LOCUS       NM_181716               1132 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens centromere protein V (CENPV), mRNA.
ACCESSION   NM_181716
VERSION     NM_181716.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1132)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1132)
  AUTHORS   Ahmeti,K.B., Ajroud-Driss,S., Al-Chalabi,A., Andersen,P.M.,
            Armstrong,J., Birve,A., Blauw,H.M., Brown,R.H., Bruijn,L., Chen,W.,
            Chio,A., Comeau,M.C., Cronin,S., Diekstra,F.P., Soraya Gkazi,A.,
            Glass,J.D., Grab,J.D., Groen,E.J., Haines,J.L., Hardiman,O.,
            Heller,S., Huang,J., Hung,W.Y., Jaworski,J.M., Jones,A., Khan,H.,
            Landers,J.E., Langefeld,C.D., Leigh,P.N., Marion,M.C.,
            McLaughlin,R.L., Meininger,V., Melki,J., Miller,J.W., Mora,G.,
            Pericak-Vance,M.A., Rampersaud,E., Robberecht,W., Russell,L.P.,
            Salachas,F., Saris,C.G., Shatunov,A., Shaw,C.E., Siddique,N.,
            Siddique,T., Smith,B.N., Sufit,R., Topp,S., Traynor,B.J., Vance,C.,
            van Damme,P., van den Berg,L.H., van Es,M.A., van Vught,P.W.,
            Veldink,J.H., Yang,Y. and Zheng,J.G.
  CONSRTM   ITALSGEN consortium; ALSGEN Consortium
  TITLE     Age of onset of amyotrophic lateral sclerosis is modulated by a
            locus on 1p34.1
  JOURNAL   Neurobiol Aging 34 (1), 357 (2013)
   PUBMED   22959728
REFERENCE   3  (bases 1 to 1132)
  AUTHORS   Honda,Z., Suzuki,T. and Honda,H.
  TITLE     Identification of CENP-V as a novel microtubule-associating
            molecule that activates Src family kinases through SH3 domain
            interaction
  JOURNAL   Genes Cells 14 (12), 1383-1394 (2009)
   PUBMED   19930468
REFERENCE   4  (bases 1 to 1132)
  AUTHORS   Tadeu,A.M., Ribeiro,S., Johnston,J., Goldberg,I., Gerloff,D. and
            Earnshaw,W.C.
  TITLE     CENP-V is required for centromere organization, chromosome
            alignment and cytokinesis
  JOURNAL   EMBO J 27 (19), 2510-2522 (2008)
   PUBMED   18772885
  REMARK    GeneRIF: Results suggest that CENP-V (nuclear protein p30) is
            required for centromere organization, chromosome alignment and
            cytokinesis in human cells
REFERENCE   5  (bases 1 to 1132)
  AUTHORS   Cronshaw,J.M., Krutchinsky,A.N., Zhang,W., Chait,B.T. and
            Matunis,M.J.
  TITLE     Proteomic analysis of the mammalian nuclear pore complex
  JOURNAL   J Cell Biol 158 (5), 915-927 (2002)
   PUBMED   12196509
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ052702.1, AF514992.1 and BU618545.1.
