LOCUS       NM_001362481            6799 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens centromere protein C (CENPC), transcript variant 2,
            mRNA.
ACCESSION   NM_001362481 XM_006714064
VERSION     NM_001362481.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6799)
  AUTHORS   Tian,T., Chen,L., Dou,Z., Yang,Z., Gao,X., Yuan,X., Wang,C.,
            Liu,R., Shen,Z., Gui,P., Teng,M., Meng,X., Hill,D.L., Li,L.,
            Zhang,X., Liu,X., Sun,L., Zang,J. and Yao,X.
  TITLE     Structural insights into human CCAN complex assembled onto DNA
  JOURNAL   Cell Discov 8 (1), 90 (2022)
   PUBMED   36085283
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6799)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6799)
  AUTHORS   Nagpal,H. and Fierz,B.
  TITLE     The Elusive Structure of Centro-Chromatin: Molecular Order or
            Dynamic Heterogenetity?
  JOURNAL   J Mol Biol 433 (6), 166676 (2021)
   PUBMED   33065112
  REMARK    GeneRIF: The Elusive Structure of Centro-Chromatin: Molecular Order
            or Dynamic Heterogenetity?
            Review article
REFERENCE   4  (bases 1 to 6799)
  AUTHORS   Hoffmann,S., Izquierdo,H.M., Gamba,R., Chardon,F., Dumont,M.,
            Keizer,V., Herve,S., McNulty,S.M., Sullivan,B.A., Manel,N. and
            Fachinetti,D.
  TITLE     A genetic memory initiates the epigenetic loop necessary to
            preserve centromere position
  JOURNAL   EMBO J 39 (20), e105505 (2020)
   PUBMED   32945564
  REMARK    GeneRIF: A genetic memory initiates the epigenetic loop necessary
            to preserve centromere position.
REFERENCE   5  (bases 1 to 6799)
  AUTHORS   Watanabe,R., Hara,M., Okumura,E.I., Herve,S., Fachinetti,D.,
            Ariyoshi,M. and Fukagawa,T.
  TITLE     CDK1-mediated CENP-C phosphorylation modulates CENP-A binding and
            mitotic kinetochore localization
  JOURNAL   J Cell Biol 218 (12), 4042-4062 (2019)
   PUBMED   31676716
  REMARK    GeneRIF: CDK1-mediated CENP-C phosphorylation modulates CENP-A
            binding and mitotic kinetochore localization
REFERENCE   6  (bases 1 to 6799)
  AUTHORS   Xie,Y., Ni,Z.M., Gu,J.R., Wong,P., Wu,W.Q. and Xu,G.W.
  TITLE     Human chromosome pellicle antibody recognizing centromere protein-C
            (CENP-C), the main component of the kinetochore
  JOURNAL   Cell Res 7 (1), 13-19 (1997)
   PUBMED   9261558
REFERENCE   7  (bases 1 to 6799)
  AUTHORS   Pluta,A.F. and Earnshaw,W.C.
  TITLE     Specific interaction between human kinetochore protein CENP-C and a
            nucleolar transcriptional regulator
  JOURNAL   J Biol Chem 271 (31), 18767-18774 (1996)
   PUBMED   8702533
REFERENCE   8  (bases 1 to 6799)
  AUTHORS   Xie,Y. and Heng,H.H.
  TITLE     FISH mapping of centromere protein C (CENPC) on human chromosome
            4q31-->q21
  JOURNAL   Cytogenet Cell Genet 74 (3), 192-193 (1996)
   PUBMED   8941372
REFERENCE   9  (bases 1 to 6799)
  AUTHORS   McKay,S., Thomson,E. and Cooke,H.
  TITLE     Sequence homologies and linkage group conservation of the human and
            mouse Cenpc genes
  JOURNAL   Genomics 22 (1), 36-40 (1994)
   PUBMED   7959789
REFERENCE   10 (bases 1 to 6799)
  AUTHORS   Saitoh,H., Tomkiel,J., Cooke,C.A., Ratrie,H. 3rd, Maurer,M.,
            Rothfield,N.F. and Earnshaw,W.C.
  TITLE     CENP-C, an autoantigen in scleroderma, is a component of the human
            inner kinetochore plate
  JOURNAL   Cell 70 (1), 115-125 (1992)
   PUBMED   1339310
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC109356.3 and AC104806.3.
            
            On May 31, 2019 this sequence version replaced NM_001362481.1.
