LOCUS       NP_001373117             756 aa            linear   PRI 30-APR-2025
DEFINITION  centromere protein I isoform 1 [Homo sapiens].
ACCESSION   NP_001373117 XP_011529196
VERSION     NP_001373117.1
DBSOURCE    REFSEQ: accession NM_001386188.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 756)
  AUTHORS   Feng,Z., Cui,G., Tan,J., Liu,P., Chen,Y., Jiang,Z., Han,Y.,
            Zeng,S., Shen,H. and Cai,C.
  TITLE     Immune infiltration related CENPI associates with the malignant
            features and drug resistance of lung adenocarcinoma
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (3), 167017 (2024)
   PUBMED   38232915
  REMARK    GeneRIF: Immune infiltration related CENPI associates with the
            malignant features and drug resistance of lung adenocarcinoma.
REFERENCE   2  (residues 1 to 756)
  AUTHORS   Tian,T., Chen,L., Dou,Z., Yang,Z., Gao,X., Yuan,X., Wang,C.,
            Liu,R., Shen,Z., Gui,P., Teng,M., Meng,X., Hill,D.L., Li,L.,
            Zhang,X., Liu,X., Sun,L., Zang,J. and Yao,X.
  TITLE     Structural insights into human CCAN complex assembled onto DNA
  JOURNAL   Cell Discov 8 (1), 90 (2022)
   PUBMED   36085283
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 756)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (residues 1 to 756)
  AUTHORS   Wang,J., Liu,X., Chu,H.J., Li,N., Huang,L.Y. and Chen,J.
  TITLE     Centromere Protein I (CENP-I) Is Upregulated in Gastric Cancer,
            Predicts Poor Prognosis, and Promotes Tumor Cell Proliferation and
            Migration
  JOURNAL   Technol Cancer Res Treat 20, 15330338211045510 (2021)
   PUBMED   34617858
  REMARK    GeneRIF: Centromere Protein I (CENP-I) Is Upregulated in Gastric
            Cancer, Predicts Poor Prognosis, and Promotes Tumor Cell
            Proliferation and Migration.
REFERENCE   5  (residues 1 to 756)
  AUTHORS   Foltz,D.R., Jansen,L.E., Black,B.E., Bailey,A.O., Yates,J.R. 3rd
            and Cleveland,D.W.
  TITLE     The human CENP-A centromeric nucleosome-associated complex
  JOURNAL   Nat Cell Biol 8 (5), 458-469 (2006)
   PUBMED   16622419
REFERENCE   6  (residues 1 to 756)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   7  (residues 1 to 756)
  AUTHORS   Obuse,C., Yang,H., Nozaki,N., Goto,S., Okazaki,T. and Yoda,K.
  TITLE     Proteomics analysis of the centromere complex from HeLa interphase
            cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of
            the CEN-complex, while BMI-1 is transiently co-localized with the
            centromeric region in interphase
  JOURNAL   Genes Cells 9 (2), 105-120 (2004)
   PUBMED   15009096
REFERENCE   8  (residues 1 to 756)
  AUTHORS   Liu,S.T., Hittle,J.C., Jablonski,S.A., Campbell,M.S., Yoda,K. and
            Yen,T.J.
  TITLE     Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to
            kinetochores and is essential for mitosis
  JOURNAL   Nat Cell Biol 5 (4), 341-345 (2003)
   PUBMED   12640463
REFERENCE   9  (residues 1 to 756)
  AUTHORS   Roberts,R.G., Kendall,E., Vetrie,D. and Bobrow,M.
  TITLE     Sequence and chromosomal location of a human homologue of LRPR1, an
            FSH primary response gene
  JOURNAL   Genomics 37 (1), 122-124 (1996)
   PUBMED   8921378
REFERENCE   10 (residues 1 to 756)
  AUTHORS   Slegtenhorst-Eegdeman,K.E., Post,M., Baarends,W.M., Themmen,A.P.
            and Grootegoed,J.A.
  TITLE     Regulation of gene expression in Sertoli cells by
            follicle-stimulating hormone (FSH): cloning and characterization of
            LRPR1, a primary response gene encoding a leucine-rich protein
  JOURNAL   Mol Cell Endocrinol 108 (1-2), 115-124 (1995)
   PUBMED   7758824
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL109963.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced XP_011529196.1.
            
            Summary: This gene encodes a centromere protein that is a component
            of the CENPA-NAC (nucleosome-associated) complex. This complex is
            critical for accurate chromosome alignment and segregation and it
            ensures proper mitotic progression. This protein regulates the
            recruitment of kinetochore-associated proteins that are required to
            generate the spindle checkpoint signal. The product of this gene is
            involved in the response of gonadal tissues to follicle-stimulating
            hormone. Mutations in this gene may be involved in human X-linked
            disorders of gonadal development and gametogenesis. Alternate
            splicing results in multiple transcript variants. A pseudogene of
            this gene is found on chromosome 13. [provided by RefSeq, Jan
            2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.521159.1,
                                           SRR14038196.3262265.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682095.1/ ENSP00000507927.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..756
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     Protein         1..756
                     /product="centromere protein I isoform 1"
                     /note="follicle-stimulating hormone primary response
                     protein; leucine-rich primary response protein 1; FSH
                     primary response 1; interphase centromere complex protein
                     19"
                     /calculated_mol_wt=86590
     Region          1..60
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92674.2)"
     Region          9..521
                     /region_name="CENP-I"
                     /note="Mis6; pfam07778"
                     /db_xref="CDD:429654"
     Site            order(141,145,149,179..180,183,186..187,190,193..196,
                     215..217,221,224,227..232,254)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:439352"
     CDS             1..756
                     /gene="CENPI"
                     /gene_synonym="CENP-I; FSHPRH1; LRPR1"
                     /coded_by="NM_001386188.2:155..2425"
                     /note="isoform 1 is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS14479.1"
                     /db_xref="GeneID:2491"
                     /db_xref="HGNC:HGNC:3968"
                     /db_xref="MIM:300065"
ORIGIN      
        1 mspqkrvknv qaqnrtsqgs ssfqttlsaw kvkqdpsnsk niskhgqnnp vgdyehaddq
       61 aeedalqmav gyfekgpika sqnkdktlek hlktvenvaw knglaseeid illnialsgk
      121 fgnavntril kcmipatvis edsvvkavsw lcvgkcsgst kvlfyrwlva mfdfidrkeq
      181 inllygfffa slqddalcpy vchllylltk kenvkpfrvr klldlqakmg mqphlqalls
      241 lykffapali svslpvrkki yfknsenlwk tallavkqrn rgpspeplkl mlgpanvrpl
      301 krkwnslsvi pvlnsssytk ecgkkemsls dclnrsgsfp leqlqsfpql lqnihclelp
      361 sqmgsvlnns lllhyincvr depvllrfyy wlsqtlqeec iwykvnnyeh gkeftnfldt
      421 iiraecflqe gfysceafly kslplwdglc crsqflqlvs wipfssfsev kpllfdhlaq
      481 lfftstiyfk csvlqslkel lqnwllwlsm dihmkpvtns plettlggsm nsvsklihyv
      541 gwlsttamrl esnntfllhf ildfyekvcd iyinynlplv vlfppgifys allsldtsil
      601 nqlcfimhry rknltaakkn elvqktksef nfssktyqef nhyltsmvgc lwtskpfgkg
      661 iyidpeilek tgvaeyknsl nvvhhpsfls yavsfllqes peertvnvss irgkkwswyl
      721 dylfsqglqg lklfirssvh hssipraegi ncnnqy
//
