LOCUS       NM_001386188            5584 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens centromere protein I (CENPI), transcript variant 4,
            mRNA.
ACCESSION   NM_001386188 XM_011530894
VERSION     NM_001386188.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5584)
  AUTHORS   Feng,Z., Cui,G., Tan,J., Liu,P., Chen,Y., Jiang,Z., Han,Y.,
            Zeng,S., Shen,H. and Cai,C.
  TITLE     Immune infiltration related CENPI associates with the malignant
            features and drug resistance of lung adenocarcinoma
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (3), 167017 (2024)
   PUBMED   38232915
  REMARK    GeneRIF: Immune infiltration related CENPI associates with the
            malignant features and drug resistance of lung adenocarcinoma.
REFERENCE   2  (bases 1 to 5584)
  AUTHORS   Tian,T., Chen,L., Dou,Z., Yang,Z., Gao,X., Yuan,X., Wang,C.,
            Liu,R., Shen,Z., Gui,P., Teng,M., Meng,X., Hill,D.L., Li,L.,
            Zhang,X., Liu,X., Sun,L., Zang,J. and Yao,X.
  TITLE     Structural insights into human CCAN complex assembled onto DNA
  JOURNAL   Cell Discov 8 (1), 90 (2022)
   PUBMED   36085283
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5584)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5584)
  AUTHORS   Wang,J., Liu,X., Chu,H.J., Li,N., Huang,L.Y. and Chen,J.
  TITLE     Centromere Protein I (CENP-I) Is Upregulated in Gastric Cancer,
            Predicts Poor Prognosis, and Promotes Tumor Cell Proliferation and
            Migration
  JOURNAL   Technol Cancer Res Treat 20, 15330338211045510 (2021)
   PUBMED   34617858
  REMARK    GeneRIF: Centromere Protein I (CENP-I) Is Upregulated in Gastric
            Cancer, Predicts Poor Prognosis, and Promotes Tumor Cell
            Proliferation and Migration.
REFERENCE   5  (bases 1 to 5584)
  AUTHORS   Foltz,D.R., Jansen,L.E., Black,B.E., Bailey,A.O., Yates,J.R. 3rd
            and Cleveland,D.W.
  TITLE     The human CENP-A centromeric nucleosome-associated complex
  JOURNAL   Nat Cell Biol 8 (5), 458-469 (2006)
   PUBMED   16622419
REFERENCE   6  (bases 1 to 5584)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   7  (bases 1 to 5584)
  AUTHORS   Obuse,C., Yang,H., Nozaki,N., Goto,S., Okazaki,T. and Yoda,K.
  TITLE     Proteomics analysis of the centromere complex from HeLa interphase
            cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of
            the CEN-complex, while BMI-1 is transiently co-localized with the
            centromeric region in interphase
  JOURNAL   Genes Cells 9 (2), 105-120 (2004)
   PUBMED   15009096
REFERENCE   8  (bases 1 to 5584)
  AUTHORS   Liu,S.T., Hittle,J.C., Jablonski,S.A., Campbell,M.S., Yoda,K. and
            Yen,T.J.
  TITLE     Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to
            kinetochores and is essential for mitosis
  JOURNAL   Nat Cell Biol 5 (4), 341-345 (2003)
   PUBMED   12640463
REFERENCE   9  (bases 1 to 5584)
  AUTHORS   Roberts,R.G., Kendall,E., Vetrie,D. and Bobrow,M.
  TITLE     Sequence and chromosomal location of a human homologue of LRPR1, an
            FSH primary response gene
  JOURNAL   Genomics 37 (1), 122-124 (1996)
   PUBMED   8921378
REFERENCE   10 (bases 1 to 5584)
  AUTHORS   Slegtenhorst-Eegdeman,K.E., Post,M., Baarends,W.M., Themmen,A.P.
            and Grootegoed,J.A.
