LOCUS       NM_014704               6431 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens centrosomal protein 104 (CEP104), mRNA.
ACCESSION   NM_014704 XM_375682
VERSION     NM_014704.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6431)
  AUTHORS   Odabasi,E., Conkar,D., Deretic,J., Batman,U., Frikstad,K.M.,
            Patzke,S. and Firat-Karalar,E.N.
  TITLE     CCDC66 regulates primary cilium length and signaling via
            interactions with transition zone and axonemal proteins
  JOURNAL   J Cell Sci 136 (3) (2023)
   PUBMED   36606424
REFERENCE   2  (bases 1 to 6431)
  AUTHORS   Khoshbakht,S., Beheshtian,M., Fattahi,Z., Bazazzadegan,N.,
            Parsimehr,E., Fadaee,M., Vazehan,R., Faraji Zonooz,M.,
            Abolhassani,A., Makvand,M., Kariminejad,A., Celik,A., Kahrizi,K.
            and Najmabadi,H.
  TITLE     CEP104 and CEP290; Genes with Ciliary Functions Cause Intellectual
            Disability in Multiple Families
  JOURNAL   Arch Iran Med 24 (5), 364-373 (2021)
   PUBMED   34196201
  REMARK    GeneRIF: CEP104 and CEP290; Genes with Ciliary Functions Cause
            Intellectual Disability in Multiple Families.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6431)
  AUTHORS   Yamazoe,T., Nagai,T., Umeda,S., Sugaya,Y. and Mizuno,K.
  TITLE     Roles of TOG and jelly-roll domains of centrosomal protein CEP104
            in its functions in cilium elongation and Hedgehog signaling
  JOURNAL   J Biol Chem 295 (43), 14723-14736 (2020)
   PUBMED   32820051
  REMARK    GeneRIF: Roles of TOG and jelly-roll domains of centrosomal protein
            CEP104 in its functions in cilium elongation and Hedgehog
            signaling.
REFERENCE   4  (bases 1 to 6431)
  AUTHORS   Latour,B.L., Van De Weghe,J.C., Rusterholz,T.D., Letteboer,S.J.,
            Gomez,A., Shaheen,R., Gesemann,M., Karamzade,A., Asadollahi,M.,
            Barroso-Gil,M., Chitre,M., Grout,M.E., van Reeuwijk,J., van
            Beersum,S.E., Miller,C.V., Dempsey,J.C., Morsy,H., Bamshad,M.J.,
            Nickerson,D.A., Neuhauss,S.C., Boldt,K., Ueffing,M.,
            Keramatipour,M., Sayer,J.A., Alkuraya,F.S., Bachmann-Gagescu,R.,
            Roepman,R. and Doherty,D.
  CONSRTM   University of Washington Center for Mendelian Genomics; Genomics
            England Research Consortium
  TITLE     Dysfunction of the ciliary ARMC9/TOGARAM1 protein module causes
            Joubert syndrome
  JOURNAL   J Clin Invest 130 (8), 4423-4439 (2020)
   PUBMED   32453716
REFERENCE   5  (bases 1 to 6431)
  AUTHORS   Crisci,A., Raleff,F., Bagdiul,I., Raabe,M., Urlaub,H., Rain,J.C.
            and Kramer,A.
  TITLE     Mammalian splicing factor SF1 interacts with SURP domains of U2
            snRNP-associated proteins
  JOURNAL   Nucleic Acids Res 43 (21), 10456-10473 (2015)
   PUBMED   26420826
REFERENCE   6  (bases 1 to 6431)
  AUTHORS   Srour,M., Hamdan,F.F., McKnight,D., Davis,E., Mandel,H.,
            Schwartzentruber,J., Martin,B., Patry,L., Nassif,C.,
            Dionne-Laporte,A., Ospina,L.H., Lemyre,E., Massicotte,C.,
            Laframboise,R., Maranda,B., Labuda,D., Decarie,J.C., Rypens,F.,
            Goldsher,D., Fallet-Bianco,C., Soucy,J.F., Laberge,A.M., Maftei,C.,
            Boycott,K., Brais,B., Boucher,R.M., Rouleau,G.A., Katsanis,N.,
            Majewski,J., Elpeleg,O., Kukolich,M.K., Shalev,S. and Michaud,J.L.
