LOCUS       NM_198544               1138 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens CENPS-CORT readthrough (CENPS-CORT), transcript
            variant 1, mRNA.
ACCESSION   NM_198544
VERSION     NM_198544.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1138)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1138)
  AUTHORS   Krona,C., Ejeskar,K., Caren,H., Abel,F., Sjoberg,R.M. and
            Martinsson,T.
  TITLE     A novel 1p36.2 located gene, APITD1, with tumour-suppressive
            properties and a putative p53-binding domain, shows low expression
            in neuroblastoma tumours
  JOURNAL   Br J Cancer 91 (6), 1119-1130 (2004)
   PUBMED   15328517
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF521016.1 and AL354956.13.
            
            On Jun 2, 2019 this sequence version replaced NM_198544.3.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring APITD1 (apoptosis-inducing,
            TAF9-like domain 1) and CORT (cortistatin) genes. Alternative
            splicing results in multiple transcript variants, two of which
            encode fusion proteins that share sequence identity with the
            products of each individual gene. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1), which shares sequence identity with the products of both the
            APITD1 and CORT genes.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.7233.1, AF521016.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 1325, 378708
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-973               AF521016.1         332-1304
            974-984             AL354956.13        12297-12307
            985-988             AF521016.1         1316-1319
            989-1138            AL354956.13        12312-12461
FEATURES             Location/Qualifiers
     source          1..1138
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..1138
                     /gene="CENPS-CORT"
                     /gene_synonym="APITD1; APITD1-CORT; CENP-S; CENPS; FAAP16;
                     MHF1"
                     /note="CENPS-CORT readthrough"
                     /db_xref="GeneID:100526739"
                     /db_xref="HGNC:HGNC:38843"
     exon            1..136
                     /gene="CENPS-CORT"
                     /gene_synonym="APITD1; APITD1-CORT; CENP-S; CENPS; FAAP16;
                     MHF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..580
                     /gene="CENPS-CORT"
                     /gene_synonym="APITD1; APITD1-CORT; CENP-S; CENPS; FAAP16;
                     MHF1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     APITD1-CORT readthrough; Centromere protein S;
                     Apoptosis-inducing TAF9-like domain-containing protein 1;
                     FANCM-associated histone fold protein 1; FANCM-interacting
                     histone fold protein 1; Fanconi anemia-associated
                     polypeptide of 16 kDa"
                     /codon_start=1
                     /product="APITD1-CORT protein isoform 1"
                     /protein_id="NP_940946.1"
                     /db_xref="GeneID:100526739"
                     /db_xref="HGNC:HGNC:38843"
                     /translation="MEEEAETEEQQRFSYQQRLKAAVHYTVGCLCEEVALDKEMQFSK
                     QTIAAISELTFRQCENFAKDLEMFARHAKRTTINTEDVKLLARRSNSLHMQEAAGIRK
                     SSLLTFLAWWFEWTSQASAGPLIGEEAREVARRQEGAPPQQSARRDRMPCRNFFWKTF
                     SSCK"
     exon            137..260
                     /gene="CENPS-CORT"
                     /gene_synonym="APITD1; APITD1-CORT; CENP-S; CENPS; FAAP16;
                     MHF1"
                     /inference="alignment:Splign:2.1.0"
     exon            261..294
                     /gene="CENPS-CORT"
