LOCUS       NM_152446               4614 bp    mRNA    linear   PRI 08-MAR-2025
DEFINITION  Homo sapiens centrosomal protein 128 (CEP128), transcript variant
            1, mRNA.
ACCESSION   NM_152446 XM_006720056 XM_496002
VERSION     NM_152446.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4614)
  AUTHORS   Lin,S., Lv,X., Lin,X., Chen,S., Li,Y., Xu,M., Qiu,Y. and Tang,L.
  TITLE     Modulation Effects of the CEP128 Gene on Radiotherapy-Related Brain
            Injury: A Longitudinal Structural Study Using Multi-Parametric
            Brain MR Images
  JOURNAL   J Magn Reson Imaging 59 (2), 648-658 (2024)
   PUBMED   37249021
  REMARK    GeneRIF: Modulation Effects of the CEP128 Gene on
            Radiotherapy-Related Brain Injury: A Longitudinal Structural Study
            Using Multi-Parametric Brain MR Images.
REFERENCE   2  (bases 1 to 4614)
  AUTHORS   Zhao,Y., Lan,Y., Chi,Y., Yang,B. and Ren,C.
  TITLE     Downregulation of Circ-CEP128 Enhances the Paclitaxel Sensitivity
            of Cervical Cancer Through Regulating miR-432-5p/MCL1
  JOURNAL   Biochem Genet 60 (6), 2346-2363 (2022)
   PUBMED   35391656
  REMARK    GeneRIF: Downregulation of Circ-CEP128 Enhances the Paclitaxel
            Sensitivity of Cervical Cancer Through Regulating miR-432-5p/MCL1.
REFERENCE   3  (bases 1 to 4614)
  AUTHORS   Kashihara,H., Chiba,S., Kanno,S.I., Suzuki,K., Yano,T. and
            Tsukita,S.
  TITLE     Cep128 associates with Odf2 to form the subdistal appendage of the
            centriole
  JOURNAL   Genes Cells 24 (3), 231-243 (2019)
   PUBMED   30623524
  REMARK    GeneRIF: Cep128 deletion decreased the stability of centriolar
            microtubules.  Cep128 associates with Odf2.
REFERENCE   4  (bases 1 to 4614)
  AUTHORS   Wang,B., Jia,X., Yao,Q., Li,Q., He,W., Li,L., Song,R., Zhang,J. and
            Zhang,J.A.
  TITLE     CEP128 is a crucial risk locus for autoimmune thyroid diseases
  JOURNAL   Mol Cell Endocrinol 480, 97-106 (2019)
   PUBMED   30393005
  REMARK    GeneRIF: This study highlight the crucial role of CEP128 in the
            pathogenesis of Grave's disease.
REFERENCE   5  (bases 1 to 4614)
  AUTHORS   Monnich,M., Borgeskov,L., Breslin,L., Jakobsen,L., Rogowski,M.,
            Doganli,C., Schroder,J.M., Mogensen,J.B., Blinkenkjaer,L.,
            Harder,L.M., Lundberg,E., Geimer,S., Christensen,S.T.,
            Andersen,J.S., Larsen,L.A. and Pedersen,L.B.
  TITLE     CEP128 Localizes to the Subdistal Appendages of the Mother
            Centriole and Regulates TGF-beta/BMP Signaling at the Primary
            Cilium
  JOURNAL   Cell Rep 22 (10), 2584-2592 (2018)
   PUBMED   29514088
  REMARK    GeneRIF: CEP128 loss affects TGF-beta1-induced phosphorylation of
            multiple proteins that regulate cilium-associated vesicle
            trafficking.
REFERENCE   6  (bases 1 to 4614)
  AUTHORS   Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
            Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
            King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
            Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
            Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
            Ferrucci,L., Fornage,M. and Mozaffarian,D.
  TITLE     Genome-wide association study identifies novel loci associated with
            concentrations of four plasma phospholipid fatty acids in the de
            novo lipogenesis pathway: results from the Cohorts for Heart and
            Aging Research in Genomic Epidemiology (CHARGE) consortium
  JOURNAL   Circ Cardiovasc Genet 6 (2), 171-183 (2013)
   PUBMED   23362303
REFERENCE   7  (bases 1 to 4614)
  AUTHORS   Sonnen,K.F., Schermelleh,L., Leonhardt,H. and Nigg,E.A.