            
            Summary: Centromere protein C 1 is a centromere autoantigen and a
            component of the inner kinetochore plate. The protein is required
            for maintaining proper kinetochore size and a timely transition to
            anaphase. A putative pseudogene exists on chromosome 12. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region compared to variant 1. The encoded protein
            (isoform 2) is shorter compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.849260.1,
                                           SRR18074969.2158673.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AC109356.3         7606-7771           c
            167-213             AC109356.3         6417-6463           c
            214-284             AC109356.3         3248-3318           c
            285-379             AC109356.3         2108-2202           c
            380-479             AC104806.3         138860-138959       c
            480-765             AC104806.3         127262-127547       c
            766-978             AC104806.3         126201-126413       c
            979-1592            AC104806.3         122119-122732       c
            1593-1760           AC104806.3         120447-120614       c
            1761-2052           AC104806.3         116859-117150       c
            2053-2199           AC104806.3         114833-114979       c
            2200-2279           AC104806.3         113250-113329       c
            2280-2333           AC104806.3         103204-103257       c
            2334-2438           AC104806.3         101929-102033       c
            2439-2567           AC104806.3         100914-101042       c
            2568-2639           AC104806.3         100225-100296       c
            2640-2794           AC104806.3         98012-98166         c
            2795-2885           AC104806.3         82933-83023         c
            2886-6799           AC104806.3         76807-80720         c
FEATURES             Location/Qualifiers
     source          1..6799
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.2"
     gene            1..6799
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /note="centromere protein C"
                     /db_xref="GeneID:1060"
                     /db_xref="HGNC:HGNC:1854"
                     /db_xref="MIM:117141"
     exon            1..166
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..2956
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     centromere autoantigen C1; CENP-C 1; interphase centromere
                     complex protein 7; centromere protein C 1"
                     /codon_start=1
                     /product="centromere protein C isoform 2"
                     /protein_id="NP_001349410.1"
                     /db_xref="GeneID:1060"
                     /db_xref="HGNC:HGNC:1854"
                     /db_xref="MIM:117141"
                     /translation="MAASGLDHLKNGYRRRFCRPSRARDINTEQGQNVLEILQDCFEE
                     KSLANDFSTNSTKSVPNSTRKIKDTCIQSPSKECQKSHPKSVPVSSKKKEASLQFVVE
                     PSEATNRSVQAHEVHQKILATDVSSKNTPDSKKISSRNINDHHSEADEEFYLSVGSPS
                     VLLDAKTSVSQNVIPSSAQKRETYTFENSVNMLPSSTEVSVKTKKRLNFDDKVMLKKI
                     EIDNKVSDEEDKTSEGQERKPSGSSQNRIRDSEYEIQRQAKKSFSTLFLETVKRKSES
                     SPIVRHAATAPPHSCPPDDTKLIEDEFIIDESDQSFASRSWITIPRKAGSLKQRTISP
                     AESTALLQGRKSREKHHNILPKTLANDKHSHKPHPVETSQPSDKTVLDTSYALIGETV
                     NNYRSTKYEMYSKNAEKPSRSKRTIKQKQRRKFMAKPAEEQLDVGQSKDENIHTSHIT
                     QDEFQRNSDRNMEEHEEMGNDCVSKKQMPPVGSKKSSTRKDKEESKKKRFSSESKNKL
