LOCUS       NM_018132               1741 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens centromere protein Q (CENPQ), mRNA.
ACCESSION   NM_018132
VERSION     NM_018132.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1741)
  AUTHORS   Tian,T., Chen,L., Dou,Z., Yang,Z., Gao,X., Yuan,X., Wang,C.,
            Liu,R., Shen,Z., Gui,P., Teng,M., Meng,X., Hill,D.L., Li,L.,
            Zhang,X., Liu,X., Sun,L., Zang,J. and Yao,X.
  TITLE     Structural insights into human CCAN complex assembled onto DNA
  JOURNAL   Cell Discov 8 (1), 90 (2022)
   PUBMED   36085283
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1741)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1741)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1741)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   5  (bases 1 to 1741)
  AUTHORS   Park,C.H., Park,J.E., Kim,T.S., Kang,Y.H., Soung,N.K., Zhou,M.,
            Kim,N.H., Bang,J.K. and Lee,K.S.
  TITLE     Mammalian Polo-like kinase 1 (Plk1) promotes proper chromosome
            segregation by phosphorylating and delocalizing the PBIP1.CENP-Q
            complex from kinetochores
  JOURNAL   J Biol Chem 290 (13), 8569-8581 (2015)
   PUBMED   25670858
  REMARK    GeneRIF: Plk1 regulates the timing of the delocalization and
            ultimate destruction of the PBIP1.CENP-Q complex.
REFERENCE   6  (bases 1 to 1741)
  AUTHORS   Eskat,A., Deng,W., Hofmeister,A., Rudolphi,S., Emmerth,S.,
            Hellwig,D., Ulbricht,T., Doring,V., Bancroft,J.M., McAinsh,A.D.,
            Cardoso,M.C., Meraldi,P., Hoischen,C., Leonhardt,H. and Diekmann,S.
  TITLE     Step-wise assembly, maturation and dynamic behavior of the human
            CENP-P/O/R/Q/U kinetochore sub-complex
  JOURNAL   PLoS One 7 (9), e44717 (2012)
   PUBMED   23028590
  REMARK    GeneRIF: Data propose that CENP-P/O/R/Q/U self-assembles on
            kinetochores with varying stoichiometry and undergoes a pre-mitotic
            maturation step that could be important for kinetochores switching
            into the correct conformation for microtubule-attachment.
REFERENCE   7  (bases 1 to 1741)
  AUTHORS   Kang,Y.H., Park,C.H., Kim,T.S., Soung,N.K., Bang,J.K., Kim,B.Y.,
            Park,J.E. and Lee,K.S.
  TITLE     Mammalian polo-like kinase 1-dependent regulation of the
            PBIP1-CENP-Q complex at kinetochores
  JOURNAL   J Biol Chem 286 (22), 19744-19757 (2011)
   PUBMED   21454580
  REMARK    GeneRIF: Mammalian polo-like kinase 1-dependent regulation of the
            PBIP1-CENP-Q complex at kinetochores.
REFERENCE   8  (bases 1 to 1741)
  AUTHORS   Okada,M., Cheeseman,I.M., Hori,T., Okawa,K., McLeod,I.X.,
            Yates,J.R. 3rd, Desai,A. and Fukagawa,T.
  TITLE     The CENP-H-I complex is required for the efficient incorporation of
            newly synthesized CENP-A into centromeres
  JOURNAL   Nat Cell Biol 8 (5), 446-457 (2006)
   PUBMED   16622420
REFERENCE   9  (bases 1 to 1741)
  AUTHORS   Foltz,D.R., Jansen,L.E., Black,B.E., Bailey,A.O., Yates,J.R. 3rd
            and Cleveland,D.W.
  TITLE     The human CENP-A centromeric nucleosome-associated complex
  JOURNAL   Nat Cell Biol 8 (5), 458-469 (2006)
   PUBMED   16622419
REFERENCE   10 (bases 1 to 1741)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590668.5 and AL590244.5.
            
            On Nov 23, 2018 this sequence version replaced NM_018132.3.