  TITLE     3D-structured illumination microscopy provides novel insight into
            architecture of human centrosomes
  JOURNAL   Biol Open 1 (10), 965-976 (2012)
   PUBMED   23213374
REFERENCE   8  (bases 1 to 4614)
  AUTHORS   Croteau-Chonka,D.C., Marvelle,A.F., Lange,E.M., Lee,N.R.,
            Adair,L.S., Lange,L.A. and Mohlke,K.L.
  TITLE     Genome-wide association study of anthropometric traits and evidence
            of interactions with age and study year in Filipino women
  JOURNAL   Obesity (Silver Spring) 19 (5), 1019-1027 (2011)
   PUBMED   20966902
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   9  (bases 1 to 4614)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            KF455965.1, AC010072.5, AC022404.7 and AC018513.5.
            
            On Nov 23, 2018 this sequence version replaced NM_152446.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.12080.1,
                                           SRR7346977.1610460.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000555265.6/ ENSP00000451162.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               KF455965.1         1-131               c
            132-158             AC010072.5         89577-89603         c
            159-314             AC010072.5         87381-87536         c
            315-476             AC010072.5         64397-64558         c
            477-563             AC010072.5         62318-62404         c
            564-690             AC010072.5         53951-54077         c
            691-809             AC010072.5         52809-52927         c
            810-901             AC010072.5         47934-48025         c
            902-974             AC010072.5         43714-43786         c
            975-1091            AC010072.5         10753-10869         c
            1092-1178           AC022404.7         212631-212717       c
            1179-1253           AC022404.7         210153-210227       c
            1254-1386           AC022404.7         208154-208286       c
            1387-1538           AC022404.7         203092-203243       c
            1539-1889           AC022404.7         164709-165059       c
            1890-2540           AC022404.7         156844-157494       c
            2541-2705           AC022404.7         149831-149995       c
            2706-2882           AC022404.7         133386-133562       c
            2883-2942           AC022404.7         128841-128900       c
            2943-3135           AC022404.7         115024-115216       c
            3136-3185           AC018513.5         135810-135859       c
            3186-3209           AC018513.5         114715-114738       c
            3210-3287           AC018513.5         86245-86322         c
            3288-3401           AC018513.5         82305-82418         c
            3402-3510           AC018513.5         60347-60455         c
            3511-4614           AC018513.5         51914-53017         c
FEATURES             Location/Qualifiers
     source          1..4614
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q31.1"
     gene            1..4614
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /note="centrosomal protein 128"
                     /db_xref="GeneID:145508"
                     /db_xref="HGNC:HGNC:20359"
                     /db_xref="MIM:620667"
     exon            1..158
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            159..314
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            315..476
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     CDS             330..3614
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /note="lens epithelium-derived protein; centrosomal
                     protein 128kDa"
                     /codon_start=1
                     /product="centrosomal protein of 128 kDa"
                     /protein_id="NP_689659.2"
                     /db_xref="CCDS:CCDS32130.1"
                     /db_xref="GeneID:145508"
                     /db_xref="HGNC:HGNC:20359"
                     /db_xref="MIM:620667"
                     /translation="MAESSSESDHFRCRDRLSPWAARSTHRGTRSLPTVEVTEKVNTI
                     TSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIDQLRSQRLLRNSGGR
                     SISVTSLSASDLDGGTGSELHHFPPTSPLKDYGDPQGIKRMRSRTGVRFVQETDDMTQ
