LOCUS       NM_001375405            4993 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens centrosomal protein 120 (CEP120), transcript variant
            3, mRNA.
ACCESSION   NM_001375405 XM_024454370
VERSION     NM_001375405.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4993)
  AUTHORS   Marshall,A.E., Lemire,G., Liang,Y., Davila,J., Couse,M.,
            Boycott,K.M. and Kernohan,K.D.
  CONSRTM   Care4Rare Canada Consortium
  TITLE     RNA sequencing reveals deep intronic CEP120 variant: A report of
            the diagnostic odyssey for two siblings with Joubert syndrome type
            31
  JOURNAL   Am J Med Genet A 194 (4), e63485 (2024)
   PUBMED   38050708
  REMARK    GeneRIF: RNA sequencing reveals deep intronic CEP120 variant: A
            report of the diagnostic odyssey for two siblings with Joubert
            syndrome type 31.
REFERENCE   2  (bases 1 to 4993)
  AUTHORS   Zhang,C., Ma,X., Wei,G., Zhu,X., Hu,P., Chen,X., Wang,D., Li,Y.,
            Ruan,T., Zhang,W., Tao,K. and Wu,C.
  TITLE     Centrosomal protein 120 promotes centrosome amplification and
            gastric cancer progression via USP54-mediated deubiquitination of
            PLK4
  JOURNAL   iScience 26 (1), 105745 (2022)
   PUBMED   36590171
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4993)
  AUTHORS   Barroso-Gil,M., Olinger,E., Ramsbottom,S.A., Molinari,E.,
            Miles,C.G. and Sayer,J.A.
  TITLE     Update of genetic variants in CEP120 and CC2D2A-With an emphasis on
            genotype-phenotype correlations, tissue specific transcripts and
            exploring mutation specific exon skipping therapies
  JOURNAL   Mol Genet Genomic Med 9 (12), e1603 (2021)
   PUBMED   33486889
  REMARK    GeneRIF: Update of genetic variants in CEP120 and CC2D2A-With an
            emphasis on genotype-phenotype correlations, tissue specific
            transcripts and exploring mutation specific exon skipping
            therapies.
REFERENCE   4  (bases 1 to 4993)
  AUTHORS   Chang,C.H., Chen,T.Y., Lu,I.L., Li,R.B., Tsai,J.J., Lin,P.Y. and
            Tang,T.K.
  TITLE     CEP120-mediated KIAA0753 recruitment onto centrioles is required
            for timely neuronal differentiation and germinal zone exit in the
            developing cerebellum
  JOURNAL   Genes Dev 35 (21-22), 1445-1460 (2021)
   PUBMED   34711653
  REMARK    GeneRIF: CEP120-mediated KIAA0753 recruitment onto centrioles is
            required for timely neuronal differentiation and germinal zone exit
            in the developing cerebellum.
REFERENCE   5  (bases 1 to 4993)
  AUTHORS   Powell,L., Barroso-Gil,M., Clowry,G.J., Devlin,L.A., Molinari,E.,
            Ramsbottom,S.A., Miles,C.G. and Sayer,J.A.
  TITLE     Expression patterns of ciliopathy genes ARL3 and CEP120 reveal
            roles in multisystem development
  JOURNAL   BMC Dev Biol 20 (1), 26 (2020)
   PUBMED   33297941
  REMARK    GeneRIF: Expression patterns of ciliopathy genes ARL3 and CEP120
            reveal roles in multisystem development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4993)
  AUTHORS   Vasan,R.S., Glazer,N.L., Felix,J.F., Lieb,W., Wild,P.S.,
            Felix,S.B., Watzinger,N., Larson,M.G., Smith,N.L., Dehghan,A.,
            Grosshennig,A., Schillert,A., Teumer,A., Schmidt,R., Kathiresan,S.,
            Lumley,T., Aulchenko,Y.S., Konig,I.R., Zeller,T., Homuth,G.,
            Struchalin,M., Aragam,J., Bis,J.C., Rivadeneira,F., Erdmann,J.,
            Schnabel,R.B., Dorr,M., Zweiker,R., Lind,L., Rodeheffer,R.J.,
            Greiser,K.H., Levy,D., Haritunians,T., Deckers,J.W., Stritzke,J.,
            Lackner,K.J., Volker,U., Ingelsson,E., Kullo,I., Haerting,J.,
            O'Donnell,C.J., Heckbert,S.R., Stricker,B.H., Ziegler,A.,
            Reffelmann,T., Redfield,M.M., Werdan,K., Mitchell,G.F., Rice,K.,
            Arnett,D.K., Hofman,A., Gottdiener,J.S., Uitterlinden,A.G.,
            Meitinger,T., Blettner,M., Friedrich,N., Wang,T.J., Psaty,B.M., van
            Duijn,C.M., Wichmann,H.E., Munzel,T.F., Kroemer,H.K.,
            Benjamin,E.J., Rotter,J.I., Witteman,J.C., Schunkert,H.,
            Schmidt,H., Volzke,H. and Blankenberg,S.
