LOCUS       NM_001812               6823 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens centromere protein C (CENPC), transcript variant 1,
            mRNA.
ACCESSION   NM_001812
VERSION     NM_001812.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6823)
  AUTHORS   Tian,T., Chen,L., Dou,Z., Yang,Z., Gao,X., Yuan,X., Wang,C.,
            Liu,R., Shen,Z., Gui,P., Teng,M., Meng,X., Hill,D.L., Li,L.,
            Zhang,X., Liu,X., Sun,L., Zang,J. and Yao,X.
  TITLE     Structural insights into human CCAN complex assembled onto DNA
  JOURNAL   Cell Discov 8 (1), 90 (2022)
   PUBMED   36085283
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6823)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6823)
  AUTHORS   Nagpal,H. and Fierz,B.
  TITLE     The Elusive Structure of Centro-Chromatin: Molecular Order or
            Dynamic Heterogenetity?
  JOURNAL   J Mol Biol 433 (6), 166676 (2021)
   PUBMED   33065112
  REMARK    GeneRIF: The Elusive Structure of Centro-Chromatin: Molecular Order
            or Dynamic Heterogenetity?
            Review article
REFERENCE   4  (bases 1 to 6823)
  AUTHORS   Hoffmann,S., Izquierdo,H.M., Gamba,R., Chardon,F., Dumont,M.,
            Keizer,V., Herve,S., McNulty,S.M., Sullivan,B.A., Manel,N. and
            Fachinetti,D.
  TITLE     A genetic memory initiates the epigenetic loop necessary to
            preserve centromere position
  JOURNAL   EMBO J 39 (20), e105505 (2020)
   PUBMED   32945564
  REMARK    GeneRIF: A genetic memory initiates the epigenetic loop necessary
            to preserve centromere position.
REFERENCE   5  (bases 1 to 6823)
  AUTHORS   Watanabe,R., Hara,M., Okumura,E.I., Herve,S., Fachinetti,D.,
            Ariyoshi,M. and Fukagawa,T.
  TITLE     CDK1-mediated CENP-C phosphorylation modulates CENP-A binding and
            mitotic kinetochore localization
  JOURNAL   J Cell Biol 218 (12), 4042-4062 (2019)
   PUBMED   31676716
  REMARK    GeneRIF: CDK1-mediated CENP-C phosphorylation modulates CENP-A
            binding and mitotic kinetochore localization
REFERENCE   6  (bases 1 to 6823)
  AUTHORS   Xie,Y., Ni,Z.M., Gu,J.R., Wong,P., Wu,W.Q. and Xu,G.W.
  TITLE     Human chromosome pellicle antibody recognizing centromere protein-C
            (CENP-C), the main component of the kinetochore
  JOURNAL   Cell Res 7 (1), 13-19 (1997)
   PUBMED   9261558
REFERENCE   7  (bases 1 to 6823)
  AUTHORS   Pluta,A.F. and Earnshaw,W.C.
  TITLE     Specific interaction between human kinetochore protein CENP-C and a
            nucleolar transcriptional regulator
  JOURNAL   J Biol Chem 271 (31), 18767-18774 (1996)
   PUBMED   8702533
REFERENCE   8  (bases 1 to 6823)
  AUTHORS   Xie,Y. and Heng,H.H.
  TITLE     FISH mapping of centromere protein C (CENPC) on human chromosome
            4q31-->q21
  JOURNAL   Cytogenet Cell Genet 74 (3), 192-193 (1996)
   PUBMED   8941372
REFERENCE   9  (bases 1 to 6823)
  AUTHORS   McKay,S., Thomson,E. and Cooke,H.
  TITLE     Sequence homologies and linkage group conservation of the human and
            mouse Cenpc genes
  JOURNAL   Genomics 22 (1), 36-40 (1994)
   PUBMED   7959789
REFERENCE   10 (bases 1 to 6823)
  AUTHORS   Saitoh,H., Tomkiel,J., Cooke,C.A., Ratrie,H. 3rd, Maurer,M.,
            Rothfield,N.F. and Earnshaw,W.C.
  TITLE     CENP-C, an autoantigen in scleroderma, is a component of the human
            inner kinetochore plate
  JOURNAL   Cell 70 (1), 115-125 (1992)
   PUBMED   1339310
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC109356.3 and AC104806.3.
            
            On Nov 23, 2018 this sequence version replaced NM_001812.3.