                     LHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSD
                     RVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQ
                     TETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQIS
                     KQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKD
                     KEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRH
                     AEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQS
                     ETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEK
                     LRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQA
                     QDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATI
                     ITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAES
                     LEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISI
                     EEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSG
                     PDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQ
                     CLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQVALDHLESV
                     PEKLSLLEDFKDFRDSCSSSERTDGRYSKYRVRRNSLQHHQDDTKYRTKSFKGDRTFL
                     EGSHTRGLDHSSSWQDHSRFLSSPRFSYVNSFTKRTVAPDSASNKEDATMNGTSSQPK
                     KEEYGS"
     exon            477..563
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            564..690
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            691..809
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            810..901
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            902..974
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1091
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1178
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1253
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1386
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1538
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1889
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2540
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2705
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2882
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..2942
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3135
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3185
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            3186..3209
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3287
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            3288..3401
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            3402..3510
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     exon            3511..4614
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4588..4593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /note="hexamer: AATAAA"
     polyA_site      4614
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /note="major polyA site"
ORIGIN      
        1 agttcaagtt gccatagctg cgagtctggg gagagcacag tcggttgagt cgctgcgttt
       61 ggtcagttgc accttctggg tcactggtag ccgcgggagc cgggtggggc ctaggcgatg
      121 atccggcatt aaggagctgg gatcatcctc cgtctcaggt ggtttgggga aagtgtaggg
      181 gcaaccaaag atcatcggct tgactaggcc ctttgccctg aacctcatga agaaatgata
      241 ggaggcagac atatgtgcct aaaaagagcg ttgagctcag agaagagcaa ctcggagttt
      301 tgggggtgtg ctttgatttg tgtacatcaa tggcagaatc atccagcgaa tcagatcact
      361 tccgctgtcg tgaccgattg agtccatggg ctgccagatc aacgcacagg ggaactcgaa
      421 gtcttcctac agtagaagtt accgagaagg tcaacactat aacaagtact ttacaggata
      481 ccagtcggaa cctgcgacaa gtggaccaga tgcttggacg ataccgagaa tacagtaatg
      541 gacaggcggg tgcgatagaa catttaaaag aaagcttgga acaatcaatc gaccaactcc
      601 ggagtcaacg tttattgaga aactcaggag ggagaagtat ttctgttaca agtttgagtg
      661 caagtgacct tgatggtggc actgggtcag agctccatca ttttccacct acctcacctc
      721 tcaaggacta tggggatcca cagggtatta aacgaatgag atcaagaact ggtgtccggt
      781 ttgttcaaga gactgatgat atgactcagc ttcatggttt tcatcagtct cttcgagacc
      841 tcagcagtga acaaattcgc cttggagatg atttcaacag ggagctttcc agaaggagcc
      901 ggtcagatgc cgaaacaaaa agggctttgg aagaattgac tgaaaaactt aatgaagccc
      961 agaaacaaga agtggtttca gatcgggtgg agcggcggct tcaggaactg gagagagaga
     1021 tgcgcacaga aagggagctg gtggaaagac gccaggatca actgggactc atgtccctgc
     1081 agctacagga ggcactaaag aaacaagaag ctaaagcaga tgagcatgag ggggcaataa