  CONSRTM   Care4Rare Canada Consortium
  TITLE     Joubert Syndrome in French Canadians and Identification of
            Mutations in CEP104
  JOURNAL   Am J Hum Genet 97 (5), 744-753 (2015)
   PUBMED   26477546
  REMARK    GeneRIF: Mutations in CEP104 is associated with Joubert Syndrome.
REFERENCE   7  (bases 1 to 6431)
  AUTHORS   Satish Tammana,T.V., Tammana,D., Diener,D.R. and Rosenbaum,J.
  TITLE     Centrosomal protein CEP104 (Chlamydomonas FAP256) moves to the
            ciliary tip during ciliary assembly
  JOURNAL   J Cell Sci 126 (Pt 21), 5018-5029 (2013)
   PUBMED   23970417
REFERENCE   8  (bases 1 to 6431)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   9  (bases 1 to 6431)
  AUTHORS   Kumar,K.N., Babcock,K.K., Johnson,P.S., Chen,X., Ahmad,M. and
            Michaelis,E.K.
  TITLE     Cloning of the cDNA for a brain glycine-, glutamate- and
            thienylcyclohexylpiperidine-binding protein
  JOURNAL   Biochem Biophys Res Commun 216 (1), 390-398 (1995)
   PUBMED   7488117
REFERENCE   10 (bases 1 to 6431)
  AUTHORS   Parisi,M. and Glass,I.
  TITLE     Joubert Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL691523.6 and AL365330.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014704.3.
            
            Summary: This gene encodes a centrosomal protein required for
            ciliogenesis and for ciliary tip structural integrity. The
            mammalian protein contains three amino-terminal hydrophobic
            domains, two glycosylation sites, four cysteine-rich motifs, and
            two regions with homology to the glutamate receptor ionotropic,
            NMDA 1 protein. During ciliogenesis, the encoded protein
            translocates from the distal tips of the centrioles to the tip of
            the elongating cilium. Knockdown of the protein in human retinal
            pigment cells results in severe defects in ciliogenesis with
            structural deformities at the ciliary tips. Allelic variants of
            this gene are associated with the autosomal-recessive disorder
            Joubert syndrome, which is characterized by a distinctive
            mid-hindbrain and cerebellar malformation, oculomotor apraxia,
            irregular breathing, developmental delay, and ataxia. [provided by
            RefSeq, Feb 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.131782.1,
                                           SRR1803616.70953.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378230.8/ ENSP00000367476.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-323               AL691523.6         27520-27842         c
            324-450             AL691523.6         22926-23052         c
            451-624             AL691523.6         19239-19412         c
            625-763             AL691523.6         18106-18244         c
            764-826             AL691523.6         15920-15982         c
            827-903             AL691523.6         15538-15614         c
            904-1072            AL691523.6         10239-10407         c
            1073-1228           AL691523.6         9595-9750           c
            1229-1456           AL691523.6         7923-8150           c
            1457-1654           AL691523.6         7126-7323           c