  TITLE     Regulation of gene expression in Sertoli cells by
            follicle-stimulating hormone (FSH): cloning and characterization of
            LRPR1, a primary response gene encoding a leucine-rich protein
  JOURNAL   Mol Cell Endocrinol 108 (1-2), 115-124 (1995)
   PUBMED   7758824
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL109963.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2020 this sequence version replaced NM_001386188.1.
            
            Summary: This gene encodes a centromere protein that is a component
            of the CENPA-NAC (nucleosome-associated) complex. This complex is
            critical for accurate chromosome alignment and segregation and it
            ensures proper mitotic progression. This protein regulates the
            recruitment of kinetochore-associated proteins that are required to
            generate the spindle checkpoint signal. The product of this gene is
            involved in the response of gonadal tissues to follicle-stimulating
            hormone. Mutations in this gene may be involved in human X-linked
            disorders of gonadal development and gametogenesis. Alternate
            splicing results in multiple transcript variants. A pseudogene of
            this gene is found on chromosome 13. [provided by RefSeq, Jan
            2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.521159.1,
                                           SRR14038196.3262265.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682095.1/ ENSP00000507927.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AL109963.4         1302-1346
            46-141              AL109963.4         1542-1637
            142-380             AL109963.4         4156-4394
            381-518             AL109963.4         5372-5509
            519-637             AL109963.4         12571-12689
            638-745             AL109963.4         12989-13096
            746-794             AL109963.4         23500-23548
            795-841             AL109963.4         23836-23882
            842-931             AL109963.4         29807-29896
            932-1060            AL109963.4         30236-30364
            1061-1228           AL109963.4         30596-30763
            1229-1349           AL109963.4         31814-31934
            1350-1441           AL109963.4         33080-33171
            1442-1559           AL109963.4         35288-35405
            1560-1624           AL109963.4         35490-35554
            1625-1719           AL109963.4         43764-43858
            1720-1855           AL109963.4         48162-48297
            1856-1980           AL109963.4         49251-49375
            1981-2029           AL109963.4         50861-50909
            2030-2248           AL109963.4         51041-51259
            2249-2290           AL109963.4         64626-64667
            2291-5584           AL109963.4         65931-69224
FEATURES             Location/Qualifiers
     source          1..5584
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..5584
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /note="centromere protein I"
                     /db_xref="GeneID:2491"
                     /db_xref="HGNC:HGNC:3968"
                     /db_xref="MIM:300065"
     exon            1..45
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            46..141
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            142..380
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..2425
