LOCUS       NM_001012507             809 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens centromere protein W (CENPW), transcript variant 2,
            mRNA.
ACCESSION   NM_001012507
VERSION     NM_001012507.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 809)
  AUTHORS   Tian,T., Chen,L., Dou,Z., Yang,Z., Gao,X., Yuan,X., Wang,C.,
            Liu,R., Shen,Z., Gui,P., Teng,M., Meng,X., Hill,D.L., Li,L.,
            Zhang,X., Liu,X., Sun,L., Zang,J. and Yao,X.
  TITLE     Structural insights into human CCAN complex assembled onto DNA
  JOURNAL   Cell Discov 8 (1), 90 (2022)
   PUBMED   36085283
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 809)
  AUTHORS   Yawut,N., Kaowinn,S., Cho,I.R., Budluang,P., Kim,S., Kim,S.,
            Youn,S.E., Koh,S.S. and Chung,Y.H.
  TITLE     Translocalization of enhanced PKM2 protein into the nucleus induced
            by cancer upregulated gene 2 confers cancer stem cell-like
            phenotypes
  JOURNAL   BMB Rep 55 (2), 98-103 (2022)
   PUBMED   35000669
  REMARK    GeneRIF: Translocalization of enhanced PKM2 protein into the
            nucleus induced by cancer upregulated gene 2 confers cancer stem
            cell-like phenotypes.
REFERENCE   3  (bases 1 to 809)
  AUTHORS   Aygun,N., Elwell,A.L., Liang,D., Lafferty,M.J., Cheek,K.E.,
            Courtney,K.P., Mory,J., Hadden-Ford,E., Krupa,O., de la
            Torre-Ubieta,L., Geschwind,D.H., Love,M.I. and Stein,J.L.
  TITLE     Brain-trait-associated variants impact cell-type-specific gene
            regulation during neurogenesis
  JOURNAL   Am J Hum Genet 108 (9), 1647-1668 (2021)
   PUBMED   34416157
  REMARK    GeneRIF: Brain-trait-associated variants impact cell-type-specific
            gene regulation during neurogenesis.
REFERENCE   4  (bases 1 to 809)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 809)
  AUTHORS   Zhou,Y., Chai,H., Guo,L., Dai,Z., Lai,J., Duan,J., Liu,Y. and
            Ding,Q.
  TITLE     Knockdown of CENPW Inhibits Hepatocellular Carcinoma Progression by
            Inactivating E2F Signaling
  JOURNAL   Technol Cancer Res Treat 20, 15330338211007253 (2021)
   PUBMED   33973496
  REMARK    GeneRIF: Knockdown of CENPW Inhibits Hepatocellular Carcinoma
            Progression by Inactivating E2F Signaling.
REFERENCE   6  (bases 1 to 809)
  AUTHORS   Park,E.H., Park,E.H., Cho,I.R., Srisuttee,R., Min,H.J., Oh,M.J.,
            Jeong,Y.J., Jhun,B.H., Johnston,R.N., Lee,S., Koh,S.S. and
            Chung,Y.H.
  TITLE     CUG2, a novel oncogene confers reoviral replication through Ras and
            p38 signaling pathway
  JOURNAL   Cancer Gene Ther 17 (5), 307-314 (2010)
   PUBMED   20075984
  REMARK    GeneRIF: data indicate that activation of p38 MAPK and Ras has
            critical roles in reoviral replication in CUG2-expressing tumor
            cells.
REFERENCE   7  (bases 1 to 809)
  AUTHORS   Kim,H., Lee,M., Lee,S., Park,B., Koh,W., Lee,D.J., Lim,D.S. and
            Lee,S.
  TITLE     Cancer-upregulated gene 2 (CUG2), a new component of centromere
            complex, is required for kinetochore function
  JOURNAL   Mol Cells 27 (6), 697-701 (2009)
   PUBMED   19533040
  REMARK    GeneRIF: CUG2 is a new component of the human centromeric complex
            that is required for proper chromosome segregation during mitosis.
REFERENCE   8  (bases 1 to 809)
  AUTHORS   Barrett,J.C., Clayton,D.G., Concannon,P., Akolkar,B., Cooper,J.D.,
            Erlich,H.A., Julier,C., Morahan,G., Nerup,J., Nierras,C.,
            Plagnol,V., Pociot,F., Schuilenburg,H., Smyth,D.J., Stevens,H.,
            Todd,J.A., Walker,N.M. and Rich,S.S.
  CONSRTM   Type 1 Diabetes Genetics Consortium
  TITLE     Genome-wide association study and meta-analysis find that over 40
            loci affect risk of type 1 diabetes
  JOURNAL   Nat Genet 41 (6), 703-707 (2009)
   PUBMED   19430480
REFERENCE   9  (bases 1 to 809)
  AUTHORS   Hori,T., Amano,M., Suzuki,A., Backer,C.B., Welburn,J.P., Dong,Y.,
            McEwen,B.F., Shang,W.H., Suzuki,E., Okawa,K., Cheeseman,I.M. and
            Fukagawa,T.