                     VPEEVTSTVTKSRRISRRPSDWWVVKSEESPVYSNSSVRNELPMHHNSSRKSTKKTNQ
                     SSKNIRKKTIPLKRQKTATKGNQRVQKFLNAEGSGGIVGHDEISRCSLSEPLESDEAD
                     LAKKKNLDCSRSTRSSKNEDNIMTAQNVPLKPQTSGYTCNIPTESNLDSGEHKTSVLE
                     ESGPSRLNNNYLMSGKNDVDDEEVHGSSDDSKQSKVIPKNRIHHKLVLPSNTPNVRRT
                     KRTRLKPLEYWRGERIDYQGRPSGGFVISGVLSPDTISSKRKAKENIGKVNKKSNKKR
                     ICLDNDERSIPLGDPLQPTRVKDPETREIILMDLVRPQDTYQFFVKHGELKVYKTLDT
                     PFFSTGKLILGPQEEKGKQHVGQDILVFYVNFGDLLCTLHETPYILSTGDSFYVPSGN
                     YYNIKNLRNEESVLLFTQIKR"
     exon            167..213
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            214..284
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            285..379
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            380..479
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            480..765
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            766..978
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1592
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1760
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..2052
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2199
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2279
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2333
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2438
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2567
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2639
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2794
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..2885
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..6799
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3058..3063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /note="hexamer: AATAAA"
     polyA_site      3079
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /note="major polyA site"
     regulatory      3263..3268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /note="hexamer: ATTAAA"
     polyA_site      3284
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /note="major polyA site"
     regulatory      6772..6777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
                     /note="hexamer: AATAAA"
     polyA_site      6799
                     /gene="CENPC"
                     /gene_synonym="CENP-C; CENPC1; hcp-4; MIF2"
ORIGIN      
        1 agctctcgcg gcagtcgcct gagacttaag gttattgctt ggccgcggcc tggtattccg
       61 gcgattcgtt tcttgctcgg cttcctggag ctgtggtccg tgtgggcttc cacctcagac
      121 agttgcgctg gctcagcggg gccggaacat ggctgcgtcc ggtctggatc atctcaaaaa
      181 tggctacaga agaagatttt gtcgaccttc cagggcacgt gacattaaca cagagcaagg
      241 ccagaatgtt ctggaaatct tacaagactg ttttgaagaa aaaagtcttg ccaatgattt
      301 tagtacaaat tctacaaaat cagtgcctaa ttcaacacgc aaaataaaag acacttgtat
      361 tcagtcacca agcaaagagt gccagaaatc acatccaaag tcagttccag tttcttcaaa
      421 gaagaaagaa gcctctctac agtttgttgt agaaccaagt gaagccacaa acagatcagt
      481 tcaggcccat gaagttcatc agaaaattct ggcaactgat gttagttcca aaaatacacc
      541 tgactcgaaa aaaatatcaa gtagaaacat aaatgatcat cacagtgaag ctgatgaaga
      601 attttactta tccgttggct caccttctgt tcttttggat gcaaaaacat ctgtatcaca
      661 aaatgttatt ccatctagtg cccaaaagag agagacttac acttttgaaa attcagtaaa
      721 tatgctgcct tcaagtacag aggtttcagt taaaaccaaa aaaaggttaa actttgatga
      781 taaagttatg ttaaagaaaa tagaaataga taataaagta tcagatgaag aggataaaac
      841 atcggaagga caagaaagaa aaccatcagg atcatctcag aatagaatac gagattcaga
      901 atatgaaatt caacgacaag ctaaaaaaag tttttcaaca ttgtttttag aaacagtaaa
      961 acgaaaaagt gaatccagtc ccattgttag gcatgcggca actgctccac ctcattcgtg
