LOCUS       NM_020802               7048 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens centrosomal protein 126 (CEP126), transcript variant
            1, mRNA.
ACCESSION   NM_020802 XM_374927
VERSION     NM_020802.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7048)
  AUTHORS   Zheng,S., Liu,Q., Ma,R., Tan,D., Shen,T., Zhang,X. and Lu,X.
  TITLE     Let-7b-5p inhibits proliferation and motility in squamous cell
            carcinoma cells through negative modulation of KIAA1377
  JOURNAL   Cell Biol Int 43 (6), 634-641 (2019)
   PUBMED   30958603
  REMARK    GeneRIF: It was exhibited that KIAA1377 was able to promote the
            proliferation and motility of both KYSE-150 and HeLa cells, which
            can be reverted by re-expression of let-7b-5p. The luciferase
            reporter assay verified that let-7b-5p can diametrically target
            KIAA1377. Collectively, our data demonstrated that let-7b-5p can
            directly but negatively regulate KIAA1377 in SCC cell lines,
            Ecal109, and HeLa cells.
REFERENCE   2  (bases 1 to 7048)
  AUTHORS   Bonavita,R., Walas,D., Brown,A.K., Luini,A., Stephens,D.J. and
            Colanzi,A.
  TITLE     Cep126 is required for pericentriolar satellite localisation to the
            centrosome and for primary cilium formation
  JOURNAL   Biol Cell 106 (8), 254-267 (2014)
   PUBMED   24867236
  REMARK    GeneRIF: CEP126 is a regulator of microtubule organisation at the
            centrosome that acts through modulation of the transport of
            pericentriolar satellites, and consequently, of the organisation of
            cell structure
REFERENCE   3  (bases 1 to 7048)
  AUTHORS   Tipton,A.R., Wang,K., Oladimeji,P., Sufi,S., Gu,Z. and Liu,S.T.
  TITLE     Identification of novel mitosis regulators through data mining with
            human centromere/kinetochore proteins as group queries
  JOURNAL   BMC Cell Biol 13, 15 (2012)
   PUBMED   22712476
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7048)
  AUTHORS   Lim,Y.M., Koh,I., Park,Y.M., Kim,J.J., Kim,D.S., Kim,H.J.,
            Baik,K.H., Choi,H.Y., Yang,G.S., Also-Rallo,E., Tizzano,E.F.,
            Gamez,J., Park,K., Yoo,H.W., Lee,J.K. and Kim,K.K.
  TITLE     Exome sequencing identifies KIAA1377 and C5orf42 as susceptibility
            genes for monomelic amyotrophy
  JOURNAL   Neuromuscul Disord 22 (5), 394-400 (2012)
   PUBMED   22264561
  REMARK    GeneRIF: KIAA1377 and C5orf42 gene synergistically play a role as
            susceptibility genes for monomelic amyotrophy.
REFERENCE   5  (bases 1 to 7048)
  AUTHORS   Chen,T.C., Lee,S.A., Hong,T.M., Shih,J.Y., Lai,J.M., Chiou,H.Y.,
            Yang,S.C., Chan,C.H., Kao,C.Y., Yang,P.C. and Huang,C.Y.
  TITLE     From midbody protein-protein interaction network construction to
            novel regulators in cytokinesis
  JOURNAL   J Proteome Res 8 (11), 4943-4953 (2009)
   PUBMED   19799413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003383.2, DB455438.3, BX647415.1 and AB037798.1.