     1141 aaaataagct aagacaaact gaaactgaga agaatcaact tgaacaggaa ttggagctat
     1201 ctcgaaggtt attgaatcaa tcagaaggca gccgagaaac acttttgcat caggtagaag
     1261 aactgcgtac acaacttacg aaagcagaag gtgatcgaaa gggtttacag catcaagtat
     1321 ctcagatttc caagcaacag tcaaactatc aggatgaaca aggggaggac tggagattta
     1381 ggagaggggt tgagcgggaa aaacaggacc tggagaagca aatgtcagat ttgagagtgc
     1441 agctgaactt cagcgcaatg gcatctgagt tagaggaagt gaaacggtgc atggagagaa
     1501 aagacaagga gaaagcacat ttggcatcac aagtagagaa tttaacacgt gaactggaga
     1561 atggggaaaa acagcaactg cagatgttgg atcgacttaa ggagatccag aatcactttg
     1621 acacatgtga ggccgagcgt aagcatgctg accttcagat ctcagagctg actcgccatg
     1681 cggaggatgc aaccaagcag gctgagcggt acctcagtga gctccagcag tcagaggctc
     1741 tgaaagagga ggcggagaag aggagggaag acctgaaact gaaagctcaa gaatccatta
     1801 ggcagtggaa gcttaagcat aagaagttag aacgagcgtt ggagaaacaa tctgaaactg
     1861 ttgatgaact gacaggcaag aataatcaga ttttaaaaga aaaggatgaa ttgaaaaccc
     1921 agctgtatgc agcattacaa caaatagaga atcttcgaaa ggaattgaat gatgtcctaa
     1981 caaagcgtgc ccttcaggag gaggagcttc actccaagga ggagaaatta cgtgatatta
     2041 agtctcatca agctgacctt gaattggaag ttaagaattc cctggatacc atccatagac
     2101 tggagagcga attgaaaaag cagagtaaga tccaaagcca gatgaaagtt gagaaagctc
     2161 acttggagga agaaattgca gagctcaaga agagccaggc ccaggacaaa gctaaacttc
     2221 ttgagatgca agagtccatc aaggacctga gtgccatccg agcagatctt gctaataaat
     2281 tggctgagga agagagagcc aagaaagcag tgcttaagga cctttctgac ctcactgcac
     2341 aggcaaaatc cagggatgaa gaaacagcta caatcatcac acagttaaag ctggaacgag
     2401 atgtgcacca gagggagctg aaagatctca catcatcatt gcagagtgtg aaaacaaaac
     2461 acgaacagaa tatccaggag cttatgaagc actttaagaa agaaaagagt gaggctgaga
     2521 atcatatcag gactctgaag gctgaaagtt tagaagagaa gaatatggct aaaattcatc
     2581 gtggtcagct ggagaagttg aaatcacagt gtgacagact gacagaggaa ttaacccaga
     2641 atgaaaatga gaacaaaaaa ctgaagctaa aatatcaatg tttgaaggat caactagaag
     2701 aaagggaaaa acatataagc attgaagagg agcacttaag gaggatggaa gaggccagat
     2761 tgcagctcaa ggatcaactt ctttgcttgg agactgaaca ggaatccatt cttggtgtga
     2821 taggaaagga aattgatgca gcttgtaaaa cattctccaa ggactcagtg gagaaattaa
     2881 aagttttttc atctggtcct gatatacatt atgacccaca tcgctggtta gcagaaagca
     2941 agactaaact tcagtggctc tgtgaggaac tgaaagagag agaaaacaga gagaaaaatc
     3001 tgcgacacca gctgatgctc tgcagacaac aactcaggaa tttgactgaa aacaaggaat
     3061 ctgagttgca gtgtctcttt caacagatag aaaggcagga gcagcttctg gatgaaatac
     3121 atcgtgagaa gagagatcta ctggaagaga cccaaagaaa agatgaagaa atgggatctc
     3181 tgcaggaccg tgtaattgca ttagaaacga gtacccaagt ggccttggac catctggagt
     3241 ctgtgcctga gaaactgagc ctactagaag atttcaaaga cttcagagat tcctgcagtt
     3301 catctgagag aactgatgga agatattcca aatacagggt tcgcagaaat tctcttcagc
     3361 atcaccaaga tgacaccaag tacagaacca aaagtttcaa aggtgacaga acctttctgg
     3421 aaggttccca cactcgtggg ttagatcact catcctcttg gcaggatcac agtcgcttcc
     3481 tgtctagtcc aagattttca tacgtgaact catttaccaa aagaactgtt gctccagatt
     3541 cagcttcaaa caaggaagat gccacaatga atggaacaag ttcacaaccc aaaaaagagg
     3601 aatatgggag ctaaaaaagc aaatgtaatt tgttatttta catgagtatg ttacaaataa
     3661 taacatctct attcttacag caatttggcc cagattatct aacagacata cctgcagctt
     3721 tggctctttg gtattgccaa acattgacaa aagtgacaat actgttggtc cttgtgaatg
     3781 gtaaaccaat ccaaataata tcagatcatg aatgatgtgc agctaattta tttgcaactt
     3841 atactagcac agaaagaatg atattttttc actttgtatt ttcctttttc aagtgtggtc
     3901 agtcacattt tcccaaccaa aatttggatt tctaattgag gccttttaaa aattactggc
     3961 taaaaagaag gaaaatgagt ttcccttgag gcaaaagttg ccagcacttt agattcaggg
     4021 agcatttata tacaactgat tttttgaaaa attttctccc taataaatta tcatgtgtta
     4081 taacatgtgg agatgtgcat atataacatt agacagtcca ctttataaat gctcaggact
     4141 tttatatcta tcatcttaac agtccacaac tgcataccgt agctgaaaat tatttccaat
     4201 catccatttt taatagcaat aaagaattca taaatgatat ctgaactgta gagcactgta
     4261 aagaattcat agcacaattt atttatttgt ctttttgtgg ccaaatatcc tactgtgatc
     4321 acttcagtca tatcctggac cgtctttggt ttactgtgac taaaatcata gcaccaaact
     4381 cctttgtcca tgagatttat atataatctt gtataatttg gtcctatctg cttctaccat
     4441 cccaactttt ttcatcaaag tgtctaagaa cgtattccct ttacacgctg atctcctagt
     4501 ggagaaggat ttatattaaa tgctaagtaa tagtaaactt tcaggaactg aatcctattg
     4561 ggtcatggat tctgcataga caagggcaat aaagcaatac ctttgtaata tgca
//
