LOCUS       XM_011531545            8382 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens centromere protein E (CENPE), transcript
            variant X2, mRNA.
ACCESSION   XM_011531545
VERSION     XM_011531545.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000004.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011531545.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8382
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
     gene            1..8382
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; MCPH13; PPP1R61"
                     /note="centromere protein E; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     mRNA, 40 ESTs, 2747 long SRA reads, 1 Protein, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 10 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:1062"
                     /db_xref="HGNC:HGNC:1856"
                     /db_xref="MIM:117143"
     CDS             25..7971
                     /gene="CENPE"
                     /gene_synonym="CENP-E; KIF10; MCPH13; PPP1R61"
                     /codon_start=1
                     /product="centromere-associated protein E isoform X2"
                     /protein_id="XP_011529847.1"
                     /db_xref="GeneID:1062"
                     /db_xref="HGNC:HGNC:1856"
                     /db_xref="MIM:117143"
                     /translation="MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGS
                     KSFNFDRVFHGNETTKNVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDH
                     LGVIPRAIHDIFQKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNR
                     NVYVADLTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGE
                     PSNCEGSVKVSHLNLVDLAGSERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQ
                     VGGFINYRDSKLTRILQNSLGGNAKTRIICTITPVSFDETLTALQFASTAKYMKNTPY
                     VNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNE
                     KIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKT
                     HKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYD
                     NLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHA
                     EVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMK
                     QTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKM
                     QVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALR
                     EEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEI
                     GKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQK
                     FDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLIT
                     EKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALES
                     LKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLT
                     ADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELR
                     LLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNV
                     QEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKV
                     LKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKT
                     AQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS
                     TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAK
                     IQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDE
                     MKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETIN
                     ELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQ
                     FKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLK
                     ENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENI
                     RLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLKIQEELRIA
                     HMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKK
                     DVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLR
                     RVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQ
                     ISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNL
                     SMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARD
                     RQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKE
                     IEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKE
                     EQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEIL
                     KDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNN
                     FFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQV
                     NPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDI
                     IAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNA
                     KEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGG
                     SGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERT
                     LKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPKSCFFDSRS
                     KSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHASSGKDVPECKTQ"
ORIGIN      
        1 ctgggaccag ttcagcctga taggatggcg gaggaaggag ccgtggccgt ctgcgtgcga
       61 gtgcggccgc tgaacagcag agaagaatca cttggagaaa ctgcccaagt ttactggaaa
      121 actgacaata atgtcattta tcaagttgat ggaagtaaat ccttcaattt tgatcgtgtc
      181 tttcatggta atgaaactac caaaaatgtg tatgaagaaa tagcagcacc aatcatcgat
      241 tctgccatac aaggctacaa tggtactata tttgcctatg gacagactgc ttcaggaaaa
      301 acatatacca tgatgggttc agaagatcat ttgggagtta tacccagggc aattcatgac
      361 attttccaaa aaattaagaa gtttcctgat agggaatttc tcttacgtgt atcttacatg
      421 gaaatataca atgaaaccat tacagattta ctctgtggca ctcaaaaaat gaaaccttta
      481 attattcgag aagatgtcaa taggaatgtg tatgttgctg atctcacaga agaagttgta
      541 tatacatcag aaatggcttt gaaatggatt acaaagggag aaaagagcag gcattatgga
      601 gaaacaaaaa tgaatcaaag aagcagtcgt tctcatacca tctttaggat gattttggaa
      661 agcagagaga agggtgaacc ttctaattgt gaaggatctg ttaaggtatc ccatttgaat
      721 ttggttgatc ttgcaggcag tgaaagagct gctcaaacag gcgctgcagg tgtgcggctc
      781 aaggaaggct gtaatataaa tcgaagctta tttattttgg gacaagtgat caagaaactt
      841 agtgatggac aagttggtgg tttcataaat tatcgagata gcaagttaac acgaattctc
      901 cagaattcct tgggaggaaa tgcaaagaca cgtattatct gcacaattac tccagtatct
      961 tttgatgaaa cacttactgc tctccagttt gccagtactg ctaaatatat gaagaatact
     1021 ccttatgtta atgaggtatc aactgatgaa gctctcctga aaaggtatag aaaagaaata
     1081 atggatctta aaaaacaatt agaggaggtt tctttagaga cgcgggctca ggcaatggaa
     1141 aaagaccaat tggcccaact tttggaagaa aaagatttgc ttcagaaagt acagaatgag
     1201 aaaattgaaa acttaacacg gatgctggtg acctcttctt ccctcacgtt gcaacaggaa
     1261 ttaaaggcta aaagaaaacg aagagttact tggtgccttg gcaaaattaa caaaatgaag
     1321 aactcaaact atgcagatca atttaatata ccaacaaata taacaacaaa aacacataag
     1381 ctttctataa atttattacg agaaattgat gaatctgtct gttcagagtc tgatgttttc
     1441 agtaacactc ttgatacatt aagtgagata gaatggaatc cagcaacaaa gctactaaat
     1501 caggagaata tagaaagtga gttgaactca cttcgtgctg actatgataa tctggtatta
     1561 gactatgaac aactacgaac agaaaaagaa gaaatggaat tgaaattaaa agaaaagaat
     1621 gatttggatg aatttgaggc tctagaaaga aaaactaaaa aagatcaaga gatgcaacta
     1681 attcatgaaa tttcgaactt aaagaattta gttaagcatg cagaagtata taatcaagat
     1741 cttgagaatg aactcagttc aaaagtagag ctgcttagag aaaaggaaga ccagattaag
     1801 aagctacagg aatacataga ctctcaaaag ctagaaaata taaaaatgga cttgtcatac
     1861 tcattggaaa gcattgaaga cccaaaacaa atgaagcaga ctctgtttga tgctgaaact
     1921 gtagcccttg atgccaagag agaatcagcc tttcttagaa gtgaaaatct ggagctgaag
     1981 gagaaaatga aagaacttgc aactacatac aagcaaatgg aaaatgatat tcagttatat
     2041 caaagccagt tggaggcaaa aaagaaaatg caagttgatc tggagaaaga attacaatct
     2101 gcttttaatg agataacaaa actcacctcc cttatagatg gcaaagttcc aaaagatttg