            
            Summary: Centromere protein C 1 is a centromere autoantigen and a
            component of the inner kinetochore plate. The protein is required
            for maintaining proper kinetochore size and a timely transition to
            anaphase. A putative pseudogene exists on chromosome 12. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.129656.1,
                                           SRR1803612.59143.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273853.11/ ENSP00000273853.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AC109356.3         7606-7771           c
            167-213             AC109356.3         6417-6463           c
            214-284             AC109356.3         3248-3318           c
            285-379             AC109356.3         2108-2202           c
            380-479             AC104806.3         138860-138959       c
            480-765             AC104806.3         127262-127547       c
            766-978             AC104806.3         126201-126413       c
            979-1592            AC104806.3         122119-122732       c
            1593-1760           AC104806.3         120447-120614       c
            1761-2052           AC104806.3         116859-117150       c
            2053-2199           AC104806.3         114833-114979       c
            2200-2279           AC104806.3         113250-113329       c
            2280-2333           AC104806.3         103204-103257       c
            2334-2438           AC104806.3         101929-102033       c
            2439-2567           AC104806.3         100914-101042       c
            2568-2663           AC104806.3         100225-100320       c
            2664-2818           AC104806.3         98012-98166         c
            2819-2909           AC104806.3         82933-83023         c
            2910-6823           AC104806.3         76807-80720         c
FEATURES             Location/Qualifiers
     source          1..6823
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.2"
     gene            1..6823
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /note="centromere protein C"
                     /db_xref="GeneID:1060"
                     /db_xref="HGNC:HGNC:1854"
                     /db_xref="MIM:117141"
     exon            1..166
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..2980
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     centromere autoantigen C1; CENP-C 1; interphase centromere
                     complex protein 7; centromere protein C 1"
                     /codon_start=1
                     /product="centromere protein C isoform 1"
                     /protein_id="NP_001803.2"
                     /db_xref="CCDS:CCDS47063.1"
                     /db_xref="GeneID:1060"
                     /db_xref="HGNC:HGNC:1854"
                     /db_xref="MIM:117141"
                     /translation="MAASGLDHLKNGYRRRFCRPSRARDINTEQGQNVLEILQDCFEE
                     KSLANDFSTNSTKSVPNSTRKIKDTCIQSPSKECQKSHPKSVPVSSKKKEASLQFVVE
                     PSEATNRSVQAHEVHQKILATDVSSKNTPDSKKISSRNINDHHSEADEEFYLSVGSPS
                     VLLDAKTSVSQNVIPSSAQKRETYTFENSVNMLPSSTEVSVKTKKRLNFDDKVMLKKI
                     EIDNKVSDEEDKTSEGQERKPSGSSQNRIRDSEYEIQRQAKKSFSTLFLETVKRKSES
                     SPIVRHAATAPPHSCPPDDTKLIEDEFIIDESDQSFASRSWITIPRKAGSLKQRTISP
                     AESTALLQGRKSREKHHNILPKTLANDKHSHKPHPVETSQPSDKTVLDTSYALIGETV
                     NNYRSTKYEMYSKNAEKPSRSKRTIKQKQRRKFMAKPAEEQLDVGQSKDENIHTSHIT
                     QDEFQRNSDRNMEEHEEMGNDCVSKKQMPPVGSKKSSTRKDKEESKKKRFSSESKNKL
                     VPEEVTSTVTKSRRISRRPSDWWVVKSEESPVYSNSSVRNELPMHHNSSRKSTKKTNQ
