LOCUS       NM_014984               3630 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens centrosomal protein 131 (CEP131), transcript variant
            1, mRNA.
ACCESSION   NM_014984 XM_045581
VERSION     NM_014984.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3630)
  AUTHORS   Shen,M., Li,S., Zhao,Y., Liu,Y., Liu,Z., Huan,L., Qiao,Y., Wang,L.,
            Han,L., Chen,Z. and He,X.
  TITLE     Hepatic ARID3A facilitates liver cancer malignancy by cooperating
            with CEP131 to regulate an embryonic stem cell-like gene signature
  JOURNAL   Cell Death Dis 13 (8), 732 (2022)
   PUBMED   36008383
  REMARK    GeneRIF: Hepatic ARID3A facilitates liver cancer malignancy by
            cooperating with CEP131 to regulate an embryonic stem cell-like
            gene signature.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3630)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 3630)
  AUTHORS   Kim,D.H., Ahn,J.S., Han,H.J., Kim,H.M., Hwang,J., Lee,K.H.,
            Cha-Molstad,H., Ryoo,I.J., Jang,J.H., Ko,S.K., Yang,J.O., Lee,H.G.,
            Lee,S., Song,E.J., Kim,J.Y., Huh,Y.H., Kwon,Y.T., Soung,N.K. and
            Kim,B.Y.
  TITLE     Cep131 overexpression promotes centrosome amplification and colon
            cancer progression by regulating Plk4 stability
  JOURNAL   Cell Death Dis 10 (8), 570 (2019)
   PUBMED   31358734
  REMARK    GeneRIF: These findings demonstrate that Cep131 is a novel
            substrate of Plk4, and that phosphorylation or dysregulated Cep131
            overexpression promotes Plk4 stabilization and therefore centrosome
            amplification, establishing a perspective in understanding a
            relationship between centrosome amplification and cancer
            development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3630)
  AUTHORS   Denu,R.A., Sass,M.M., Johnson,J.M., Potts,G.K., Choudhary,A.,
            Coon,J.J. and Burkard,M.E.
  TITLE     Polo-like kinase 4 maintains centriolar satellite integrity by
            phosphorylation of centrosomal protein 131 (CEP131)
  JOURNAL   J Biol Chem 294 (16), 6531-6549 (2019)
   PUBMED   30804208
  REMARK    GeneRIF: PLK4 phosphorylates CEP131 at Ser-78 to maintain
            centriolar satellite integrity.
REFERENCE   5  (bases 1 to 3630)
  AUTHORS   Gupta,S.K., Luo,L. and Yen,L.
  TITLE     RNA-mediated gene fusion in mammalian cells
  JOURNAL   Proc Natl Acad Sci U S A 115 (52), E12295-E12304 (2018)
   PUBMED   30538195
  REMARK    GeneRIF: RNA of AZI1 functions as the 'initiator' RNA to induce
            TMPRSS2-ERG fusion.
REFERENCE   6  (bases 1 to 3630)
  AUTHORS   Takahashi,M., Yamagiwa,A., Nishimura,T., Mukai,H. and Ono,Y.
  TITLE     Centrosomal proteins CG-NAP and kendrin provide microtubule
            nucleation sites by anchoring gamma-tubulin ring complex
  JOURNAL   Mol Biol Cell 13 (9), 3235-3245 (2002)
   PUBMED   12221128
REFERENCE   7  (bases 1 to 3630)
  AUTHORS   Mayor,T., Stierhof,Y.D., Tanaka,K., Fry,A.M. and Nigg,E.A.
  TITLE     The centrosomal protein C-Nap1 is required for cell cycle-regulated
            centrosome cohesion
  JOURNAL   J Cell Biol 151 (4), 837-846 (2000)
   PUBMED   11076968
REFERENCE   8  (bases 1 to 3630)
  AUTHORS   Aoto,H., Miyake,Y., Nakamura,M. and Tajima,S.