     2161 ctctgtaatt tggaattgga aggaaagatt actgatcttc agaaagaact aaataaagaa
     2221 gttgaagaaa atgaagcttt gcgggaagaa gtcattttgc tttcagaatt gaaatcttta
     2281 ccttctgaag tagaaaggct gaggaaagag atacaagaca aatctgaaga gctccatata
     2341 ataacatcag aaaaagataa attgttttct gaagtagttc ataaggagag tagagttcaa
     2401 ggtttacttg aagaaattgg gaaaacaaaa gatgacctag caactacaca gtcgaattat
     2461 aaaagcactg atcaagaatt ccaaaatttc aaaacccttc atatggactt tgagcaaaag
     2521 tataagatgg tccttgagga gaatgagaga atgaatcagg aaatagttaa tctctctaaa
     2581 gaagcccaaa aatttgattc gagtttgggt gctttgaaga ccgagctttc ttacaagacc
     2641 caagaacttc aggagaaaac acgtgaggtt caagaaagac taaatgagat ggaacagctg
     2701 aaggaacaat tagaaaatag agattctacg ctgcaaactg tagaaaggga gaaaacactg
     2761 attactgaga aactgcagca aactttagaa gaagtaaaaa ctttaactca agaaaaagat
     2821 gatctaaaac aactccaaga aagcttgcaa attgagaggg accaactcaa aagtgatatt
     2881 cacgatactg ttaacatgaa tatagatact caagaacaat tacgaaatgc tcttgagtct
     2941 ctgaaacaac atcaagaaac aattaataca ctaaaatcga aaatttctga ggaagtttcc
     3001 aggaatttgc atatggagga aaatacagga gaaactaaag atgaatttca gcaaaagatg
     3061 gttggcatag ataaaaaaca ggatttggaa gctaaaaata cccaaacact aactgcagat
     3121 gttaaggata atgagataat tgagcaacaa aggaagatat tttctttaat acaggagaaa
     3181 aatgaactcc aacaaatgtt agagagtgtt atagcagaaa aggaacaatt gaagactgac
     3241 ctaaaggaaa atattgaaat gaccattgaa aaccaggaag aattaagact tcttggggat
     3301 gaacttaaaa agcaacaaga gatagttgca caagaaaaga accatgccat aaagaaagaa
     3361 ggagagcttt ctaggacctg tgacagactg gcagaagttg aagaaaaact aaaggaaaag
     3421 agccagcaac tccaagaaaa acagcaacaa cttcttaatg tacaagaaga gatgagtgag
     3481 atgcagaaaa agattaatga aatagagaat ttaaagaatg aattaaagaa caaagaattg
     3541 acattggaac atatggaaac agagaggctt gagttggctc agaaacttaa tgaaaattat
     3601 gaggaagtga aatctataac caaagaaaga aaagttctaa aggaattaca gaagtcattt
     3661 gaaacagaga gagaccacct tagaggatat ataagagaaa ttgaagctac aggcctacaa
     3721 accaaagaag aactaaaaat tgctcatatt cacctaaaag aacaccaaga aactattgat
     3781 gaactaagaa gaagcgtatc tgagaagaca gctcaaataa taaatactca ggacttagaa
     3841 aaatcccata ccaaattaca agaagagatc ccagtgcttc atgaggaaca agagttactg
     3901 cctaatgtga aagaagtcag tgagactcag gaaacaatga atgaactgga gttattaaca
     3961 gaacagtcca caaccaagga ctcaacaaca ctggcaagaa tagaaatgga aaggctcagg
     4021 ttgaatgaaa aatttcaaga aagtcaggaa gagataaaat ctctaaccaa ggaaagagac
     4081 aaccttaaaa cgataaaaga agcccttgaa gttaaacatg accagctgaa agaacatatt
     4141 agagaaactt tggctaaaat ccaggagtct caaagcaaac aagaacagtc cttaaatatg
     4201 aaagaaaaag acaatgaaac taccaaaatc gtgagtgaga tggagcaatt caaacccaaa
     4261 gattcagcac tactaaggat agaaatagaa atgctcggat tgtccaaaag acttcaagaa
     4321 agtcatgatg aaatgaaatc tgtagctaag gagaaagatg acctacagag gctgcaagaa
     4381 gttcttcaat ctgaaagtga ccagctcaaa gaaaacataa aagaaattgt agctaaacac
     4441 ctggaaactg aagaggaact taaagttgct cattgttgcc tgaaagaaca agaggaaact
     4501 attaatgagt taagagtgaa tctttcagag aaggaaactg aaatatcaac cattcaaaag
     4561 cagttagaag caatcaatga taaattacag aacaagatcc aagagattta tgagaaagag
     4621 gaacaattta atataaaaca aattagtgag gttcaggaaa aagtgaatga actgaaacaa
     4681 ttcaaggagc atcgcaaagc caaggattca gcactacaaa gtatagaaag taagatgctc
     4741 gagttgacca acagacttca agaaagtcaa gaagaaatac aaattatgat taaggaaaaa
     4801 gaggaaatga aaagagtaca ggaggccctt cagatagaga gagaccaact gaaagaaaac
     4861 actaaagaaa ttgtagctaa aatgaaagaa tctcaagaaa aagaatatca gtttcttaag
     4921 atgacagctg tcaatgagac tcaggagaaa atgtgtgaaa tagaacactt gaaggagcaa
     4981 tttgagaccc agaagttaaa cctggaaaac atagaaacgg agaatataag gttgactcag
     5041 atactacatg aaaaccttga agaaatgaga tctgtaacaa aagaaagaga tgaccttagg
     5101 agtgtggagg agactctcaa agtagagaga gaccagctca aggaaaacct tagagaaact
     5161 ataactagag atctgaaaat acaagaggaa ctaagaattg ctcacatgca tctgaaagag
     5221 cagcaggaaa ctattgacaa actcagagga attgtttctg agaagacaga taaactatca