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /note="isoform 1 is encoded by transcript variant 4;
                     follicle-stimulating hormone primary response protein;
                     leucine-rich primary response protein 1; FSH primary
                     response 1; interphase centromere complex protein 19"
                     /codon_start=1
                     /product="centromere protein I isoform 1"
                     /protein_id="NP_001373117.1"
                     /db_xref="CCDS:CCDS14479.1"
                     /db_xref="GeneID:2491"
                     /db_xref="HGNC:HGNC:3968"
                     /db_xref="MIM:300065"
                     /translation="MSPQKRVKNVQAQNRTSQGSSSFQTTLSAWKVKQDPSNSKNISK
                     HGQNNPVGDYEHADDQAEEDALQMAVGYFEKGPIKASQNKDKTLEKHLKTVENVAWKN
                     GLASEEIDILLNIALSGKFGNAVNTRILKCMIPATVISEDSVVKAVSWLCVGKCSGST
                     KVLFYRWLVAMFDFIDRKEQINLLYGFFFASLQDDALCPYVCHLLYLLTKKENVKPFR
                     VRKLLDLQAKMGMQPHLQALLSLYKFFAPALISVSLPVRKKIYFKNSENLWKTALLAV
                     KQRNRGPSPEPLKLMLGPANVRPLKRKWNSLSVIPVLNSSSYTKECGKKEMSLSDCLN
                     RSGSFPLEQLQSFPQLLQNIHCLELPSQMGSVLNNSLLLHYINCVRDEPVLLRFYYWL
                     SQTLQEECIWYKVNNYEHGKEFTNFLDTIIRAECFLQEGFYSCEAFLYKSLPLWDGLC
                     CRSQFLQLVSWIPFSSFSEVKPLLFDHLAQLFFTSTIYFKCSVLQSLKELLQNWLLWL
                     SMDIHMKPVTNSPLETTLGGSMNSVSKLIHYVGWLSTTAMRLESNNTFLLHFILDFYE
                     KVCDIYINYNLPLVVLFPPGIFYSALLSLDTSILNQLCFIMHRYRKNLTAAKKNELVQ
                     KTKSEFNFSSKTYQEFNHYLTSMVGCLWTSKPFGKGIYIDPEILEKTGVAEYKNSLNV
                     VHHPSFLSYAVSFLLQESPEERTVNVSSIRGKKWSWYLDYLFSQGLQGLKLFIRSSVH
                     HSSIPRAEGINCNNQY"
     exon            381..518
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            519..637
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            638..745
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..794
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            795..841
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            842..931
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1060
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1228
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1349
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1441
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1559
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1624
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1719
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1855
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1980
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2029
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2248
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2290
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..5584
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3110..3115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /note="hexamer: AATAAA"
     polyA_site      3136
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /note="major polyA site"
     regulatory      5460..5465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /note="hexamer: AAGAAA"
     polyA_site      5481
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /note="major polyA site"
     regulatory      5560..5565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /note="hexamer: AATAAA"
     polyA_site      5584
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
ORIGIN      