                     SSKNIRKKTIPLKRQKTATKGNQRVQKFLNAEGSGGIVGHDEISRCSLSEPLESDEAD
                     LAKKKNLDCSRSTRSSKNEDNIMTAQNVPLKPQTSGYTCNIPTESNLDSGEHKTSVLE
                     ESGPSRLNNNYLMSGKNDVDDEEVHGSSDDSKQSKVIPKNRIHHKLVLPSNTPNVRRT
                     KRTRLKPLEYWRGERIDYQGRPSGGFVISGVLSPDTISSKRKAKENIGKVNKKSNKKR
                     ICLDNDERKTNLMVNLGIPLGDPLQPTRVKDPETREIILMDLVRPQDTYQFFVKHGEL
                     KVYKTLDTPFFSTGKLILGPQEEKGKQHVGQDILVFYVNFGDLLCTLHETPYILSTGD
                     SFYVPSGNYYNIKNLRNEESVLLFTQIKR"
     exon            167..213
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            214..284
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            285..379
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            380..479
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            480..765
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            766..978
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1592
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1760
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..2052
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2199
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2279
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2333
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2438
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2567
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2663
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..2818
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2819..2909
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..6823
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3082..3087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /note="hexamer: AATAAA"
     polyA_site      3103
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /note="major polyA site"
     regulatory      3287..3292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /note="hexamer: ATTAAA"
     polyA_site      3308
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /note="major polyA site"
     regulatory      6796..6801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /note="hexamer: AATAAA"
     polyA_site      6823
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
ORIGIN      
        1 agctctcgcg gcagtcgcct gagacttaag gttattgctt ggccgcggcc tggtattccg
       61 gcgattcgtt tcttgctcgg cttcctggag ctgtggtccg tgtgggcttc cacctcagac
      121 agttgcgctg gctcagcggg gccggaacat ggctgcgtcc ggtctggatc atctcaaaaa
      181 tggctacaga agaagatttt gtcgaccttc cagggcacgt gacattaaca cagagcaagg
      241 ccagaatgtt ctggaaatct tacaagactg ttttgaagaa aaaagtcttg ccaatgattt
      301 tagtacaaat tctacaaaat cagtgcctaa ttcaacacgc aaaataaaag acacttgtat
      361 tcagtcacca agcaaagagt gccagaaatc acatccaaag tcagttccag tttcttcaaa
      421 gaagaaagaa gcctctctac agtttgttgt agaaccaagt gaagccacaa acagatcagt
      481 tcaggcccat gaagttcatc agaaaattct ggcaactgat gttagttcca aaaatacacc
      541 tgactcgaaa aaaatatcaa gtagaaacat aaatgatcat cacagtgaag ctgatgaaga
      601 attttactta tccgttggct caccttctgt tcttttggat gcaaaaacat ctgtatcaca
      661 aaatgttatt ccatctagtg cccaaaagag agagacttac acttttgaaa attcagtaaa
      721 tatgctgcct tcaagtacag aggtttcagt taaaaccaaa aaaaggttaa actttgatga
      781 taaagttatg ttaaagaaaa tagaaataga taataaagta tcagatgaag aggataaaac
      841 atcggaagga caagaaagaa aaccatcagg atcatctcag aatagaatac gagattcaga
      901 atatgaaatt caacgacaag ctaaaaaaag tttttcaaca ttgtttttag aaacagtaaa
      961 acgaaaaagt gaatccagtc ccattgttag gcatgcggca actgctccac ctcattcgtg
