LOCUS       NM_001271006             765 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens centromere protein X (CENPX), transcript variant 1,
            mRNA.
ACCESSION   NM_001271006
VERSION     NM_001271006.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 765)
  AUTHORS   Tian,T., Chen,L., Dou,Z., Yang,Z., Gao,X., Yuan,X., Wang,C.,
            Liu,R., Shen,Z., Gui,P., Teng,M., Meng,X., Hill,D.L., Li,L.,
            Zhang,X., Liu,X., Sun,L., Zang,J. and Yao,X.
  TITLE     Structural insights into human CCAN complex assembled onto DNA
  JOURNAL   Cell Discov 8 (1), 90 (2022)
   PUBMED   36085283
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 765)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 765)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 765)
  AUTHORS   Girard,C., Crismani,W., Froger,N., Mazel,J., Lemhemdi,A., Horlow,C.
            and Mercier,R.
  TITLE     FANCM-associated proteins MHF1 and MHF2, but not the other Fanconi
            anemia factors, limit meiotic crossovers
  JOURNAL   Nucleic Acids Res 42 (14), 9087-9095 (2014)
   PUBMED   25038251
REFERENCE   5  (bases 1 to 765)
  AUTHORS   Fox,D. 3rd, Yan,Z., Ling,C., Zhao,Y., Lee,D.Y., Fukagawa,T.,
            Yang,W. and Wang,W.
  TITLE     The histone-fold complex MHF is remodeled by FANCM to recognize
            branched DNA and protect genome stability
  JOURNAL   Cell Res 24 (5), 560-575 (2014)
   PUBMED   24699063
  REMARK    GeneRIF: The MHF complex, which is a heterotetramer that comprises
            two MHF1-MHF2 heterodimers, is remodeled by FANCM to favor
            recognition of branched DNA over dsDNA.
REFERENCE   6  (bases 1 to 765)
  AUTHORS   Singh,T.R., Saro,D., Ali,A.M., Zheng,X.F., Du,C.H., Killen,M.W.,
            Sachpatzidis,A., Wahengbam,K., Pierce,A.J., Xiong,Y., Sung,P. and
            Meetei,A.R.
  TITLE     MHF1-MHF2, a histone-fold-containing protein complex, participates
            in the Fanconi anemia pathway via FANCM
  JOURNAL   Mol Cell 37 (6), 879-886 (2010)
   PUBMED   20347429
  REMARK    GeneRIF: provide biochemical evidence that MHF1 and MHF2 assemble
            into a heterodimer that binds DNA and enhances the DNA branch
            migration activity of FANCM.
REFERENCE   7  (bases 1 to 765)
  AUTHORS   Yan,Z., Delannoy,M., Ling,C., Daee,D., Osman,F., Muniandy,P.A.,
            Shen,X., Oostra,A.B., Du,H., Steltenpool,J., Lin,T., Schuster,B.,
            Decaillet,C., Stasiak,A., Stasiak,A.Z., Stone,S., Hoatlin,M.E.,
            Schindler,D., Woodcock,C.L., Joenje,H., Sen,R., de Winter,J.P.,
            Li,L., Seidman,M.M., Whitby,M.C., Myung,K., Constantinou,A. and
            Wang,W.
  TITLE     A histone-fold complex and FANCM form a conserved DNA-remodeling
            complex to maintain genome stability
  JOURNAL   Mol Cell 37 (6), 865-878 (2010)
   PUBMED   20347428
REFERENCE   8  (bases 1 to 765)
  AUTHORS   Amano,M., Suzuki,A., Hori,T., Backer,C., Okawa,K., Cheeseman,I.M.
            and Fukagawa,T.
  TITLE     The CENP-S complex is essential for the stable assembly of outer
            kinetochore structure
  JOURNAL   J Cell Biol 186 (2), 173-182 (2009)
   PUBMED   19620631
  REMARK    GeneRIF: Results identified a centromere protein S
            (CENP-S)-containing subcomplex that includes the new constitutive
            kinetochore protein CENP-X [Stra13]
REFERENCE   9  (bases 1 to 765)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   10 (bases 1 to 765)
  AUTHORS   Scott,L.M., Mueller,L. and Collins,S.J.
