LOCUS       NM_022145               1731 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens centromere protein K (CENPK), transcript variant 1,
            mRNA.
ACCESSION   NM_022145
VERSION     NM_022145.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1731)
  AUTHORS   Li,G., Shen,J., Cheng,W., Wang,X., Wang,D., Song,Y., Chen,Y.,
            Li,X., Zhang,M., Ding,Y., Ma,X., Qian,Q., Zhang,G., Ji,J. and
            Liu,B.
  TITLE     CENPK orchestrates ovarian cancer progression via GOLPH3-Mediated
            activation of mTOR signaling
  JOURNAL   Mol Cell Endocrinol 589, 112253 (2024)
   PUBMED   38670220
  REMARK    GeneRIF: CENPK orchestrates ovarian cancer progression via
            GOLPH3-Mediated activation of mTOR signaling.
REFERENCE   2  (bases 1 to 1731)
  AUTHORS   Li,X., Han,Y.R., Xuefeng,X., Ma,Y.X., Xing,G.S., Yang,Z.W.,
            Zhang,Z., Shi,L. and Wu,X.L.
  TITLE     Lentivirus-mediated short hairpin RNA interference of CENPK
            inhibits growth of colorectal cancer cells with overexpression of
            Cullin 4A
  JOURNAL   World J Gastroenterol 28 (37), 5420-5443 (2022)
   PUBMED   36312839
  REMARK    GeneRIF: Lentivirus-mediated short hairpin RNA interference of
            CENPK inhibits growth of colorectal cancer cells with
            overexpression of Cullin 4A.
REFERENCE   3  (bases 1 to 1731)
  AUTHORS   Tian,T., Chen,L., Dou,Z., Yang,Z., Gao,X., Yuan,X., Wang,C.,
            Liu,R., Shen,Z., Gui,P., Teng,M., Meng,X., Hill,D.L., Li,L.,
            Zhang,X., Liu,X., Sun,L., Zang,J. and Yao,X.
  TITLE     Structural insights into human CCAN complex assembled onto DNA
  JOURNAL   Cell Discov 8 (1), 90 (2022)
   PUBMED   36085283
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1731)
  AUTHORS   Tian,H., Wang,F., Deng,Y., Ying,L., Fang,W., Chen,D., Miao,C.,
            Li,H., Sun,S., Ma,Y., Cai,H. and Guo,T.
  TITLE     Centromeric protein K (CENPK) promotes gastric cancer proliferation
            and migration via interacting with XRCC5
  JOURNAL   Gastric Cancer 25 (5), 879-895 (2022)
   PUBMED   35715658
  REMARK    GeneRIF: Centromeric protein K (CENPK) promotes gastric cancer
            proliferation and migration via interacting with XRCC5.
REFERENCE   5  (bases 1 to 1731)
  AUTHORS   Lin,X., Wang,F., Chen,J., Liu,J., Lin,Y.B., Li,L., Chen,C.B. and
            Xu,Q.
  TITLE     N6-methyladenosine modification of CENPK mRNA by ZC3H13 promotes
            cervical cancer stemness and chemoresistance
  JOURNAL   Mil Med Res 9 (1), 19 (2022)
   PUBMED   35418160
  REMARK    GeneRIF: N(6)-methyladenosine modification of CENPK mRNA by ZC3H13
            promotes cervical cancer stemness and chemoresistance.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1731)
  AUTHORS   Okada,M., Cheeseman,I.M., Hori,T., Okawa,K., McLeod,I.X.,
            Yates,J.R. 3rd, Desai,A. and Fukagawa,T.
  TITLE     The CENP-H-I complex is required for the efficient incorporation of
            newly synthesized CENP-A into centromeres
  JOURNAL   Nat Cell Biol 8 (5), 446-457 (2006)
   PUBMED   16622420
REFERENCE   7  (bases 1 to 1731)
  AUTHORS   Foltz,D.R., Jansen,L.E., Black,B.E., Bailey,A.O., Yates,J.R. 3rd
            and Cleveland,D.W.
  TITLE     The human CENP-A centromeric nucleosome-associated complex
  JOURNAL   Nat Cell Biol 8 (5), 458-469 (2006)
   PUBMED   16622419
REFERENCE   8  (bases 1 to 1731)
  AUTHORS   Obuse,C., Yang,H., Nozaki,N., Goto,S., Okazaki,T. and Yoda,K.