     1021 tcctcccgat gatacgaagt tgatagagga tgaatttata attgatgagt cggatcaaag
     1081 ttttgccagt agatcttgga ttacaatacc aagaaaggca gggtctctga aacaacgcac
     1141 aatatccccg gctgagagca ctgcactcct tcaaggtaga aagtcaagag aaaagcatca
     1201 taatatatta cctaagactt tggcaaatga caaacattcc cataaacctc acccagtaga
     1261 gacatctcag ccctctgata aaacagtact ggatacaagt tatgctttga taggtgaaac
     1321 agtaaataat tatagatcta caaaatatga aatgtattcc aagaatgcag aaaaaccatc
     1381 tagaagcaaa aggactataa aacaaaaaca gagaagaaaa ttcatggcta aaccagctga
     1441 agaacagctt gatgtgggac agtctaaaga tgaaaacata catacatcac atattaccca
     1501 agacgaattt caaagaaatt cagacagaaa tatggaagag catgaagaga tgggaaatga
     1561 ttgtgtttcc aaaaaacaga tgccacctgt gggaagcaag aaaagtagca ctagaaaaga
     1621 taaggaagaa tctaaaaaga agcgcttttc cagtgagtcc aagaacaaac ttgtacctga
     1681 agaagtgact tcaactgtca cgaaaagtcg aagaatttcc aggcgtccat ctgattggtg
     1741 ggtggtaaaa tcagaggaga gtcctgttta tagcaattct tcagtaagaa atgaattacc
     1801 aatgcatcac aatagtagcc gaaaatctac taagaaaaca aatcagtcat ctaagaatat
     1861 taggaaaaaa actattccac ttaaaaggca gaagacagca actaaaggca accaaagagt
     1921 acagaagttt ttaaatgctg aaggttctgg aggtatcgtt ggtcatgatg aaatttccag
     1981 atgttcgctg agtgagccat tggaaagtga tgaggcagac ttggctaaga agaaaaatct
     2041 tgattgttct agatctacaa gaagctcaaa gaatgaagat aacattatga ctgcacagaa
     2101 tgttccccta aagcctcaga ccagtggata tacatgtaat ataccaacag agtcaaactt
     2161 ggattctgga gagcataaga cttcagtttt agaggaaagt ggaccttcca ggctcaataa
     2221 taattattta atgtctggaa agaatgatgt ggatgatgag gaagttcatg gaagttcaga
     2281 tgactcaaaa caatctaaag tgataccaaa gaacagaatc catcacaaac tagtattgcc
     2341 ctccaacaca ccaaatgttc gcaggaccaa gagaacacgt ttgaaacctt tggagtactg
     2401 gcgaggagag cgaatagatt atcaaggaag gccatcagga ggattcgtga ttagtggagt
     2461 actatctcca gacacaatat cgtctaaaag gaaggcaaaa gaaaatattg gaaaagtcaa
     2521 caaaaaatct aataagaaaa ggatctgtct tgataacgat gaaagaagta tacctcttgg
     2581 agatcctttg cagccaacga gggtaaagga cccagaaaca agagagatta ttctcatgga
     2641 tcttgtaagg ccacaagata catatcaatt ttttgttaag catggtgagt tgaaggtata
     2701 caagacattg gatacaccct ttttttctac tgggaaattg atattaggac cacaagaaga
     2761 aaagggaaag cagcatgttg gccaggatat attggttttt tatgttaact ttggtgacct
     2821 tttgtgtact ttacatgaaa caccttatat attaagtact ggggattcgt tctatgttcc
     2881 ttcaggtaac tattataaca tcaaaaatct ccggaatgag gaaagtgttc ttctttttac
     2941 tcagataaaa agatgaaaga tcaaccaacc ttaaatatat gtatgtatat atgtatatgt
     3001 gaaaaacagt ttgtatagtt ggaatatttg tctttgtaat tacttgtgat gttttaaaat
     3061 aaaaatttta ttcagttttc tgtagacttg tatttgataa acatttctaa ctcacatgtt
     3121 ttttctgatt tttcagtgac tgtacataat agcttgtagc gatgtccata tttatgatat
     3181 tatttttata atttgacaag aatatgaaaa tgaaatatag aacatttctg tgtcaaaaga
     3241 gacctgatta atatgtctac tcattaaaaa acatcttttc caaatactaa ttttaaatca
     3301 tttattatta aataatccaa tgggagagaa ctgtggtaaa aggcatgttt gtattaattt
     3361 cctagaactg ctgtaacaaa ataccacaaa atgagtgact taaagcaaca gaaatttatt
     3421 atctcagttc tagaggctag aagtctgaaa tcaaggtgtt gtcaaggccg tgatgtcttt
     3481 gaaaacctgt aagggagaga atccttcctt attcctaact tctggtggtt tactggcaat
     3541 ttctggcatt ccttggcttg caccggtagc atttcaatct acttgcatta tcacatggta
     3601 ttctcacctt gtgtgtctgt gttggcatga catctattta gtatattaca tgtaaatgtt
     3661 tttccattat gctttttggt tcatattttc tgttggaggc agtgtccttc gccattgctt
     3721 tctgtatgtg gcctcaactt tcccttttta atatcaatca atacatctaa gctaaaaatt
     3781 ctaatcaagg tttttggtat ggttagcata taattctcat taactctgaa gaaattgatg
     3841 ttttacggta aaaatatttt taggccaact cccttttcag gtcttattta accattaaat
