtc
     3181 aaacggacag tttttttctg cattatgcac aaggtgtttt aaattgtcag cttaaggttt
     3241 agatgaagat aatctttaac tttgtttaca atttttgcta ttttgcatta tccccctttt
     3301 tccataaaaa ataaagtgaa tatgtgtgca tatttatttt gaatcaaaat taaacttatt
     3361 ttgagatta
//