  TITLE     Proteomics analysis of the centromere complex from HeLa interphase
            cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of
            the CEN-complex, while BMI-1 is transiently co-localized with the
            centromeric region in interphase
  JOURNAL   Genes Cells 9 (2), 105-120 (2004)
   PUBMED   15009096
REFERENCE   9  (bases 1 to 1731)
  AUTHORS   Yamashita,A., Ito,M., Takamatsu,N. and Shiba,T.
  TITLE     Characterization of Solt, a novel SoxLZ/Sox6 binding protein
            expressed in adult mouse testis
  JOURNAL   FEBS Lett 481 (2), 147-151 (2000)
   PUBMED   10996314
REFERENCE   10 (bases 1 to 1731)
  AUTHORS   Taki,T., Hayashi,Y., Taniwaki,M., Seto,M., Ueda,R., Hanada,R.,
            Suzukawa,K., Yokota,J. and Morishita,K.
  TITLE     Fusion of the MLL gene with two different genes, AF-6 and
            AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8
            and 11 in infant leukemia
  JOURNAL   Oncogene 13 (10), 2121-2130 (1996)
   PUBMED   8950979
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC008504.1.
            
            On Nov 24, 2018 this sequence version replaced NM_022145.4.
            
            Summary: CENPK is a subunit of a CENPH (MIM 605607)-CENPI (MIM
            300065)-associated centromeric complex that targets CENPA (MIM
            117139) to centromeres and is required for proper kinetochore
            function and mitotic progression (Okada et al., 2006 [PubMed
            16622420]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008504.1, SRR1163658.452865.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396679.6/ ENSP00000379911.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1731              BC008504.1         1-1731
FEATURES             Location/Qualifiers
     source          1..1731
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q12.3"
     gene            1..1731
                     /gene="CENPK"
                     /gene_synonym="AF5alpha; CENP-K; FKSG14; P33; Solt"
                     /note="centromere protein K"
                     /db_xref="GeneID:64105"
                     /db_xref="HGNC:HGNC:29479"
                     /db_xref="MIM:611502"
     exon            1..71
                     /gene="CENPK"
                     /gene_synonym="AF5alpha; CENP-K; FKSG14; P33; Solt"
                     /inference="alignment:Splign:2.1.0"
     exon            72..173
                     /gene="CENPK"
                     /gene_synonym="AF5alpha; CENP-K; FKSG14; P33; Solt"
                     /inference="alignment:Splign:2.1.0"
     exon            174..323
                     /gene="CENPK"
                     /gene_synonym="AF5alpha; CENP-K; FKSG14; P33; Solt"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1022
                     /gene="CENPK"
                     /gene_synonym="AF5alpha; CENP-K; FKSG14; P33; Solt"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine zipper protein FKSG14; SoxLZ/Sox6-binding protein
                     Solt; protein AF-5alpha; interphase centromere complex
                     protein 37"
                     /codon_start=1
                     /product="centromere protein K isoform 1"
                     /protein_id="NP_071428.2"
                     /db_xref="CCDS:CCDS3984.1"
                     /db_xref="GeneID:64105"
                     /db_xref="HGNC:HGNC:29479"
                     /db_xref="MIM:611502"
                     /translation="MNQEDLDPDSTTDVGDVTNTEEELIRECEEMWKDMEECQNKLSL
                     IGTETLTDSNAQLSLLIMQVKCLTAELSQWQKKTPETIPLTEDVLITLGKEEFQKLRQ
                     DLEMVLSTKESKNEKLKEDLEREQRWLDEQQQIMESLNVLHSELKNKVETFSESRIFN
                     ELKTKMLNIKEYKEKLLSTLGEFLEDHFPLPDRSVKKKKKNIQESSVNLITLHEMLEI
                     LINRLFDVPHDPYVKISDSFWPPYVELLLRNGIALRHPEDPTRIRLEAFHQ"
     exon            324..380
                     /gene="CENPK"
                     /gene_synonym="AF5alpha; CENP-K; FKSG14; P33; Solt"