            
            On Nov 22, 2018 this sequence version replaced NM_181716.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.49141.1, BC052604.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299736.5/ ENSP00000299736.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                BQ052702.1         30-64
            36-966              AF514992.1         1-931
            967-1132            BU618545.1         21-186              c
FEATURES             Location/Qualifiers
     source          1..1132
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..1132
                     /gene="CENPV"
                     /gene_synonym="3110013H01Rik; CENP-V; p30; PRR6"
                     /note="centromere protein V"
                     /db_xref="GeneID:201161"
                     /db_xref="HGNC:HGNC:29920"
                     /db_xref="MIM:608139"
     exon            1..443
                     /gene="CENPV"
                     /gene_synonym="3110013H01Rik; CENP-V; p30; PRR6"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..852
                     /gene="CENPV"
                     /gene_synonym="3110013H01Rik; CENP-V; p30; PRR6"
                     /note="proline rich 6; nuclear protein p30; proline-rich
                     protein 6"
                     /codon_start=1
                     /product="centromere protein V"
                     /protein_id="NP_859067.2"
                     /db_xref="CCDS:CCDS32575.1"
                     /db_xref="GeneID:201161"
                     /db_xref="HGNC:HGNC:29920"
                     /db_xref="MIM:608139"
                     /translation="MRRSRSSAAAKLRGQKRSGASAAPAASAAAALAPSATRTRRSAS
                     QAGSKSQAVEKPPSEKPRLRRSSPRAQEEGPGEPPPPELALLPPPPPPPPTPATPTSS
                     ASNLDLGEQRERWETFQKRQKLTSEGAAKLLLDTFEYQGLVKHTGGCHCGAVRFEVWA
                     SADLHIFDCNCSICKKKQNRHFIVPASRFKLLKGAEHITTYTFNTHKAQHTFCKRCGV
                     QSFYTPRSNPGGFGIAPHCLDEGTVRSMVTEEFNGSDWEKAMKEHKTIKNMSKE"
     exon            444..542
                     /gene="CENPV"
                     /gene_synonym="3110013H01Rik; CENP-V; p30; PRR6"
                     /inference="alignment:Splign:2.1.0"
     exon            543..612
                     /gene="CENPV"
                     /gene_synonym="3110013H01Rik; CENP-V; p30; PRR6"
                     /inference="alignment:Splign:2.1.0"
     exon            613..727
                     /gene="CENPV"
                     /gene_synonym="3110013H01Rik; CENP-V; p30; PRR6"
                     /inference="alignment:Splign:2.1.0"
     exon            728..1132
                     /gene="CENPV"
                     /gene_synonym="3110013H01Rik; CENP-V; p30; PRR6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1111..1116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPV"
                     /gene_synonym="3110013H01Rik; CENP-V; p30; PRR6"
                     /note="hexamer: AATAAA"
     polyA_site      1132
                     /gene="CENPV"
                     /gene_synonym="3110013H01Rik; CENP-V; p30; PRR6"
                     /note="major polyA site"
ORIGIN      
        1 gctgcgaggc ctgcgcgcca ggctgcggga gccatgcggc gatcgaggag ctctgcggcc
       61 gccaagctgc gcgggcagaa gcggtccggg gcctccgcgg cccccgcggc ctccgcggcc
      121 gctgccttgg cacccagcgc cacccgcaca cggcgctccg ctagccaggc cgggagcaag
      181 agccaggcgg tggagaagcc gccgtcggag aagccgcggc tgaggcgctc gtcgccgcgg
      241 gcccaggagg agggcccggg ggagccgccg ccgcctgagc tggcgttgct cccgccaccg
      301 ccgccgccgc cgccgactcc cgcgaccccg acgtcctcgg cgtccaacct ggacctgggc
      361 gagcagcggg agcgctggga gacgttccag aagcggcaga agcttacctc cgagggtgcc
      421 gccaagctcc tgctagacac ctttgaatac cagggcctgg tgaagcacac aggaggctgc
      481 cactgtggag cagttcgttt tgaagtttgg gcctcagcag acttgcatat atttgactgc
      541 aattgcagca tttgcaagaa gaagcagaat agacacttca ttgttccagc ttctcgcttc
      601 aagctcctga agggagctga gcacataacg acttacacgt tcaatactca caaagcccag
      661 cataccttct gtaagagatg tggcgttcag agcttctata ctccacgatc aaaccccgga
      721 ggcttcggaa ttgcccccca ctgcctggat gagggcactg tgcggagtat ggtcactgag
      781 gaattcaatg gcagcgattg ggagaaggcc atgaaagagc acaagaccat caagaacatg
      841 tctaaagagt gagcttctgc ctctcctgcc ctgaaaagga ggaatgattg gggccagcaa
      901 ctttgctctc cctgccgtgc ctcggtggtg ctcctgaatg tggctgacct gggctgctgg
      961 ttccgttgac tagggtcatc ttgatctctg cagtttgctc cagctaccag tttctttagg
     1021 cagctctttg tcctccctct gcccagattt tgatgtagtc taattgacat ccttctcttc
     1081 ccaacttttg tgtgatcttt taggaaaaaa aataaatatt tttaacatta aa
//
