LOCUS       NM_025082               2580 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens centromere protein T (CENPT), mRNA.
ACCESSION   NM_025082 XM_005256167
VERSION     NM_025082.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2580)
  AUTHORS   Tian,T., Chen,L., Dou,Z., Yang,Z., Gao,X., Yuan,X., Wang,C.,
            Liu,R., Shen,Z., Gui,P., Teng,M., Meng,X., Hill,D.L., Li,L.,
            Zhang,X., Liu,X., Sun,L., Zang,J. and Yao,X.
  TITLE     Structural insights into human CCAN complex assembled onto DNA
  JOURNAL   Cell Discov 8 (1), 90 (2022)
   PUBMED   36085283
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2580)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2580)
  AUTHORS   Ding,M., Jiang,J., Yang,F., Zheng,F., Fang,J., Wang,Q., Wang,J.,
            Yao,W., Liu,X., Gao,X., Mullen,M., He,P., Rono,C., Ding,X.,
            Hong,J., Fu,C., Liu,X. and Yao,X.
  TITLE     Holliday junction recognition protein interacts with and specifies
            the centromeric assembly of CENP-T
  JOURNAL   J Biol Chem 294 (3), 968-980 (2019)
   PUBMED   30459232
  REMARK    GeneRIF: these data define a novel molecular mechanism underlying
            the assembly of CENP-T onto the centromere by a temporally
            regulated HJURP-CENP-T interaction.
REFERENCE   4  (bases 1 to 2580)
  AUTHORS   Hung,C.Y., Volkmar,B., Baker,J.D., Bauer,J.W., Gussoni,E.,
            Hainzl,S., Klausegger,A., Lorenzo,J., Mihalek,I., Rittinger,O.,
            Tekin,M., Dallman,J.E. and Bodamer,O.A.
  TITLE     A defect in the inner kinetochore protein CENPT causes a new
            syndrome of severe growth failure
  JOURNAL   PLoS One 12 (12), e0189324 (2017)
   PUBMED   29228025
  REMARK    GeneRIF: report a novel disease gene encoding the constitutive
            inner kinetochore member CENPT, which is involved in kinetochore
            targeting and assembly, resulting in severe growth failure in two
            siblings of a consanguineous family
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2580)
  AUTHORS   Giunta,S. and Funabiki,H.
  TITLE     Integrity of the human centromere DNA repeats is protected by
            CENP-A, CENP-C, and CENP-T
  JOURNAL   Proc Natl Acad Sci U S A 114 (8), 1928-1933 (2017)
   PUBMED   28167779
  REMARK    GeneRIF: Levels of centromere aberrations increase upon depletion
            of CENP-A, CENP-C, and CENP-T/W, during replicative senescence, and
            in cancer cells.
REFERENCE   6  (bases 1 to 2580)
  AUTHORS   Izuta,H., Ikeno,M., Suzuki,N., Tomonaga,T., Nozaki,N., Obuse,C.,
            Kisu,Y., Goshima,N., Nomura,F., Nomura,N. and Yoda,K.
  TITLE     Comprehensive analysis of the ICEN (Interphase Centromere Complex)
            components enriched in the CENP-A chromatin of human cells
  JOURNAL   Genes Cells 11 (6), 673-684 (2006)
   PUBMED   16716197
REFERENCE   7  (bases 1 to 2580)
  AUTHORS   Okada,M., Cheeseman,I.M., Hori,T., Okawa,K., McLeod,I.X.,
            Yates,J.R. 3rd, Desai,A. and Fukagawa,T.
  TITLE     The CENP-H-I complex is required for the efficient incorporation of
            newly synthesized CENP-A into centromeres
  JOURNAL   Nat Cell Biol 8 (5), 446-457 (2006)
   PUBMED   16622420
REFERENCE   8  (bases 1 to 2580)
  AUTHORS   Foltz,D.R., Jansen,L.E., Black,B.E., Bailey,A.O., Yates,J.R. 3rd
            and Cleveland,D.W.
  TITLE     The human CENP-A centromeric nucleosome-associated complex
  JOURNAL   Nat Cell Biol 8 (5), 458-469 (2006)
   PUBMED   16622419
REFERENCE   9  (bases 1 to 2580)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   10 (bases 1 to 2580)
  AUTHORS   Obuse,C., Yang,H., Nozaki,N., Goto,S., Okazaki,T. and Yoda,K.
  TITLE     Proteomics analysis of the centromere complex from HeLa interphase
            cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of
            the CEN-complex, while BMI-1 is transiently co-localized with the
            centromeric region in interphase
  JOURNAL   Genes Cells 9 (2), 105-120 (2004)
   PUBMED   15009096
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC040162.5, AK056097.1, CD242240.1 and AK225399.1.
            
            On Nov 23, 2018 this sequence version replaced NM_025082.3.
