LOCUS       NM_025009               5596 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens centrosomal protein 135 (CEP135), mRNA.
ACCESSION   NM_025009 XM_496694
VERSION     NM_025009.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5596)
  AUTHORS   Wang,K., Wang,X., Zhao,F., Zhao,Q., Kong,S., Ma,P., Wu,G., Wang,W.
            and Zhang,X.
  TITLE     Centrosomal Protein CEP135 Regulates the Migration and Angiogenesis
            of Endothelial Cells in a Microtubule-Dependent Manner
  JOURNAL   Front Biosci (Landmark Ed) 28 (11), 303 (2023)
   PUBMED   38062802
  REMARK    GeneRIF: Centrosomal Protein CEP135 Regulates the Migration and
            Angiogenesis of Endothelial Cells in a Microtubule-Dependent
            Manner.
REFERENCE   2  (bases 1 to 5596)
  AUTHORS   O'Neill,A.C., Uzbas,F., Antognolli,G., Merino,F., Draganova,K.,
            Jack,A., Zhang,S., Pedini,G., Schessner,J.P., Cramer,K.,
            Schepers,A., Metzger,F., Esgleas,M., Smialowski,P., Guerrini,R.,
            Falk,S., Feederle,R., Freytag,S., Wang,Z., Bahlo,M., Jungmann,R.,
            Bagni,C., Borner,G.H.H., Robertson,S.P., Hauck,S.M. and Gotz,M.
  TITLE     Spatial centrosome proteome of human neural cells uncovers
            disease-relevant heterogeneity
  JOURNAL   Science 376 (6599), eabf9088 (2022)
   PUBMED   35709258
REFERENCE   3  (bases 1 to 5596)
  AUTHORS   Chu,Z. and Gruss,O.J.
  TITLE     Mitotic Maturation Compensates for Premature Centrosome Splitting
            and PCM Loss in Human cep135 Knockout Cells
  JOURNAL   Cells 11 (7), 1189 (2022)
   PUBMED   35406752
  REMARK    GeneRIF: Mitotic Maturation Compensates for Premature Centrosome
            Splitting and PCM Loss in Human cep135 Knockout Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5596)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5596)
  AUTHORS   Steib,E., Laporte,M.H., Gambarotto,D., Olieric,N., Zheng,C.,
            Borgers,S., Olieric,V., Le Guennec,M., Koll,F., Tassin,A.M.,
            Steinmetz,M.O., Guichard,P. and Hamel,V.
  TITLE     WDR90 is a centriolar microtubule wall protein important for
            centriole architecture integrity
  JOURNAL   Elife 9, e57205 (2020)
   PUBMED   32946374
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5596)
  AUTHORS   Casenghi,M., Meraldi,P., Weinhart,U., Duncan,P.I., Korner,R. and
            Nigg,E.A.
  TITLE     Polo-like kinase 1 regulates Nlp, a centrosome protein involved in
            microtubule nucleation
  JOURNAL   Dev Cell 5 (1), 113-125 (2003)
   PUBMED   12852856
REFERENCE   7  (bases 1 to 5596)
  AUTHORS   Takahashi,M., Yamagiwa,A., Nishimura,T., Mukai,H. and Ono,Y.
  TITLE     Centrosomal proteins CG-NAP and kendrin provide microtubule
            nucleation sites by anchoring gamma-tubulin ring complex
  JOURNAL   Mol Biol Cell 13 (9), 3235-3245 (2002)
   PUBMED   12221128
REFERENCE   8  (bases 1 to 5596)
  AUTHORS   Mayor,T., Stierhof,Y.D., Tanaka,K., Fry,A.M. and Nigg,E.A.
  TITLE     The centrosomal protein C-Nap1 is required for cell cycle-regulated
            centrosome cohesion
  JOURNAL   J Cell Biol 151 (4), 837-846 (2000)
   PUBMED   11076968
REFERENCE   9  (bases 1 to 5596)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
REFERENCE   10 (bases 1 to 5596)
  AUTHORS   Verloes,A., Drunat,S., Gressens,P. and Passemard,S.
  TITLE     Primary Autosomal Recessive Microcephalies and Seckel Syndrome
            Spectrum Disorders - RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301772
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BK005586.1, BC136535.1,
            CA438857.1 and BU734129.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_025009.4.