            
            On May 17, 2019 this sequence version replaced NM_020802.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.214391.1,
                                           SRR1660805.180015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263468.13/ ENSP00000263468.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AP003383.2         43248-43252
            6-369               DB455438.3         1-364
            370-2152            BX647415.1         115-1897
            2153-2153           AP003383.2         91151-91151
            2154-3504           AB037798.1         1492-2842
            3505-3519           AP003383.2         115265-115279
            3520-4578           AB037798.1         2858-3916
            4579-7048           AP003383.2         126831-129300
FEATURES             Location/Qualifiers
     source          1..7048
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.1"
     gene            1..7048
                     /gene="CEP126"
                     /gene_synonym="KIAA1377"
                     /note="centrosomal protein 126"
                     /db_xref="GeneID:57562"
                     /db_xref="HGNC:HGNC:29264"
                     /db_xref="MIM:614634"
     exon            1..403
                     /gene="CEP126"
                     /gene_synonym="KIAA1377"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..3629
                     /gene="CEP126"
                     /gene_synonym="KIAA1377"
                     /note="isoform 1 is encoded by transcript variant 1;
                     centrosomal protein of 126 kDa; centrosomal protein
                     126kDa"
                     /codon_start=1
                     /product="centrosomal protein of 126 kDa isoform 1"
                     /protein_id="NP_065853.3"
                     /db_xref="CCDS:CCDS31658.1"
                     /db_xref="GeneID:57562"
                     /db_xref="HGNC:HGNC:29264"
                     /db_xref="MIM:614634"
                     /translation="MLAGRPGTRSAVGELGTESSDNLDRAPLGPRESGGHHRPGSYLD
                     MKIHLEKNLEEERQILLQQQKICRNRARKYFVESNRRKKAFEEKRKEQEEKEHQIREQ
                     ILQQRKQKFEEVTEKFQRAHVPLSQRRKAVSRKPVPPLEEALKQIQESNLKSEVNLPF
                     SRRPTINWRAIDSALPSALSKNDHKHQKQLLSKINCEKEMNENMRATLATSKNVFQLK
                     LEETQKLLEDQHLSNLQKFCDEVNQITNSETLSSIDSLEATEHEEIYLTLNKEHSTSI
                     QRNTISLKPANMQSTNLSCFDEDKLAFSKTQHINNWLTNLDASNTQNVTAFSDILSKS
                     NVLPSWEYFNSKEQNPSPLNGTVERATNTANNSVPFVSSPPMFVLDKKCEKTSETSTM
                     RTTDSTSGAFKRERPLVTESPTFKFSKSQSTSDSLTQEVATFPDQEKYSELNQENGTT
                     SIPTSCVPVATPLVLPSNIQSARPSAKNSIHIKEIDAVQCSDKLDELKDGKEEEIKYF
                     NCNKEELPLFSDSFQDAYIPHNPDSKDEKQKLAETSSLSNVTSNYDFVGQHKKMKYNI
                     HERNGVRFLKSILKKESKYEHGYLKALIINQSFKFGNQKAAAIRDSIELTKEKGAEIP
                     KTIKKLRWFDETSNIENNAENSHSLKNKTGTTQQHSQQFHIQSGAGSNIISVSTCAVN
                     SADTKKSREDSISENVTTLGGSGADHMPLNCFIPSGYNFAKHAWPASKKEESKIPVHD