  TITLE     Genetic variants associated with cardiac structure and function: a
            meta-analysis and replication of genome-wide association data
  JOURNAL   JAMA 302 (2), 168-178 (2009)
   PUBMED   19584346
  REMARK    GeneRIF: Meta-analysis and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 4993)
  AUTHORS   Thorleifsson,G., Walters,G.B., Gudbjartsson,D.F.,
            Steinthorsdottir,V., Sulem,P., Helgadottir,A., Styrkarsdottir,U.,
            Gretarsdottir,S., Thorlacius,S., Jonsdottir,I., Jonsdottir,T.,
            Olafsdottir,E.J., Olafsdottir,G.H., Jonsson,T., Jonsson,F.,
            Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Lauritzen,T., Aben,K.K., Verbeek,A.L., Roeleveld,N., Kampman,E.,
            Yanek,L.R., Becker,L.C., Tryggvadottir,L., Rafnar,T., Becker,D.M.,
            Gulcher,J., Kiemeney,L.A., Pedersen,O., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Genome-wide association yields new sequence variants at seven loci
            that associate with measures of obesity
  JOURNAL   Nat Genet 41 (1), 18-24 (2009)
   PUBMED   19079260
REFERENCE   8  (bases 1 to 4993)
  AUTHORS   Xie,Z., Moy,L.Y., Sanada,K., Zhou,Y., Buchman,J.J. and Tsai,L.H.
  TITLE     Cep120 and TACCs control interkinetic nuclear migration and the
            neural progenitor pool
  JOURNAL   Neuron 56 (1), 79-93 (2007)
   PUBMED   17920017
  REMARK    GeneRIF: Functional characterization of the homologous mouse gene,
            and comparison to the human protein.
REFERENCE   9  (bases 1 to 4993)
  AUTHORS   Guerrier,S. and Polleux,F.
  TITLE     The ups and downs of neural progenitors: Cep120 and TACCs control
            interkinetic nuclear migration
  JOURNAL   Neuron 56 (1), 1-3 (2007)
   PUBMED   17920006
REFERENCE   10 (bases 1 to 4993)
  AUTHORS   Parisi,M. and Glass,I.
  TITLE     Joubert Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC106792.2, AC010369.7,
            KC877115.1 and KC877116.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 25, 2019 this sequence version replaced XM_024454370.1.
            
            Summary: This gene encodes a protein that functions in the
            microtubule-dependent coupling of the nucleus and the centrosome. A
            similar protein in mouse plays a role in both interkinetic nuclear
            migration, which is a characteristic pattern of nuclear movement in
            neural progenitors, and in neural progenitor self-renewal.