            1655-1822           AL691523.6         5556-5723           c
            1823-1996           AL691523.6         4493-4666           c
            1997-2173           AL691523.6         1677-1853           c
            2174-2380           AL691523.6         422-628             c
            2381-2384           AL691523.6         1-4                 c
            2385-2488           AL365330.16        60136-60239         c
            2489-2525           AL365330.16        57578-57614         c
            2526-2592           AL365330.16        57240-57306         c
            2593-2701           AL365330.16        56628-56736         c
            2702-2840           AL365330.16        54294-54432         c
            2841-2908           AL365330.16        54044-54111         c
            2909-2999           AL365330.16        47150-47240         c
            3000-6431           AL365330.16        42956-46387         c
FEATURES             Location/Qualifiers
     source          1..6431
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.32"
     gene            1..6431
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /note="centrosomal protein 104"
                     /db_xref="GeneID:9731"
                     /db_xref="HGNC:HGNC:24866"
                     /db_xref="MIM:616690"
     exon            1..323
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /inference="alignment:Splign:2.1.0"
     exon            324..450
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..3115
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /note="centrosomal protein 104kDa"
                     /codon_start=1
                     /product="centrosomal protein of 104 kDa"
                     /protein_id="NP_055519.1"
                     /db_xref="CCDS:CCDS30571.1"
                     /db_xref="GeneID:9731"
                     /db_xref="HGNC:HGNC:24866"
                     /db_xref="MIM:616690"
                     /translation="MPHKIGFVVVSSSGHEDGFSARELMIHAPTVSGWRSPRFCQFPQ
                     EIVLQMVERCRIRKLQLLAHQYMISSKIEFYISESLPEYFAPYQAERFRRLGYVSLCD
                     NEKTGCKARELKSVYVDAVGQFLKLIFHQNHVNKYNIYNQVALVAINIIGDPADFSDE
                     SNTASREKLIDHYLGHNSEDPALEGTYARKSDYISPLDDLAFDMYQDPEVAQIIRKLD
                     ERKREAVQKERYDYAKKLKQAIADLQKVGERLGRYEVEKRCAVEKEDYDLAKEKKQQM
                     EQYRAEVYEQLELHSLLDAELMRRPFDLPLQPLARSGSPCHQKPMPSLPQLEERGTEN
                     QFAEPFLQEKPSSYSLTISPQHSAVDPLLPATDPHPKINAESLPYDERPLPAIRKHYG
                     EAVVEPEMSNADISDARRGGMLGEPEPLTEKALREASSAIDVLGETLVAEAYCKTWSY
                     REDALLALSKKLMEMPVGTPKEDLKNTLRASVFLVRRAIKDIVTSVFQASLKLLKMII
                     TQYIPKHKLSKLETAHCVERTIPVLLTRTGDSSARLRVTAANFIQEMALFKEVKSLQI
                     IPSYLVQPLKANSSVHLAMSQMGLLARLLKDLGTGSSGFTIDNVMKFSVSALEHRVYE
                     VRETAVRIILDMYRQHQASILEYLPPDDSNTRRNILYKTIFEGFAKIDGRATDAEMRA
                     RRKAATEEAEKQKKEEIKALQGQLAALKEIQAEVQEKESDAVKPKNQDIQGGKAAPAE
                     ALGIPDEHYLDNLCIFCGERSESFTEEGLDLHYWKHCLMLTRCDHCKQVVEISSLTEH
                     LLTECDKKDGFGKCYRCSEAVFKEELPRHIKHKDCNPAKPEKLANRCPLCHENFSPGE
                     EAWKAHLMGPAGCTMNLRKTHILQKAPALQPGKSSAVAASGPLGSKAGSKIPTPKGGL
                     SKSSSRTYAKR"
     exon            451..624
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /inference="alignment:Splign:2.1.0"