            
            Summary: This gene encodes a centrosomal protein, which acts as a
            scaffolding protein during early centriole biogenesis, and is also
            required for centriole-centriole cohesion during interphase.
            Mutations in this gene are associated with autosomal recessive
            primary microcephaly-8. [provided by RefSeq, Jun 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.172259.1, BK005586.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257287.5/ ENSP00000257287.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1165              BK005586.1         75-1239
            1166-4606           BC136535.1         1130-4570
            4607-4694           CA438857.1         4-91                c
            4695-5106           BK005586.1         4768-5179
            5107-5596           BU734129.1         18-507              c
FEATURES             Location/Qualifiers
     source          1..5596
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q12"
     gene            1..5596
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /note="centrosomal protein 135"
                     /db_xref="GeneID:9662"
                     /db_xref="HGNC:HGNC:29086"
                     /db_xref="MIM:611423"
     exon            1..115
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            116..273
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..3583
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /note="centrosomal protein 4; centrosome protein cep135;
                     centrosomal protein 135kDa"
                     /codon_start=1
                     /product="centrosomal protein of 135 kDa"
                     /protein_id="NP_079285.2"
                     /db_xref="CCDS:CCDS33986.1"
                     /db_xref="GeneID:9662"
                     /db_xref="HGNC:HGNC:29086"
                     /db_xref="MIM:611423"
                     /translation="MTTAVERKYINIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTT
                     ESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLREHSDQHVKE
                     LKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGK
                     KRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQE
                     KLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQ
                     VDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKE
                     EVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDL
                     ETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGI
                     EEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDEL
                     QRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTAPHNIVSL
                     MEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEK
                     YELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDD
                     YQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQ
                     ETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQ
                     LDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVH
                     KYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSI
                     DTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLN
                     DLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTV
                     KNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQ
                     LQTDYDALKRQISTERYERERAIQEMRRHGLATPPLSSTLRSPSHSPEHRNV"
     exon            274..464
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            465..632
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            633..774
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            775..859
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            860..988
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1204
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1270
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1409
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1633
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1786
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1939