            
            Summary: The centromere is a specialized chromatin domain, present
            throughout the cell cycle, that acts as a platform on which the
            transient assembly of the kinetochore occurs during mitosis. All
            active centromeres are characterized by the presence of long arrays
            of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see
            MIM 601128). CENPT is an additional factor required for centromere
            assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM,
            Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056097.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000562787.6/ ENSP00000457810.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               AC040162.5         168184-168418
            236-2273            AK056097.1         1-2038
            2274-2346           CD242240.1         130-202
            2347-2580           AK225399.1         1601-1834
FEATURES             Location/Qualifiers
     source          1..2580
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..2580
                     /gene="CENPT"
                     /gene_synonym="C16orf56; CENP-T; SSMGA"
                     /note="centromere protein T"
                     /db_xref="GeneID:80152"
                     /db_xref="HGNC:HGNC:25787"
                     /db_xref="MIM:611510"
     exon            1..293
                     /gene="CENPT"
                     /gene_synonym="C16orf56; CENP-T; SSMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            294..414
                     /gene="CENPT"
                     /gene_synonym="C16orf56; CENP-T; SSMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            415..543
                     /gene="CENPT"
                     /gene_synonym="C16orf56; CENP-T; SSMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            544..894
                     /gene="CENPT"
                     /gene_synonym="C16orf56; CENP-T; SSMGA"
                     /inference="alignment:Splign:2.1.0"
     CDS             785..2470
                     /gene="CENPT"
                     /gene_synonym="C16orf56; CENP-T; SSMGA"
                     /note="interphase centromere complex protein 22"
                     /codon_start=1
                     /product="centromere protein T"
                     /protein_id="NP_079358.3"
                     /db_xref="CCDS:CCDS42182.1"
                     /db_xref="GeneID:80152"
                     /db_xref="HGNC:HGNC:25787"
                     /db_xref="MIM:611510"
                     /translation="MADHNPDSDSTPRTLLRRVLDTADPRTPRRPRSARAGARRALLE
                     TASPRKLSGQTRTIARGRSHGARSVGRSAHIQASGHLEEQTPRTLLKNILLTAPESSI
                     LMPESVVKPVPAPQAVQPSRQESSCGSLELQLPELEPPTTLAPGLLAPGRRKQRLRLS
                     VFQQGVDQGLSLSQEPQGNADASSLTRSLNLTFATPLQPQSVQRPGLARRPPARRAVD
                     VGAFLRDLRDTSLAPPNIVLEDTQPFSQPMVGSPNVYHSLPCTPHTGAEDAEQAAGRK
                     TQSSGPGLQKNSPGKPAQFLAGEAEEVNAFALGFLSTSSGVSGEDEVEPLHDGVEEAE
                     KKMEEEGVSVSEMEATGAQGPSRVEEAEGHTEVTEAEGSQGTAEADGPGASSGDEDAS
                     GRAASPESASSTPESLQARRHHQFLEPAPAPGAAVLSSEPAEPLLVRHPPRPRTTGPR
                     PRQDPHKAGLSHYVKLFSFYAKMPMERKALEMVEKCLDKYFQHLCDDLEVFAAHAGRK
                     TVKPEDLELLMRRQGLVTDQVSLHVLVERHLPLEYRQLLIPCAYSGNSVFPAQ"
     exon            895..985
                     /gene="CENPT"
                     /gene_synonym="C16orf56; CENP-T; SSMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1073
                     /gene="CENPT"
                     /gene_synonym="C16orf56; CENP-T; SSMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1170
                     /gene="CENPT"
                     /gene_synonym="C16orf56; CENP-T; SSMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1307
                     /gene="CENPT"
                     /gene_synonym="C16orf56; CENP-T; SSMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1344
                     /gene="CENPT"
                     /gene_synonym="C16orf56; CENP-T; SSMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1487
                     /gene="CENPT"
                     /gene_synonym="C16orf56; CENP-T; SSMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1646
                     /gene="CENPT"
                     /gene_synonym="C16orf56; CENP-T; SSMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1970