     exon            625..763
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /inference="alignment:Splign:2.1.0"
     exon            764..826
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /inference="alignment:Splign:2.1.0"
     exon            827..903
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1072
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1228
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1456
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1654
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1822
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1996
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2173
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2380
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2488
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2525
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2592
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2701
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2840
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..2908
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..2999
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..6431
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3713..3718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /note="hexamer: AATAAA"
     polyA_site      3732
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /note="major polyA site"
     regulatory      6414..6419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /note="hexamer: AATAAA"
     polyA_site      6431
                     /gene="CEP104"
                     /gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
                     ROC22"
                     /note="major polyA site"
ORIGIN      
        1 agggctgggc ttggttgtca tgagagtgga ggctgcggcc ggggctatgg gcagaggtgg
       61 ccgggtctgc ttcttccctg tcactgccgc agcagcttgg ggtgcaaggc ggcctggggc
      121 ggcggaaggg gcgccccccg agttccgtct gaggaagcgg cggctgccga ggaagtccac
      181 gagagccggg tcccgcacgc ccctggggtc cgggtgctga ggcgccgcct ggccgcctcc
      241 ccgggccgcg gcaccgctcc gacccagccg ccctctccac cggggccgcg gcagcgccag
      301 tcggggccct tccctctaag cagcccaaac gtgcagaatg ccccacaaga ttggatttgt
      361 agtcgtcagc tcatctggac acgaagacgg cttcagtgcc cgggagctca tgatccacgc
      421 gccaactgtc agtgggtggc ggtcacctag attttgccag tttccacaag aaattgtcct
      481 tcaaatggtg gagagatgtc gaataaggaa actgcagtta cttgctcacc agtatatgat
      541 ttcaagtaaa attgagttct acattagtga aagcttgcct gaatattttg caccctatca
      601 agcagagcgg tttcgaagac ttggctacgt gtctctctgt gataatgaaa agacaggttg
      661 caaagcccgg gaactaaaat cagtttatgt ggatgcagta ggacaatttc ttaaactgat
      721 ttttcaccaa aaccatgtca acaaatacaa catatataat caggttgctt tggttgccat
      781 aaatatcatt ggagaccctg cagatttcag tgatgaaagc aatactgcct ctcgagagaa
      841 gttgattgac cactaccttg ggcacaacag cgaggaccct gctctagaag gaacgtacgc
      901 caggaaatct gactatatct ctccgctaga tgacttagct tttgatatgt accaagatcc
      961 agaagttgca cagatcatac gaaaattaga tgaaagaaaa cgggaagctg tccaaaagga
     1021 acgctatgat tatgccaaga aactaaaaca agccattgct gatttgcaaa aggttggtga
     1081 acgccttggg aggtatgagg tagagaaacg ctgtgccgtg gagaaggaag actacgatct
     1141 cgccaaggag aagaagcagc agatggagca gtatcgtgcc gaggtgtacg agcagctgga