                     DSKTKQGKPQRGRAKIIRKPGSAKVQSGFICTNRKGAVIQPQSASKVNIFTQAQGKLI
                     IPCPPPQSTSNIRSGKNIQVSQCQPVTPENPQNIITHNSFNSKHVLPTEHSLNQWNQE
                     SSSPLSNACSDLVTVIPSLPSYCSSECQTFAKINHSNGTQAVARQDATLYCTQRSPVC
                     EESYPSVTLRTAEEESVPLWKRGPNVLHQNKRATGSTVMRRKRIAETKRRNILEQKRQ
                     NPGSVGQKYSEQINNFGQSVLLSSSEPKQTTRGTSYIEEVSDSTSEFLMAENLVKASV
                     PEDEILTVLNSKQIQKSNLPLNKTQQFNICTLSAEEQKILESLNDLSERLHYIQESIC
                     KNPSIKNTLQIIPLLEKREDRTSSCRDKR"
     exon            404..523
                     /gene="CEP126"
                     /gene_synonym="KIAA1377"
                     /inference="alignment:Splign:2.1.0"
     exon            524..669
                     /gene="CEP126"
                     /gene_synonym="KIAA1377"
                     /inference="alignment:Splign:2.1.0"
     exon            670..781
                     /gene="CEP126"
                     /gene_synonym="KIAA1377"
                     /inference="alignment:Splign:2.1.0"
     exon            782..980
                     /gene="CEP126"
                     /gene_synonym="KIAA1377"
                     /inference="alignment:Splign:2.1.0"
     exon            981..3120
                     /gene="CEP126"
                     /gene_synonym="KIAA1377"
                     /inference="alignment:Splign:2.1.0"
     exon            3121..3233
                     /gene="CEP126"
                     /gene_synonym="KIAA1377"
                     /inference="alignment:Splign:2.1.0"
     exon            3234..3309
                     /gene="CEP126"
                     /gene_synonym="KIAA1377"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3519
                     /gene="CEP126"
                     /gene_synonym="KIAA1377"
                     /inference="alignment:Splign:2.1.0"
     exon            3520..3584
                     /gene="CEP126"
                     /gene_synonym="KIAA1377"
                     /inference="alignment:Splign:2.1.0"
     exon            3585..7048
                     /gene="CEP126"
                     /gene_synonym="KIAA1377"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3995..4000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP126"
                     /gene_synonym="KIAA1377"
                     /note="hexamer: AATAAA"
     polyA_site      4016
                     /gene="CEP126"
                     /gene_synonym="KIAA1377"
                     /note="major polyA site"
     regulatory      4024..4029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP126"
                     /gene_synonym="KIAA1377"
                     /note="hexamer: ATTAAA"
     polyA_site      4047
                     /gene="CEP126"
                     /gene_synonym="KIAA1377"
                     /note="major polyA site"
     regulatory      7022..7027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP126"
                     /gene_synonym="KIAA1377"
                     /note="hexamer: AATAAA"