  TITLE     Genomic organization of the mouse AZ1 gene that encodes the protein
            localized to preacrosomes of spermatids
  JOURNAL   Genomics 40 (1), 138-141 (1997)
   PUBMED   9070930
REFERENCE   9  (bases 1 to 3630)
  AUTHORS   Aoto,H., Tsuchida,J., Nishina,Y., Nishimune,Y., Asano,A. and
            Tajima,S.
  TITLE     Isolation of a novel cDNA that encodes a protein localized to the
            pre-acrosome region of spermatids
  JOURNAL   Eur J Biochem 234 (1), 8-15 (1995)
   PUBMED   8529672
REFERENCE   10 (bases 1 to 3630)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC027601.25.
            
            On Nov 22, 2018 this sequence version replaced NM_014984.3.
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 3. This
            results in a shorter protein (isoform a), compared to isoform c.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC136578.1, DRR138512.201054.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000450824.7/ ENSP00000393583.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AC027601.25        70139-70335         c
            198-391             AC027601.25        67250-67443         c
            392-486             AC027601.25        56298-56392         c
            487-601             AC027601.25        54495-54609         c
            602-729             AC027601.25        54114-54241         c
            730-843             AC027601.25        50864-50977         c
            844-1002            AC027601.25        49610-49768         c
            1003-1120           AC027601.25        47699-47816         c
            1121-1237           AC027601.25        47089-47205         c
            1238-1406           AC027601.25        46751-46919         c
            1407-1501           AC027601.25        46247-46341         c
            1502-1684           AC027601.25        45485-45667         c
            1685-1861           AC027601.25        45082-45258         c
            1862-1987           AC027601.25        44300-44425         c
            1988-2113           AC027601.25        44071-44196         c
            2114-2230           AC027601.25        43205-43321         c
            2231-2333           AC027601.25        42240-42342         c
            2334-2535           AC027601.25        41296-41497         c
            2536-2643           AC027601.25        40106-40213         c
            2644-2761           AC027601.25        39846-39963         c
            2762-2836           AC027601.25        39688-39762         c
            2837-2979           AC027601.25        38563-38705         c
            2980-3157           AC027601.25        38277-38454         c
            3158-3321           AC027601.25        38009-38172         c
            3322-3382           AC027601.25        37285-37345         c
            3383-3630           AC027601.25        36966-37213         c
FEATURES             Location/Qualifiers
     source          1..3630
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..3630
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /note="centrosomal protein 131"
                     /db_xref="GeneID:22994"
                     /db_xref="HGNC:HGNC:29511"
                     /db_xref="MIM:613479"
     exon            1..197
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            198..391
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..3457
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /note="isoform a is encoded by transcript variant 1;
                     pre-acrosome localization protein 1; 5-azacytidine induced
                     1; centrosomal protein 131 kDa; 5-azacytidine-induced
                     protein 1; centrosomal protein of 131 kDa; centrosomal
                     protein 131kDa"
                     /codon_start=1
                     /product="centrosomal protein of 131 kDa isoform a"
                     /protein_id="NP_055799.2"
                     /db_xref="CCDS:CCDS45808.1"