            Mutations in this gene are predicted to result in neurogenic
            defects. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (3), as well as variant 1, encodes
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853565.23518.1,
                                           SRR14038197.2608595.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306467.10/ ENSP00000303058.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-454               AC106792.2         14278-14731         c
            455-611             AC106792.2         9687-9843           c
            612-726             AC106792.2         7338-7452           c
            727-868             AC010369.7         159116-159257       c
            869-1017            AC010369.7         145853-146001       c
            1018-1215           AC010369.7         140017-140214       c
            1216-1443           AC010369.7         137827-138054       c
            1444-1660           AC010369.7         136641-136857       c
            1661-1835           AC010369.7         135149-135323       c
            1836-1985           AC010369.7         133235-133384       c
            1986-2130           AC010369.7         131706-131850       c
            2131-2168           KC877115.1         517-554             c
            2169-2265           AC010369.7         129703-129799       c
            2266-2418           AC010369.7         129454-129606       c
            2419-2508           AC010369.7         128828-128917       c
            2509-2601           AC010369.7         125053-125145       c
            2602-2763           AC010369.7         124091-124252       c
            2764-2886           AC010369.7         119367-119489       c
            2887-2985           AC010369.7         111213-111311       c
            2986-3131           KC877116.1         294-439
            3132-4993           AC010369.7         91609-93470         c
FEATURES             Location/Qualifiers
     source          1..4993
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.2"
     gene            1..4993
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /note="centrosomal protein 120"
                     /db_xref="GeneID:153241"
                     /db_xref="HGNC:HGNC:26690"
                     /db_xref="MIM:613446"
     exon            1..454
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /inference="alignment:Splign:2.1.0"
     CDS             406..3366
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /note="isoform 1 is encoded by transcript variant 3;
                     centrosomal protein of 120 kDa; coiled-coil
                     domain-containing protein 100; centrosomal protein 120kDa"
                     /codon_start=1
                     /product="centrosomal protein of 120 kDa isoform 1"
                     /protein_id="NP_001362334.1"
                     /db_xref="CCDS:CCDS4134.2"
                     /db_xref="GeneID:153241"
                     /db_xref="HGNC:HGNC:26690"
                     /db_xref="MIM:613446"
                     /translation="MVSKSDQLLIVVSILEGRHFPKRPKHMLVVEAKFDGEQLATDPV
                     DHTDQPEFATELAWEIDRKALHQHRLQRTPIKLQCFALDPVTSAKETIGYIVLDLRTA
                     QETKQAPKWYQLLSNKYTKFKSEIQISIALETDTKPPVDSFKAKGAPPRDGKVPAILA
                     GLDPRDIVAVLNEEGGYHQIGPAEYCTDSFIMSVTIAFATQLEQLIPCTMKLPERQPE
                     FFFYYSLLGNDVTNEPFNDLINPNFEPERASVRIRSSVEILRVYLALQSKLQIHLCCG
                     DQSLGSTEIPLTGLLKKGSTEINQHPVTVEGAFTLDPPNRAKQKLAPIPVELAPTVGV
                     SVALQREGIDSQSLIELKTQNEHEPEHSKKKVLTPIKEKTLTGPKSPTVSPVPSHNQS
                     PPTKDDATESEVESLQYDKDTKPNPKASSSVPASLAQLVTTSNASEVASGQKIAVPAT
                     SHHFCFSIDLRSIHALEIGFPINCILRYSYPFFGSAAPIMTNPPVEVRKNMEVFLPQS
                     YCAFDFATMPHQLQDTFLRIPLLVELWHKDKMSKDLLLGIARIQLSNILSSEKTRFLG
                     SNGEQCWRQTYSESVPVIAAQGSNNRIADLSYTVTLEDYGLVKMREIFISDSSQGVSA
                     VQQKPSSLPPAPCPSEIQTEPRETLEYKAALELEMWKEMQEDIFENQLKQKELAHMQA
                     LAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKEL
                     QSERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILE
                     KEFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELA
                     RLKQREQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQE
                     QKQYQDSTEIASGKKDGPHGSVLEEGLDDYLTRLIEERDTLMRTGVYNHEDRIISELD
                     RQIREILAKSNASN"
     exon            455..611
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /inference="alignment:Splign:2.1.0"
     exon            612..726
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /inference="alignment:Splign:2.1.0"
     exon            727..868
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1017
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1215
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1443
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1660
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1835
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1985
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2168
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2265
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2418
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2508
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2601
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2763
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2886
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..2985
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3131
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..4993
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4893..4898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /note="hexamer: AATAAA"
     polyA_site      4914
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /note="major polyA site"
     regulatory      4972..4977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /note="hexamer: AATAAA"
     polyA_site      4993
                     /gene="CEP120"
                     /gene_synonym="CCDC100; JBTS31; SRTD13"
                     /note="major polyA site"
ORIGIN      
        1 gttgtcctcc aacctcccct gggcactggg cctgcgggcc tggttgctag gcggaagctg
       61 ggcgcggcgg cggccgctgc ggccgcccgg gcgtttgaaa agcggctacg caggcggcaa
      121 aaggtcctcg ggtggcgggc ttgtctctgc ttgcagactg gcagggctgc agcgtggctt
      181 tttccttgag tcggggcaca gttaggatct gggctggcgg cccgaggcag aggagccggg
      241 cgcgctgcag cagacggcgg tgggacctgg ctgcggagcg gggtccgggc atcagggacc
      301 gggggcgggc agtgggggtc ccgccggggg tcccggatta cccgcgactc aactggacct
      361 cacttccccc cagccgcctt cgcccccgga ccgctcaccg caaccatggt ctccaaatcc
      421 gaccaattgc tcatcgtcgt gtccatccta gaaggtcggc atttccccaa acgtccaaag
      481 catatgcttg tagtggaagc aaagtttgat ggagaacagt tggctactga tcctgtggac
      541 cacactgacc agccagaatt tgctactgag ttagcttggg aaattgacag gaaagcgctt
      601 catcagcaca ggctacagcg tactcctatc aaactccaat gttttgcctt ggatcctgta
      661 acttcagcca aggaaaccat aggttacatc gttctggatt taagaaccgc tcaagaaaca
      721 aagcaggcac caaaatggta ccagttgctg agtaataaat acaccaaatt caagtctgag
      781 atacagataa gtattgcttt ggaaaccgat acaaagccac cagtggatag ctttaaagca
      841 aagggggctc cccctcgaga tggaaaagta cctgccatcc tggctggact tgaccccagg
      901 gacattgtgg ctgtgctgaa tgaagaggga ggctaccatc agattggacc agcagaatac
      961 tgtactgact cctttattat gtcagtgacc atagcatttg ctacccagtt ggaacagtta
     1021 attccatgta ccatgaaact tccagaaaga cagcctgagt ttttctttta ctactcttta
     1081 ctgggaaatg atgttacaaa tgaacccttc aatgatttaa tcaacccaaa ctttgagcca
     1141 gagagagcat cagttcgcat ccgtagcagt gtagaaattc ttcgtgttta cctggctctt
     1201 cagtctaaac tgcagattca cctctgctgt ggagaccagt cacttggaag tacagaaata
     1261 cctttaactg gattacttaa aaagggcagt acagaaatca accagcaccc agtcacagtc
     1321 gaaggtgctt ttacccttga ccctccaaac agagccaaac agaagcttgc acctattcct
     1381 gtggagctag ccccaactgt gggagtgtct gtggctctgc agagagaagg catagactcc
     1441 cagtctttaa ttgaattaaa gacccagaat gaacatgagc cagagcattc aaagaagaaa
     1501 gttttaaccc ccataaagga gaagacactt actgggccaa aatcaccaac agtgtcccct
     1561 gttccatctc acaaccagtc acctccaaca aaagatgatg caacagaaag tgaagtggaa
     1621 agtttacagt atgataagga caccaaacca aatccaaaag ccagttcttc tgtacctgct