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2017
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2169
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2285
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2440
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2496
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2665
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2776
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2962
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3172
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3375
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..3480
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            3481..3594
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     exon            3595..5596
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5322..5327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /note="hexamer: AATATA"
     polyA_site      5345
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
     regulatory      5579..5584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /note="hexamer: AATAAA"
     polyA_site      5596
                     /gene="CEP135"
                     /gene_synonym="CEP4; KIAA0635; MCPH8"
                     /note="major polyA site"
ORIGIN      
        1 attttcaaac tgctctagcg ccggagcccg tgcctggacg gaaggagcta gtgggggact
       61 cgaggcctga gggcaatgcg gctggaggcg gaggcaacgg cggctggagc tgccggactt
      121 taatttttgg aagtgaataa aacttgtttt agaagacgag atgactacag ctgtagagag
      181 aaagtatatt aatattagga aaaggctgga tcagctggga taccgccaga ctctgacagt
      241 ggagtgttta cctttggtag aaaaactttt cagcgactta gttcatacaa ctgagagcct
      301 tcggcaatca aaattatctg ctgtgaaagc tgaaaaagaa agtgccaatt ttgattttgt
      361 tttggaaccc tataaacttg aaaatgcaag attgagtaga gaaaataatg aattatacct
      421 agagttaatg aaactgagag aacattcaga ccaacacgtt aaagagttga aaacttcatt
      481 gaagaaatgt gcacgtgaaa cagctgatct gaaatttctg aataaccaat atgctcataa
      541 actcaaactg ttggagaaag agagcaaagc taagaatgaa agaattcaac aacttcaaga
      601 aaagaatttg catgctgtag tacaaactcc aggtggcaag aaaagaagta ttgctttcag
      661 gcgccagcgt atgcaaattg atgaaccggt tcctccctct gaagtcagtt catatccagt
      721 tcctcaacca gatgaccctt acattgcaga cctccttcaa gtggctgata acaggattca
      781 agaacttcaa caggaagtcc accagctaca agaaaagtta gcaatgatgg aaagtggggt
      841 gagagactat agcaagcaga ttgagctaag agaacgagag atagaacgac tgtcagttgc
      901 tttggatggt ggtcggtccc ctgatgtcct ttctctggag tctagaaata aaaccaatga
      961 aaagcttatt gctcatttaa atattcaggt tgactttctt cagcaagcta ataaagacct
     1021 ggagaagcgt atacgagagc ttatggaaac caaggaaaca gtgacatctg aagtcgttaa
     1081 tttaagtaac aaaaatgaaa aactctgcca agaattaact gaaatagatc agttagcaca
     1141 gcagttggaa agacataaag aagaagtgct tgagactgct gataaagagc ttggggaagc
     1201 aaagaaagag attaaaagaa agctctctga aatgcaggat cttgaagaaa caatggcaaa
     1261 acttcagctg gaattgaact tatgccagaa agaaaaggag agactgagtg atgaactcct
     1321 tgtaaaatca gacctagaaa ctgttgttca tcagcttgaa caagaaaagc aaagacttag
     1381 caaaaaagtt gaaagttttg cagttacaga acgacaactt actctggagg ttgagaggat
     1441 gagactagaa catggaataa aacgtcgaga caggtcacct tctcgtttag atacatttct
     1501 gaaaggtata gaagaagaac gagattatta taagaaagag ctagagagac tccaacatat
     1561 aatacagcga agatcttgct ctacaagtta tagcgcacgt gaaaaaagtt caatatttag
     1621 aacaccagaa aagggtgatt acaattcaga aattcatcag atcacaagag aaagagatga
     1681 acttcagcgt atgctagaaa gatttgaaaa atatatggaa gatatacagt ccaatgttaa
     1741 attattgaca gcagaaagag ataaactaag tgtcttatat aatgaagctc aggaagaatt
     1801 atctgcccta agaaaggaat ccacccaaac cacagcaccc cataatattg ttagtcttat
     1861 ggaaaaggaa aaagaacttg cgttatctga cttaagaaga attatggcag aaaaggaagc
     1921 tttaagagaa aaattagagc atattgaaga agtgagtctt tttggaaaat cagaattaga
     1981 gaaaactatt gaacatttga catgtgttaa tcatcagctt gaaagcgaaa aatatgaatt
     2041 aaagtctaaa gtgttaataa tgaaagaaac aatagagtcg ttagagaaca aattaaaagt
     2101 ccaagctcaa aaatttagcc atgtggctgg tgactcatct catcagaaaa cagaggtgaa
     2161 ctcacttagg atagtgaatg agcagctaca gcggtcagtt gatgactatc agcaccgact
     2221 ttccataaaa agaggtgaac ttgaatcagc ccaagcacaa attaaaatac tggaggaaaa