                     /db_xref="GeneID:22994"
                     /db_xref="HGNC:HGNC:29511"
                     /db_xref="MIM:613479"
                     /translation="MKGTRAIGSVPERSPAGVDLSLTGLPPPVSRRPGSAATTKPIVR
                     SVSVVTGSEQKRKVLEATGPGGSQAINNLRRSNSTTQVSQPRSGSPRPTEPTDFLMLF
                     EGSPSGKKRPASLSTAPSEKGATWNVLDDQPRGFTLPSNARSSSALDSPAGPRRKECT
                     VALAPNFTANNRSNKGAVGNCVTTMVHNRYTPSERAPPLKSSNQTAPSLNNIIKAATC
                     EGSESSGFGKLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQ
                     RWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQ
                     ARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQAL
                     KANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGS
                     AKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKL
                     SAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEV
                     STSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATI
                     QRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMS
                     ATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDER
                     ASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVA
                     EERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLK
                     QQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEE
                     SEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQK
                     ERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLEL
                     EEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK"
     exon            392..486
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            487..601
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..729
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..843
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1002
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1120
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1237
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1406
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1501
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1684
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1861
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1987
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2113
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2230
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2333
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2535
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2643
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2761
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..2836
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2837..2979
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3157
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3158..3321
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..3382
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3383..3630
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3607..3612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /note="hexamer: AGTAAA"
     polyA_site      3630
                     /gene="CEP131"
                     /gene_synonym="AZ1; AZI1; ZA1"
                     /note="major polyA site"
ORIGIN      
        1 agctgccgcc gctgctcacc ccggccgtcc ggccgcttca ttgtcaccgg gcctcggggc
       61 agtgttgggg gtggcggggc gccaggtcgc cgacccgagg tttgggcgcg actggttccg
      121 catcccctcc ccgccggccg aatctgcagg ccccgcgcgc caggcaggct tcgcggctgc
      181 gcccccggcc cgcgcaggac ctgccttgtc caccatgaaa ggcacccggg ccatcggcag
      241 cgtcccggag cgcagcccag caggtgtgga cctgagtctg acaggtctcc ctccgcctgt
      301 gtcccggcgt cctggcagtg ccgccaccac caagcccatc gtccgctctg tctccgtggt
      361 cacaggcagc gagcagaaga ggaaggtgct ggaggccaca gggcctgggg gctcccaggc
      421 catcaacaac cttagaagat ccaacagcac cacgcaggtc agccagcctc ggagcggctc