                     /gene="CENPT"
                     /gene_synonym="C16orf56; CENP-T; SSMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2064
                     /gene="CENPT"
                     /gene_synonym="C16orf56; CENP-T; SSMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2241
                     /gene="CENPT"
                     /gene_synonym="C16orf56; CENP-T; SSMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2346
                     /gene="CENPT"
                     /gene_synonym="C16orf56; CENP-T; SSMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2580
                     /gene="CENPT"
                     /gene_synonym="C16orf56; CENP-T; SSMGA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2560..2565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPT"
                     /gene_synonym="C16orf56; CENP-T; SSMGA"
                     /note="hexamer: AATAAA"
     polyA_site      2580
                     /gene="CENPT"
                     /gene_synonym="C16orf56; CENP-T; SSMGA"
                     /note="major polyA site"
ORIGIN      
        1 agatcctcta agacaagaca gggataaagt ctcccgtgga atcccctccc gcctcatatt
       61 ccctgaccct gccctccctg cgagaactcc agtccgggct ccacaaaggg cgcggtaaga
      121 aacgtacact tccgaggggc agacaaggag ggggcgttca cctacacccc ggccgggcta
      181 tggtcgggaa cagggtgagg ggcccaagcc ccggctgcgg caggcgggcg cccttaccca
      241 tgctgactct ggagcgggcc gggtggcgct gcccatcccc ggatccttcg tagatggagt
      301 cttgcttagt cgcccaagct ggagtagtgt ggctcgatct cagctctgca acctctgcct
      361 cccagggttc aagcaattct cctgcctcag tttccagagt agctggaatt atagtgcaga
      421 ttctgggaaa gtgaactcca cggaagactc agaaaccaag ttctaattca gttgccatga
      481 aaacttaagg tgagaggatt gtcaaccagt gaaaaatacg gaggaaaaca ctaacagaat
      541 atgatgaaga agccaagact tgggctgctt gcattacatt aaccgaggtt tacccgcagc
      601 gaggctgcct ccaaagcatc cggagtttgc aaccatcact gtccaccccg cgagctgcga
      661 tagtgcgaga actacaattc ccgtggggct gtgcgggagc atcgcgagag ttacattaac
      721 tgtggcggcg ggaaggcgga gcctgcagct ggctgggcgg ttaggagggc ccggggccga
      781 gacgatggct gaccacaacc ctgacagcga ctccacgccg cgcacgctgc tgcgacgcgt
      841 gctggataca gcggacccgc gcaccccgcg gcgaccccgg agtgctcggg ctggagcccg
      901 gagagccctg cttgaaacgg cttcccccag gaagttgagt ggccaaacaa ggacgatagc
      961 cagagggcgt tcccatggag ccaggtctgt tggcagatcg gcccatattc aggccagtgg
     1021 gcacttggag gaacagacac ctcggacgct gctgaagaac atcctactaa ctgccccaga
     1081 atcttccatc ctgatgcctg agtcggtagt gaagccagtg ccagcaccgc aggcggtcca
     1141 accctccaga caagagagca gttgcggcag cctggagctg caacttcctg agctcgagcc
     1201 ccccacaacc ctggctccag gtctgctggc ccctggcagg aggaaacaga ggctgagact
     1261 gtcagtgttt cagcagggag tggaccaggg gctgtctctc tcccaagagc ctcaagggaa
     1321 tgctgatgcc tcttccctca ccagatccct caacctgacc tttgccacac ctcttcagcc
     1381 acagtcagtg cagaggcctg gcttggcccg cagacctcca gcccgccgag ctgtagacgt
     1441 gggtgccttt ttgcgggatc tgcgagatac ttccctggct cctccaaaca ttgtgttgga
     1501 ggacacccag ccgttctctc agcccatggt tggctccccc aacgtgtatc actccctgcc
     1561 ctgcacgcct cacactgggg ctgaagacgc tgagcaggct gccggtcgca agacacagag
     1621 cagtgggcct gggctgcaga agaatagccc tgggaaacca gcccagtttc tggcaggaga
     1681 ggcagaggag gtcaatgcct ttgctctggg cttcctgagc accagcagtg gtgtctctgg
     1741 agaagatgaa gtagagccct tacacgatgg agttgaagag gcagagaaaa agatggaaga
     1801 agaaggtgtg agtgtgagtg aaatggaggc aacaggagca caaggaccca gcagggtaga
     1861 agaggctgag ggacacacag aggtgacaga agcagaggga tcccagggga ctgctgaggc
     1921 tgacgggcca ggagcatctt caggggatga ggatgcctct ggcagggcag caagtccaga
     1981 gtcggcctcc agcacccctg agtctctcca ggccaggcga catcatcagt ttcttgagcc
     2041 agccccagcg cctggtgctg cagtcttatc ttcagagcct gcagagcctc tgttggtcag
     2101 gcatccccct aggccccgga ccaccggccc caggccccgg caagatcccc acaaggctgg
     2161 actgagccac tatgtgaaac tctttagctt ctatgccaag atgcccatgg agaggaaggc
     2221 tcttgagatg gtggagaagt gcctagataa atatttccag catctttgtg atgatctgga
     2281 ggtatttgct gctcatgctg gccgcaagac tgtgaagcca gaggacctgg agctgctgat
     2341 gcggcggcag ggcctggtca ctgaccaagt ctcactgcac gtgctagtgg agcggcacct
     2401 gcccctggag taccggcagc tgctcatccc ctgtgcatac agtggcaact ctgtcttccc
     2461 tgcccagtag tggccaggct tcaacacttt ccctgtcccc acctggggac tcttgccccc
     2521 acatatttct ccaggtctcc tccccacccc cccagcatca ataaagtgtc ataaacagaa
//
