LOCUS       NM_001387287            2706 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens centromere protein L (CENPL), transcript variant 7,
            mRNA.
ACCESSION   NM_001387287
VERSION     NM_001387287.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2706)
  AUTHORS   He,K., Xie,M., Hong,W., Li,Y., Yin,Y., Gao,X., He,Y., Chen,Y.,
            You,C. and Li,J.
  TITLE     CENPL accelerates cell proliferation, cell cycle, apoptosis, and
            glycolysis via the MEK1/2-ERK1/2 pathway in hepatocellular
            carcinoma
  JOURNAL   Int J Biochem Cell Biol 166, 106481 (2024)
   PUBMED   37914022
  REMARK    GeneRIF: CENPL accelerates cell proliferation, cell cycle,
            apoptosis, and glycolysis via the MEK1/2-ERK1/2 pathway in
            hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 2706)
  AUTHORS   Cui,Z., Du,L., Wang,J., Li,Z., Xu,J., Ou,S., Li,D., Li,S., Hu,H.,
            Chen,G. and Wu,Z.
  TITLE     Overexpression of CENPL mRNA potentially regulated by miR-340-3p
            predicts the prognosis of pancreatic cancer patients
  JOURNAL   BMC Cancer 22 (1), 1354 (2022)
   PUBMED   36572856
  REMARK    GeneRIF: Overexpression of CENPL mRNA potentially regulated by
            miR-340-3p predicts the prognosis of pancreatic cancer patients.
            Erratum:[BMC Cancer. 2023 Jan 5;23(1):12. doi:
            10.1186/s12885-023-10504-2.. PMID: 36604665]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2706)
  AUTHORS   Tian,T., Chen,L., Dou,Z., Yang,Z., Gao,X., Yuan,X., Wang,C.,
            Liu,R., Shen,Z., Gui,P., Teng,M., Meng,X., Hill,D.L., Li,L.,
            Zhang,X., Liu,X., Sun,L., Zang,J. and Yao,X.
  TITLE     Structural insights into human CCAN complex assembled onto DNA
  JOURNAL   Cell Discov 8 (1), 90 (2022)
   PUBMED   36085283
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2706)
  AUTHORS   Zeng,Z., Jiang,X., Pan,Z., Zhou,R., Lin,Z., Tang,Y., Cui,Y.,
            Zhang,E. and Cao,Z.
  TITLE     Highly expressed centromere protein L indicates adverse survival
            and associates with immune infiltration in hepatocellular carcinoma
  JOURNAL   Aging (Albany NY) 13 (19), 22802-22829 (2021)
   PUBMED   34607313
  REMARK    GeneRIF: Highly expressed centromere protein L indicates adverse
            survival and associates with immune infiltration in hepatocellular
            carcinoma.
REFERENCE   5  (bases 1 to 2706)
  AUTHORS   Cui,Z., Xiao,L., Chen,F., Wang,J., Lin,H., Li,D. and Wu,Z.
  TITLE     High mRNA Expression of CENPL and Its Significance in Prognosis of
            Hepatocellular Carcinoma Patients
  JOURNAL   Dis Markers 2021, 9971799 (2021)
   PUBMED   34457090
  REMARK    GeneRIF: High mRNA Expression of CENPL and Its Significance in
            Prognosis of Hepatocellular Carcinoma Patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2706)
  AUTHORS   McKinley,K.L., Sekulic,N., Guo,L.Y., Tsinman,T., Black,B.E. and
            Cheeseman,I.M.
  TITLE     The CENP-L-N Complex Forms a Critical Node in an Integrated
            Meshwork of Interactions at the Centromere-Kinetochore Interface
  JOURNAL   Mol Cell 60 (6), 886-898 (2015)
   PUBMED   26698661
  REMARK    GeneRIF: Study demonstrate that the CENP-L-N complex plays a
            crucial role at the core of the 16-subunit Constitutive
            Centromere-Associated Network through interactions with CENP-C and
            CENP-H-I-KM.
REFERENCE   7  (bases 1 to 2706)
  AUTHORS   Izuta,H., Ikeno,M., Suzuki,N., Tomonaga,T., Nozaki,N., Obuse,C.,
            Kisu,Y., Goshima,N., Nomura,F., Nomura,N. and Yoda,K.
  TITLE     Comprehensive analysis of the ICEN (Interphase Centromere Complex)
            components enriched in the CENP-A chromatin of human cells
  JOURNAL   Genes Cells 11 (6), 673-684 (2006)
   PUBMED   16716197
REFERENCE   8  (bases 1 to 2706)
  AUTHORS   Okada,M., Cheeseman,I.M., Hori,T., Okawa,K., McLeod,I.X.,
            Yates,J.R. 3rd, Desai,A. and Fukagawa,T.