      481 ccccaggcca acggagccca cagacttcct gatgctcttc gagggcagcc ccagtgggaa
      541 aaagaggcct gccagcctga gcacagcccc cagcgagaag ggagccacct ggaacgtcct
      601 ggatgaccag ccccggggct tcaccttgcc atccaatgcc cggagttcca gtgcccttga
      661 ctcaccagcg ggcccgcgga ggaaagaatg caccgtggcc ctggccccca acttcactgc
      721 taacaacagg agcaacaagg gagcagtggg caactgcgtc accaccatgg tgcacaaccg
      781 ctacaccccc tcggagaggg cgcctccgct caagagctcc aaccagactg ccccctccct
      841 caacaacatc atcaaggcag ccacctgtga gggcagtgag agcagcggct ttgggaagct
      901 gccgaagaat gtctccagtg ccacccactc agcccggaac aatactgggg gcagcacggg
      961 cttgcccagg cggaaggagg tgacggagga ggaggctgag aggtttatcc accaggtgaa
     1021 ccaggccact gtcaccatcc agcgctggta ccggcaccag gtgcagcggc gcggagcagg
     1081 agctgcccgc ctggagcact tgcttcaggc caagcgggag gagcagcggc agcggtcagg
     1141 cgaggggacc ctcttggacc tgcaccagca gaaagaggca gccaggagga aggcccggga
     1201 ggagaaggca cgccaagcca ggcgagcagc cattcaggag ctgcaacaga aacgagccct
     1261 gagagcccag aaggcgagca ctgccgagcg tgggccacct gagaatccca gggagaccag
     1321 agtgccagga atgcggcagc ctgctcagga gctgtccccc acaccaggcg gcactgccca
     1381 ccaggccctc aaggccaaca atactggtgg tggcctccct gctgcaggcc ccggagaccg
     1441 ctgcctgccc acctccgact catccccaga accacagcag cctccagagg acaggacgca
     1501 ggacgttctt gcccaggatg cagctgggga caacctggag atgatggccc cgagcagggg
     1561 gagcgccaag tccagggggc cactggagga gctgctgcac acactgcagc tgctggagaa
     1621 ggagccggac gtgctgcccc gccccaggac ccatcacagg ggcagatacg cctgggccag
     1681 cgaggaggat gacgccagct ctctgacagc tgacaacttg gagaaatttg gaaaactcag
     1741 tgcgttcccc gaacctcctg aggatgggac gctgctatcg gaggccaagc tacaaagcat
     1801 catgagcttc ttggacgaga tggagaagtc tgggcaggac cagctggact cccagcagga
     1861 ggggtgggtg ccggaggcgg ggccggggcc cctggagctg gggtccgagg tgagcacgtc
     1921 tgtgatgcgg ctgaagctgg aggtggagga gaagaagcag gccatgctgc tgctgcagag
     1981 agcgctggcg cagcagcgag acctcacggc ccggcgggtc aaggagacag agaaggcgct
     2041 gagccggcag ctgcagcggc agagggagca ctacgaggcc accatccagc ggcacttggc
     2101 cttcattgac cagctgattg aggacaagaa ggtcctgagt gaaaagtgcg aggctgtggt
     2161 ggccgagctg aagcaggagg accagagatg caccgagcgt gtggcccagg cacaggcgca
     2221 gcacgagctg gagattaaaa aactcaaaga attaatgagc gccaccgaga aagcccgccg
     2281 ggagaagtgg atcagtgaga aaaccaagaa gatcaaggag gtcactgtcc gaggtctgga
     2341 gcccgagatc cagaagctga ttgcaaggca caagcaggaa gtgcggaggc tcaagagcct
     2401 gcacgaggcg gagctgctgc agtcggatga gcgggcctcg cagcgctgcc tgcgccaggc
     2461 cgaggagctg cgggagcagc tggagcggga gaaggaggcg ctgggccagc aggagcgcga
     2521 acgtgctcgg cagcggttcc agcagcacct ggagcaggag cagtgggcgc tgcagcagca
     2581 acggcagcgg ctgtacagtg aggtggctga ggagagggag cggctgggcc agcaggcagc
     2641 caggcagcgg gcggagctgg aagagctgag gcagcagctg gaggagagca gctctgcact
     2701 gacccgagcc ctgagggctg agtttgagaa gggcagggag gagcaggagc gccggcacca
     2761 gatggagctg aataccctga agcagcagct ggagctggag aggcaggcgt gggaggccgg
     2821 ccgcaccagg aaggaggagg cgtggctgct gaaccgggaa caggagctga gggaagaaat
     2881 ccggaaaggc cgggacaagg agattgagct ggtcattcac cggctggagg ccgacatggc
     2941 gctggccaag gaggagagtg agaaggctgc cgagagccgc atcaagcgct tacgggacaa
     3001 gtacgaggcc gagctctccg agctggagca gtcggagcgg aagcttcagg agcggtgctc
     3061 ggagctgaag ggccagcttg gggaggccga gggcgagaat ctgcgtctgc agggccttgt
     3121 gcggcagaag gagcgggcgc tggaggatgc gcaggcggtg aacgagcagc tttctagcga
     3181 gcgcagcaac ctggcccagg tgatccgcca ggagttcgag gaccggctgg cagcctctga
     3241 ggaggagacg cggcaggcca aggccgagct ggccacgctg caggcccgcc agcagctgga
     3301 gctggaggag gtgcaccgga gggtgaagac agccctcgcg aggaaggagg aggccgtgag
     3361 cagcctccgg acacaacatg aggctgcggt gaagcgggcc gaccacctgg aggagctgct
     3421 ggagcagcac aggaggccca cgccaagtac caagtgacca gggatgccgg gaacactgtc
     3481 gaagaacgga aggcagagga cagaggctgg acgtgggccc agaggcccac agggacgccc
     3541 acctgccccc cacagaggct ggtggttgag atgcccacgg ctaagcacct gtggctgcat
     3601 tttaacagta aaggaggccg ttgttttcag
//