     polyA_site      7048
                     /gene="CEP126"
                     /gene_synonym="KIAA1377"
ORIGIN      
        1 gcgccgtcgg ttgttgtcaa gatggcggct gcagggttgc tgccgcccca tctgctattg
       61 cccggcgagg tcgccgctgc ctcagctgcc atcgccgcta caggcaccag tgccgctgcg
      121 cgggagctag ggctgtcgag gccaaccctt ccgcgcccgt gacgcggggc ctgagagacg
      181 gagtgtaggg aggggccgag caggaggagg aggaagccgg agctgccatg agggaggttc
      241 tgggggcgag cagacaggcg gcgctgaagt gaaggatgct ggcggggagg cccggaaccc
      301 ggagcgcggt cggggaactg ggcactgaat catcggacaa cctcgacaga gcccccctcg
      361 gccctcggga gagcggcggg catcaccgac ctggctctta cctagatatg aaaatccatc
      421 tggagaaaaa tttagaagaa gagcgccaga tattactgca gcaacaaaaa atatgtcgaa
      481 atcgagcacg taaatatttt gtggagtcaa atcggagaaa aaaagctttt gaggagaaac
      541 gaaaagaaca ggaagaaaaa gaacaccaaa ttagagaaca aatacttcaa caaagaaaac
      601 agaagtttga agaagttact gaaaaattcc agcgtgccca tgttcctctt tcacagcgga
      661 ggaaagcagt ttcccgaaaa ccagttcctc cattagaaga ggccctcaaa caaattcagg
      721 aatccaactt aaaatcagaa gtaaaccttc ccttttcccg tagaccaaca ataaactgga
      781 gagctataga ttctgccttg ccttccgcat tatcaaaaaa tgatcacaag catcagaaac
      841 aactcttatc caaaatcaat tgtgagaaag aaatgaatga aaacatgagg gcaaccttgg
      901 ctactagcaa aaatgtgttc cagcttaaac tggaggaaac tcagaaactc ctcgaagatc
      961 aacatctaag caatttgcaa aaattttgtg atgaagttaa tcagataacc aattctgaaa
     1021 ccctctcaag tatagacagt cttgaggcta cagagcatga agaaatatat ttaacactta
     1081 ataaggagca ttccacatcc atccagcgga ataccatttc cctcaaacca gcaaatatgc
     1141 aatcaactaa tctcagctgc tttgatgaag ataaactggc attctctaaa actcaacata
     1201 taaataattg gcttacaaat ttagatgctt caaatactca gaatgtcaca gctttctcag
     1261 atattttaag taaatctaat gttctgcctt catgggaata ttttaatagt aaagaacaaa
     1321 atccatctcc tttgaatgga acagtggaaa gagccacaaa tactgctaat aattcagtac
     1381 cctttgtatc tagcccaccc atgtttgtac tagataaaaa atgtgaaaag acctctgaaa
     1441 ctagcactat gaggacaact gactccactt ctggagcatt caaaagagag agaccattag
     1501 ttactgagag cccaacattt aaatttagca aatcccaaag cacttcagat tctctaaccc
     1561 aggaagtggc tacatttcca gaccaagaga aatattctga attaaatcaa gaaaatggaa
     1621 ctacttcaat tcctacttca tgtgtaccag tggcaacgcc tttagttttg ccatctaata
     1681 tacagtcagc tagaccttca gcaaagaaca gtatacacat aaaagaaatt gatgcagtgc
     1741 agtgttctga taagttagat gaattgaaag atggtaaaga agaagagata aaatatttta
     1801 attgcaataa ggaagagttg cctttatttt cagacagttt tcaagatgcc tatatacctc
     1861 acaatcctga ttcaaaagat gaaaaacaaa aattagctga aacatcatcc ttgtctaatg
     1921 taacttctaa ttatgacttt gttggccagc ataagaaaat gaaatacaac atccatgaga
     1981 gaaatggtgt gagatttctt aaaagtattt taaagaaaga atctaaatat gaacatggtt
     2041 atcttaaggc attaattata aatcagagct ttaagtttgg aaatcaaaaa gcagcagcta
     2101 tcagagatag tattgaatta acaaaggaaa aaggtgcaga aattccaaag accattaaaa
     2161 aactgaggtg gtttgatgaa actagcaata tagaaaacaa tgctgaaaac agtcattcac
     2221 tgaagaataa aacaggaaca actcaacagc attctcaaca attccacatt caaagtggtg