  TITLE     The CENP-H-I complex is required for the efficient incorporation of
            newly synthesized CENP-A into centromeres
  JOURNAL   Nat Cell Biol 8 (5), 446-457 (2006)
   PUBMED   16622420
REFERENCE   9  (bases 1 to 2706)
  AUTHORS   Foltz,D.R., Jansen,L.E., Black,B.E., Bailey,A.O., Yates,J.R. 3rd
            and Cleveland,D.W.
  TITLE     The human CENP-A centromeric nucleosome-associated complex
  JOURNAL   Nat Cell Biol 8 (5), 458-469 (2006)
   PUBMED   16622419
REFERENCE   10 (bases 1 to 2706)
  AUTHORS   Obuse,C., Yang,H., Nozaki,N., Goto,S., Okazaki,T. and Yoda,K.
  TITLE     Proteomics analysis of the centromere complex from HeLa interphase
            cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of
            the CEN-complex, while BMI-1 is transiently co-localized with the
            centromeric region in interphase
  JOURNAL   Genes Cells 9 (2), 105-120 (2004)
   PUBMED   15009096
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL109921.21.
            
            Summary: CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM
            300065)-associated centromeric complex that targets CENPA (MIM
            117139) to centromeres and is required for proper kinetochore
            function and mitotic progression (Okada et al., 2006) [PubMed
            16622420].[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.136339.1,
                                           SRR5189661.88787.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682279.1/ ENSP00000507473.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-672               AL109921.21        98784-99455         c
            673-766             AL109921.21        98498-98591         c
            767-941             AL109921.21        85704-85878         c
            942-1193            AL109921.21        81839-82090         c
            1194-1736           AL109921.21        77535-78077         c
            1737-2706           AL109921.21        74122-75091         c
FEATURES             Location/Qualifiers
     source          1..2706
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.1"
     gene            1..2706
                     /gene="CENPL"
                     /gene_synonym="C1orf155; CENP-L; dJ383J4.3"
                     /note="centromere protein L"
                     /db_xref="GeneID:91687"
                     /db_xref="HGNC:HGNC:17879"
                     /db_xref="MIM:611503"
     exon            1..672
                     /gene="CENPL"
                     /gene_synonym="C1orf155; CENP-L; dJ383J4.3"
                     /inference="alignment:Splign:2.1.0"
     exon            673..766
                     /gene="CENPL"
                     /gene_synonym="C1orf155; CENP-L; dJ383J4.3"
                     /inference="alignment:Splign:2.1.0"
     exon            767..941
                     /gene="CENPL"
                     /gene_synonym="C1orf155; CENP-L; dJ383J4.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             774..1808
                     /gene="CENPL"
                     /gene_synonym="C1orf155; CENP-L; dJ383J4.3"
                     /note="isoform 2 is encoded by transcript variant 7;
                     interphase centromere complex protein 33"
                     /codon_start=1
                     /product="centromere protein L isoform 2"
                     /protein_id="NP_001374216.1"
                     /db_xref="CCDS:CCDS30938.1"
                     /db_xref="GeneID:91687"
                     /db_xref="HGNC:HGNC:17879"
                     /db_xref="MIM:611503"
                     /translation="MDSYSAPESTPSASSRPEDYFIGATPLQKRLESVRKQSSFILTP
                     PRRKIPQCSQLQEDVDPQKVAFLLHKQWTLYSLTPLYKFSYSNLKEYSRLLNAFIVAE
                     KQKGLAVEVGEDFNIKVIFSTLLGMKGTQRDPEAFLVQIVSKSQLPSENREGKVLWTG
                     WFCCVFGDSLLETVSEDFTCLPLFLANGAESNTAIIGTWFQKTFDCYFSPLAINAFNL
                     SWMAAMWTACKMDHYVATTEFLWSVPCSPQSLDISFAIHPEDAKALWDSVHKTPGEVT
                     QEEVDLFMDCLYSHFHRHFKIHLSATRLVRVSTSVASAHTDGKIKILCHKYLIGVLAY
                     LTELAIFQIE"
     exon            942..1193
                     /gene="CENPL"
