LOCUS       NM_024053                938 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens centromere protein M (CENPM), transcript variant 1,
            mRNA.
ACCESSION   NM_024053
VERSION     NM_024053.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 938)
  AUTHORS   Tong,Y., Zhou,T., Wang,X., Deng,S. and Qin,L.
  TITLE     Upregulation of CENPM promotes breast carcinogenesis by altering
            immune infiltration
  JOURNAL   BMC Cancer 24 (1), 54 (2024)
   PUBMED   38200449
  REMARK    GeneRIF: Upregulation of CENPM promotes breast carcinogenesis by
            altering immune infiltration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 938)
  AUTHORS   Zhang,Z.C., Liu,Y.F., Xi,P., Nie,Y.C., Sun,T. and Gong,B.B.
  TITLE     Upregulation of CENPM is associated with poor clinical outcome and
            suppression of immune profile in clear cell renal cell carcinoma
  JOURNAL   Hereditas 160 (1), 1 (2023)
   PUBMED   36635779
  REMARK    GeneRIF: Upregulation of CENPM is associated with poor clinical
            outcome and suppression of immune profile in clear cell renal cell
            carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 938)
  AUTHORS   Tian,T., Chen,L., Dou,Z., Yang,Z., Gao,X., Yuan,X., Wang,C.,
            Liu,R., Shen,Z., Gui,P., Teng,M., Meng,X., Hill,D.L., Li,L.,
            Zhang,X., Liu,X., Sun,L., Zang,J. and Yao,X.
  TITLE     Structural insights into human CCAN complex assembled onto DNA
  JOURNAL   Cell Discov 8 (1), 90 (2022)
   PUBMED   36085283
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 938)
  AUTHORS   Liu,T., Ma,L., Song,L., Yan,B., Zhang,S., Wang,B., Zuo,N., Sun,X.,
            Deng,Y., Ren,Q., Li,Y., Zhou,J., Liu,Q. and Wei,L.
  TITLE     CENPM upregulation by E5 oncoprotein of human papillomavirus
            promotes radiosensitivity in head and neck squamous cell carcinoma
  JOURNAL   Oral Oncol 129, 105858 (2022)
   PUBMED   35462155
  REMARK    GeneRIF: CENPM upregulation by E5 oncoprotein of human
            papillomavirus promotes radiosensitivity in head and neck squamous
            cell carcinoma.
REFERENCE   5  (bases 1 to 938)
  AUTHORS   Basilico,F., Maffini,S., Weir,J.R., Prumbaum,D., Rojas,A.M.,
            Zimniak,T., De Antoni,A., Jeganathan,S., Voss,B., van Gerwen,S.,
            Krenn,V., Massimiliano,L., Valencia,A., Vetter,I.R., Herzog,F.,
            Raunser,S., Pasqualato,S. and Musacchio,A.
  TITLE     The pseudo GTPase CENP-M drives human kinetochore assembly
  JOURNAL   Elife 3, e02978 (2014)
   PUBMED   25006165
  REMARK    GeneRIF: CENP-M is crucially required for the assembly and
            stability of a tetramer also comprising CENP-I, CENP-H, and CENP-K,
            the HIKM complex, which we extensively characterize through a
            combination of structural, biochemical, and cell biological
            approaches.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 938)
  AUTHORS   Brickner,A.G., Evans,A.M., Mito,J.K., Xuereb,S.M., Feng,X.,
            Nishida,T., Fairfull,L., Ferrell,R.E., Foon,K.A., Hunt,D.F.,
            Shabanowitz,J., Engelhard,V.H., Riddell,S.R. and Warren,E.H.
  TITLE     The PANE1 gene encodes a novel human minor histocompatibility
            antigen that is selectively expressed in B-lymphoid cells and B-CLL
  JOURNAL   Blood 107 (9), 3779-3786 (2006)
   PUBMED   16391015
  REMARK    GeneRIF: an alternative transcript of the proliferation-associated
            nuclear element 1 (PANE1) gene encodes a novel
            (HLA)-A(*)0301-restricted mHAg that is selectively expressed in
            B-lymphoid cells
REFERENCE   7  (bases 1 to 938)
  AUTHORS   Bierie,B., Edwin,M., Melenhorst,J.J. and Hennighausen,L.
  TITLE     The proliferation associated nuclear element (PANE1) is conserved
            between mammals and fish and preferentially expressed in activated
            lymphoid cells
  JOURNAL   Gene Expr Patterns 4 (4), 389-395 (2004)
   PUBMED   15183305
  REMARK    GeneRIF: Expression of the human PANE1 gene was detected
            preferentially in immune cells
REFERENCE   8  (bases 1 to 938)
  AUTHORS   Obuse,C., Yang,H., Nozaki,N., Goto,S., Okazaki,T. and Yoda,K.
  TITLE     Proteomics analysis of the centromere complex from HeLa interphase
            cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of
            the CEN-complex, while BMI-1 is transiently co-localized with the
            centromeric region in interphase
  JOURNAL   Genes Cells 9 (2), 105-120 (2004)
   PUBMED   15009096
REFERENCE   9  (bases 1 to 938)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   10 (bases 1 to 938)
  AUTHORS   Collins,J.E., Goward,M.E., Cole,C.G., Smink,L.J., Huckle,E.J.,
            Knowles,S., Bye,J.M., Beare,D.M. and Dunham,I.