     1201 gctgcacagc ctcctggatg ccgagctgat gcgaagacct tttgatttgc ccctccagcc
     1261 cctcgctcgt tctggcagtc cttgccacca aaagccaatg ccctcactac cacaactgga
     1321 agaaagagga acagaaaacc agtttgcaga acctttcctt caggaaaagc cttcatcata
     1381 ttctctaact atttctcctc agcattctgc agtagacccg ttactccctg ccacagatcc
     1441 tcatccaaag atcaatgcag agtccctgcc ctacgatgag cggcctcttc cagctattcg
     1501 taagcattat ggggaggcag tggtggagcc ggaaatgagt aatgcagaca tcagcgatgc
     1561 tcggagggga ggcatgttag gggagccaga gcccttaacc gagaaggcct tgagagaagc
     1621 cagctctgcc atcgatgtgt tgggagaaac cttggttgct gaggcctatt gtaagacgtg
     1681 gtcctaccga gaggatgcac tgcttgcctt gtctaagaag ttaatggaaa tgcctgttgg
     1741 aaccccaaaa gaagatttaa agaacacact gagagcatcc gtctttctcg ttagaagagc
     1801 cataaaggac attgtgacct ccgtttttca ggcttctttg aaattgttga aaatgatcat
     1861 tacacaatat attcctaaac ataaactgag taaacttgaa acagctcact gtgtggagag
     1921 gaccattccc gttttgctca ccagaactgg agattcttct gcccgcctcc gcgtcacagc
     1981 tgcaaatttt attcaggaaa tggccttgtt taaagaagtt aagtctctcc aaattattcc
     2041 atcctacctg gtgcagccat tgaaagcaaa ctcttcagtt cacctggcaa tgagtcagat
     2101 gggcctcctg gcccggctgc tgaaagacct gggcactggc agctcgggct tcaccattga
     2161 caacgtgatg aagttttcag tgagtgccct ggagcataga gtgtatgagg tccgcgagac
     2221 ggcggttcga attattttgg acatgtacag acagcaccag gcttccatcc tggagtacct
     2281 tcctccagac gacagcaaca cacgcaggaa cattctctac aaaacaattt ttgagggatt
     2341 tgctaaaata gatggcagag ctacagatgc tgagatgagg gcacggagaa aagcggctac
     2401 agaagaagca gaaaaacaaa agaaagaaga aataaaagct ttacaagggc agctggcagc
     2461 actgaaagaa attcaggctg aagttcagga aaaagaaagt gatgctgtga agccaaagaa
     2521 tcaggacatt caaggaggga aagcagcccc tgctgaagct ctgggaatcc cggatgagca
     2581 ctatctagat aatttgtgta ttttttgtgg ggaaaggagt gaatccttca cagaggaagg
     2641 tctggatctc cactactgga agcactgtct catgctgaca agatgtgacc actgcaaaca
     2701 ggtggtcgag atatccagtc tgacggagca cttgctgacg gaatgtgaca aaaaagacgg
     2761 gtttggaaag tgttaccgtt gcagtgaggc tgttttcaag gaagagctgc ccagacacat
     2821 aaaacacaag gattgcaacc ctgccaaacc ggagaagctg gcaaaccggt gtcccctgtg
     2881 tcatgagaac ttcagccctg gagaagaggc atggaaagct cacctgatgg gcccagccgg
     2941 ctgcacgatg aacctgcgca agacacacat tctgcagaag gccccggcac tgcagccagg
     3001 gaaaagctca gctgtggccg catcaggccc cttggggtca aaggccggaa gcaagatccc
     3061 caccccgaag ggcggactga gcaagagctc cagcaggacg tacgccaagc gctgacgcgg
     3121 cgctcgggct ccttggtctc tgtgagggat ggagcgggtc tcctgattct acaccatctc
     3181 tccagaactc tctggccttg gtggccccat gctctggctg ctgtccccag ctccccgccg
     3241 tgcacgcctc ttacgcgtct gtgccgtcag ctctcgtgca aacgatatgg atgcagctaa
     3301 ccaaagatcc tgcgtgcagt gccaggacct ggccgcactg tacattaagc cttcagggct
     3361 gtctcaggcc ttccttagaa tcagagaagg aagcgtcctg tttggagaga gccagagagc
     3421 accgccggga ggcgctcgcg caaggccacg gtcagcacag gcacggtccc gctttcctta
     3481 gtgcttggag caatttccat aaaacattca ccagaaacct tttgcacatc ggtctctgcc
     3541 acacgcagta gaatttccgc agggctgtgg ctcggccagc agcggttcca ggagagtggc
     3601 ggtgcgcacg ggcctccagc cgtgccttcc ccctgcaggc cccgtctgct gggcctgctg
     3661 cccagtgcac tcagccccag gtagcagaac tcacgttccc actatagcaa gaaataaagg
     3721 caaaagagaa catctttttt ttaatcgtag tttttttgag aattggtccc acctcagccg
     3781 caccttgctg gatgcttctc cagtagtgct gcccctgtga caggcatcag ctccctgctg