     2281 gatagatgaa ctaaacctta agatgacttc acaggatgag gaggctcatg taatgaaaaa
     2341 gaccattggt gttattgata aagaaaaaga ctttctccag gagactgtag atgagaagac
     2401 agaaaagatt gcaaatttgc aagaaaacct agctaataaa gaaaaagctg ttgctcaaat
     2461 gaagataatg atctcagagt gtgaatcatc tgtgaaccag ctgaaagaaa cattggttaa
     2521 tcgagatcgt gagataaaca gcctccggcg ccagcttgat gcagctcaca aagaactcga
     2581 tgaagtagga agatctagag aaatcgcttt taaggaaaac agaagactgc aagatgacct
     2641 ggctacaatg gcaagagaaa atcaagaaat ctcattggaa ttggaagcag cagtgcaaga
     2701 aaaagaagaa atgaagagca gagttcataa atacataaca gaggtgtcac gatgggagag
     2761 cttaatggct gccaaggaaa aagaaaatca agatttgtta gatagatttc agatgcttca
     2821 taaccgtgct gaagactggg aggtcaaagc ccatcaagct gagggagaaa gcagctcagt
     2881 tcgactggaa cttctttcta ttgacactga gaggagacat cttcgagaaa gagtggagct
     2941 attagaaaaa gaaattcaag agcacataaa tgcccatcat gcttatgaat ctcagatctc
     3001 atcaatggca aaagccatgt ctcgattaga agaagagctg agacatcaag aagatgagaa
     3061 agcaacagta ttaaatgact tgtcatctct tagagaactt tgcattaaac ttgattcagg
     3121 caaagatatt atgacccagc aattgaattc gaaaaacctt gagtttgaga gggttgtggt
     3181 ggaattagaa aatgtaaagt cagagtcaga cctactgaaa aaacaacttt caaatgagag
     3241 acatacagtt aaaaacctcg aatcattgtt ggctacaaac agagataaag aatttcattc
     3301 tcacttaacc tcccacgaga aggatacaga aatccagcta cttaaggaga agttaaccct
     3361 ttctgaaagc aaattaacta gtcaaagccg ggaaaacacc atgcttcgag ctaaagtggc
     3421 acagttacaa acagattatg atgctctgaa aaggcagatc tcaactgaaa gatacgaacg
     3481 agaacgagca atccaagaga tgcgtcgaca tggtcttgct acaccacccc ttagttccac
     3541 tctgaggtct ccttcacatt ctcctgaaca tagaaatgtg taattatcag aaagaataat
     3601 ggctttcaat gagttcctat gtggattttt aaaagaacag aacagtaatg aaatatttga
     3661 agtacttgtt gctgaaaatc atgaacatgg acacaaattc tacctctgtc aacttttatt
     3721 taaatcagtg aatatgttaa aaagtttggt ttaaaagaac tatatctata tgtatatttt
     3781 catatatatg acagaacaag aatatgtatt aatagtgcct aatgtatcta tatttttatt
     3841 attcatgaat taaattacta aaagtatgtt tatactgtga attaatataa tgtattcaca
     3901 ttattcttta ataatctgtt tattaataag ccatgatatg tgtatgtaaa tattcttaca
     3961 gtacttgttt ttagttgtca tgcctatgtt tagaccatat cttaatgtat tcacaaagaa
     4021 ttatcaactt tgatgctatg ctgtcatgct taactttttc ttcttaaaat tattcataga
     4081 tctactgtct gttgtcaagg ggaatatatt caggtctagt cttcttataa tagcagaggt
     4141 cttggtaaaa taactaccat atataacgtg ttattgccat ctagaagaac tatgatgaga
     4201 aagatacatt tatatattat gtaaaatgtt aactatcatc atatggactc tatgtaacac
     4261 aaattcaaaa gcaaactaaa agctatatgc agagttttgt ataaaacaat agaacagaaa
     4321 tttgggacat ttttctagga aataaaattc ctcggtgtat taatctaagg tttcaaagta
     4381 taaaagtata tggggtaggc cgggtgcagt ggctcacgcc tgtaatccca gcactttggg
     4441 aggccgaggc gagtggattt cctaaggtca ggagtttgag accagcctga gcaatgtggt
     4501 gaaaccccat ctctactaaa aatacaaaaa ttatctgggc ttggtggcgg gcacctgtaa
     4561 tcccagccac ttgggaggct gaggcaggag aattgcttga acccgggagg tggaggctgc
     4621 ggtgagccaa gatcatgcca ttgcactcca gcctgggtga cagagtaaca ctctgtctca
     4681 gaaaaaaaaa aaaagaaaaa tatatggggt aaatacagta aaacgttttg ttaaattcca
     4741 atatacattc agtgatacca ctctttttct tctaagcctg tgtgttataa tttaccagtt
     4801 ccccaaaatg ccatttttaa cgccgaactg tgtaatatac atggaaaaca gctttttaca
     4861 attaattttc aaagttgtaa ttttaaagaa tttgggtgta tacctatgtt aatgaaacaa
     4921 cagaagtaca aaaaagaata tcagatacaa aaatcaatcg tgaagaaaat ctgttcttaa
     4981 tatatttcat tatgattgaa aaacataaaa actaacatag gaaagtgaat gatcagttac
     5041 ttatgatata ttttgtttcc tcttgtggtt taataaagtg aagtgtgtgt gtgtgtgtgt
     5101 gtgtgtatac ctgggggtgg gcagtgctct ttttctaaaa ctaatatggc ttatatatct
     5161 gaattatgcc ctttttagtg tgtattagga tgtgggctgg tttgcttttc taccaccttt
     5221 gtaattttat gtatcccatc tcctttgtgt gaattcatat attatagcaa aatacaagag
     5281 acatgggact gtttgcaata ccatatggaa atcttttaat aaatatatgt aaataaaata
     5341 aaaaatattt gtctccacct tttccccaaa agcaacagca agacatattt tgttagatat
     5401 tttattttta atgttttcta taatttaaaa atgtatagcc tgccaaatgt tgttttcata
     5461 accatgatat tgttttgaaa aaattttatc ttaaaatact gaatgttctg accttttata
     5521 gatgtttttg attttgtttt aaataatttt aaattatgga gcttgaccta gatttgccaa
     5581 taaactttct agccta
//