  TITLE     Reevaluating human gene annotation: a second-generation analysis of
            chromosome 22
  JOURNAL   Genome Res 13 (1), 27-36 (2003)
   PUBMED   12529303
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU556693.1, BC007495.2 and
            BC000705.2.
            
            On Nov 22, 2018 this sequence version replaced NM_024053.4.
            
            Summary: The protein encoded by this gene is an inner protein of
            the kinetochore, the multi-protein complex that binds spindle
            microtubules to regulate chromosome segregation during cell
            division. It belongs to the constitutive centromere-associated
            network protein group, whose members interact with outer
            kinetochore proteins and help to maintain centromere identity at
            each cell division cycle. The protein is structurally related to
            GTPases but cannot bind guanosine triphosphate. A point mutation
            that affects interaction with another constitutive
            centromere-associated network protein, CENP-I, impairs kinetochore
            assembly and chromosome alignment, suggesting that it is required
            for kinetochore formation. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000705.2, BX458535.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215980.10/ ENSP00000215980.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BU556693.1         13-40
            29-41               BC007495.2         1-13
            42-938              BC000705.2         1-897
FEATURES             Location/Qualifiers
     source          1..938
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..938
                     /gene="CENPM"
                     /gene_synonym="C22orf18; CENP-M; PANE1"
                     /note="centromere protein M"
                     /db_xref="GeneID:79019"
                     /db_xref="HGNC:HGNC:18352"
                     /db_xref="MIM:610152"
     exon            1..133
                     /gene="CENPM"
                     /gene_synonym="C22orf18; CENP-M; PANE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..619
                     /gene="CENPM"
                     /gene_synonym="C22orf18; CENP-M; PANE1"
                     /note="isoform a is encoded by transcript variant 1;
                     interphase centromere complex protein 39;
                     proliferation-associated nuclear element protein 1"
                     /codon_start=1
                     /product="centromere protein M isoform a"
                     /protein_id="NP_076958.1"
                     /db_xref="CCDS:CCDS14025.1"
                     /db_xref="GeneID:79019"
                     /db_xref="HGNC:HGNC:18352"
                     /db_xref="MIM:610152"
                     /translation="MSVLRPLDKLPGLNTATILLVGTEDALLQQLADSMLKEDCASEL
                     KVHLAKSLPLPSSVNRPRIDLIVFVVNLHSKYSLQNTEESLRHVDASFFLGKVCFLAT
                     GAGRESHCSIHRHTVVKLAHTYQSPLLYCDLEVEGFRATMAQRLVRVLQICAGHVPGV
                     SALNLLSLLRSSEGPSLEDL"
     exon            134..213
                     /gene="CENPM"
                     /gene_synonym="C22orf18; CENP-M; PANE1"
                     /inference="alignment:Splign:2.1.0"
     exon            214..306
                     /gene="CENPM"
                     /gene_synonym="C22orf18; CENP-M; PANE1"
                     /inference="alignment:Splign:2.1.0"
     exon            307..386
                     /gene="CENPM"
                     /gene_synonym="C22orf18; CENP-M; PANE1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..478
                     /gene="CENPM"
                     /gene_synonym="C22orf18; CENP-M; PANE1"
                     /inference="alignment:Splign:2.1.0"
     exon            479..938
                     /gene="CENPM"
                     /gene_synonym="C22orf18; CENP-M; PANE1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      902..907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPM"
                     /gene_synonym="C22orf18; CENP-M; PANE1"
                     /note="hexamer: AACAAA"
     polyA_site      938
                     /gene="CENPM"
                     /gene_synonym="C22orf18; CENP-M; PANE1"
                     /note="major polyA site"
ORIGIN      
        1 gctctagggg ctggactcag ggcggtttga aagatcggcg cgcaccgcag gagcaacggt
       61 tggtcctgcg gctgtgatgt cggtgttgag gcccctggac aagctgcccg gcctgaacac
      121 ggccaccatc ttgctggtgg gcacggagga tgctcttctg cagcagctgg cggactcgat
      181 gctcaaagag gactgcgcct ccgagctgaa ggtccacttg gcaaagtccc tccctttgcc
      241 ctccagtgtg aatcggcccc gaattgacct gatcgtgttt gtggttaatc ttcacagcaa
      301 atacagtctc cagaacacag aggagtccct gcgccatgtg gatgccagct tcttcttggg
      361 gaaggtgtgt ttcctcgcca caggtgctgg gcgggagagc cactgcagca ttcaccggca
      421 caccgtggtg aagctggccc acacctatca aagccccctg ctctactgtg acctggaggt
      481 ggaaggcttt agggccacca tggcgcagcg cctggtgcgc gtgctgcaga tctgtgctgg
      541 ccacgtgccc ggtgtctcag ctctgaacct gctgtccctg ctgagaagct ctgagggccc
      601 ctccctggag gacctgtgag ggtggctggc ccctgggctg ccccttctca tggcttcgtg
      661 ctgactccat aaacattctc tgttgaggat gtccagtcag ggcttgacag gcccaggctc
      721 agcccgccgt ggctgggaag gttccctgca gtgccagtgc tgcagcaggg agagctgggc
      781 agaagcagcg agggggccca gctggcgaga ctgtagcccc ctcccactcc cacactcact
      841 cttgcagagc ctgtgtcttt aagcagctgg cgtgttacat ctccatttaa ggtttccttt
      901 gaacaaaagg tctgtggcta aaaaaagttt aaaaatca
//