  TITLE     E3, a hematopoietic-specific transcript directly regulated by the
            retinoic acid receptor alpha
  JOURNAL   Blood 88 (7), 2517-2530 (1996)
   PUBMED   8839844
  REMARK    GeneRIF: Identification of human and mouse homologs of clone D9 of
            a murine promyelocyte cell line that was upregulated by retinoic
            acid.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY110543.1 and BQ648002.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001271006.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.16776.1,
                                           SRR5189661.175772.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154405 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392359.8/ ENSP00000376168.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-499               HY110543.1         22-520
            500-765             BQ648002.1         166-431
FEATURES             Location/Qualifiers
     source          1..765
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..765
                     /gene="CENPX"
                     /gene_synonym="CENP-X; D9; FAAP10; MHF2; STRA13"
                     /note="centromere protein X"
                     /db_xref="GeneID:201254"
                     /db_xref="HGNC:HGNC:11422"
                     /db_xref="MIM:615128"
     exon            1..53
                     /gene="CENPX"
                     /gene_synonym="CENP-X; D9; FAAP10; MHF2; STRA13"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..263
                     /gene="CENPX"
                     /gene_synonym="CENP-X; D9; FAAP10; MHF2; STRA13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     FANCM-interacting histone fold protein 2; Fanconi
                     anemia-associated polypeptide of 10 kDa; stimulated by
                     retinoic acid 13 homolog; retinoic acid-inducible gene D9
                     protein homolog; stimulated by retinoic acid gene 13
                     protein homolog; FANCM associated histone fold protein 2"
                     /codon_start=1
                     /product="centromere protein X isoform 1"
                     /protein_id="NP_001257935.1"
                     /db_xref="CCDS:CCDS59303.1"
                     /db_xref="GeneID:201254"
                     /db_xref="HGNC:HGNC:11422"
                     /db_xref="MIM:615128"
                     /translation="MEGAGAGSGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKV
                     FVVEAAVRGVRQAQAEDALRVDVDQLEKVLPQLLLDF"
     exon            54..105
                     /gene="CENPX"
                     /gene_synonym="CENP-X; D9; FAAP10; MHF2; STRA13"
                     /inference="alignment:Splign:2.1.0"
     exon            106..159
                     /gene="CENPX"
                     /gene_synonym="CENP-X; D9; FAAP10; MHF2; STRA13"
                     /inference="alignment:Splign:2.1.0"
     exon            160..248
                     /gene="CENPX"
                     /gene_synonym="CENP-X; D9; FAAP10; MHF2; STRA13"
                     /inference="alignment:Splign:2.1.0"
     exon            249..765
                     /gene="CENPX"
                     /gene_synonym="CENP-X; D9; FAAP10; MHF2; STRA13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      742..747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPX"
                     /gene_synonym="CENP-X; D9; FAAP10; MHF2; STRA13"
                     /note="hexamer: AATAAA"
     polyA_site      765
                     /gene="CENPX"
                     /gene_synonym="CENP-X; D9; FAAP10; MHF2; STRA13"
                     /note="major polyA site"
ORIGIN      
        1 gcgttgaggc tgcggtcatg gagggagcag gagctggatc cggcttccgg aaggagctgg
       61 tgagcaggct gctgcacctg cacttcaagg atgacaagac caaagtgagc ggggacgcgc
      121 tgcagctcat ggtggagttg ctgaaggtct tcgttgtgga agcagcagtc cgcggcgtgc
      181 ggcaggccca ggcagaagac gcgctccgtg tggacgtgga ccagctggag aaggtgcttc
      241 cgcagctgct cctggacttc tagggatctc agccgtggct gaggccaccc ccagaggagc
      301 ccctggtcca cagaagcagg ccttgtgttt ccagcggcct ctgataagag gcagggaagg
      361 acctgaagga tttggagttg attcaaacaa gatctctggg agtctccagc ctgtgcagaa
      421 ggggcaggac tgcagtgcac tgcgggcctt ggagtgtcca gtggggacac tggtgtggga
      481 aggggcagca cctggggagt ccctgcctct cctccctggg acaatagtgt gcatgccacc
      541 cggggtccta caggcaggtg ctgggaaagg cctggccagc aggtagcctg tgtgtttgac
      601 aaacagcagc tggcagcgct gcctcctgcc cacattcctg ccacccgaca tcaaagctgg
      661 cgtgtgacct ttccagccat gcgatattcc ccttggaaga tgcttcccca ggctataaat
      721 ttgttctcac aaagcaacat caataaatca aaactgtctc tccca
//