     1021 tcctcccgat gatacgaagt tgatagagga tgaatttata attgatgagt cggatcaaag
     1081 ttttgccagt agatcttgga ttacaatacc aagaaaggca gggtctctga aacaacgcac
     1141 aatatccccg gctgagagca ctgcactcct tcaaggtaga aagtcaagag aaaagcatca
     1201 taatatatta cctaagactt tggcaaatga caaacattcc cataaacctc acccagtaga
     1261 gacatctcag ccctctgata aaacagtact ggatacaagt tatgctttga taggtgaaac
     1321 agtaaataat tatagatcta caaaatatga aatgtattcc aagaatgcag aaaaaccatc
     1381 tagaagcaaa aggactataa aacaaaaaca gagaagaaaa ttcatggcta aaccagctga
     1441 agaacagctt gatgtgggac agtctaaaga tgaaaacata catacatcac atattaccca
     1501 agacgaattt caaagaaatt cagacagaaa tatggaagag catgaagaga tgggaaatga
     1561 ttgtgtttcc aaaaaacaga tgccacctgt gggaagcaag aaaagtagca ctagaaaaga
     1621 taaggaagaa tctaaaaaga agcgcttttc cagtgagtcc aagaacaaac ttgtacctga
     1681 agaagtgact tcaactgtca cgaaaagtcg aagaatttcc aggcgtccat ctgattggtg
     1741 ggtggtaaaa tcagaggaga gtcctgttta tagcaattct tcagtaagaa atgaattacc
     1801 aatgcatcac aatagtagcc gaaaatctac taagaaaaca aatcagtcat ctaagaatat
     1861 taggaaaaaa actattccac ttaaaaggca gaagacagca actaaaggca accaaagagt
     1921 acagaagttt ttaaatgctg aaggttctgg aggtatcgtt ggtcatgatg aaatttccag
     1981 atgttcgctg agtgagccat tggaaagtga tgaggcagac ttggctaaga agaaaaatct
     2041 tgattgttct agatctacaa gaagctcaaa gaatgaagat aacattatga ctgcacagaa
     2101 tgttccccta aagcctcaga ccagtggata tacatgtaat ataccaacag agtcaaactt
     2161 ggattctgga gagcataaga cttcagtttt agaggaaagt ggaccttcca ggctcaataa
     2221 taattattta atgtctggaa agaatgatgt ggatgatgag gaagttcatg gaagttcaga
     2281 tgactcaaaa caatctaaag tgataccaaa gaacagaatc catcacaaac tagtattgcc
     2341 ctccaacaca ccaaatgttc gcaggaccaa gagaacacgt ttgaaacctt tggagtactg
     2401 gcgaggagag cgaatagatt atcaaggaag gccatcagga ggattcgtga ttagtggagt
     2461 actatctcca gacacaatat cgtctaaaag gaaggcaaaa gaaaatattg gaaaagtcaa
     2521 caaaaaatct aataagaaaa ggatctgtct tgataacgat gaaagaaaga ctaacttaat
     2581 ggtaaatcta ggtatacctc ttggagatcc tttgcagcca acgagggtaa aggacccaga
     2641 aacaagagag attattctca tggatcttgt aaggccacaa gatacatatc aattttttgt
     2701 taagcatggt gagttgaagg tatacaagac attggataca cccttttttt ctactgggaa
     2761 attgatatta ggaccacaag aagaaaaggg aaagcagcat gttggccagg atatattggt
     2821 tttttatgtt aactttggtg accttttgtg tactttacat gaaacacctt atatattaag
     2881 tactggggat tcgttctatg ttccttcagg taactattat aacatcaaaa atctccggaa
     2941 tgaggaaagt gttcttcttt ttactcagat aaaaagatga aagatcaacc aaccttaaat
     3001 atatgtatgt atatatgtat atgtgaaaaa cagtttgtat agttggaata tttgtctttg
     3061 taattacttg tgatgtttta aaataaaaat tttattcagt tttctgtaga cttgtatttg
     3121 ataaacattt ctaactcaca tgttttttct gatttttcag tgactgtaca taatagcttg
     3181 tagcgatgtc catatttatg atattatttt tataatttga caagaatatg aaaatgaaat
     3241 atagaacatt tctgtgtcaa aagagacctg attaatatgt ctactcatta aaaaacatct
     3301 tttccaaata ctaattttaa atcatttatt attaaataat ccaatgggag agaactgtgg
     3361 taaaaggcat gtttgtatta atttcctaga actgctgtaa caaaatacca caaaatgagt
     3421 gacttaaagc aacagaaatt tattatctca gttctagagg ctagaagtct gaaatcaagg
     3481 tgttgtcaag gccgtgatgt ctttgaaaac ctgtaaggga gagaatcctt ccttattcct
     3541 aacttctggt ggtttactgg caatttctgg cattccttgg cttgcaccgg tagcatttca
     3601 atctacttgc attatcacat ggtattctca ccttgtgtgt ctgtgttggc atgacatcta
     3661 tttagtatat tacatgtaaa tgtttttcca ttatgctttt tggttcatat tttctgttgg
     3721 aggcagtgtc cttcgccatt gctttctgta tgtggcctca actttccctt tttaatatca
     3781 atcaatacat ctaagctaaa aattctaatc aaggtttttg gtatggttag catataattc
     3841 tcattaactc tgaagaaatt gatgttttac ggtaaaaata tttttaggcc aactcccttt
     3901 tcaggtctta tttaaccatt aaatacacac atttaaagca actctggtgt aggacttagg