                     /inference="alignment:Splign:2.1.0"
     exon            381..453
                     /gene="CENPK"
                     /gene_synonym="AF5alpha; CENP-K; FKSG14; P33; Solt"
                     /inference="alignment:Splign:2.1.0"
     exon            454..500
                     /gene="CENPK"
                     /gene_synonym="AF5alpha; CENP-K; FKSG14; P33; Solt"
                     /inference="alignment:Splign:2.1.0"
     exon            501..583
                     /gene="CENPK"
                     /gene_synonym="AF5alpha; CENP-K; FKSG14; P33; Solt"
                     /inference="alignment:Splign:2.1.0"
     exon            584..682
                     /gene="CENPK"
                     /gene_synonym="AF5alpha; CENP-K; FKSG14; P33; Solt"
                     /inference="alignment:Splign:2.1.0"
     exon            683..809
                     /gene="CENPK"
                     /gene_synonym="AF5alpha; CENP-K; FKSG14; P33; Solt"
                     /inference="alignment:Splign:2.1.0"
     exon            810..863
                     /gene="CENPK"
                     /gene_synonym="AF5alpha; CENP-K; FKSG14; P33; Solt"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1731
                     /gene="CENPK"
                     /gene_synonym="AF5alpha; CENP-K; FKSG14; P33; Solt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1706..1711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPK"
                     /gene_synonym="AF5alpha; CENP-K; FKSG14; P33; Solt"
                     /note="hexamer: AATAAA"
     polyA_site      1731
                     /gene="CENPK"
                     /gene_synonym="AF5alpha; CENP-K; FKSG14; P33; Solt"
                     /note="major polyA site"
ORIGIN      
        1 gcagaagtcc ggggctggca agcgcttcct gcgcagcgcc taggcgacct ggagtttgtg
       61 acgctgtgat ggtctagagg ctggagattc aagatctggg tgccatcatt ttctggttct
      121 gttgatgacc ctcttccagg ttacatacag cttacatctt gcatcctcaa gcgtttttct
      181 tataaggcta aaaattcaca aagcatatat caatgaatca ggaggatcta gatccggata
      241 gtactacaga tgtgggagat gttacaaata ctgaagaaga acttattaga gaatgtgaag
      301 aaatgtggaa agatatggaa gaatgtcaga ataaattatc acttattgga actgaaacac
      361 tcaccgattc aaatgctcag ctatcattgt taattatgca agtaaaatgt ttaaccgctg
      421 aactcagtca atggcagaaa aaaacacctg aaacaattcc cttgactgaa gacgttctca
      481 taacattagg aaaagaagag ttccaaaagc tgagacaaga tcttgaaatg gtactgtcca
      541 ctaaggagtc aaagaatgaa aagttaaagg aagacttaga aagggaacaa cggtggttgg
      601 atgaacagca acagataatg gaatctctta atgtactaca cagtgaattg aaaaataagg
      661 ttgaaacatt ttctgaatca agaatcttta atgaactgaa aactaaaatg cttaatataa
      721 aagaatataa ggagaaactc ttgagtacct tgggcgagtt tctagaagac cattttcctc
      781 tgcctgatag aagtgttaaa aagaaaaaga aaaacattca agaatcatct gtaaacctga
      841 taacactgca tgaaatgtta gagattctta taaatagatt atttgatgtt ccacatgatc
      901 catatgtcaa aattagtgat tccttttggc caccttatgt tgagctgctg ctgcgtaatg
      961 gaattgcctt gagacatcca gaagatccaa cccgaataag attagaagct ttccatcagt
     1021 aaaaggatgt tttctttttt cacacagtaa aaattcttat cattcaagga tattggaacc
     1081 acaggactat ttggataaaa aacattattt gcaaattaat gcgcataggc catcttactt
     1141 ttattgcaaa atggcatgtg ctgccatcta ttattcattt ttaaatggtc atttcttatt
     1201 cagtgagtgc tttagtgttt taaactatat ggataagaat gcaggtagat aatattctag
     1261 gcataaaaca tttaatgtac cttacctcat gcaatattct ttggattctt tgttgattta
     1321 tgatattgct aatataatat tttcttaaaa tatataacaa tatcttttat gcattttgag
     1381 ttccagctgg tgcttcttta tatttagaaa ttataatggg aaggtcattt aatttacaga
     1441 tggttttaaa attgaggtaa tatctgaggt ggcataattt aaaaatattt agcaaatttg
     1501 tttcatatat actgtcttat ttctagattt gtttaaaatt ggaatatgaa aaactaatgg
     1561 ataaagctag cataaaattg atattttagt ttgtattatt aatatatcat gttaccttat
     1621 atattaatct actcttgatt ctgctaatta ttaccaacaa aattgtattc atgacatttt
     1681 attaatcctc tgtgaatttt ctgtaaataa aattatttct gaaaatctct a
//