            
            Summary: CENPQ is a subunit of a CENPH (MIM 605607)-CENPI (MIM
            300065)-associated centromeric complex that targets CENPA (MIM
            117139) to centromeres and is required for proper kinetochore
            function and mitotic progression (Okada et al., 2006 [PubMed
            16622420]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.77771.1,
                                           SRR3476690.1009017.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335783.4/ ENSP00000337289.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AL590668.5         53041-53124
            85-204              AL590668.5         59830-59949
            205-259             AL590668.5         60645-60699
            260-380             AL590668.5         61734-61854
            381-449             AL590668.5         62461-62529
            450-579             AL590244.5         3312-3441
            580-699             AL590244.5         10713-10832
            700-777             AL590244.5         10968-11045
            778-1741            AL590244.5         14505-15468
FEATURES             Location/Qualifiers
     source          1..1741
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.3"
     gene            1..1741
                     /gene="CENPQ"
                     /gene_synonym="C6orf139; CENP-Q"
                     /note="centromere protein Q"
                     /db_xref="GeneID:55166"
                     /db_xref="HGNC:HGNC:21347"
                     /db_xref="MIM:611506"
     exon            1..84
                     /gene="CENPQ"
                     /gene_synonym="C6orf139; CENP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            85..204
                     /gene="CENPQ"
                     /gene_synonym="C6orf139; CENP-Q"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..909
                     /gene="CENPQ"
                     /gene_synonym="C6orf139; CENP-Q"
                     /codon_start=1
                     /product="centromere protein Q"
                     /protein_id="NP_060602.2"
                     /db_xref="CCDS:CCDS4925.1"
                     /db_xref="GeneID:55166"
                     /db_xref="HGNC:HGNC:21347"
                     /db_xref="MIM:611506"
                     /translation="MSGKANASKKNAQQLKRNPKRKKDNEEVVLSENKVRNTVKKNKN
                     HLKDLSSEGQTKHTNLKHGKTAASKRKTWQPLSKSTRDHLQTMMESVIMTILSNSIKE
                     KEEIQYHLNFLKKRLLQQCETLKVPPKKMEDLTNVSSLLNMERARDKANEEGLALLQE
                     EIDKMVETTELMTGNIQSLKNKIQILASEVEEEEERVKQMHQINSSGVLSLPELSQKT
                     LKAPTLQKEILALIPNQNALLKDLDILHNSSQMKSMSTFIEEAYKKLDAS"
     exon            205..259
                     /gene="CENPQ"
                     /gene_synonym="C6orf139; CENP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            260..380
                     /gene="CENPQ"
                     /gene_synonym="C6orf139; CENP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            381..449
                     /gene="CENPQ"
                     /gene_synonym="C6orf139; CENP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            450..579
                     /gene="CENPQ"
                     /gene_synonym="C6orf139; CENP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            580..699
                     /gene="CENPQ"
                     /gene_synonym="C6orf139; CENP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            700..777
                     /gene="CENPQ"
                     /gene_synonym="C6orf139; CENP-Q"
                     /inference="alignment:Splign:2.1.0"
     exon            778..1741
                     /gene="CENPQ"
                     /gene_synonym="C6orf139; CENP-Q"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1648..1653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPQ"
                     /gene_synonym="C6orf139; CENP-Q"
                     /note="hexamer: TATAAA"
     polyA_site      1675
                     /gene="CENPQ"
                     /gene_synonym="C6orf139; CENP-Q"
                     /note="major polyA site"
     regulatory      1717..1722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPQ"
                     /gene_synonym="C6orf139; CENP-Q"
                     /note="hexamer: AATAAA"
     polyA_site      1741
                     /gene="CENPQ"
                     /gene_synonym="C6orf139; CENP-Q"
                     /note="major polyA site"
ORIGIN      
        1 acttccgggt ctcctctgtt tacgaatgtt tgggcgcgaa ttactctaag cgcggctctc
       61 agaagggtgc aagaagaatc agtgcactgt gtttagatca agatgtctgg taaagcaaat
      121 gcttccaaga aaaacgctca acagttaaaa agaaatccaa agagaaaaaa ggataatgag
      181 gaagttgtgt tgtcagagaa taaggttaga aacacagtga aaaaaaataa aaatcatctg
      241 aaagatctgt cttctgaagg acaaacaaag cacactaacc taaaacacgg aaagacagca
      301 gccagcaaga gaaaaacctg gcaacctctg tcaaagagta ccagagacca tttgcaaact
      361 atgatggaat cagtaataat gacaattttg agtaacagta ttaaagaaaa agaagaaata
      421 caataccatc tcaacttcct gaagaaaaga ttgctacaac agtgtgaaac tctgaaagtc
      481 cctcccaaaa agatggaaga tttaactaat gtatcaagtc tactgaatat ggaaagggca
      541 cgagacaaag ctaatgaaga aggtctggca ttactacagg aagaaataga taaaatggta
      601 gagaccacag agttaatgac tgggaatatt cagagcctaa agaacaaaat tcagattctg
      661 gcaagtgagg tggaagaaga agaggagaga gtaaaacaga tgcatcaaat aaatagtagt
      721 ggagtactct ctcttccgga actttctcag aaaactctca aagcacccac acttcagaaa
      781 gaaattttgg cgctaattcc aaaccagaat gctcttctaa aggacttgga tattcttcat
      841 aattcatcac agatgaagag catgtcaacc ttcattgaag aagcctataa gaaactggat
      901 gcatcttaaa gagtgttttt tttttagatt gttccatatt aatttaatgt tcgtgaattt
      961 gtaaaactgt taacctatga ttatatgtac agaggctaag gcttctgcag gatttattat
     1021 ctcctgatat gcactttaaa attagtcttt gtagttctat cattagcatc taatgtagtt
     1081 ctgaagactg tttttagcag ttgccaaatc taggaaacta acatttatat tgctgtatct
     1141 ataagtattt gcctaaaacc ataaaatagg aattgcctta aggatctagt agtttataat
     1201 gcctgaatgg aactcattta ttggttaaca gctcatatca ggagctgtga taagtaagtg
     1261 tttacataca ctgtctagtg cataaaaacc ttagtgtttg ctatcattca ttctgtagcc
     1321 aatggcttac agtttctgtc tggtcatctg gaacttgaaa aatcctcaaa tgccttcact
     1381 cttttaccta actccctagt ctttttggga agtagttaag atatgcctgc tatctttaac
     1441 tttggaggta gtatcaaaat tttacttctt tggttgttta gtgaattaat gttgaatatt
     1501 ttctactgtc atcaaaacat attcccaaaa agtattaaaa aggaacctta gcacatttat
     1561 tttattaaaa caagaaaacc caaaatatat aaaccttttc ttattatgat aataagctta
     1621 tatatgtgaa taagttataa cctagtgtat aaaaaattat ttctaacaaa ctacagtata
     1681 ctgtcttggg tttttttttt tttttttagt ctgtaaaata aaatgactgc aattactttt
     1741 t
//