                     /gene_synonym="C1orf155; CENP-L; dJ383J4.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1736
                     /gene="CENPL"
                     /gene_synonym="C1orf155; CENP-L; dJ383J4.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..2706
                     /gene="CENPL"
                     /gene_synonym="C1orf155; CENP-L; dJ383J4.3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2683..2688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPL"
                     /gene_synonym="C1orf155; CENP-L; dJ383J4.3"
                     /note="hexamer: ATTAAA"
     polyA_site      2706
                     /gene="CENPL"
                     /gene_synonym="C1orf155; CENP-L; dJ383J4.3"
                     /note="major polyA site"
ORIGIN      
        1 ggtcacaagg tatacgccct tctcctcttt ccacgcttct cgagaggctc ccgcggccag
       61 aaccggaaaa caaggagtaa cagtcgcgtt tcaaatctcg cagacctgct ggccgatttc
      121 gagtcttctg aaagaggaag gcgagcaaag ccaaaattct cccagagcgc gaacccaaac
      181 acagatcgcc gctggggtcc aagcgccctt caactccgcc cgctagtgcc caagattacc
      241 gggaaggaat tcaacgaatc agtggtgagg tgccgccgcc atgcctacta cgggcggaaa
      301 tttgagagaa agcttcgcac cggtaggaaa actgaggagc aaccgagcac gattggaaag
      361 gttgacgata gtggttaagt ggctcggcct tgccctcagt taaaatggca attttagttg
      421 cttcactgat acggaatcgg cgaggcgcca aggaggcttc ctgcgtgggg ccgcagagcg
      481 agtcgggaaa cgattttaaa ctgaagaggc ggcggagggc cgaattccct tttctcaacg
      541 gcttgatttc agagctgggc tggtctctga caggctcagc tggagaggga cgggttggga
      601 cgcactgtcc ttttgccctt ccccctccgc gagcagaagc tgactccgca ggagcgaggg
      661 tcgcagagct gggggatttc agtctccaca tagttttgga gccggacttt tgaagaatga
      721 ttcgtgaatc cggaatgggt gacagcgtca tcacggcatt ttattgacag accatggatt
      781 cttacagtgc accagagtca actcctagtg catcctcaag acctgaagat tactttatag
      841 gtgccactcc tctgcagaaa cgattagaat cggtcaggaa gcagagttca tttatcctga
      901 ctccacctcg aaggaaaatt ccccagtgtt cgcagttgca ggaagatgtt gaccctcaaa
      961 aggttgcatt ccttctgcat aaacagtgga ctttatatag tttaactccc ttatataaat
     1021 tctcctatag taatctcaaa gagtattcta gacttctcaa tgcttttatt gttgctgaaa
     1081 agcaaaaagg acttgctgtg gaagtgggag aagacttcaa catcaaagtg attttttcta
     1141 ctctcctagg aatgaaagga acacaaaggg acccggaagc atttcttgtc cagattgtgt
     1201 caaaatctca attgccatct gagaatagag aaggtaaagt gctgtggact ggctggttct
     1261 gctgtgtatt tggagacagt cttctggaga ctgtttcaga agatttcacc tgtctgccct
     1321 tattccttgc aaatggagca gagtctaaca cagcaataat tggaacttgg tttcagaaaa
     1381 cctttgactg ttatttcagt cctttagcaa tcaatgcatt taatctttcc tggatggctg
     1441 ccatgtggac tgcatgcaaa atggaccatt atgtggctac tactgaattt ctttggtctg
     1501 taccctgtag ccctcaaagt ctggacattt ctttcgcaat acatccagag gatgcaaaag
     1561 ctctatggga cagtgtccac aaaacacctg gggaggttac ccaggaagaa gttgacctat
     1621 tcatggattg cctttattca catttccata gacatttcaa aattcattta tcagccacaa
     1681 gattagttcg tgtttcaaca tctgtagctt cagcacatac tgatggaaaa ataaagattc
     1741 tgtgtcataa ataccttatt ggagtgttag catatttgac agaactggca atttttcaaa
     1801 ttgagtgaag ccttatgtgg actataagtt atagattata tactcttatt gataacttgc
     1861 ctaattgcta tgctgaaaga gactgcagga gaaataggca tctatctctg catctgtttt
     1921 ccccaccatg cctttggagt tgccaagatg gaagccaaga aggatctaga agaacaaaga
     1981 atatggtagt agatgagcca cagccaggtg cccatgtact aatcatgata acctgacatg
     2041 ccattctcaa aatgctgagt tgttaatttc ttgtcatctt taaatatata tatataggct
     2101 gggcttggtg gctcacacct gtaattccag cactttggga ggctgaggtg ggtggatcat
     2161 ttgaggccag gaattcaaga ccagcctggc caacatggtg aaaccccttc tctactgaaa
     2221 atacaataat tagctgggcg tggtggcaca tgcctatgat cccagctact ggggaggctg
     2281 aggcaggaga atcgttttaa cccagaagac aggctgcagt gagccaagac tgcaccactg
     2341 cactccagcc tgggcaacaa agtgagactc tgcctcaaaa aataaaaaag aaataaaata
     2401 aataaataca gcgtttatta tgtttaaact cttaggattc aaatgagatg tatctaatgg
     2461 atatttctga tttgggtctt taaaaccttt aatctctttt aagcatttta gacttgcatt
     2521 cagaaagaat tctgtcttct aaagacattt tcctagcatt tcactgcgga gaactggcaa
     2581 tcaaaatccc ctcaaaaggg aactaaagat taatatacac atttttttag tcattaatat
     2641 gcttctgttt taaatacagt tcaactcctg ttgcaatgtt gaattaaatg tttattttaa
     2701 aatgaa
//