     3901 acacacattt aaagcaactc tggtgtagga cttaggaaga atgaagtgtg atggctcttt
     3961 ttttatactt tataattttc tattgtgatt tctcttttat tgagtcattt ttaatttttt
     4021 ttttactttt atttctttga atatatttgt tatgaagtct tattgaaggc ttgactaatc
     4081 aagtatctgg gcccatacag atttagtttt cactgaatgc tttttttcct ttagtatatt
     4141 tcactttcat atgtttttac atgtctaata atttttggtt gacagctgga cattttaggt
     4201 agcatattgt agcaactcaa ttttgtttta tatctaaggg atttgtattg ttttaaattt
     4261 agcattttga ctggactcaa attgtggaat ctatcttata tatgatgtga agttattgct
     4321 gtctgtgctc agtttttaag ttctttattt caatatttat tcttgcttgc taggggtagt
     4381 tcctgtgtct gcatagctta gcagtcagcc aatcatttgg acaaaggtta agatcaaaca
     4441 cttgagtcta taagccttcc acccactgtt ggttgttctg tgtgggatgg gggatgcatt
     4501 cattgtagga ggcagttccc aaattcccct tggtttttac atttgccatg ctctcttgag
     4561 tctcccctgt gcatgcatca tttcagtttg ccaaagatgt ttggagagct catgttaccc
     4621 ttttctgccc ttctgtttcc aggaccttgt taaatgtctg gctgctctgt tgctcttcaa
     4681 gaactaggac tgtaaccttt ggttagcaac tacagatact ccttgtccat tcctaagtga
     4741 tttttttact tttgacttac aaagttgtag gtttatacct ctgctgtaaa tcaagactcc
     4801 tcttacggca aagttgctag tttttcagtt agctacagcc agacaaaact gtagttttta
     4861 ccaatcaacc taggggtggg tgagacctca ctcaaggagg ccacagattc caacagttct
     4921 tttccaaagc tttagcaata ttttttcttt attttctttt ttcttttctt ttcttttttt
     4981 ttttttttga ggcagagttt cactcttgtt gcctgggctg gagtgcgatg gtgtgatctc
     5041 ggctcactgc aacctccacc tcccgggttc aagcaattct cctgcgtcag cctcctgagt
     5101 agctgggatt acagttgctt gccaccacgc ctggctagtt tttgtgtttt tagtagagac
     5161 agattttcac catgttggcc agggctgtct cgaattcctg acctcagggt gatccaccca
     5221 cctcagcctc ccaaagtgtt gggattacag gtgtgagcca ctgtgcccag cttaagtgta
     5281 gcctttcttt gtctaaactg aaagcccata tggttcagca aaggctctcc attctgcttg
     5341 gtcagagcca cgtctgattt ttgccacctc tgtactctgt tcagctcata ggcttctgtc
     5401 atgtctcaga attttgctct gcacatttgc agcctactgt tcagccaact gttcagccaa
     5461 cttctagggc tataatggct gatacagtag tcacaagttg tagctattta aaattaattt
     5521 aaaatattgt ttcttacttg catttgccac atttcaagtg cttagtagca catggtactg
     5581 gtggctacca cattagatgt cacagataca agttgcagaa agttctgttc ttgggcacct
     5641 cgtgcagatt tctggagctc tttttcagtg gagtttccac ttctgtaccc tgcatcacaa
     5701 ttcagttttc tcaacagccc taaattgtga tctttctgtg cccattaaga ccactgttct
     5761 ttttgagctt aactctctgt gtccagtttt ggagagtgcc cccaggcata aaactgggtg
     5821 actatggagt taatttcatg tctttaaaga atcacagtcc tgcctacttt gtcaggcagc
     5881 cctcatgctc atgaagggtc ttaaagaaag agacttctac ccgggcatgg tggctcatgc
     5941 ctgtaatccc aacactttgg gaggctaagt cgggtggatc atgaggtcag gagttcgaga
     6001 ccagcctggc taacatggtg aaaccccgtc tctactaaaa tacaaaagtt agccgggcat
     6061 gatggcaggt gcctgtaatc ccagctactc agaggctgag gcaggagaat tgcttgaacc
     6121 tgggagatga tggttgcagt gagccaagat cacgcaactg cactccaggc tgggcagccg
     6181 agcaagactc tgactcaaaa aaagaaaaca aaagaatcac cgtccttcac ttttgtccaa
     6241 tgtctgcata gagttacctt ttatcttttt ctattttaaa gtttgttgga ggagggcaaa
     6301 tttgataccc attaatccat cgtgggcatc acccatgaga gtttttttaa tgatttttct
     6361 aatttttatt gttggatagg attccacagt ttgttgtcca tttacttacc acatggatgc
     6421 atgtgtcttt aatttcttcc aatggttact tacatctatg taactacaat gcagaaaaca
     6481 ggaatttggc aaggatacaa tgcatgtgta tagttctatt tcatcatatg tgtgaatttg
     6541 tgtaactact gcaatcaaca tagaactgtt tcatcatcac taatttgttc ttcatctctg
     6601 taatattgtc acttatatat tgttgtagca atggaataat atagtgtatg acctttggtt
     6661 tttctcactc agcataaagc ccttaagatc atccaagcag ttatacctat caatagctca
     6721 tttctttttt attgctaagt ggtattctct agtatggatg actgtaccac aaataaagat
     6781 gaagtgaaca cttcctaca
//