                     /gene_synonym="APITD1; APITD1-CORT; CENP-S; CENPS; FAAP16;
                     MHF1"
                     /inference="alignment:Splign:2.1.0"
     exon            295..361
                     /gene="CENPS-CORT"
                     /gene_synonym="APITD1; APITD1-CORT; CENP-S; CENPS; FAAP16;
                     MHF1"
                     /inference="alignment:Splign:2.1.0"
     exon            362..1138
                     /gene="CENPS-CORT"
                     /gene_synonym="APITD1; APITD1-CORT; CENP-S; CENPS; FAAP16;
                     MHF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      624..629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPS-CORT"
                     /gene_synonym="APITD1; APITD1-CORT; CENP-S; CENPS; FAAP16;
                     MHF1"
                     /note="hexamer: AATAAA"
     polyA_site      644
                     /gene="CENPS-CORT"
                     /gene_synonym="APITD1; APITD1-CORT; CENP-S; CENPS; FAAP16;
                     MHF1"
                     /note="major polyA site"
     regulatory      863..868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPS-CORT"
                     /gene_synonym="APITD1; APITD1-CORT; CENP-S; CENPS; FAAP16;
                     MHF1"
                     /note="hexamer: AATAAA"
     polyA_site      887
                     /gene="CENPS-CORT"
                     /gene_synonym="APITD1; APITD1-CORT; CENP-S; CENPS; FAAP16;
                     MHF1"
     regulatory      965..970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPS-CORT"
                     /gene_synonym="APITD1; APITD1-CORT; CENP-S; CENPS; FAAP16;
                     MHF1"
                     /note="hexamer: ATTAAA"
     polyA_site      983
                     /gene="CENPS-CORT"
                     /gene_synonym="APITD1; APITD1-CORT; CENP-S; CENPS; FAAP16;
                     MHF1"
     regulatory      1047..1052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPS-CORT"
                     /gene_synonym="APITD1; APITD1-CORT; CENP-S; CENPS; FAAP16;
                     MHF1"
                     /note="hexamer: ATTAAA"
     polyA_site      1080
                     /gene="CENPS-CORT"
                     /gene_synonym="APITD1; APITD1-CORT; CENP-S; CENPS; FAAP16;
                     MHF1"
ORIGIN      
        1 gcgccgcggc gggaaaatcc gacctggccg cgcaccaccg ccccttctcg gccctcctgc
       61 gtttgcccag ggtcggcccg cagtgatgga ggaggaggcg gagaccgagg agcagcagcg
      121 attctcttac caacagaggc taaaggcagc agttcactat actgtgggtt gtctttgcga
      181 ggaagttgca ttggacaaag agatgcagtt cagcaaacag accattgcgg ccatttcgga
      241 gctgactttc cgacagtgtg aaaattttgc caaagacctt gaaatgtttg caagacatgc
      301 gaaaagaacc acaattaaca ctgaagatgt gaagctctta gccaggagga gtaattcact
      361 gcatatgcag gaagcggcag gaataaggaa aagcagcctc ctgactttcc tcgcttggtg
      421 gtttgagtgg acctcccagg ccagtgccgg gcccctcata ggagaggaag cccgggaggt
      481 ggccaggcgg caggaaggcg caccccccca gcaatctgcg cgccgggaca gaatgccctg
      541 caggaacttc ttctggaaga ccttctcctc ctgcaaataa aacctcaccc atgaatgctc
      601 acgcaagtgt aatgacagac ctgaataaaa tgtattaagc agcagtgatc tttcctctcc
      661 tccttcccaa gtcatttgaa aagtgtttgt tatttaaatt ccaataatgc ccaatactga
      721 cgtgtcttga gtaatttgga acccaaagtg aagatctttg ataaagattt ttttgtggtt
      781 cgactggact gtgctgagtg cgggcactgg gcttttcttc tgatgttcat tatggtgctg
      841 ggaagctctg tctttgattt aaaataaaat agctaaaggc tacacaatta agagttcaga
      901 ataacatctt atttcagttt atgaattgat atgaattgtc taatttaaaa aatatttccc
      961 tcacattaaa agcaaatttt taatatcagg ctcgaagagc aaaatgatta ttcctcatgt
     1021 tttagctgaa attaatttta aaacatatta aacagaaaac ctgctgacat gcctgtgaaa
     1081 ctgatactcg aacttgctgt tatgtaccag ttttaattag tagcttaatg ggttgcaa
//