  TITLE     CCAN makes multiple contacts with centromeric DNA to provide
            distinct pathways to the outer kinetochore
  JOURNAL   Cell 135 (6), 1039-1052 (2008)
   PUBMED   19070575
  REMARK    GeneRIF: Study demonstrates that CENP-W forms a DNA-binding complex
            together with the CCAN component CENP-T; this complex directly
            associates with nucleosomal DNA and with canonical histone H3, but
            not with CENP-A, in centromeric regions.
REFERENCE   10 (bases 1 to 809)
  AUTHORS   Lee,S., Gang,J., Jeon,S.B., Choo,S.H., Lee,B., Kim,Y.G., Lee,Y.S.,
            Jung,J., Song,S.Y. and Koh,S.S.
  TITLE     Molecular cloning and functional analysis of a novel oncogene,
            cancer-upregulated gene 2 (CUG2)
  JOURNAL   Biochem Biophys Res Commun 360 (3), 633-639 (2007)
   PUBMED   17610844
  REMARK    GeneRIF: These findings suggest CUG2 is a novel tumor-associated
            gene that is commonly activated in various human cancers and
            exhibits high transforming activities; it possibly belongs to a
            transcription regulator family that is involved in tumor
            biogenesis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC039556.2, AC020559.4 and BM721156.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001012507.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1,
            resulting in an isoform (b) that is shorter than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM721156.1, SRR14038196.1053535.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368328.5/ ENSP00000357311.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-540               BC039556.2         9-548
            541-699             AC020559.4         174847-175005
            700-809             BM721156.1         644-753
FEATURES             Location/Qualifiers
     source          1..809
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.32"
     gene            1..809
                     /gene="CENPW"
                     /gene_synonym="C6orf173; CENP-W; CUG2"
                     /note="centromere protein W"
                     /db_xref="GeneID:387103"
                     /db_xref="HGNC:HGNC:21488"
                     /db_xref="MIM:611264"
     exon            1..285
                     /gene="CENPW"
                     /gene_synonym="C6orf173; CENP-W; CUG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..426
                     /gene="CENPW"
                     /gene_synonym="C6orf173; CENP-W; CUG2"
                     /note="isoform b is encoded by transcript variant 2;
                     cancer-upregulated gene 2; cancer-up-regulated gene 2
                     protein"
                     /codon_start=1
                     /product="centromere protein W isoform b"
                     /protein_id="NP_001012525.1"
                     /db_xref="CCDS:CCDS34529.1"
                     /db_xref="GeneID:387103"
                     /db_xref="HGNC:HGNC:21488"
                     /db_xref="MIM:611264"
                     /translation="MALSTIVSQRKQIKRKAPRGFLKRVFKRKKPQLRLEKSGDLLVH
                     LNCLLFVHRLAEESRTNACASKCRVINKEHVLAAAKVILKKSRG"
     exon            286..399
                     /gene="CENPW"
                     /gene_synonym="C6orf173; CENP-W; CUG2"
                     /inference="alignment:Splign:2.1.0"
     exon            400..809
                     /gene="CENPW"
                     /gene_synonym="C6orf173; CENP-W; CUG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      521..526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPW"
                     /gene_synonym="C6orf173; CENP-W; CUG2"
                     /note="hexamer: ATTAAA"
     polyA_site      542
                     /gene="CENPW"
                     /gene_synonym="C6orf173; CENP-W; CUG2"
                     /note="major polyA site"
     regulatory      717..722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPW"
                     /gene_synonym="C6orf173; CENP-W; CUG2"
                     /note="hexamer: ATTAAA"
     polyA_site      737
                     /gene="CENPW"
                     /gene_synonym="C6orf173; CENP-W; CUG2"
ORIGIN      
        1 gttccgttgg cggcggattc gaacgttcgg actgaggttt ttctgcctga agaagcgtca
       61 tacggaccgg attgttttcg ctggcccagt gtccccggag cttgtgtgcg atacagagag
      121 cacctcggaa gctgaggcag ctggtacttg acagagagga tggcgctgtc gaccatagtc
      181 tcccagagga agcagataaa gcggaaggct ccccgtggct ttctaaagcg agtcttcaag
      241 cgaaagaagc ctcaacttcg tctggagaaa agtggtgact tattggtcca tctgaactgt
      301 ttactgtttg ttcatcgatt agcagaagag tccaggacaa acgcttgtgc gagtaaatgt
      361 agagtcatta acaaggagca tgtactggcc gcagcaaagg taattctaaa gaagagcaga
      421 ggttagaagt caaagaacat attcttgaaa gttatgatgc attcttttgg gtggtaacag
      481 atcataaaga cattttttac acatcagtta atatgggatt attaaatatt ggctataagt
      541 gatgtgtgtg tttgtatttt ttttctggca tgaaatatct caagtaaatg cataggacta
      601 tttaaccctt ttatgggaat tactattatt tttattttaa atgtcctcta gttcagtttg
      661 cttttgtttt gttgctgctg caaatatttt atgtatcaaa aatgaaatct tactatatta
      721 aatactttga aaatgtactt cttagaatta agtttatata tatttagatt tagccacagt
      781 taactatgga atttaatctc tgaagaaag
//