     3841 gaactgaggt agacacaggt gtgggccctt cccgtgcctt tgctcagagg cgcttcactt
     3901 tctccacact ttcgaattcc taaagacatg tggaggaagt cactgttaaa tgaatttcca
     3961 cctgatcacc ctgtgttcac agcaggcaga agcccactgg tatgggcctc ccgccccttc
     4021 cacatccatg ttgtgattgg atccataagt ttactttctt caaagagttg ataggatgtt
     4081 taaaacatca acacattgct taaaatgatg aaaccaaccc tcaaaaaaca gtctcctaac
     4141 cagccatccc ctcctgtggg agtgagctgg gggttttgtc catagctttg gttgggcctg
     4201 tgtcacatcc aggcagccat gtggagggag tcagggtctg tctggaagca tccaccctct
     4261 cgctgcccca gcctgtgctc ccaggggcct aggctaccat ggactgaagg gcagtcccct
     4321 cccacctggt gcccagggct tctgcttgcc tcgctgatgt tgcatgggca gacttcaaaa
     4381 aggatagtta gaaaggtttg ggttgatgga gtttgcatta atgcaattag tgtataaata
     4441 tgttttaatt gccaaccgtg tgaaacaaca aaatatctaa aaactaatcc cgatttgaac
     4501 aatgtactcc ctggcctgga tacattaata accataaatt tgcatgaatt aatctccacg
     4561 tttggtaaac taatacctct ggttgactga gaatactgag taagatataa gacctaccag
     4621 gaacctttaa gaatatgctc tgctcagtgt tgtttgtctg cttgtttgcg acggagtctc
     4681 actgtgtcgc ccgggctgca gtgcaatggc gtgatcttgg ctcacagtaa cctccacctc
     4741 ctgggttcaa gcaattctcc tgcctcagcc tccctagtag ctgggattac aggtgcacac
     4801 caccatgctc ggctaatttt ttctattttt agtagagatg gggtttcacc atgttggcca
     4861 ggctggtctc gaactcgtga cctcataatc tgcccacctt ggcctcccaa agtgctggga
     4921 ttacaggcgt gagccaccac gcccaggtta aatgtgttta taaggagaga ggaggccagg
     4981 cgcggtggct cacgctgtaa tcccagcact ttgggaggcc gaggcgggcg gaccacctga
     5041 ggtcaggagt tcgagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatac
     5101 aaaaatgagc caggcgtggt ggcctgtagt cccagctact tgagaggctg aggcaggaaa
     5161 attgcttgaa cccgggaggt ggaggttgca ttgagcccac atcatgccat tgcactccag
     5221 cccaggcgac agagcgagac tccgtctcga aaaaaaaaaa aagtataagg agagaaataa
     5281 ctttaaagtt tattagacaa aacagagtat agatgccaag atgtctgtaa aatgattttt
     5341 tctggtttta aagagatgtt ggccattatt ttctaatcca tttttaaaat acagacaaaa
     5401 cacttcttta aacagaacaa gaatgagaaa agttaaccaa ggaattattc ttttctcacc
     5461 aatcaacact tttaagaaat atatatatat atatacacac atatacacat gccttctata
     5521 tattgtaact taaagaaaat acttataaaa agacttcatt tttagtgatt gacaagcaaa
     5581 cgggttcatt taaaacaggt tcctcttttg ttagttacag ggggtttttt tgttgttttt
     5641 ttgtttttgt ttttgttttg cgggggtggt ggggtttgag acggagtctt gctctgttgc
     5701 ctaggctgga gtgcagtggc gcgatcttgg ccccctgcaa cctccgcctc ccgggttcga
     5761 gcaattctcc tgcctcagcc tcccgagtag ctgggattac aggcgtgtgt caccacgcct
     5821 ggctaatttt tttgtatttt tagtagagac ggggtttcac catattggcc aggctggtct
     5881 caaactcctg accttgtgat ccacccacct cggcctccca aagtgctgga attacaggca
     5941 tgagccaccg cgcccggccc aatcatgtgt ttttgttgaa atgatcctac cagtgattag
     6001 tggctattga gagttttaca gggttataca ttgttaaggg accaagaatc aagtacaaaa
     6061 aattaaaaag gaactgtaaa atcccttggt cattcataaa taaatatcta aattaggaat
     6121 actaattaat tgaattttca ctcatgagta tgttctgaat atttaatatt tatttctatt
     6181 attttcatat gttaagatat tccattaaat ctaacttaaa agaattgtat gtataaattg
     6241 gcattaggat acaaatgtaa atgtttttaa tgaaattttg caacttttta atattttaac
     6301 atagttttct atttgtcttt atttcaagta ccagaattac aaaatatcta agtaatatat
     6361 ttttgttgtc gttttagggc ttaagggtta attcacccag agtatattaa tataataaaa
     6421 agatcactaa a
//