     2281 ctggaagcaa cataattagt gtttctactt gtgctgtaaa ttctgctgat acaaagaagt
     2341 ccagggagga ttctatctct gaaaatgtta cgactttagg aggatctgga gcagaccata
     2401 tgcctttgaa ctgttttata ccttcaggtt ataactttgc taaacatgcc tggccagcct
     2461 caaaaaaaga agaaagtaaa atccctgtac atgatgattc taaaactaag caaggtaagc
     2521 cacaaagagg tagagcaaaa ataattagaa aaccaggatc tgcaaaagtc caatcaggct
     2581 ttatatgtac aaacagaaaa ggcgctgtca ttcaaccaca gtctgcaagc aaagtcaaca
     2641 tatttacaca agctcaggga aaattaatta taccttgtcc tcctcctcaa tctacatcaa
     2701 atattagaag tggtaaaaat atacaagtgt ctcagtgtca accagtaact cctgaaaatc
     2761 ctcaaaacat tattacacat aactctttta attcaaaaca tgtgcttcca acagaacaca
     2821 gtttgaatca gtggaatcag gaaagtagtt ctccactctc aaatgcttgt tctgacctag
     2881 tcactgtgat accatcactg ccatcatatt gttcttcaga gtgccaaact ttcgcaaaaa
     2941 taaatcattc aaatggcact caagcagttg cccggcaaga tgcgacatta tattgcaccc
     3001 aaagaagtcc tgtttgtgaa gaaagttatc cgtctgtgac tctaagaact gctgaagaag
     3061 aatcagttcc cttatggaaa agaggtccta atgtcctgca tcaaaataag agggctacag
     3121 ggtctactgt tatgagaaga aaacgaattg ctgaaactaa gcggagaaat attttagagc
     3181 agaaaagaca aaaccctgga tctgtaggac agaagtacag tgagcaaatt aataattttg
     3241 gacaaagtgt cctgctaagt tcaagtgagc caaaacaaac tacaaggggt acttcttata
     3301 ttgaagaagt ttcagatagt acttctgagt ttttgatggc tgaaaactta gtgaaagcat
     3361 cagtgccgga ggatgagatt ctgactgtct tgaatagcaa acagatacag aaatcaaatc
     3421 tacctttaaa taaaactcaa caattcaaca tctgcacact gtcagctgaa gaacagaaga
     3481 tcctagagtc ccttaatgat ctcagtgaaa gactacatta tatacaagaa tccatttgca
     3541 aaaacccatc catcaaaaat actttacaaa taataccact tctggagaag agagaagata
     3601 gaaccagcag ctgcagagac aagagataat tccagcagaa tccgtctaag aagacctttc
     3661 atgtacttcc ctaggactag atgcataccg ttttgtgaaa accagccata ggaaaacatg
     3721 tgagcaacaa cccccatgaa catttgtcct aactcagatt ttgtgagcag tgaagtttaa
     3781 cagagcagtg acatttaaca aagcagtgaa gtttaacaga gttctgagaa taccatgaaa
     3841 gacattatgc ctgcctaaac aaaaagcagg acataaccta gctctgaata catgccacaa
     3901 ggatgaagct tgtgagtaga gcaaacaaac gtttttccaa agaattcaca gtgctccttt
     3961 gcaatttata gatttcatgt tgaaatatat gttaaataaa atttctgttt attgaacctc
     4021 tttattaaac ctctaactta ctgataagat gtttatgaag tatggcatat tttgattttt
     4081 ttaattgtaa taaatattct taaagttacc acatcccaca aaatggccct tggtggcagc
     4141 aatagagcaa aggttacctt tttgtatggt gaagggaggc cttcctatgg ctgtacaatt
     4201 acatcgattc ttccaaattt catatttcat acatggcact ttggcatacc gaaaaaacat
     4261 gaaatttttc attaaaatgc catgaatcaa gccagggccg ttggcttatg cctgtaatcc
     4321 cagcactttg caggccgagg tagacagatg gcttgagctc aggagttcgt gaccagcctg
     4381 ggcaaccctg tctctacaaa aaatacaaaa attaaccagg catggtggca tgcacctgta
     4441 gtcccagcta cttggggtgc tgaggcggga ggattacttg agcccaggag gattacttca
     4501 acctgggagg ttgaggctgc agtgagctgt gtttcgccac tgcacaccag cctgggtgac
     4561 agtgtgagac ccagcctcaa aaaaaaaaaa aaaaaagtga tgaatcaaaa ttagaaatta
     4621 agagttttaa gaaaacatgt ggccttttat taataacact actaaatttt ggttcctcca