        1 attcggtggt cagaggcctg tgcggctgca ggtagagtgt cttaggaacc taggaaataa
       61 ctcggaacct gtaacgtccc actggtttgg acatattcct ctcctgatct ggcctcatct
      121 gttccaggga ggtgggattg aaacatatgc agtaatgtca cctcaaaaga gagttaagaa
      181 cgtccaggca caaaacagga cttcacaagg tagtagtagt tttcagacca cgctttcagc
      241 ctggaaagta aaacaggatc caagcaactc gaagaacatc tcaaaacatg gacaaaacaa
      301 tccagtggga gattatgaac atgctgatga tcaagctgaa gaagatgctt tgcaaatggc
      361 agtgggatat tttgagaaag gtcccattaa agcttcacag aataaagata aaaccttgga
      421 aaaacacttg aaaactgtgg aaaatgtggc ttggaagaat gggttagctt cagaagaaat
      481 tgatattcta ttaaatattg cactcagtgg caaatttgga aatgctgtaa acacacggat
      541 attgaagtgc atgatcccag caacagtaat atcagaagat tctgtggtta aggcagtctc
      601 ctggctttgt gttggcaagt gttctggtag caccaaggta cttttttatc gttggctggt
      661 tgcaatgttt gacttcattg atcgtaagga gcaaattaac ttgctctatg gcttcttttt
      721 tgcttcattg caagatgatg cactgtgccc ttatgtttgc catttgttat atttacttac
      781 caaaaaagag aatgtcaaac catttcgtgt gagaaaactg cttgatcttc aggccaaaat
      841 gggaatgcag cctcatctcc aggctttgtt gtcactgtat aagttctttg ctcctgctct
      901 gatttcagta tctttgcctg taaggaagaa gatatatttt aagaattcag agaatctatg
      961 gaagacggct ctgcttgccg tgaagcaaag aaaccgggga ccttctccag aacctctgaa
     1021 gttgatgtta ggtccagcta atgttcgtcc tctaaaaaga aagtggaatt ctctctcagt
     1081 tataccagtg ctcaattcca gtagctacac taaagaatgt ggaaaaaaag agatgagtct
     1141 ttctgattgt ctgaatagaa gtggatcatt tccactagaa caacttcaaa gcttccccca
     1201 acttttacag aacatccatt gcttagagct gccttctcag atgggctcag tgctaaacaa
     1261 ctctctgctg cttcactaca ttaactgtgt cagagatgag ccagtcttgc tgaggtttta
     1321 ttactggttg agtcaaacat tacaagaaga atgtatttgg tacaaggtga ataattatga
     1381 acatggaaaa gaatttacca acttcctgga taccatcatc agggcagagt gcttcttaca
     1441 agaggggttt tattcctgtg aagcattcct gtataagagc cttcctctct gggatggcct
     1501 ttgttgtcgg tcacagttcc ttcagcttgt gagctggatt ccttttagta gcttctctga
     1561 ggtgaaacca cttctttttg accatctagc gcagctcttc tttacatcaa ccatttattt
     1621 caagtgtagt gtgcttcaga gtctgaaaga gctattgcag aattggctgt tgtggctttc
     1681 tatggacatt cacatgaaac ctgttacaaa cagtcctcta gagacaactt tgggtggatc
     1741 catgaactct gtgtctaaac tgatccacta tgtagggtgg ctatccacta ctgcaatgcg
     1801 cttggagagc aacaatactt tcttgctgca ctttattttg gatttctatg agaaggtgtg
     1861 tgacatatat ataaattata accttccatt agtggtattg tttcctcctg ggatcttcta
     1921 ttctgcactc ctcagcctgg ataccagcat cctgaaccag ctgtgtttta ttatgcacag
     1981 atatcgtaaa aatttgactg ccgcaaagaa aaatgagttg gtacaaaaga caaaatcaga
     2041 gttcaatttc agcagcaaga cttatcaaga atttaatcac tatttgacat caatggttgg
     2101 ttgcctgtgg acgtccaaac cctttgggaa aggaatatat attgaccctg aaatcctaga
     2161 aaaaactgga gtggctgaat ataaaaacag tttaaatgta gtccatcatc cttctttctt
     2221 gagttacgct gtttcctttt tgctacagga aagcccagaa gaaaggacag taaatgtgag
     2281 ctctattcgg ggaaagaaat ggagctggta tttggactat ttattttcac aggggttaca
     2341 aggcttgaaa ctttttataa gaagtagtgt tcatcattct tccattccca gagcagaggg
     2401 cataaactgc aacaatcaat attaaatgaa tgttgacata aactgaacac actggactaa
     2461 actcactcct cattgctaga gcaaagtggc tcatcttgag ttcccatttt catttcactg
     2521 acagactgcc atcctcaagg agtactcaga ctggccttct gttcatggct taggagagcc
     2581 ttggtgtgcc taactgattt ttcaaaattt agattttttt agcctaccag tgaaaaatga
     2641 ccccttcatc atcaggctct gcgttctacc aaattgtatg taaaaagaca catctgtttt
     2701 gtggtaggat tttttcacat ttttgggtac tatgagctgc attgatggaa gacagcaggc
     2761 aatatgtggt gacagttaac tcacagacat aaacatgcaa aatactttgc tgtctctggg