     5281 aatatgcaaa aagatttaga aaattcaaat gctaaattac aagaaaagat tcaagaactt
     5341 aaggcaaatg aacatcaact tattacgtta aaaaaagatg tcaatgagac acagaaaaaa
     5401 gtgtctgaaa tggagcaact aaagaaacaa ataaaagacc aaagcttaac tctgagtaaa
     5461 ttagaaatag agaatttaaa tttggctcag aaacttcatg aaaaccttga agaaatgaaa
     5521 tctgtaatga aagaaagaga taatctaaga agagtagagg agacactcaa actggagaga
     5581 gaccaactca aggaaagcct gcaagaaacc aaagctagag atctggaaat acaacaggaa
     5641 ctaaaaactg ctcgtatgct atcaaaagaa cacaaagaaa ctgttgataa acttagagaa
     5701 aaaatttcag aaaagacaat tcaaatttca gacattcaaa aggatttaga taaatcaaaa
     5761 gatgaattac agaaaaagat ccaagaactt cagaaaaaag aacttcaact gcttagagtg
     5821 aaagaagatg tcaatatgag tcataaaaaa attaatgaaa tggaacagtt gaagaagcaa
     5881 tttgaggccc aaaacttatc tatgcaaagt gtgagaatgg ataacttcca gttgactaag
     5941 aaacttcatg aaagccttga agaaataaga attgtagcta aagaaagaga tgagctaagg
     6001 aggataaaag aatctctcaa aatggaaagg gaccaattca tagcaacctt aagggaaatg
     6061 atagctagag accgacagaa ccaccaagta aaacctgaaa aaaggttact aagtgatgga
     6121 caacagcacc ttacggaaag cctgagagaa aagtgctcta gaataaaaga gcttttgaag
     6181 agatactcag agatggatga tcattatgag tgcttgaata gattgtctct tgacttggag
     6241 aaggaaattg aattccaaaa agagctttca atgagagtta aagcaaacct ctcacttccc
     6301 tatttacaaa ccaaacacat tgaaaaactt tttactgcaa accagagatg ctccatggaa
     6361 ttccacagaa tcatgaagaa actgaagtat gtgttaagct atgttacaaa aataaaagaa
     6421 gaacaacatg aatccatcaa taaatttgaa atggatttta ttgatgaagt ggaaaagcaa
     6481 aaggaattgc taattaaaat acagcacctt caacaagatt gtgatgtacc atccagagaa
     6541 ttaagggatc tcaaattgaa ccagaatatg gatctacata ttgaggaaat tctcaaagat
     6601 ttctcagaaa gtgagttccc tagcataaag actgaatttc aacaagtact aagtaatagg
     6661 aaagaaatga cacagttttt ggaagagtgg ttaaatactc gttttgatat agaaaagctt
     6721 aaaaatggca tccagaaaga aaatgatagg atttgtcaag tgaataactt ctttaataac
     6781 agaataattg ccataatgaa tgaatcaaca gagtttgagg aaagaagtgc taccatatcc
     6841 aaagagtggg aacaggacct gaaatcactg aaagagaaaa atgaaaaact atttaaaaac
     6901 taccaaacat tgaagacttc cttggcatct ggtgcccagg ttaatcctac cacacaagac
     6961 aataagaatc ctcatgttac atcaagagct acacagttaa ccacagagaa aattcgagag
     7021 ctggaaaatt cactgcatga agctaaagaa agtgctatgc ataaggaaag caagattata
     7081 aagatgcaga aagaacttga ggtgactaat gacataatag caaaacttca agccaaagtt
     7141 catgaatcaa ataaatgcct tgaaaaaaca aaagagacaa ttcaagtact tcaggacaaa
     7201 gttgctttag gagctaagcc atataaagaa gaaattgaag atctcaaaat gaagcttgtg
     7261 aaaatagacc tagagaaaat gaaaaatgcc aaagaatttg aaaaggaaat cagtgctaca
     7321 aaagccactg tagaatatca aaaggaagtt ataaggctat tgagagaaaa tctcagaaga
     7381 agtcaacagg cccaagatac ctcagtgata tcagaacata ctgatcctca gccttcaaat
     7441 aaacccttaa cttgtggagg tggcagcggc attgtacaaa acacaaaagc tcttattttg
     7501 aaaagtgaac atataaggct agaaaaagaa atttctaagt taaagcagca aaatgaacag
     7561 ctaataaaac aaaagaatga attgttaagc aataatcagc atctttccaa tgaggtcaaa
     7621 acttggaagg aaagaaccct taaaagagag gctcacaaac aagtaacttg tgagaattct
     7681 ccaaagtctc ctaaagtgac tggaacagct tctaaaaaga aacaaattac accctctcaa
     7741 tgcaaggaac ggaatttaca agatcctgtg ccaaaggaat caccaaaatc ttgttttttt
     7801 gatagccgat caaagtcttt accatcacct catccagttc gctattttga taactcaagt
     7861 ttaggccttt gtccagaggt gcaaaatgca ggagcagaga gtgtggattc tcagccaggt
     7921 ccttggcacg cctcctcagg caaggatgtg cctgagtgca aaactcagta gactcctctt
     7981 tgtcacttct ctggagatcc agcattcctt atttggaaat gactttgttt atgtgtctat
     8041 ccctggtaat gatgttgtag tgcagcttaa tttcaattca gtctttactt tgccactaga
     8101 gttgaaagat aagggaacag gaaatgaatg cattgtggta atttagaatg gtgatagcaa
     8161 taccttcttc ttgcatatgg taatactttt aaaagttgaa ttgttttatt tatttgtata
     8221 ttttgtaaag aataaagtta ttgaaagaaa tgtaaagtta tctacatgac ttagcatatt
     8281 ccaaagcata atacatacat taatataaaa catcatttta ttaacaaaat tgtaaatgtt
     8341 tttaatacct tacacattca ataaatgttt agtagttctg aa
//