     4681 tagaattagt tttgaaacac ttgatgtagt gagaaatgca ttaacatgtt gaatgcctac
     4741 catgtaccaa attttgtgca tatatttttt atttaatctg accagccacc caaaccatgg
     4801 gtatttttgt ctccacttta gagatgagaa actgagccaa ggccacatag ctacctacag
     4861 tgacagaatc aaaattcaaa ctcaggttta tctagttcca aaacccatgt tctttctgcc
     4921 acaccatgtt agtagaaatg gaaactattg gatgaaatga ggaaaaacag gaaaagaatt
     4981 cactttttaa atgaagaaat tagtgaaaaa attgacctaa tgaaggaaac atttgtgctt
     5041 tcctatattt ttaattttaa gaataggatt tcggaaggcg acagaaaatt tagttcttag
     5101 acatttaaat agaaagttgt gtgcccctat agaaaatatt tgagaatttc ttatactatc
     5161 aagaaaaaat tctgtgaatt aagatgtaat ttataaaata acatttcaat gggggtaaac
     5221 aggccagaag agtgtgccaa gttgtttgtg aatcattcca agcacctcag atgaaaactc
     5281 acttttatta aaaaaaaaaa agacaagggt ttatattcat atacactagt atatatgtac
     5341 acagcagcat cctgcatgcc aaagtagctt caccgttagt aatccctcac tttaatacct
     5401 cttaggaacc aaagaatgcc tctacaagca aaaagatagt tgaaaatagt taagatccaa
     5461 agtcagaata ggccaaaaaa aaaaaaaaaa aaagcctaaa tagtaagctg gtgaaacaag
     5521 ataagatttg cattttacta gaacttgcac attatgatat tgtcctttta tgaaactgtc
     5581 atatgaccag aattcttctg taattctgcc catgactcct ccagaatttt agtagataca
     5641 gggtgggttc attaagagtg ataaaagtgg gaagacataa agagcctttg tgaattaaag
     5701 tggaagagaa taacactttg catgctataa acgtgaaaac taacattttt ggccagacac
     5761 agtggctcat gcatgtaatt ctagcacttt ggaggccaag gcaggaggac tgcttgagcc
     5821 caggagtttg agaccagcct gggcaatgta gcaagacccc atctctatat aaaatataaa
     5881 aatgttggct gtgcacggta gcttatgcct gtaatctcag cactttggga ggccaaggca
     5941 ggcagatcat gaggtcaaga gatcaagacc atcctggcca acatggtgaa accctgtctc
     6001 tactaaaaat acaaaaatag ctgggcatgg tggcacgcac ctctactccc agctactagg
     6061 aggctgaggc aggagaatcg tttgaaccca ggaggtagag gttgcagtga gctgagattg
     6121 caccactgca ccagcctggc aacagagcaa gactccgtct cacaaaaatg aataaataaa
     6181 ataaaaataa aaatgttact ttttaaaaag taactttttt aataatataa gaaagaaaaa
     6241 tgccctttca cactgaatct tcaagttcta aggaagaaaa gagtctcctt tcgaatgtga
     6301 agaagtaaat ttagaggaaa tcaaacaagc atcactttcc tcagtggaaa aacttatgaa
     6361 acttcttata agagagagta atctcaggcc ggacatgctg gctcatacct gtaatcccag
     6421 aactttggga ggccgaggca ggtggatcat ttgagctcag gaattcaaga ccagcctggg
     6481 taatatggca agagcccaac tctactaaaa atacaaaaag aaaagaaaac agccaagctt
     6541 ggtggtatgt gcctgtggtc ccagctactg gggaggctga ggtgggagga tcgtttgagc
     6601 ctgggaggca gaggttgcag tgatcaggaa ttgtgccact gcactccaac ctgagtgaca
     6661 gagcaacact ctgtcttaaa agaaaaaaaa aaaagagaga gatagtaatc tcttgggcaa
     6721 aaggtatcaa ataattgaaa gaaaagttta aacacatttc cgagaggcag ggcaactaat
     6781 aactggtcag aaaaatttag acggtcttca ttttaaaatt ggcatcagga aggattacca
     6841 tgaacttatt ttaaatccat attgtaccag aatgactatg tctgtgtttc ttaggaatgt
     6901 tgaagctttt tgtgaaaact gtactgtata catatataaa tatacacaca cttacatgta
     6961 tgtattttga tagatattac atggactaaa ttttgtcaat ttcatgtaat ttaccctttg
     7021 caataaaaat gattcattaa atatataa
//