     2821 gatattgcca tttttcttac tgtgagcaac agcaccaaca ccaagttaac aggatgcaac
     2881 atgtgtatga ctctaaaagc cctaagtagt tggtaacttc ctgggccttc aatcatagca
     2941 atttgatgag ggaaggaagg ggagaggatt tgttgggtaa tcaagacatt cccgtatatg
     3001 tctgatttca tggaactgct ctattttgtt tgtgtgtatt gtatatgtat atgtgtatgt
     3061 gtgcgtgtat gtgtgtgtct gtagcttcag tttttaagtg taaggactaa ataaactaac
     3121 tgaaatttta ctttcagaag gaattctgaa gttttaaaaa agttaataat agctagaata
     3181 tcttgctgaa aatgtactat aaaattttgc ctgctgggcg tggtggctca cgcctgtaat
     3241 cccagcactt tgggaggcca aggtgggtgg atcatgaggt caggagttcg agatgaggct
     3301 ggccaatatg gtaaaaccct gtctctacta aaaatacaaa aaattggccg ggcatgccgg
     3361 cacgtgcctg tagtcccagc tactcaggag gctggggcag gagaatcgct tgaacccggg
     3421 aggcggaggt tgcagtgagc caagatcgcg ccactgcact ccagcgagac tctgtctcaa
     3481 aaaaaaaaaa aaaaattacc tcaatgctat tgaataattc tcccttctag taaaattcgt
     3541 atcatttgag aagaatcaag ctgaattaat ttttgtcttt aaggatgcat acttggggtt
     3601 cttttttttc cccatttaaa aaacaaaccc taaactatat tattggatgg cgttcagact
     3661 agaaatccca ctcgtccatt gactcattaa ttgattcaat aaatatttat tgagctcctt
     3721 tctctgtgcc aggtactctt ctgtgtgctg gttatacagt tgtgaccaat acaaagtacc
     3781 cgggtttttg tttttgtttt tgttttttga gatggagtct cactctgttg cccaggctgg
     3841 agtgcagagg catgatcttg gctcactgca acctctactt tctggttcaa gcaattctcc
     3901 tgcctcagcc tcacgaatag ctgggattac aggcacctac caccacgccc agccaatttt
     3961 tgtattttta gtagagacag ggttccgtca tgttgaccag gctggacttg aactcttgat
     4021 ctcaagtgat caacccgcct tggcctccca aagtgttggg attagaggtg tgagccattg
     4081 cacccagccc aaagtacctg tttttatgga gtttacattc caatggagaa gacagacaat
     4141 aacatatatc aaatgctata aagaaagggc agggaatagg gatacaatgt gttgaatttt
     4201 gtcaaatgct ttttttgtat cttttgagat tatcatatgg cttttgtcct tcattctgtt
     4261 aacatgatat atcacattta ctgatttgtg tatactgaat catctttgca tcccgggatg
     4321 aatcccactg ggacagaatg tggagagggt tgaaacttta gataagatgg tttgggaaag
     4381 cctgtttgaa gagatgacat atgcagaggc cccagtgaag taagcatatg agtcatataa
     4441 atatttgggg aaagagcatt ctggacaaag gtaaaaaaca agtgaaaagg ccctaaaatg
     4501 ttaacttact tggcatgttt gaggaataac aaagaggcca gtaaggttac agcatagtga
     4561 ttaagagaga agaatggtaa gaagtgacat aaggaagaaa gccaggtcct tatagcctgg
     4621 catggatatg taaatgggaa gcaattagat tgagaagagg agtgacataa tttgatttac
     4681 ctttatgaaa tatggagcta caatgtcaag gttagactga agaagattaa agaggaaagc
     4741 agagactggt taggttatta tagtgtccta ggtaacagtt ttggacaagt gtgataaatg
     4801 ttgaggtggg aggggttaga ggttggattc agactctgtt ttgtaagtag agaagataat
     4861 gtctgctgat agcttggata tgaggaggaa aaggagagga gtaaaggatg actcagattt
     4921 ttgacctgtc aattgggtga actctgagat taaattctgt tttggctatg ttaggttgga
     4981 aatgctgtgt aggcaattgg atatccaagt ctggacttca gagtacaatt tgggactaga
     5041 aaattaattt gggagtcatt agggaataac catgactttg gatgagatca cctagtacag
     5101 ctagagaaga gaaggtagca aaagacagag acctaaggta tgccagcatt gagaagtaga
     5161 ggagaagagg aaccagcaaa agactgagaa ggacccacca gtgacctaga agaaaaatca
     5221 ggaggctggt attctggaag ccatcagaag aaaatgtttc acaaaaggaa ggtagtattg
     5281 aatggtgtga aatgttacct atatacctgg aaaaaagcaa cttcagctgc tttttaagta
     5341 aatgtgatag tttgtactgc aaataacttt ccatattgct tttcagatca tgatattttg
     5401 gtccttaaga tcatgtagaa ctttccattg tgagaaggga gttgattatt ttatcattaa
     5461 agaaactttt ctaaacttaa atttatgaaa aataattttt cccttaggtt tgtctttttg
     5521 ttcaataatg attccctggg tatctttttt tgccccacaa ataaaatact tagacatacc
     5581 tgga
//