     1681 tcactggccc agctagtgac tacatccaat gcttcagaag tagcttcagg acagaagatt
     1741 gctgtaccag caacatcaca tcatttttgc ttttcaatag acttaaggag tatacatgcc
     1801 ttggagattg gttttccaat caactgtata ttaaggtact catatccatt ctttggaagt
     1861 gcagctccta ttatgactaa tcctcctgta gaagttcgga aaaacatgga agtttttctt
     1921 ccccagtctt actgtgcatt tgattttgca actatgcctc atcagctgca agacaccttc
     1981 ttaaggattc cattactggt tgaactatgg cacaaggata aaatgagtaa agatttactt
     2041 ctgggaattg cgagaatcca gctttctaac atcttgtctt cagaaaaaac tcgtttttta
     2101 ggttctaatg gtgaacagtg ttggcgtcaa acttacagtg aaagtgtgcc tgttatagca
     2161 gcacaaggat caaataacag gatagcagat ctttcttaca cagtgactct agaagattat
     2221 ggactagtaa aaatgcgtga gatttttatc tctgattcat ctcagggtgt atctgccgta
     2281 cagcaaaagc cgtcttctct tcctccagca ccttgtcctt cagagatcca gacagagcct
     2341 cgtgaaacgt tagaatacaa agcagcactt gagctagaaa tgtggaagga gatgcaagaa
     2401 gatatatttg aaaatcagct gaagcagaaa gaactggctc atatgcaggc tcttgcagag
     2461 gaatggaaga aaagggaccg agaaagagaa tcactagtaa agaaaaaggt ggctgaatat
     2521 actattctag aaggaaaact tcaaaaaact ctaattgact tggagaagcg agagcagcag
     2581 cttgctagtg tggaatcaga gcttcaaaga gaaaaaaagg aactgcaatc agaacgtcag
     2641 cggaacctgc aagaactgca ggactctatc cgtagggcca aagaggactg tattcaccaa
     2701 gtagaactag aaaggttaaa aatcaaacag ctcgaagagg ataaacaccg ccttcagcaa
     2761 cagcttaatg atgctgaaaa taagtataag attttggaaa aagagttcca acagttcaag
     2821 gaccagcaaa acaacaaacc agaaatccgt ctacagtctg aaataaatct tctcaccttg
     2881 gaaaaggttg aacttgaaag aaagttggaa tctgcaacta agtctaaact gcattacaag
     2941 cagcagtggg gacgagcttt gaaagaactt gccagactta aacagaggga gcaagaaagt
     3001 caaatggctc gtcttaaaaa acagcaggaa gaattggaac agatgagact acgttacctt
     3061 gccgctgagg aaaaagatac agtaaaaacc gagcgacaag aattgttgga tataagaaat
     3121 gaattgaaca ggttaaggca acaagagcaa aaacaatacc aggattccac agagattgca
     3181 agtggaaaaa aggatggccc ccatggcagt gtattggaag aaggtttgga tgattatttg
     3241 actcgcctga tagaagaaag ggatactttg atgagaacgg gtgtgtataa tcacgaggat
     3301 cgaataataa gtgaactcga ccgacagatc agagagattt tggcaaaaag caatgccagt
     3361 aattaataac atttggaaaa gctttataga gactctaagt ctaaatttta atttctttgt
     3421 aaaaacctca aaagtgagga aaatggatgt tttaaaatgg tattttcaat tttttataag
     3481 caaaattttg tatgttattg tatagtattt atttgatctt atttacttta tgctacctct
     3541 cccacactgg ttttatttgt aatttgcatt tatatactca ttttaaatga cttttcagtg
     3601 tttttcatag tttataatct gatggctaac taactttcaa aacagctttt aactaagttt
     3661 gttgtaggag aaatgactgc ggtaatttcc agttctataa tgtttcatgt tgagccaaaa
     3721 gagtatatct tgcactttaa aaacgctgcg tcctattcca tttgaatgta aattcttaaa
     3781 agttgagacc aattgtaacc agtttaactc attttagatg accttttttt cttataatat
     3841 ttgcaagtga caagtttgaa aacaaagcaa gatcagtgca gagaagccac atgacatgtt
     3901 gggtgacaga ttggtcattt atttaaataa agttaataca gattaaattt gtttcaagag
     3961 ctattgaatt ttcaaatttt cagtgtattt ataactttta agaacatgaa gtattagctt
     4021 aatatagttt tctctgttgg tttcttcctc aagtttgcat tgttttcttt tgttaaaatt
     4081 agagatttct ttttattttc cagttatagt aatactagct gtcagcttaa accctctgta
     4141 atagaacatg gaaacagaca cataaagaca ttagctgaaa aaatagagtg aaaatcaact
     4201 attttttact cccgctaatt tcaatcaatc gttttcaaaa gcgcacgaga ttcactcatt
     4261 ggatttatgc agtgccctgt ctgtataaaa actcttaaga gttcctttat atcatattct
     4321 tcagagccaa catttgtcct caaagcaacg tttcccacct ccttttactg agtactgaaa
     4381 aagttttagc aaagtcacag attaggttga atttcaaaat atatgtactt taaaaagttc
     4441 tgatttccaa atataataaa gttaaaatta agtatatact ttaggaagtt accaataact
     4501 tccatcaaag cagagtagga tatatggtaa cattaatttt cggtcatttc aaatgaggta
     4561 tatttcttat tagggaaatt aaagtcccta tatttattat atattttttc cttattaaca
     4621 gagtattaat ctagtaaaaa ataacccagc agtaaataat aaagaaatta ctgaatgaga
     4681 ggataatgaa tctgaatcat agcaggaatt tgcaatatta attatggtta gctatttttc
     4741 tctcattgat ttttgtgcca cttgaatgga acagaagcaa gccttatgtt ttggaaggtc
     4801 tgcggtaaaa tgctgtgact gtttactttc aattgcattg tgtgttgcct gtgactgctt
     4861 tcaaacgcta gagggggcct ctgatttaaa gaaataaaaa ggacttttct aaaatggatg
     4921 tgtagtttat tttgcctttt gtaaagctct tttggctatt gtaacttaac aaataaaatc
     4981 ataattgtgt gca
//