     3961 aagaatgaag tgtgatggct ctttttttat actttataat tttctattgt gatttctctt
     4021 ttattgagtc atttttaatt ttttttttac ttttatttct ttgaatatat ttgttatgaa
     4081 gtcttattga aggcttgact aatcaagtat ctgggcccat acagatttag ttttcactga
     4141 atgctttttt tcctttagta tatttcactt tcatatgttt ttacatgtct aataattttt
     4201 ggttgacagc tggacatttt aggtagcata ttgtagcaac tcaattttgt tttatatcta
     4261 agggatttgt attgttttaa atttagcatt ttgactggac tcaaattgtg gaatctatct
     4321 tatatatgat gtgaagttat tgctgtctgt gctcagtttt taagttcttt atttcaatat
     4381 ttattcttgc ttgctagggg tagttcctgt gtctgcatag cttagcagtc agccaatcat
     4441 ttggacaaag gttaagatca aacacttgag tctataagcc ttccacccac tgttggttgt
     4501 tctgtgtggg atgggggatg cattcattgt aggaggcagt tcccaaattc cccttggttt
     4561 ttacatttgc catgctctct tgagtctccc ctgtgcatgc atcatttcag tttgccaaag
     4621 atgtttggag agctcatgtt acccttttct gcccttctgt ttccaggacc ttgttaaatg
     4681 tctggctgct ctgttgctct tcaagaacta ggactgtaac ctttggttag caactacaga
     4741 tactccttgt ccattcctaa gtgatttttt tacttttgac ttacaaagtt gtaggtttat
     4801 acctctgctg taaatcaaga ctcctcttac ggcaaagttg ctagtttttc agttagctac
     4861 agccagacaa aactgtagtt tttaccaatc aacctagggg tgggtgagac ctcactcaag
     4921 gaggccacag attccaacag ttcttttcca aagctttagc aatatttttt ctttattttc
     4981 ttttttcttt tcttttcttt tttttttttt ttgaggcaga gtttcactct tgttgcctgg
     5041 gctggagtgc gatggtgtga tctcggctca ctgcaacctc cacctcccgg gttcaagcaa
     5101 ttctcctgcg tcagcctcct gagtagctgg gattacagtt gcttgccacc acgcctggct
     5161 agtttttgtg tttttagtag agacagattt tcaccatgtt ggccagggct gtctcgaatt
     5221 cctgacctca gggtgatcca cccacctcag cctcccaaag tgttgggatt acaggtgtga
     5281 gccactgtgc ccagcttaag tgtagccttt ctttgtctaa actgaaagcc catatggttc
     5341 agcaaaggct ctccattctg cttggtcaga gccacgtctg atttttgcca cctctgtact
     5401 ctgttcagct cataggcttc tgtcatgtct cagaattttg ctctgcacat ttgcagccta
     5461 ctgttcagcc aactgttcag ccaacttcta gggctataat ggctgataca gtagtcacaa
     5521 gttgtagcta tttaaaatta atttaaaata ttgtttctta cttgcatttg ccacatttca
     5581 agtgcttagt agcacatggt actggtggct accacattag atgtcacaga tacaagttgc
     5641 agaaagttct gttcttgggc acctcgtgca gatttctgga gctctttttc agtggagttt
     5701 ccacttctgt accctgcatc acaattcagt tttctcaaca gccctaaatt gtgatctttc
     5761 tgtgcccatt aagaccactg ttctttttga gcttaactct ctgtgtccag ttttggagag
     5821 tgcccccagg cataaaactg ggtgactatg gagttaattt catgtcttta aagaatcaca
     5881 gtcctgccta ctttgtcagg cagccctcat gctcatgaag ggtcttaaag aaagagactt
     5941 ctacccgggc atggtggctc atgcctgtaa tcccaacact ttgggaggct aagtcgggtg
     6001 gatcatgagg tcaggagttc gagaccagcc tggctaacat ggtgaaaccc cgtctctact
     6061 aaaatacaaa agttagccgg gcatgatggc aggtgcctgt aatcccagct actcagaggc
     6121 tgaggcagga gaattgcttg aacctgggag atgatggttg cagtgagcca agatcacgca
     6181 actgcactcc aggctgggca gccgagcaag actctgactc aaaaaaagaa aacaaaagaa
     6241 tcaccgtcct tcacttttgt ccaatgtctg catagagtta ccttttatct ttttctattt
     6301 taaagtttgt tggaggaggg caaatttgat acccattaat ccatcgtggg catcacccat
     6361 gagagttttt ttaatgattt ttctaatttt tattgttgga taggattcca cagtttgttg
     6421 tccatttact taccacatgg atgcatgtgt ctttaatttc ttccaatggt tacttacatc
     6481 tatgtaacta caatgcagaa aacaggaatt tggcaaggat acaatgcatg tgtatagttc
     6541 tatttcatca tatgtgtgaa tttgtgtaac tactgcaatc aacatagaac tgtttcatca
     6601 tcactaattt gttcttcatc tctgtaatat tgtcacttat atattgttgt agcaatggaa
     6661 taatatagtg tatgaccttt ggtttttctc actcagcata aagcccttaa gatcatccaa
     6721 gcagttatac ctatcaatag ctcatttctt ttttattgct aagtggtatt ctctagtatg
     6781 gatgactgta ccacaaataa agatgaagtg aacacttcct aca
//
